QwerkyScience - casual

@everyone welcome to the new channel. You can just talk like a human now. No science needed. Plz don’t be uptight. Try to show everyone how cool u r and prove that you deserve friends

3:16 PM

Refrain from excessive use of correct grammar

hola

1

How’s life

shit sucks rn tbh

1

3:18 PM

been feeling fatigue and ive been lightheaded for like a week and i cant fix it no matter what i try

:0

3:18 PM

Are you on any drugs

but ill get better hopefully

Adderall can do it

no ive quit all drugs in an attempt to fix it

Do you control ur electrolytes

been a very long time since ive taken adderal

Calcium?

yeah i do

3:19 PM

calcium maybe not

3:19 PM

maybe ill try supplementing it

3:20 PM

hope youre doing well

Calcium helped my light headed feeling very quickly

3:20 PM

I’m in suck too. My dad refused to co-sign loans or help with going to university

3:21 PM

I’m not sure if it’s an issue yet. I think something will work out

damn that sucks

3:21 PM

does he not have the money or hes just being a bit of an ass?

Hmmm. He probably doesn’t have the money. There’s no investment unless I backout though right?

3:27 PM

I didn’t talk to him, my grandma did. I think he opposes the idea of me going to uni though

I hope something will work out

4:14 PM

for both of you (edited)

4:14 PM

and that I won't be as toxic as chernobyl because of the fact that this channel exists

4:15 PM

wait, I already prolly was, I am and I will, I am just usually trying to hide it haha

4:15 PM

Hey

So... I feel like I am already dead. The only hope is reading studies, trying to figure out what to do in order to fix this shit. I am extremely tired, most of the time totally not-functional for years. There is not a single fucking positive emotion inside me. Blank mind, it makes everythimg creepy as fuck, alienates me from people and society in general. I hope that's enough for today

Enjoy. (edited)

5:31 PM

Now I realised I shouldn't use this channel at all after reading shit I've written above " You can just talk like a human now."

Lol

man getting high can be so weird sometimes, like my eyes go so red and i look way higher than i am

6:31 PM

i deffo need to stop, being with too many stoners causes a loopy distant cycle

6:32 PM

gonna be a last sess today and maybe a lot for a camping trip, but that's good

6:33 PM

remembering stuff is also strange, like when im fully high throughout a day ill need events to fully recall a situation the following day

"#casual" "Try to show everyone how cool u r and prove that you deserve friends" yeah thanks @qwerkyscience way to help ppl's confidence

2

woo i'm normal

11:43 PM

friends don't deserve me

you're the best normal

12:04 AM

no normal better than you

@Raisin-In-The-Rum For those who fail this process, they will be eliminated and banished from the server. This should serve as motivation to prove one’s normalness.

that's not really funny

@Raisin-In-The-Rum I don’t really expect ppl to be normal. I meant for this channel to be for more general chat. Because sometimes in the past ppl only chat about science. I’m just letting ppl know it’s freedom here

4:01 AM

Also I’ve been watching 3% on Netflix which involves “the process”

I'm having ADHD and bipolar disorder

7:13 AM

working at McDonalds for a part time job

7:13 AM

but damn this is too overwhelming for me, and they can't give me easy tasks

7:14 AM

I only take an anti depressant with anti anxiety pill and a memoplus and that's it.

7:14 AM

Getting tired fast, I need a part time job for students but hard to find with ADHD

Aw

McDonald’s sounds crappy

7:41 AM

I’m bipolar and adhd also

7:42 AM

I’m scared to work and be a student simultaneously. That’s literally the core issue I’m worrying about in life currently.

I was extremely afraid of workign

1:36 PM

any kind of novelty

1:36 PM

in each field of life

1:37 PM

extreme avoidant personality

1:37 PM

I don't feel like studying , like I was capable to do it

1:38 PM

so ye, it, 2:37 pm, I rook some benzo which doesn't really work

1:38 PM

at least it doesn't induce amnesia

1:38 PM

drinking wine

I avoid aversive novelty

hmm, you're maybe right, I can meet with new ppl, however if something reminds me of things associated with trauamtic stuff I've gone through and I am aversive and sometimes kinda paranoid, however I try to avoid such situations as meeting new ppl due to humiliating life situation I am stucked in (edited)

When I’m manic it’s the opposite of this. I tend to be far too open with new people. As if I’ve forgotten what even normal levels of risk are. I’ll break social norms like talking personally or almost intimately just casually to ppl. It doesn’t come off as weird to others. Actually I think ppl love this except I start to notice it’s way too open and then try to be careful. I think “omg what are you doing you don’t know this person even”.

8:51 PM

I think maybe it’s your families judgments at the core of your feeling

I can relate, tho in my case i think it’s cyclothymia rather than bipolar (amphetamine exacerbates it). Officially, i have adhd-pi and gad. I’m also drug dependent, which hasn’t caused any major issues before, but tmrw i’m travelling to uk to meet a girl and i don’t know how i’ll manage. Don’t want drugs to thwart this opportunity but it’s causing so much anxiety, and i’m scared i’ll hurt her by appearing distant and aloof, emotionally inept, flat, faceless (edited)

9:27 PM

I’ve tried to explain it to her, but she has bpd so she’s very delicate, and conditioned responses obscure her perspective (she thinks i’m fabricating excuses so that i can reject her)

totally relate. I think people love this cause they subcsoncsioussly want such kind of meaningful convos but yep... social norms.

12:49 PM

and family judgments, conditioning

warehouse jobs are less reliant on the social aspect of McDs, the roles are usually simple as well

5:49 PM

@qwerkyscience yeah ive recently been like that, but after you meet someone boundaries are so weird to get by, like if they don't mention something rly personal, should you? it's odd but there is that feeling you get of risking sharing something deeply and not receiving the same type of trust, i really don't know

5:49 PM

i need a best friend i reckon

I can’t work in the service sector. The amount of social interaction required would wear me out mentally, even with proper medication (edited)

5:52 PM

I’ve developed some new friendships the past two years. These are people that, just like me, exist in the social periphery

5:55 PM

I can put restrictions on my personality, play charades, but it leaves me hollow and feeling fraudulent. Merely enforces feelings of loneliness. So, i need friends that are openminded and naturally subversive

6:00 PM

Omw to the airport atm. Then off to london (: Anticipation anxiety is not as intense as i expected. I’m properly medicated tho lol (edited)

I have almost no anxiety

10:34 PM

along with numbness

That’s cool

3:49 AM

Unless your saying your numb

3:49 AM

Idk that’s ok too

i have a form of anxiety when im high

5:08 AM

but it's mostly due to thinking about other random shit, but simultaneously trying to keep myself in whatever conversation that's happening

5:09 AM

i still haven't found that balance, any tips lads

heh, it's not cool, well

7:23 PM

I remember when I was like 15~ I said to myself that I'd prefer not to feel anything than feel this anxiety all the time

7:23 PM

dreams came true

7:23 PM

...

Lmao

I feel sad for you honestly

who lol

6:28 AM

@Doc

Upside down ?

6:29 AM

I just don’t see why he wants no emotion

yeah sounds like a girl that's been hurt by dudes and pretends emotions don't really matter etc

6:34 AM

doc i haven't cried in a couple months what do u think

Lol from feeling sad?

need to be more in tune with my feels i reckon

6:34 AM

yeah

6:35 AM

i don't cry often, feel like im sorta suffering from cultures of masculinity around me

6:35 AM

at least i feel crying helps cope with my emotions more

If you dont feel sad thats fine but at some point gonna get hit with a alot of depression

but it doesn't happen and i feel weird about it sometimes

6:35 AM

yeah x

Also

6:36 AM

It very ok to feel sad it is society that suppresses male sadness under other shit

6:38 AM

I don’t know why but when i smoke how it comes out is in tears which feels good but i ain’t sad when it happens

6:38 AM

Have you ever had an ego death?

6:39 AM

@surajsoib

@Doc I didn't say I don't want emotions. I said I had such wish back in the days before I actually turned numb and becoming numb didn't have anything to do with my "wishful thinking" which took place 10 years earlier or so. your assumptions @surajsoib are based on pretty fked up stereotypes. (edited)

1

Oof got em now tho right?

@Mr Nobody u were destined to be a fucked up person then lol

could be

4:07 PM

I knew I should've done something with this hoe from Doelphi

What is destiny

6:01 PM

Is it a religion

it's some bullshit which some people want you to believe in

7:54 PM

so they can manipulate you

7:55 PM

7:58 PM

self fulfilling prophecy y know

7:58 PM

shit like this

7:58 PM

sounds wise, so I thought it'd be a good idea to pretend I am wise

been to pschologist also it was a place destined to TREAT ADDICTS (edited)

3:35 PM

she asked me if I am under influence of anything

3:36 PM

I sniffed 4f-mph before... but it didn't work... so I jumped into conclusion that I won't tell it cause it doesn't influence me, mentioned some herbs, bacopa, ginkgo, green tea etc, but she obviously doesn't consider them as a drugs (edited)

3:36 PM

also took diclazepam... it should knock the fuck out of me I think but I finally discovered why doesn't it happen, still gotta confirm

3:37 PM

whether diclazepam has any affinity on its own or MOST or all of his actions is reliant on metabolites- if the latter (edited)

3:37 PM

then green tea+ diclazepam= waste of powder (edited)

3:37 PM

due to CYP3A4 inhibition, knew DXM screwed it up for me due to the same reason in the past (edited)

3:38 PM

anyway this visit wasn't as weird as I expected lol

3:38 PM

she told me to visit their psychiatrist... i need to somehow make myself think of what theories I want to discuss with him, she knows I am not functional

3:40 PM

wondering if there's a chance for pidnolol/tianeptine/mirtazapine... but again I am afraid of downregulation so I'd prefer to avoid it (2a- mirta), also prazosin... (edited)

3:40 PM

what can be his reaction if I will be able to explain my suspicions to him

3:40 PM

telling him that sniffing cocaine, and other stims doesn't work at all for me

3:41 PM

Idk how to play it

3:41 PM

also how to make him not to think that I think I am more knowledgable than him (obviously I am not) (edited)

3:41 PM

whie telling such things at the same time

Could say caffeine doesn’t work like it used to or something

This doesn't look very normal

@Bigitalian69 What are genders?

10:44 PM

@zza Normal is defined as any behavior that exists in this channel

That's cheating

You got censored @Bigitalian69

Now your getting it yes! Yes you are censored @Bigitalian69

https://www.theguardian.com/science/2019/jul/03/group-of-biologists-tries-to-bury-the-idea-that-plants-are-conscious

Group of biologists tries to bury the idea that plants are conscious

Environmental crisis clouding scientific objectivity about plants’ feelings, says botanist

@zza ofc I am going there assuming that I HAVE TO LIE about some aspects of my existence

4:49 PM

I am not this stupid to tell the truth knowing how system works (edited)

4:49 PM

and being locked up in mental hospital and things like this

The only thing I am considering is whether it is worth trying talking with psychiatrist, telling him that I was taking SSRI, stopped, then got socially isolated for a year, after this period I wanted to try psychedelics and they haven't ever worked again therefore I suspect there is some issue with 5ht2a and would like to fix it due to the fact that it suppresses KOR with high probability and since I was deprived from my mother after birth plus experienced a lot of weird stuff leading to anxiety and even dissociation earlier in life, fucked up spatial memory, anhedonia, now even stimulants don't produce any pleasure and we know that each of these things is influenced by stress- like spatial memory, anhedonia, there's even study on rats about suppressant effect of 5ht2a on GABA release in rat's basolateral amygdala so it, doesn't calm it. Then we know hippocampus is being "shrunk" by stress which is also connected with spatial memory. There's lower binding of D2r in OCD. Lol. This all cannot be coincident. Like I'd believe if there was one factor which is connected with another one but for me personally it's too much.

5:03 PM

Then we know that maternal deprivation fucks up your glutamate/GABA balance by influencing respective ions transporters in the brain and it is too pernament

5:03 PM

what does it mean? Welcome neuroses, anxiety and later GABAergic addiction

5:04 PM

especially if this predisposition was just tip of a stress one experienced iceberg

I know couple of ppl who had early life like this

5:07 PM

I’m probably one of them

5:08 PM

I used to rock or like gently push my head into the pillow repetitively

I was hitting my head

5:08 PM

like harder I think

5:09 PM

but it was later

I did it through high school lmao

5:09 PM

Since birth

I was shaking etc

5:09 PM

couldn't sleep at nights due to anxiety

I started harder but went softer because I thought what if it causes brain damage

5:10 PM

Me too yeah that’s how I slept haha

and it lasted for the whole childhood with breaks

I’d move rhythmically to music

damn

5:10 PM

I even had some pain in the ass

5:10 PM

lmao

5:11 PM

sounds weird

5:11 PM

but it's actually medical issue (?) and is connected with stress

5:12 PM

and it happened repetitively during nights when I was going to school. Being woken up by incredible pain in my intestines? or idk how to call this part

Hmmm.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602260/

Proctalgia fugax

5:13 PM

o, it has its nice name lol

5:14 PM

well, could be coincidence cause they mention other factors

5:14 PM

and I may fall into confirmation bias according this one

I think I had this when I sublingualed cytisine

5:15 PM

Which I think is dangerous to do

5:16 PM

Sometimes if I sublingual tianeptine too I think

5:16 PM

I would be rapidly crippled with horrible pain

5:16 PM

And start like bending my body lol

Hmm

5:17 PM

checking moa of cytisine

Cholinergic like nicotine

had a thought that it might be some increased blood pressure

5:17 PM

and this blood pressure there causes pain

5:17 PM

but well, gut is full of neurons

I thought for me it’s like the drug is forcing stomach contracting

5:18 PM

Or all the muscle to squeeze

I was doing it always

5:18 PM

clenching fists, each muscle of my body

5:19 PM

but it wasn't ever drug induced thing

5:19 PM

just some reaction to stress

Hmm. I used to have some weird body things but I think after eating healthy maybe not as much

5:19 PM

Sometimes like twitching seizure type stuff happened

for me it was definately connected with stress

5:20 PM

I was like epileptic sometimes

5:20 PM

everything was fucking shaking

5:21 PM

then first time in hi-school before some tests

5:21 PM

being stressed af, during the night, couldn't fall asleep

5:21 PM

I dissociated and it was like weird contrast to the whole shit that I experienced haha

5:21 PM

everything looking so unfamiliar, like in some fairy tale

I used to like those kind of effects

ye

5:23 PM

ofc

5:23 PM

it was like natural anti anxiety pill

Noopept induced stuff like that sometimes

5:24 PM

Weed very much too

never happened to me under drugs influence

For me, weed has been one of the craziest drugs I’ve ever experienced

for me paranoia inducer

5:27 PM

nothing else really

5:27 PM

psychedelics were something beautiful, unique and I miss em so much

I wonder if you just go straight to dmt

well, would love to

5:32 PM

hard to accomplish here

5:32 PM

and given my situation especially

5:33 PM

well, prolly DNM

5:33 PM

lol

5:33 PM

so not this hard

5:34 PM

but generally idk if it's worth it

5:34 PM

if I tried like 10 different psychedelics

5:34 PM

without any effect

5:34 PM

if not more

5:34 PM

well, there was some effect

If you maxed the dose of dmt out I think you’d get the breakthrough

slight OEVs, not moving, dancing at all

And maybe it would have some after effects

no psychedelia

5:35 PM

just extreme sadness

5:35 PM

last time I can remember

Woah

5:35 PM

I’ve had sadness on them a few times

ye, it's normal

5:36 PM

but it was weird

5:36 PM

anyway it induced some introspection and self-compassiuon

5:36 PM

and I cried for the first time for a long, long time, back then

5:37 PM

not sure whether it was the effect of psychedelic itself, or realization that there's something fucked up inside my brain

5:38 PM

for sure I jumped into conclusion that I am fucked up, trapped

5:38 PM

and I see no way out

I think so much of your feeling is about the diminishing possibilities you view in your life

ye, I already wasted my whole adolescence

Like maybe you think the future will be more endlessly predictable and unwell

5:41 PM

Age is all nonsense to me

like years 18-26

5:41 PM

but experience and memories aren't

I’ve been judged by age

5:42 PM

You should set up goals

yep, I think it will be unwell

It doesn’t have to be. If you want out there will probably be ways but it will require full investment of yourself

like if it was for the past let's say 8 - extremely

5:42 PM

or 7

5:42 PM

idk where to dig atm

What do you want? What do you not want? Besides bodily feels

basically society offers me 2 options

5:43 PM

psychologist

5:43 PM

psychiatrists

5:43 PM

I want to be healthy

5:43 PM

learn

5:43 PM

be able to feel something

You think you can escape where u love to a new country?

5:43 PM

Live

be able to get lost in something that interests me

5:44 PM

instead of being interested "mentally"

5:44 PM

like I know I'd be studying what I am trying to study if I was healthy

5:44 PM

hmm

5:44 PM

afraid due to memory issues

5:44 PM

means not on my own

5:44 PM

tried to move to friend

5:45 PM

he was trying to get me job there but it didn't work out so far

5:45 PM

and tbh I hate being around people irl

5:45 PM

internet is different

5:45 PM

here I can tell this shit

5:45 PM

irl people react differently most of the time and tell me "ah, ur jsut lazy fuck"

5:46 PM

or something like this

5:46 PM

so I try to keep in touch with people who had simmilar experiences and/or had simmilar interests

You gotta go to California man

5:46 PM

Lol

lol

5:47 PM

in poland

My grandma is open to me talking about lsd

I am a fucking junkie, I should be locked up in some detox facility

5:47 PM

sic

5:47 PM

hippie movement was strong in cali?

5:48 PM

back in the 80's (it was 80's?)

It depends what drugs u do here. Meth and heroin are stigmatized. Not cocaine much. None of the psychedelics.

5:48 PM

I know official chocolate stores that secretly sell shroom infused chocolate

5:48 PM

Hippy culture yeah. Lots of activism. Vegans. Liberalism.

I'd like to experiment with opio

Opioids are probably stigmatized here

5:49 PM

Maybe depends which ones

5:49 PM

People don’t really care but they will think it’s a bad choice

5:49 PM

They will try to convince you do use weed

I wonder if mor agonism would make me responsive to stims

I think they have synergetic effect but in my experience I got tics and ocd like stuff. Not mental ocd but habitual compulsive behaviors

5:50 PM

As if it programmed me to uncontrollably move

hmm

5:51 PM

well, MU and dopamine receptors are influencing each other

Yeah. For Pavlovian conditioning

only?

Idk

or simply dopamine release/reuptake blockade and hitting some postsynaptics

5:52 PM

activates MOR

5:52 PM

therefore- euphoria

I think when both bind, mu and d1 the dopamine release and glutamate effect is enhanced

and in the opposite way too

5:53 PM

hmm

5:53 PM

that's why NMDAr antagonists are anti-addictive maybe

5:54 PM

hmm, how I interpreted ur article it happens for habit formation, but not necessarily bad habits formation

5:55 PM

like normal, healthy habits like learning, going to job too

5:56 PM

hmm, well I suppose u have especially this on ur mind

It seems to be any habits like even reaching for a door to open

5:58 PM

Then what if you keep reaching over and over and looping

ah

For me it was like I would look over my shoulder and keep looking again and again

5:58 PM

Compulsively like I had to remember to maintain control

but it applies to some low dopamine levels

5:58 PM

near baseline

5:59 PM

later D2 is more stimulated?

Lack of D2

right?

5:59 PM

or ye, lack of D2 is an issue

5:59 PM

then dopamine has no choice

D2 maybe frees the compulsions

and binds to D1

Yea

otherwise if it increased it'd bind to D2

6:00 PM

and will increase motivation would allow one to exit this "pavlovian prison"

6:00 PM

and person would evolve via exploration

6:00 PM

and yep

Become conscious

here we go to fucking KOR and D2 hypofunction

6:00 PM

stress

6:00 PM

OCD- D2 hypofunction

6:00 PM

DRD4 polymorphism?

6:00 PM

it's fucked up

KOR enhances D2 but I think commonly it can result in later tolerance. But I think with KOR it’s that state of mind of dissociation and it’s like being more conscious but unable to access memories and being biased to fears and negative stuff

yep

It’s almost like an opposite to psychedelia

I was thinking about it recently

6:01 PM

since it makes sense

6:02 PM

that stress creates aversion at the beginning

6:02 PM

pfff

6:02 PM

not at the beginning

6:02 PM

later

6:02 PM

opposite

6:02 PM

in the beginning it motivates u to get out of the shit u found urself in

6:02 PM

so it enhances D2

6:02 PM

that was my way of thinking

6:03 PM

as a result of constant stress, constant KOR activation D2 downregulates, and that's when aversion is created

6:03 PM

it was mentioned that KOR activation icnreases some "euphoric effects" of drugs

6:03 PM

or something like this

6:03 PM

ie sensetizes to them

6:04 PM

which would make sense- person is experiencing pain, pain killers aka drugs is what body wants you to do theoretically

6:04 PM

but well, it's short term solution... later it has to downregulate D2 and create aversion, cause it doesn't work obviously...

6:04 PM

I think it has such a biphasic effect

6:05 PM

depends what kind of stress it is

6:05 PM

and the same analogy can be found in adrenergic system

6:06 PM

aka activation of alpha-1 during non-stressful situations (but it's based only on conclusion that alpha-1 is necessary for stims to work) but it is destructive long term

6:06 PM

therefore suicide victims have lower alpha-1 binding

6:06 PM

and it is overlap with anhedonia

6:07 PM

like whole body is being chased by the tiger

6:07 PM

so heart has to do its job twice as much, muscles, brain etc (edited)

6:08 PM

later it gets fucked up and things like anhedonia and issues with energy etc are being developed

6:08 PM

so downregulated alpha-1a despite it's theoreticallly "negative" impact during stress

6:08 PM

is a bad thing

6:09 PM

idk how thing looks like with alpha-2 and forgot whole heteromers, would have to check

6:10 PM

anyway hope we will continue this convo later, cause u always add something I don't know or u tell me where I say total bullshit

6:10 PM

what's highly appreciated

6:10 PM

now gtg, take care

6:11 PM

lol, u told exactly the same thing regarding D2... @qwerkyscience

fookinghell

same

9:44 PM

well, need to get the fuck out of here

9:44 PM

to another country to make for living and to treat myself somehow

1

9:44 PM

cause I am living in extremely toxic enviroment with people I hate

9:45 PM

who expect that I will ever shut the fuck up and accept their lies as if they were truth

9:46 PM

which is like a good example of family nexus thing

9:46 PM

they blame me for being addict

Pffttt conservatives

9:47 PM

I’m jk

ye, but the only problem is fucking anhedonia, spatial memory, suicidal thoughts

9:47 PM

lol

If you can escape the nexus, you will probably be free of those symptoms

escape like realizing that they are just protecting their pov

I bet I’m stuck in some now that I’m not conscious of

to save their psyche

I mean escaping their influence

ye

9:48 PM

that's the problem I don't feel like I am

9:49 PM

I was hoping to move to germany to friend to work

It’s hard. Escaping influence is super hard

it's not an issue

9:49 PM

I just cannot leave country alone

9:49 PM

without knowing anyone I trust

Hmm what skills do you have

0

Lol

9:50 PM

Can you drive

no driving license

9:50 PM

just english, which could count

9:51 PM

I went to hi-school and wanted to go to uni

9:51 PM

but life got fucked up in-between

Mine sort of was fucked up. I was extremely cautious to control my nexus tho

9:51 PM

It still negatively influenced me

9:51 PM

But I never expressed anger for example

wdym?

9:51 PM

how can u control it?

9:52 PM

now I did

Getting mad makes everyone turn against you

Idk what's worse

They think it’s justified to hate u

self-supression is fucking destructive as well

It can be yeah

each time I do it I dissociate

Yeah. Anhedonia seems related to it too

and self harm

It depends. I have to express happiness and like I’m showing all my efforts

so when I feel anger and urge to tell them something

9:53 PM

I do it

9:53 PM

hmm

9:53 PM

wdym?

Hard to explain there.

I was just called a junkie and told to kill myself

9:53 PM

lol

it was actually funny

9:54 PM

in some fked up way

You can learn to code

Hmm, that's an option

9:55 PM

but I'd just want to feel like a human

9:55 PM

I have no motivation, anhedonia, no spatial memory, I even don't want ot accept living like this

The ppl you are surrounded by seem deeply uneducated

yep, they're stupid af

9:55 PM

and ignorant

9:56 PM

they just don't want to find out anything which might destroy their belief system

9:56 PM

so I am junkie

9:56 PM

I am guilty because of it

9:56 PM

being abused in the childhood has nothing to do with it

9:56 PM

and it's my way to "justify" my laziness

9:57 PM

and there's nothing wrong with me

9:57 PM

I just need job

9:57 PM

that's basically my family's way of thinking

9:58 PM

sometimes there are days when I am able to talk with mother, idk why I still do it tho, and on these days she seems to realize that uh, well, things didn't happen without a reason

9:58 PM

but only when she doesn't realize she played a role in it

Yeah. The dissonance

then it's like she denies it, cannot stand it, I think self-defense mechanism

That’s how veganism is too lmao

which I get

Did it trigger u just now

9:59 PM

I’m jk

9:59 PM

Lol

what had to trigger me?

9:59 PM

haha

But yes. I think the dissonance. Because if it’s her fault then she must fight you and justify herself

well, the only thing I want is helping myself

10:01 PM

nothing else, if I was not feeling like this, I'd cut off the contact completely

10:01 PM

but 1) I am restrircted by law in trying things I think might be helpful

10:01 PM

2) I have difficulties spending time with ppl

10:02 PM

3) everything is fucking boring

10:02 PM

4) I am like this classic 12yo depressed girl thinking about razors

10:02 PM

well it is metaphor

10:02 PM

but ye

10:02 PM

let's not take it seriously like I am some whiny complaining bitch

Yeah haha

10:03 PM

What if you try internet stuff

wdym?

10:03 PM

atm I am trying to upregulate AMPAr

That’s sort of what I was doing about the blogging

and forskolin seems to upregulate NMDAr via cAMP interactions

10:03 PM

ahhhh

It’s sometimes stressful and took a while to get here

but u mean

10:03 PM

like

10:03 PM

becoming a blogger?

Sure or YouTuber or something

I was thinking about this

10:05 PM

but idk what to write about and my cognitive functioning is like 0

10:05 PM

that's generally good idea, I was thinking about writing a boook back in the days

10:05 PM

but it was only when I felt great

10:06 PM

cause it's quite possible to figure something totally out of air while having some base knowledge about something plus experiencing this thing on ur own

10:06 PM

or it's just result of self-awareness

10:06 PM

lol

Make a blog about chapters of your story

and anyway while even planning such things I think many of the things I'd want to write about would be something u already figured out

My cognitive function isn’t always good

10:09 PM

You can write about OCD related stuff. This I will probably not post about

well hmm

My cognition is worse today for example

10:10 PM

I tried to write but I’m too disorganized

I need to be totally sober from benzo

10:10 PM

to see if my OCD doesn't come back haha

Did you take bacopa

took it all the time along with benzos

10:11 PM

anyway thte lsat few weeks I couldn't get thigh on benzo

Bacopa should cure the withdrawals of benzos

due to DXM first, then green tea

10:11 PM

I wanna confirm it at first

Woah

10:11 PM

Dxm does reduce gaba yes

whether it was the cause

10:11 PM

nope

10:11 PM

enzymes

10:11 PM

I had enzymes on my mind

Oooo it also reduces gaba too tho

source on it?

10:12 PM

hmm

10:13 PM

I thought it reduces benzo/alc tolerance via another mechanism

10:13 PM

wait, u prolly have nAChr downstream on ur mind

10:13 PM

I totally forgot how nAChr antagonism affects GABA but it does it for sure

https://www.ncbi.nlm.nih.gov/m/pubmed/10526144/

NMDA receptor-mediated control of GABA release from neurointermedi...

Brain Res. 1999 Sep 25;842(2):469-72. Research Support, Non-U.S. Gov't

https://www.ncbi.nlm.nih.gov/pubmed/20140217

Lack of nAChR activity depresses cochlear maturation and up-regula...

PLoS One. 2010 Feb 4;5(2):e9058. doi: 10.1371/journal.pone.0009058. Research Support, N.I.H., Extramural

https://www.ncbi.nlm.nih.gov/m/pubmed/8120631/

NMDA receptor antagonists decrease GABA outflow from the septum an...

J Neurosci. 1994 Mar;14(3 Pt 1):1358-65. Research Support, Non-U.S. Gov't

yeeeeeeeeeee

10:24 PM

tru, thanks

(edited)

10:24 PM

I was reading it like year ago

10:25 PM

trying to figure out if my NMDAr antagonists induced psychosis fucked me up

10:25 PM

or not haha

10:25 PM

Hmm, the question is whether NMDAr downregulates in response to GABA receptors downregulation? (edited)

10:25 PM

or totally opposite?

10:26 PM

well, I think the latter one

10:26 PM

also fi NMDAr antagonists upregulate in response to antagonism lmao

10:26 PM

never found info on this one

so... I think it might be generally good way to take some NMDAr antagonists while taking breaks from benzos if one is forced to do so

10:34 PM

or is alcoholic etc

10:34 PM

same goes for bacopa

10:35 PM

but with bacopa there was a study that it even is able to potentiate benzo? And upregulation occurs through some weird mechanism plus reversal of enzymes alterations (GAD and prolly something else?)

10:37 PM

anyway DXM could inhibit benzos due to reducing GABA, or by enzyme interaction thus not allowing drug to be metabolized into active metabolite cause I think diclazepam is inactive on its own and diazepam's metabolites are the ones responsible for its action

10:37 PM

now the same shit happens with green tea I think lol, when I am no longer taking DXM

10:38 PM

kurwa, ale rozkminka

It might potentiate for unrelated reasons

I mean because of something like dopamine idk

11:34 PM

Or the enzymes I mean yeah

11:40 PM

Unrelated to NMDAr antagonism* sorry I’m so unclear at the moment

np

Omfg

3:37 PM

I think I have taken 450mg of diclazepam during 2 months

3:38 PM

most of the time I thought it didn't work what I think was true due to DXM/green tea/bacopa interactions (edited)

3:38 PM

but sometimes I just overdosed and was pretty sure next day when I woke up that it didn't work neither

3:38 PM

so I didn't give a fuck

3:39 PM

I hope they cheated on me regarding the amount of powder in the zip-bag

3:39 PM

cause this number terrifies me

what might be wrong with me if I sleep for 16h sober, eat something, and fall asleep again for another 2h? (edited)

Hmmm I’m not sure. Maybe gut microbiole is too much gaba

4:47 PM

Do you ever have probiotics

been just eating sauerkraut

10:25 PM

for quite a long time

10:25 PM

stopped few months ago, started again

10:26 PM

I wonder if chamomile could put me to sleep for so long lol

Oooooo yeaaaa I get so sleepy on saurkraut

What kind of content should I make?

hmm

4:29 AM

never noticed such an effect and I've been eating like 300g per day for over a year

4:30 AM

then gave up, and now trying to implement some healthy habits once again...

@Ariadne your thoughts in life maybe. Combined with your art as transitions or background things. I’d be down to collab too on some stuff

8:58 AM

I got sleepy effects when I took it. Maybe the brand? I think it contains gaba and glutamate @Mr Nobody (edited)

Do you still do trippy visuals?

My latest song and visual thing was this https://youtu.be/BInUWNOI4eE

Qwerky Science

The Eternal Breathe Of A Tree

9:01 AM

It’s been quite a bit though. I’ve mostly done photography because I have less time lately. Focusing on writing articles and figuring out school and stuff like that

9:01 AM

Do you have Instagram?

Technically, but I rarely use it I've been looking at it more since I got a phone that had it preinstalled

Pre installed wow. It’s fun to do art and media.

3:12 PM

idk

8:04 PM

gaba doesn't cross BBB

8:04 PM

anyway

8:04 PM

or barely crosses it iirc, reading some study that it isn't so black and white

I think it still has effects tho

2:08 AM

Couldn’t it peripherally later things that do cross the blood brain barrier?

ye, I think it just looks like it on paper

3:00 AM

but people kept telling that GABA or picamilon works for them

3:01 AM

also who knows what else these bacteria alter. IIRC BDNF (edited)

3:01 AM

and prolly many other things

3:03 AM

I seem to pass out after meals generally

3:03 AM

or it's this chamomile tea... wtf

Does glutamate cross bbb

4:52 PM

Or monoamine

4:53 PM

Wouldn’t gaba alter monoamine? Maybe that would mimic MAO and cause depression and anxiety contrary to the intended effect of gaba lol which I’ve actually heard!

fucking just came back from psychiatrist

9:33 PM

and got prescribed lamotrygine

9:33 PM

and I'm wondering if it can be useful

9:33 PM

lmao

9:35 PM

if it blocks Na2+ channels then it will reduce action potentials and will lower glutamate, therefore allow AMPAr, NMDAr upregulation?

9:35 PM

I am not sure, just looking at the simplest explaination of its MOA from wiki and my memory lmao (edited)

ah, it fits here. Slept for 14,5h and I am still sleepy

12:14 PM

what the fuck

I wanted to try lamictal

I will give it a try

https://www.youtube.com/watch?v=y4aHEqEJ8Ys

Jordan Turnbull

Psychedelic Breathing - Wim Hof, Stanislav Grof, DMT

there was also a book about getting rid of birth trauma via breathing exercises

12:16 AM

in water

12:17 AM

cannot recall the title

12:18 AM

Leonard Orr's one

Chamomile is nice tho. Apigenin is enticing

2:34 AM

Sirt1 activator (through nad+ increase)

2:37 AM

Hdac inhibitor too if i recall correctly

yep, also SNDRE

Enhancer? How omg but that’s probably bad haha

well, it is weak tho lmao

posted in studies

why do u think it's a bad idea?

9:16 PM

well, I realize it won't be pleasurable

9:20 PM

it might be the way to sensetize dopaminergic system... reduce ach... via suppression of D1... anyway taking DXM, so it will neutralize SNRI effects of DXM to some extent or totally, I will be left with sigma agonism which I don't understand fully, nAChr antagonism which will reduce monoamine release further but they will get sensetized and that's what I want to achieve lmao

9:21 PM

and NMDAr antagonism, well... plus suppression of glutamate release by lamotrigine (edited)

9:21 PM

sounds like I will be a total zombie

9:21 PM

not that I am not zombie when I don't take anything

9:26 PM

DXM with lamictal is cardiotoxic tho

Woah that’s weird

4:49 PM

Why

4:49 PM

Messes up calcium?

sorry, I messed it up with stimulants

7:43 PM

prolly

7:48 PM

anyway need to check source cause it makes logically no sense if I get it correctly

7:52 PM

DXM with lamictal sounds good... for me

I just noticed most of the channels are gone

8:07 PM

Has anyone experienced marijuana contact high? It's a weird kind of placebo effect

yes

I've noticed it affecting people that I talk to even on voice chat

In the newest video I talk about contact highs

2:03 PM

You can even listen to a recording of your high voice and it works. It’s social contagion

Interesting

my eyes flickered whilst i was high the other day

5:40 AM

sometimes it takes me out of my self like it came natural and similar things happen

@Theo Riginal you say everyone reacts differently to the same drugs in the debate involving MOR/KOR topic. That is only kind of true. Heroin reliably kills people in the same ways over and over. It stops breathing. Heroin also makes a lot of people nod out. People have stereotyped the effects of heroin into memes. The way you argue sounds like maybe some people on heroin react actually completely different. I think one could act more energized on heroin but even when they are energetic their muscles might be acting similar to the lazy person. I think this is very contextual too. Someone who continuously suffers might get lazy as if they have a moment to finally relax. But someone who lives some fast paced life maybe would just feel good and keep moving about. I don’t think it’s truly about the drug reacting different based on chemistry even. I mean technically everything is chemistry even the contexts that alter us based on incoming light waves in which their shapes signal brain chemistry alterations based on learned patterns of sensory stimuli. I think combining drugs is what taking a drug is like. Everyday situations are intoxicating us and interacting with the chemicals we ingest. Our diet as well. This makes drugs less predictable but it’s also not honest to view drugs as completely unpredictable. When you say bottom up, I feel there are neuro studies involving KOR that actually do attempt working on this level. They check for behaviors that correlate to KOR stimulation and attempt to generalize it. That doesn’t mean the KOR is entirely responsible for the behavior alone but it still means a lot.

1:47 PM

I also think weed is not one of the more safe drugs for mental health necessarily

I did not say such, please dont interprete more into what I actually said. I did say people react different to various drugs and that doesn't mean some drugs are bad for all of us. In fact most drugs are having more bad effects than good ones.

1:48 PM

That's why I suggest you drop the entire MOR/KOR LH, and whatever other chemicals you heard about and focus on psychology first.

I would say opioids have mostly good effects except if people abuse them in high doses

1:48 PM

I write about both

Very dangerous to say

1:49 PM

unscientific aswell

How do

1:49 PM

So

No psychoactive substance is mostly having good effects for anybody

Do you only know me from in here? Have you read my posts?

1:50 PM

As far as I can tell opioids don’t really negatively impact the body tho except in high doses like nodding out doses

I've read many posts and you seem to be also a bit DIY psychiatry approach following with lack of psychological background first

Have you read the purely psychological posts

There are people who trip badly on a simple joint, others never come back from LSD trips, you cant make such generalizing positive statements about psychotropic substances

Like AntiNarcissism

1:52 PM

You are mischaracterizing me

I've read the Narcisism article, yes Nice hypothesis but not scientific theory either

Weed is definitely psychotic more than most drugs

1:53 PM

Never coming back from LSD trip? Seems to go against science lol

I love your enthusiasm and auto didaction but you need to study much deeper to get to chemistry and also psychotherapy first

Where are you getting that from even

>> qwerkyscienceDziś o 14:48 I would say opioids have mostly good effects except if people abuse them in high doses I write about both >>Theo RiginalDziś o 14:49 Very dangerous to say unscientific aswell How is it unscientific?

If not opiates you wouldn't prolly be living the life u're living. Edit: I tell about endogenous ones. (edited)

I think you are doing what you accuse me of also

I've studied 2 years psychology, have 2 doctor parents one with psychiatry specialisation and worked in mental hospitals

That’s good

I know many friends and patients that were longterm changed by drug usage

Yes that happens

1:55 PM

Especially on strong doses of drugs

1:55 PM

Taxi driving also restructures the brain

Better to learn and work with psychology first and then eventually if psychology says here you need psychiatry you might dive into chemistry, but that's such a risky trial&error field even for the best professionals that every good psychologist warns you of drug usage and self prescription (edited)

I have been studying psychology, that is my official major

and what psychologists know about drugs

1:56 PM

and brain chemistry?

1:57 PM

generally speaking? I am aware that there exist people that are really knowledgable in both of these fields

1:57 PM

but it's kinda rare

A hell lot of, but they also learned to treat patients without adding external drugs but therapy to balance the own endo-cannabinoid systems

Exercise should fix endocannibinoid problems

I can show you what we had to learn, it's huge into physiology, neurology and biochemistry

Omega 3

CB1 antagonists (edited)

lol that's another too generalized statement, but exercise can help certainly

1:58 PM

and they throw a few chemical names in again

But that’s what you are doing

1:59 PM

Why are you blind to yourself

1:59 PM

Do you have a bachelors in psychology also?

1:59 PM

Or an associates?

no, I'm not. I'm suggesting strongly to stop throwing around with chemical terms and studies about them and first learn neurology and psychology and approaches without drug addition!

How to fix opioid system?

I have read a lot about psychology though

I'd love to reverse changes that occured in my childhood in my opioid system.

Sky diving

They say that stress alters GABA function aka makes u less sensitive to endogenous GABA so you're simply becoming an alcoholic/benzo abuser. How to fix it?

Extremely hot chili’s

2:01 PM

Lol I’m jk idk

It was question to @Theo Riginal (edited)

2:02 PM

but ye, I wish I knew such ways

2:02 PM

source on exercise and endocanabinoid system? I will find it while searching through ur research ?

you treat your body completely false if you go this chemical route. Dont listen to what "they say", do therapy

Theo you are tending to accuse of behaviors that you are exhibiting yourself. You brought up endocannibinoids and I’m not sure why. Then when I responded about how exercise and omega 3 hoping you’d maybe see non drug intervention you are upset again lol but why do you even bring up the cannibinoid system

GImme single research about decreasing KOR responsiveness in response to any form of therapy @Theo Riginal in people previously shown to have it upregulated with history of trauma

Theo is saying to ignore KOR entirely

great

2:05 PM

approach

2:06 PM

who cares about some KOR, it is useless and has no effect. CBT will prolly downregulate it.

you brought that up: "If not opiates you wouldn't prolly be living the life u're living. Edit: I tell about endogenous ones." to make that distinction clear that you have own endogenous brain-chemistry and you guys seem to think it's a good idea to introduce additional chemicals before trying psychological treatment

Ok, it was mean a lil' bit but it wasn't the point.

2:07 PM

Do you understand that reward system is basically changed into punishment system when ur severely traumatised?

I say ignore your chemical knowledge entirely, it's dangerous and not scientific. Do the right scientific approach and carefully learn about neuro sciences and psychotherapy first before fiddling with hardware not even the best professionals really understand yet.

so some people simply don't respond to endorphins as you do

2:07 PM

they cannot feel pleasure and motivation to do things at all

2:07 PM

they're living like zombies

2:08 PM

I'd say ignore the bullshit they're trying to tell you that psychology is able to fix everything unless there's an actual proove such things happen in the brain

2:08 PM

otherwise it's more an approach "do it, we don't have anything to back up its efficacy, but still, seems safer than taking some psychoactive substances, cause they will FOR SURE make things worse"

We all have constant punishment and enforcements. We feel shame, or anger, frustration, hate ourselves, sometimes we have success experiences and it gives us an uplift. We tend to fool ourselves and bring us down because we have anxiety and bad coping mechanisms

2:09 PM

I did never say it can fix everything

well, the balance between them is what I meant

2:09 PM

you seem to be completely not aware that such problems exist

Being trapped in stigmas is constant punishment

look for stories of how heroin addict's life history looked life

2:10 PM

you will most likely find a lot of useful info which might somehow change ur pov

I clearly said there's a place for psychiatry (drugs) but it's totally exaggerated and no one here of us has even the remote knowledge how to apply neuro pharma. Way better to go the proper scientific approach where every science must be empirically verifiable and consistent with eachother, not trial&error chemistry with your personality

2:11 PM

I've been raised in heroin addicts hospital, my mom was the doc there

and? What did u find out about em?

2:11 PM

Why did they start taking drugs?

we went to all kinds of activities, some made it out with great struglle, others didn't make it, gave up or killed themselves.

2:12 PM

Everybody takes drugs to get a better feeling

BETTER

2:12 PM

u falsely assume some people are already feeling GOOD

But heroin is going to make your life a lot more hell in the long run

2:12 PM

I dont

no, they don't

better can also start from miserable, that's how I turned to weed

what society should focus up is harm reduction of their drug usage

2:13 PM

that's all

2:14 PM

I am not even mentioning that we're living in 21st century and it should be possible to tell easily who requires exogenous opioids to life the live like a normal human being

2:14 PM

yet no one does such things ie tests

what? yes that's exactly why you need a good psychologist and not a psychiatrist (or DIY)

and how psychologist will tell me to reduce harm of my drug usage?

2:15 PM

will she help me to not develop benzodiazepine withdrawals after 2 months binge?

2:15 PM

nope, she told me to stay sober. Great fix.

2:16 PM

I haven't ever tried being sober in my entire life. I am so ignorant and blindfolded that I automatically assume such approach cannot help and it's bs (edited)

I find a major problem for using opioids is that if the people around you are aware of this, they will have all these confirmation biases that become dangerous during the withdrawal phase

ye, person feels unsafe without em prolly, during withdrawal it is potentiated and instead of support they receive some ultimatums, they are pushed away etc

You’ll become depressed and could probably take 3 days recovery and be almost normal but the issue would be that people around you are going to freak out if you get depressed

2:18 PM

Then once things start going bad you will have more lasting issues in the environment

I wouldn't be so sure if recovery will take 3 days tbh

2:18 PM

would have to check it but my enviroment isn't the best way to do it lmao

2:22 PM

"I clearly said there's a place for psychiatry (drugs) but it's totally exaggerated and no one here of us has even the remote knowledge how to apply neuro pharma." Idk how it applies to other countries but here psychiatry is simply pseudoscience. Not treating the most possible underlying causes of the behaviour at all. And there is no exception from this rule for my country.

"I haven't ever tried being sober in my entire life. I am so ignorant and blindfolded that I automatically assume such approach cannot help and it's bs" That's what I would be concerned about. Why limit yourself that way?

it was irony

2:24 PM

ofc I did

I do not support any psychotropic intake experiments, that starts with drinking a lot of coffee. Any drug usage is more a flight and not a fight with the real causes of your problems.

define what's real

2:28 PM

like real cause

That's my psychological approach instead of the psychiatry one: software problem, you just have made a bad programming virus you couldn't yet get rid of yourself. The psychotropic substances might cover some symptomatics and make life easier or supportable at all but don't really fix it ever because not adressing the underlying software cause that could be fixed with simple psychotherapy

1. It isn't usually the person who has such problems which is responsible for this "programming failure"

2:32 PM

2. This person might ofc worsen this problems via his/her drug usage which is an attempt to sooth the pain resulting from traumas he/she experienced

There's no free will, nobody is responsible for the way they are and became, but accountable

3. Psychotropic substances influence the symptoms in various ways. They might make life easier or harsher. Depends on how one deals with them.

2:36 PM

4. Idk why u think psychotropic substances won't ever fix anything. Of course some of them might fix underlying cause- at least temporarily until one comes back to its baseline again. (edited)

2:37 PM

5. Source for the research on how psychotherapy influence GABA system which is known to be altered during stress/reward system/changes in alpha-adrenergic receptors etc etc

2:38 PM

I'd love to know what approach I have to take to fix potential issues in each of these fields known to be altered by stress

You keep repeating what I clearly already said multiple times I dont think (4.) (edited)

You claimed psychotherapy is adressing underlying software and it can fix it

2:42 PM

One was separeted from his mother when he was born for quite a long time. It shifts the balance between some sodium/potassium transporters in the brain resulting in hyperglutamatergic and hypogabaergic state. How psychology sees such issue and how does it fix it?

2:43 PM

When the research claims that changes in these transporters are prolly life-long (edited)

2:45 PM

To be clear, I am not presenting anti-psychology approach. I just find that its role in treating mental disorders is sometimes overrated and some of the things simply cannot be fixed this way. It's great anyway. I think everyone should have at least some basic psychological knowledge and it'd serve a huge benefit for the society or even humanity as a whole. (edited)

https://www.youtube.com/watch?v=OrNBEhzjg8I maternal attachment deficits are known to psychology long time and are indeed deep wired in sensible development stages in the youth. It can bring out general anxiety or social disorders in adult life. Humans are treatable, our amazing plasticity of our brains allows us to rewire and help get over any terrible misprogramming. Only harmful tendencies that seem to be natural cant be fixed themselves but learned to deal with (i.e. pedophilia) or problems from real hardware damages might need additional chemistry support, but I want that functional MRI first before you do risky psychotropic chemistry addition to you. Better try good psychological approach first, might turn out your hardware is fine, you just took up a software virus like most of us do from time to time, sometimes without being able to solve it ourselves without the right hint or help.

Michael Baker

Harlow's Studies on Dependency in Monkeys

2:58 PM

horrible animal experiments we've been doing but helped psychology a lot

1

well, this study mentioned life-long deficits resulting from maternal deprivation following birth (only in hospital) not such things as neglect etc which are pure traumas later in life and following the logic from the study about maternal deprivation following birth (in hospital) one can pretty safely jump into conclusion that deficits in one's (in this example) GABAergic/Glutamatergics system will be even worse if this child will be constantly experiencing neglect, being abused etc. But again. Show me a single study showing efficacy of plasticity when it comes to changes in these systems due to stress. I haven't ever seen a SINGLE STUDY. Neuroplasticity is beautiful as a theory when it comes to actually treating certain disorders imo. Otherwise I'd be glad to see some proof. Ofc I would like to do functional MRI first and I plan to do it in the future. I just need to be in posession of something when I will be doing this.

3:07 PM

I am visiting psychologist. I feel she didn't know how to help anhedonia. It was some therapy for addicts and since I am barely using any drugs these days she told me that well... it's rehab facility (which was total BS) and I don't fit there.

3:08 PM

She simply didn't know how to help me so she suggested to try another approach aka psychodynamic therapy or it's my false assumption, who knows

(edited)

3:09 PM

She was too biased in her own beliefs I think, maybe I am too and I am unaware of it, but the only thing which can solve it in my case is seeing actual research and well, it'd be great to diagnose myself and it isn't really possible in the country I live in. It'd require fMRI (but it still won't reveal the real causes), so most likely PET-CT with some radioactive ligands of receptors I suspect are influencing negatively my state of mind

3:10 PM

In case I have brain damage then I don't think I will want to fix anything really. Life with total anhedonia isn't simply possible despite what people are telling such person to do or to try over and over.

Good vid @Theo Riginal

sounds like you need urgently to change psychologist. She cant help you if you mistrust her advice. She should be aware of that and refer you to a colleague if she was a good psychologist

3:28 PM

You need to find a trustworthy psychologist that gives you reason to try psychological approaches, she obviously couldn't help you and it's a waste of time to go to a psychologist when you lack the trusting relationship to him/her.

3:30 PM

I experience you here as (negative: biased with psychotropic chemical half-knowledge and a DIY attitude towards psychiatric selftreatment) but really very rational and intelligent, so I wouldn't underestimate the possibility you have no hardware damage but not received the proper software help yet. (edited)

3:32 PM

https://www.psychiatryadvisor.com/home/topics/anxiety/cbt-better-than-medication-for-treating-social-anxiety-disorder/

Haymarket Media

CBT Better Than Medication For Treating Social Anxiety Disorder - ...

Meta-analysis finds cognitive-behavioral therapy best type of psychotherapy in treating SAD, and more efficacious than using drugs.

well, she changed me

3:36 PM

not that I changed her

3:37 PM

she told me that she cannot help me anymore since I don't have problems with drugs abuse

drug abuse is a symptom, not the cause

3:52 PM

change psychologist urgently, that's just wasting your time with her

yep

3:59 PM

it's self medicating anxiety/depression etc

3:59 PM

but that's generally approach seen in the therapies for addicts here lol

4:00 PM

they believe u just have to abstain from drug usage blbalbal and it will fix ur issues

no that can only prevent additional problems deriving from the drug usage, but it didn't yet adress the problem why you needed the drugs in the first place. That's very common overlooked but no good psychologist would do that

I need drugs in the first place because I am anhedonic

4:03 PM

it's pretty obvious

Neither would any good psychologist tell you "I cant help you anymore" but keep you in therapy without sending you to a colleague who might! That's making me angry that's such bad doctor behavior

and i don't need psychologist to tell it to me

4:04 PM

he/she can only jump into conclusions based on info I give to him, therefore is unable to get into my shoes and experience what I am experiencing rn

you need the MRI to see if there are real hardware damages and a psychologist to therapy the cause of anhedonia if it came from software problems

4:04 PM

which we all fall into

ye, but software problems causing anhedonia for 5 years

4:05 PM

welll

I was 20 years depressed, so get back in line, some people are way more fucked up that they cant argue reasonable over discord with others like you do here

ofc, I haven't ever said there aren't people who feel worse

4:06 PM

lol

you have to make yourself aware it could be you alone who can change it and that you're not responsible for it

4:07 PM

but accountable

yep

4:07 PM

Maybe I will try what she suggested

I would change psychologist if you have no good trust relation to her and try what the next one you have some confidence in says. He might suggest the same but your previous psychologist may lack the social capability to relate to you

4:09 PM

you know about placebo and nocebo effects, right?

she dropped me

4:10 PM

ye

and didnt recommend to take it up with a colleague of hers?

4:10 PM

just said end of line?

ye

4:11 PM

well, it was some place for addicts

4:12 PM

but well, she prolly knows psychologists not specialized in addictions

4:12 PM

so she could refer me to some of her colleagues

4:12 PM

but she told me that there is some facility somewhere where I can go to get prolonged therapy

4:12 PM

while living in different city for this time

4:12 PM

etc

I also have some minor neurodermitis. I had sometimes red wounds in my face that I totally was ashamed and didn't go out. It has been a struggle aswell but I needed the confrontation and expulsion and first to accept my genetic disposition. It also really humbled me to see what that disease usually looks like, and I'm too ashamed to go out for a few red spots. Brought it back into perspective that I dont have the worst cards...

so well, she kinda recommended

that sounds good

4:13 PM

so she might not be that bad afterall

nah, she wasn't

4:13 PM

generally she tried to convince me that going out is the solution

4:13 PM

etc

4:14 PM

that the fact that I am avoiding ppl irl is worsening it

4:14 PM

but I told her what's the issue

4:14 PM

and why I consciouslly decide to do it

obviously you need to investigate and therapy the reason you needed the drugs, not just forcing yourself to withstand from them or reduce their dosage. It doesn't help you if you didn't find the causes

then she changed her attitude

4:14 PM

I know the reasons

well people also told me to go out when I was pulling back but I was ashamed and didn't think I can

for a long time

4:15 PM

I am going out, I simply sometimes avoid it because I lack normla human reactions

4:15 PM

and I am simply toxic

so that tipp even if it would help can be unhelpful sometimes because of the specific circumstances

people won't tell u straight that ur making em feel worse

4:15 PM

but I am aware enough to jump into conclusion that looking at my face isn't pleasant

for me it was enough that people observed my face and I noticed their irritation

especially when one cares about me at least a bit

got totally socio-phobic for that own unforgivingness with skin problems in public

so well, I'd have to lie, act differently than I feel

4:16 PM

which is totally fucked up approach

4:17 PM

just not to make other people upset

4:17 PM

avoidance sounds least harmful

4:17 PM

for me

hmm dont see it too black and white

ofc, not

best is to fight and struggle against the own demon but that means often going against one's own comfort zone or evasive behavior

4:18 PM

it's a pain in the ass and sometimes a bit of a mask but it helps in the end if you realize why

well, it's something different

4:18 PM

ofc exposing urself to anxiety causing situations

4:18 PM

is good

4:18 PM

but when ur numb... it doesn't work lol

4:18 PM

ur still numb when u meet ppl

4:18 PM

u r still numb when u play games

4:18 PM

when u watch tv

you're not numb at all

4:19 PM

you're desensibilized or received too little successful enforcement emotionally

yes, and it creates such symptoms

4:19 PM

shapes ur brain

4:19 PM

shuts down reward

4:20 PM

so well ur numb

sometimes that can be the lack of cloth on your wireframe mother

?

but your brain is plastic till the end, you can always get over any trauma (given no significant hardware damage)

no research on it

tons of studys on it, I tell you, people neglect psychology because of the psychiatry propaganda from the pharma industry

we know that neuroplasticity takes place in the brain, that hippocampus can produce some new cells, they can prolly migrate, idk if other regions are able to do it too

4:23 PM

we know that experiencing things is making certain connections between neurons etc

no, that's not entirely true

we know that brain changes in response to experience

4:23 PM

but mostly the research is based on the negative ones

4:24 PM

and there's no research that these changes are reversed via such an approach

4:24 PM

what's not entirely true?

imagine your brain having like your center/gate of consciousness and emotions in the limbic system (amygdala, hypocampus & co) your CPU+RAM if you want and connected to the Neocortex which is kind of GPU and HDD (edited)

4:25 PM

whatever goes through the limbic system forms (enforces or weakens) connections to your neo cortex, your peripheral systems and longtime memory

4:26 PM

some old memorys are hurtful and not well progressed, they can chronically impeach your life quality but are nothing but badly layed highways you have to transform into backstreets and get better highways to happy cognition (edited)

4:28 PM

I got some awesome neurology and psychology referates but most are in German since that's my mother language

I don't even read a shit atm

4:28 PM

too tired

4:30 PM

and I doubt these changes can be reversed this way

4:30 PM

no research on these things again

We can have a voice chat once when you feel like it. I think you're in need to realize your own potential and capabilities of our brain plasticity to heal yourself for good and go a bit away from trying to understand your brain as a biological PC you can fix with hardware exchanges.

4:31 PM

Also the traps we all face to betray ourselves and keep us in unjustified anxiety and discomfort

well, I will prolly still keep trying to do it if I won't find a way to log out (edited)

4:31 PM

cause nothing else matters atm

Those are all natural mechanisms to protect us that can lead to very selfdestructive or not-living-worth life conditions, it has to be taken serious the software aspects before fiddling with the hardware, but I see great potential in the way you can discuss it with me.

I think this software atittude is great when it comes to initial stages of someone else's problems

4:33 PM

like when a kid with anxiety goes to the psychologist at the very beginning

4:33 PM

damn ofc, it will change his/her entire life

I'm also still smoking weed but I have now a much better perspective, new hope and can therapy myself without additional psychotropic substances but with deep selfreflection and questioning myself and fighting the demon inside me

4:34 PM

based on true psychological research and evading making own false conclusions or risky attempts

but when such stress/anxiety lasts for years and years is chronic, then well 1) research shows changes in brain structure 2) how receptors change interactions between each other ie ones are up, others are downregulated etc etc etc

you can condition both bad and good reactions

4:34 PM

pawlows dog

there is not a single research on whether in this stage changes can be reversed via behavioral approach

Or teaching helplessness to mice

I've had anxiety since I was 9, developed panic attacks when I was like 16, then OCD at 21 or so along with anhedonia

ofc there is, why do you think that?

because I asked u multiple times

4:35 PM

about it and u ignored it

4:36 PM

and i haaven't found any proof on my own

I posted the one study that psychotherapy is better to stress/anxiety disorders than psychotropic drugs

I mean certain examples, I know CBT can change one fear responses etc

4:36 PM

but it's different that reward system deficits

4:36 PM

than*

And every pawlow dog should show you that you can condition everything or spider phobia expulsion

you simply cannot tell a person to be happy

4:37 PM

or expose herself to happiness

no you cant tell, but you can help that person to become happy

people aren't total idiots to assume they cannot feel pleasure while not exposing themselves to situations which are supposed to create this sort of feeling

4:37 PM

at the same time

but I'm no full educated therapist myself, I'm afraid I cant do that. But you can if you find a trustworthy professional and have the guts to struggle against your own demons

well, I will prolly try

awesome

4:38 PM

already the open exchange with me is good

4:40 PM

I respect your intelligence and want to preserve that delicate personality of yours, my concerns to drug abuse shouldn't come across as pedantic or teacher-like but that as I see your intelligence and working brain and want to warn you of the often ignored software approaches that can be much deeper and more healing than drug sympom fights.

4:40 PM

Every life is respectable and ought to be helped to get to happyness imo

4:42 PM

And like with optical illusions, the illusion of free will and rational mind often let's us ignore how we betray ourselves and trick us into bad backstreets without escape chronically, which we could prevent with just stepping back a bit and letting our rationality and feelings be observed with a bit distance but detail

I am highly skeptical

4:43 PM

but yeah, it should be beneficial anyway

4:43 PM

I have nothing to lose at this moment

4:43 PM

literally nothing

4:43 PM

and thanks for your attitude towards me

That's exactly the point I started aswell from in my appartment with sociol-anxiety and my tiny skin problem and unhealthy expectations how I am supposed to look like.

4:44 PM

Nothing to lose but unwilling to keep on suffering like that!

just sometimes biting my tongue

4:45 PM

heh

It might even be that the neurodermitis was triggered by the failed love depression (epigenetics!), but in any way suicide was no option just because I thought I have to be there in case

so could have helped against me suiciding at least

4:47 PM

also I loved gaming and game design and comedy, entertainment. I just totally pulled out of social life

4:48 PM

Wanted to become a purely digital consciousness in the internet preferably, no body

well, I feel like it in a kind of way

4:49 PM

how did u want to kill urself?

You have no idolized failed love you need to be there for, can be positive or negative. But my attempt is to try to persuade you that you might be hardware okay and just software stuck like I had to find out. I didn't know I'm idolizing and forbidding myself to become happy, I thought it's unchangeable and all I can do is live my half-grey life on weed/entertainment and such distractions and symptoms covering.

I won't check this out

4:53 PM

atm anyway

4:53 PM

gotta prepare myself for this

I never wanted to suicide, I thought I had to live with every suffering I go through. But as a doctor's son, I learned there are medicines (which names I always forget) to have a peaceful suicide. It's horrible how much suffering people go through to end their suffering of life. My best friend tried first with cutting his aorta and hand arterias and failed and finally successfully killed himself with CO-toxication which must also be quite cruel without me knowing he still wants to suicide.

well the problem is access to these meds

Because we all feel ashamed to talk about our failures and problems. Same for me

4:55 PM

Never spoke to anyone about any of these problems as I do now here on the internet.

and I think people should be allowed to choose painless way (edited)

4:55 PM

and it pisses me off terribly

4:55 PM

well i cannot feel this feeling

4:55 PM

but still, it's fucked up

You can always get access to the medicine if you know what you need or make it yourself

even dogs are killed by some sleeping pills

But ending your life is really the worst idea since you haven't really tried everything else

well, hard to get fent/morphine/heroin in huge doses (edited)

4:57 PM

DNM

4:57 PM

but ye

I am really 20 years into thinking and experiencing no more feelings of love as I used to, but I had to realize (reading psychology advice on it) that it must be myself in my way, not allowing to let go of my anxiety and fall in love again. It's retarded but amazing in a way how we can only change ourselves but from within us. And how we often rather unconsciously betray ourselves...

let it go approach pretty much reminds me of some new age bs

4:59 PM

automatically lmao

4:59 PM

if it was this simple as it is for monks if their claims are true in fact

But I came to be a skeptical atheist and only now I know finally dont trust any authority, especially not yourself. Go to the bottom of facts scientifically and do what you have to do according to the best representation of reality, dont fool yourself and especially dont throw my own life or happyness in it away if I can change it.

I always ask myself how would they behave if they were shaped by different experiences or just put into destructive enviroment

Yeah lol I had to find out it's not as easy as that. It's a hardwired fear inside me I have to recondition

5:01 PM

But it can only start that I understand now that I am idolizing and didn't allow myself, I might be capable of changing it afterall, it can be only me!

5:01 PM

That neuro science state of the art showed me we have no free will, but we can do our best in good communication to evade horrible things or lifes of suffering

5:02 PM

and how easy even me, thinking I'm so super rational and impulse controlled fool myself so easily and selfdestructively

5:03 PM

And now I can laugh and dont even have to forgive it myself, because I know I'm not responsible for it, only accountable and the only guy who can change it and overcome it to be happy again.

5:03 PM

Humbling but empowering, but still a constant struggle against the own inner demon, but now with new hope

well, i'm glad it seems ur journey is heading in the right direction

this is the only spark of hope I can try to send over to you, that you might be capable of solving your unhappyness for good with a different, purely distanced selfreflection and modern science application approach

Thanks

And I'm not making it illusionary, right? It's a struggle, but you can improve and live better if you have still the power. But I also needed to realize first that I might be capable of doing so, which I totally denied.

5:07 PM

And thatfor was powerless (edited)

well, I am pretty defeatist like atm

5:08 PM

so ye

I know that situation too well. But you must get sick of your suffering and get power in the realisation, you might be able to recondition and every psychology book tells you yes you can

5:10 PM

Ah and my new motto what also every heroin addict needed to learn: BABYSTEPS

will have to repeat the same questions atm

5:10 PM

heh

you're not responsible, be totally unblaming yourself, every little step forwrd is good, also resting sometimes at the same spot

I don't even respond to drugs

5:11 PM

as I should too

5:12 PM

so psychological approach sounds good but one has to already be in some beneficial state of mind otherwise one will constantly fall into negative confirmation biases which are totally normal and well, they make sense

5:12 PM

there is no way for me to think positively in such circumstances

5:13 PM

it's more mix of desperation and fear triggered by some realizations

doesn't it sound interesting?

what?

5:14 PM

lack of response to drugs?

5:14 PM

it's terrible and makes u think about some brain damage shit

that your hardware might be okay but you ended in a software backstreet as all of us do that you can ride yourself out again

cause well, it's really hard to find such ppl online, I didn't have such chance to meet him/her

5:15 PM

well, it makes me question that my hardware is ok

5:15 PM

when u sniff some cocaine with friends

5:15 PM

and it doesn't affect u in any way

5:15 PM

it is kinda... concerning

5:15 PM

when u don't respond to psychedelic drugs at all...

5:16 PM

well?

5:16 PM

gg

5:16 PM

not that I am complaining, that's just my reasoning behind questioning psychological approach as a treatment to my issues

yes that would also let me question the hardware intactness. But I also smoked weed for about a year in my youth before feeling anything from it. But cocaine is much heavier. That's why the fMRI brain scan would be very needed. Why hasn't it been done yet? (edited)

I'd rather tend to think that nembutal is the solution

5:17 PM

no one cares here

5:17 PM

this country is like a shithole

5:17 PM

and no one really wants to find out what is the real cause of ur condition

which country? USA?

u will be most likely prescribed SSRI cause it is depression

5:17 PM

lmao

5:18 PM

poland

that's EU, shouldn't be too bad

(edited)

and I cannot do imaging scan before I will mhmm meet some requirements

5:19 PM

well, don't want to

Well, you know my advice now. Clear hardware checkup and then optimal software analysis and therapy. And it all starts with new hope that it's you, no drugs no hardware failure, just a bad conditioning as we all run into into certain areas. Some worse than others obviously.

idk

For me it was just recently the confrontation from a mutual friend of my ex and a friend of me who accused me of "not having let go" to which I totally contradicted and said that cant be it, I try to forget and overcome since 20 years. Only then the research on psychology sites showed me I'm obviously blocking my self in idolization and thinking "can't never be the same again" to myself. Gave me new hope that I am in fact just sabotaging myself

but will consider it

1

5:26 PM

and what issues did this realiztion solved/

In order that nobody takes offense with my confrontational arguing, I hope it helps if I lay down my evasion of "appeal to authority fallacy" approach: I accept no authorities and all of you and me are considered idiots that have many unaware misconceptions and we must find out together based on the available facts to both of us.

5:27 PM

This realization that it might be myself in my way of happyness gave me the new hope to try to fight it again. I realized it might be unjustified anxiety coming from me

5:28 PM

While I thought I'm helpless and have to get my tragic life over as acceptable as it can be, but never will be happy again for 20 years.

idk

5:29 PM

atm I just want to black out

5:29 PM

over and over again

5:30 PM

well, probably totally offtopic

5:30 PM

but I didn't know how to respond to ur previous oist

5:30 PM

post*

Yeah but you know that's symptomatic fighting, not getting to the root of it, right?

ofc

5:30 PM

but I give a fuck less and less

5:31 PM

I was blacking out almost daily for 3 months

5:31 PM

recently

5:31 PM

for the entire days

5:31 PM

lmao

like coma drinking or how you reached black outs?

benzo

oh okay

5:31 PM

that's heavily selfdestructive, I guess you know

5:32 PM

better eat some shrooms, have a whiskey or a joint whatever gives a bit relieve and let's you chill, but you solve your problem for good only if you get to the bottom of it and solve it there

5:33 PM

and that presupposes you are admitting the possibility you can do it yourself

5:34 PM

A pill can give you additional placebo effect but the true reparation must be your own consciousness and behavior reconditioning your highways and backstreets up there

5:36 PM

But enough pseudo therapy from my side, I'm also an idiot and a victim of depression and drugs (but weed is all I need and is like other people's beer to them, it merely stabilizes me), I go twitching in Atlas

5:37 PM

Wish you the same empowering Heureka moment of realizing "ah I sabotage myself possibly really with negative thinking chains and old bad highways"

most likely

5:38 PM

shrooms have no effect

5:38 PM

if I was able to take shrooms once a month

5:39 PM

and feel some sort of pleasure from this trip as I used to when I tried them once back in the days

5:39 PM

I wouldn't be doing what I am doing

is weed illegal in poland btw?

ye

5:40 PM

have a nice day

You too, try to stick to the demonstrably less severe brain damaging drugs at least for the moment and keep your mind open to self-sabotage "mental self-betrayals"

benzo doesn't damage brain

5:42 PM

afaik

5:43 PM

well, withdrawal most likely can

5:43 PM

but since I don't develop withdrawals following benzo usage, I think it's a good sign

ah no, I misunderstood "withdrawal"

like when u stop taking benzo

5:44 PM

then it can be neurotoxic

5:45 PM

but it can be prevented aswell if one knows how

5:45 PM

so ye

5:45 PM

for sure there are some changes due to mental retardation aka you don't "train ur brain" in any way and just waste time when ur on benzo

5:45 PM

most of the time

Benzos is linked to brain damage and I’m guessing because of withdrawal too but I think even as you take them

Benzodiazepines can have severe byeffects such as brain damage and addiction to it and should only be taken very shortly and not over longer periods of time as is done so horribly prominently today.

5:48 PM

Pharma business

as you take em, they're neuroprotective

I'm btw from Basel,

where all those LSD and Benzos are invented, home of Hoffmann-LaRoche and Novartis

(edited)

withdrawal is mediated through AMPAr, then through NMDAr activation

5:48 PM

pff

5:48 PM

overactivation

I didn’t read this yet also it’s psychologtoday lol but whatever https://www.psychologytoday.com/us/blog/side-effects/201011/brain-damage-benzodiazepines-the-troubling-facts-risks-and-history-minor

Brain Damage from Benzodiazepines: The Troubling Facts, Risks, and...

Researchers have long-known that benzodiazepines can cause brain damage

yep that's known

afaik there was not single actual research showing benzodiazepines are causing brain damage

5:50 PM

despite that this myth is repeated over and over again

that's the first "allaround defense" you need to throw away

5:52 PM

He just posted a narticle with plenty of evidence to the contrary

I will refer to it

5:52 PM

when I will read it

5:52 PM

I didn't read this article yet (edited)

5:53 PM

and you don't have to psychoanalyze me whether I fall into my own confirmation biases all the time haha

Just saying "there is no study showing that afaik." is about the most useless statement you can make, there's probably a study about every bullshit hypothesis but it doesn't matter that there is one, it matters how accurate and reproduceable it shows to be.

who said anything like this

5:56 PM

?

https://discordapp.com/channels/307540693826666507/593444179749634070/605079580671213569

5:57 PM

https://discordapp.com/channels/307540693826666507/593444179749634070/605038369327808512

beyond replication we should also value how it sits with all of the other research (edited)

good point

5:58 PM

consistency to neighbour science fields (neuro science, psychology, medicine, pharmacology)

Since lots of neuro is understudied I go this route very often while writing

5:58 PM

I’ll show a bunch of studies that overlap in the biology, behavior, psychology and see if it’s all coherent together

1

but that's the immense problem of psychiatry

6:02 PM

it involves so many topics and is such a interdepending highly complex field (edited)

@Theo Riginal well, I don't think it's useless statement at all

6:03 PM

it simply tells that there is no such study so no one ever investigated it for some reason

1

you'd have to be bio-chemistry pro, physiology and pathology pro (medicine), psychology pro (behavior & cognition science)

6:03 PM

nobody has a complete image and the need for interdisciplinary work is there greater than in most other sciences

ofc

6:04 PM

I am aware of it

It's a totally unargumentative claim you make

I am aware that I know a shit

which is demonstrably wrong

but I try to use the info I have

6:04 PM

prolly will find out more than once that I was wrong in the future

6:04 PM

but it's better approach than simply not forming any hypothesis at all (edited)

6:05 PM

otherwise it'd feel like doing something totally useless for me

the afaik makes it a bit less wrong but thatfor more useless in argumentation power

just for sake of getting info

6:05 PM

idc about argumentation power

6:05 PM

it was just a matter of me being too lazy to check the source

hypothesis forming is genrally okay if you can falsify it

6:05 PM

which most of you dont I assume

6:06 PM

it's a covert appeal to popularity/authority if you look at it

corrected the sentence

6:07 PM

"The cerebral ventricular enlargement reported in patients with anxiety/panic disorders who were long-term benzodiazepine users could be due to the disorder or to other factors rather than to the drugs, but wisdom advises caution"

and nope, hypothesis forming is sometimes okay for people giving less fucks about the fact that their hypothesis might be false (edited)

1

6:27 PM

risk one is able to take when it comes to such things varies a lot between individuals and some individuals are willing to take much more risks than a healthy person (edited)

6:27 PM

I think it's pretty obvious

6:30 PM

omission bias

I'm a longtime fan of the Atheist experience, that's where I met querky and he invited me here. The new host Jenna is talking about drug abuse today, nice coincidence https://www.youtube.com/watch?v=xXfju0-m4Nk (edited)

The Atheist Experience

Atheist Experience 23.31 with Matt Dillahunty & Jenna Belk

But I'm banned on both Street Epistemology and ACA Discord (both independent fan community mods only) for doing "incitement of drama." I still like the show but their community discords are so badly moderated and overrun by inconsiderate arm chair philosophers who deny the possibility of universal humanist ethics. As a humanist atheist community and fans of the Atheist Experience...

I feel odd about Matt because of the way he reacted to veganism

11:18 PM

But also I forgive because it’s expected. He’s living at the top of his intellectual world and gets used to patterns of dominating theists and maybe doesn’t experience outside of this bubble often

I also agree totally with him on veganism. He says it might be morally virtuous to renounce from eating meat but it's not an ethical imperative. That's exactly my stance on it.

What do you think about distinguishing animals and humans? Do you take the same stance with humans? That eating humans is not an ethical imperative?

the thing is

10:03 AM

all ppl on that atheist experience are guaranteed to have bad takes outside of what they know

10:04 AM

like how most ppl who passes with all As in HS/college would usually have awful politics due to environment and mostly parenting preventing any fun in their shallow and dull life

10:05 AM

idk man but weed defeats abstract concepts like veganism

I'll just ignore surajsoib, afaik he's a troll from the ACA discord not to be taken serious. I'm very much for distinguishing humans from other animals in some terms, yes. Aren't you? We have the most complex brains and have the most complex social structures and morals. It's not generally unethical to me if humans ate humans. I'm thinking of natural tribes who eat parts of their deceased loved ones to "embody" them ritually. (Maybe weird tradition to us, but hey, other peoples other morals) We are omnivores like pigs and rodents, our close relatives. But certainly, civilised humans dont hunt other humans to eat. Same goes for hunting or destroying apes' natural habitat. It's not unethical to hold cattle like Cows and chickens imo (under appropriate conditions). They dont realize they're our meat and can still live happy lives. (I'm skeptical that killing baby cows is okay though, I think every animal deserves at least the chance to grow up - no veal for me even though I love vitello tonnato

) Apes and humans are highly social animals and their understanding that you hunt them to eat them is cruel between close related and social, intelligent animals. If cows reach higher awareness and ethics like us humans and apes, it might become unethical aswell to hold them for meat. So far with proper farm animal welfare and housing, it is still okay imo #HappyCows https://upload.wikimedia.org/wikipedia/commons/thumb/8/83/Beautiful_Swiss_cows_-_panoramio.jpg/1200px-Beautiful_Swiss_cows_-_panoramio.jpg (edited)

I distinguish animals and even individuals yes. Here we specifically explore the distinction of animals and humans in regards to deservingness to live in a sense. In the case of eating deceased relatives, we do not eat deceased animals which I would actually be ok with. Eating meat from the trash is also ethical. As is eating road kill. It’s just killing an animal when it’s unnecessary that becomes unethical. Hunting humans was a closer analogy. It’s worth noting that cows would generally live to about 20 years in the wild but we raise them to be very young before we kill them. Pigs are raised to 6 months and pushed to grow with hormones. As for ethical awareness of animals, I actually do think animals are ethically aware but like humans, many don’t care. There are videos of animals behaving ethically on YouTube. I’ve linked some of these in articles Ive done. I think the way we relate to apes is based mostly on being more similar which makes it easier for us to comprehend their behaviors. We struggle to imagine what the perceptual experience of a mollusk may be because it is too different. So let’s go with ethical awareness. Does this mean it’s more acceptable if we hunt and ate children rather than full grown adult humans because the children have less awareness of ethics? Does this sit right with you? Would you also think torturing a child sounds more acceptable than torturing an adult?

"Here we specifically explore the distinction of animals and humans in regards to deservingness to live in a sense." No, we don't. We see if they deserve not to be held as meat producers for us. "It’s just killing an animal when it’s unnecessary that becomes unethical." Why should hunting or farming to eat meat be unethical for omnivores like humans? It's our natural diet. "It’s worth noting that cows would generally live to about 20 years in the wild but we raise them to be very young before we kill them. Pigs are raised to 6 months and pushed to grow with hormones." Yes, there it's getting unethical: if we don't allow them a normal lifespan and acceptable circumstances for them, hold or kill them with needless suffering for the animals. Must be raised social awareness and changes in law regulations. "I think the way we relate to apes is based mostly on being more similar which makes it easier for us to comprehend their behaviors. We struggle to imagine what the perceptual experience of a mollusk may be because it is too different." No, we understand the enormous but different intelligence of octopuses for example pretty good nowadays, including their limitation of culture (accumulation of experience/knowledge) due to their way of egg care, untill the mother dies and the young must learn all from scratch alone.

5:13 PM

Science always gets you a better insight than your biased own interpretations of reality can. It's not skeptical to assume all we know is biased and false. Animal psychology is also real science and can find out what makes animals happy and sad and which human rights they don't really need (i.e. political). " Does this mean it’s more acceptable if we hunt and ate children rather than full grown adult humans because the children have less awareness of ethics? Does this sit right with you? Would you also think torturing a child sounds more acceptable than torturing an adult?" Why this unfair strawman analogy, that's exactly the opposite of what I said about veal. It's more unethical to harm infants of all animals in our social ape ethical sense. In nature a lion hunts the easiest target, be it an infant or an old or sick animal that can't flight as well as others of the herd. But we have this social empathy and consideration of other lifes, that doesn't mean we must renounce from hunting & farming, but we must value the life of our meat animals aswell and respect and ensure their life quality as the dominant species on the planet imo.

5:18 PM

I'm very concerned with half-expert conclusions but I live in a direct democratic country, we vote 4 times a year on suggested laws by our population and sometimes you have to decide "whether farmers should get state subventions for not sewing the horns off their cows" that's why I'm a fan of infotainment and think the population has to get a broad general knowledge to be a good political citizen with good intentions for people & our ecology.

Would it be ok to keep people for their meat if they didn't know and lived happy lives until you killed them at 20 to eat them?

As we found out, no people and possibly higher apes might realize that which would be a violation of their dignity. Not so for cows & chicken who clearly havent got such social ethics and awareness. Pigs come closest to ape intelligence but not quite yet.

@Theo Riginal id rather be a troll than a dumbass

1

lol, I basically cannot create fb account

9:53 AM

they tell me over and over that they require real name and surname

9:53 AM

despite the fact that well, in fact I decided to partially change it to reveal at least some normal aka real name

9:54 AM

what is it supposed to mean

9:54 AM

9:55 AM

ok, seems I cannot have polish surname and english sounding name

@surajsoib you're obviously a dumbass troll

(edited)

@Theo Riginal When you rephrase “deserve to not be meat” I think this is hugely semantic. The reality is that having animals or people as meat kills them. As if you think perspective changes the actual nuances of the situation or the implications here. The ethical issue isn’t meat itself but the method in which it is acquired.

5:22 PM

I agree that we should not give irrelevant rights to animals or humans. We shouldn’t give nuclear code access to all humans for example. Nor should we give it to animals.

The reality is that having animals or people as meat kills them?

@Theo Riginal what if we hunt children who lived identical lives as cows for the same amount of time? They would likely behave fairly similar. Access to human culture could be deprived in the way the cow is deprived. For the cow it’s lack of a medium of transmission but for the human we could reject access to culture. So we leave a neglected child out in a field and maybe at least teach it how to acquire food since probably humans aren’t that intelligent, more heavily reliant on culture and becoming increasingly cognitively deficient

1

5:25 PM

@Theo Riginal lol would you suggest we slice steaks off the bodies of living cows and preserve their lives? Seems more messed up haha

We do kill animals when we think they get us the meat but that's not a requirement to farm

5:27 PM

You could also have a cow farm and only slaughter the old cows that died of natural cause theoretically

I would be ok with that

5:27 PM

I would consider it basically vegan

No only vegetarian

There’s freeganism which ppl eat meat ethically by not buying it

5:28 PM

Veganism is about harm and exploitation. I think most vegans would initially oppose the old age thing without thinking but later the culture would shift

freeganism is eating everything out of others trash, that's very ethical you dont cause more demand, neither for veggies nor meat

Yeah

but let's stay at meat gathering

What do you think about the human hunting

I told you and Ariadne already it's a violation of the dignity of higher species if they realize you hunt or farm them for meat so we mustn't do that to apes & humans (edited)

But what makes them higher species if they are basically much like the cow

5:31 PM

We can deprive them of nutrients too

also that if apes, cows & pigs develop an understanding of realizing that it would become unethical

Causing retardation to enhance this

higher mental capabilities

Is this at least sounding closer to ethical practice

5:32 PM

I think pigs especially and also the other animals do have more intelligence than you are imagining

certainly causing retardation beforehand is unethical itself and no excuse to hurt an animal. cmon man

Let’s say accidental b12 deficiency

5:33 PM

So the child is already retarded

I'm a huge psychology fan and watch every animal psychology documentary, so I think that's a wild guess of you to estimate my animal psychological understanding

And now it’s increasingly a good thing to eat them right?

5:33 PM

I’m not meaning to do that. My arguments for animal cognition are a bit “farout” but I think you’d potentially agree

5:33 PM

I can show you if you’d like

persons with defects are also persons and dont lose their human rights, cmon man

But that’s arbitrary discrimination

You're not intellectually honest again going such strawman routes

5:34 PM

discrimination?

You are saying rights are based on being human because of specifically intellectual factors and you are saying humans without these factors get the rights based on purely being human regardless of intellectual factors. So it becomes not based on intellectual factors. It becomes arbitrary clumping of categories that aren’t ethically relevant

no those are non sequitors, I only said rights are for species, not for individuals and impairments dont make you less human

Species is an arbitrary category

Also a monkey with a birth defect of no tail is a monkey obviously

5:37 PM

tell that AronRa

Being human isn’t important. Having qualities of the “higher species” would be the important part

5:37 PM

Otherwise why does species even matter? Like should ants be protected arbitrarily ?

lol we are higher mental capable species, we humans

5:37 PM

aswell as apes

But being higher mentally capable isn’t important?

or neanderthaler or other cousins of us

5:38 PM

yes that's what gives us the ethics and the empathy and the need to make ethical laws

Why do we stereotype all humans as having higher mental capability

lol

But why not act with empathy to anyone that can suffer

5:39 PM

Why is it ok to hurt the ones who seem to not have ethics (which I also disagree)

We dont stereotype them, we have science of human nd other brains

5:40 PM

It's only okay to hurt animals the least possible to get meat as omnivor

5:40 PM

The lion isn't acting unethical eating meat, so aren't we or pigs or rodents

5:41 PM

we are acting unethical if we let the animals live in suffering conditions, detroy their habitat or such

Do you admit we have the science to show that some humans are mentally deficient and unworthy of the title of “higher mental capability”

5:42 PM

The lion will die without meat tho

5:42 PM

For humans they choose to eat animals for fun

5:42 PM

Even when healthy survival as vegan is possible

5:42 PM

It’s more fucked up than lions lol

no human is unworthy of that title

This seems dogmatic to me

they're human, that's evolutionary the biggest brain per weight

It’s not actually

5:43 PM

There are whales who have larger

5:43 PM

And even have more regions of the brain that we didn’t yet evolve

No it's a discrimination to deny mentally retarded people to belong to the most intelligent species aswell, it's defamatory, untrue insult

5:44 PM

No whale has a larger brain than us compared to his body mass

5:44 PM

No animal

What if someone said white ppl are smarter and black ppl don’t deserve life because they are less smart? Then what if they found a bunch of dumb white people and said they are part of the category of more intelligent race?

that happened, had to be factually debunked

5:45 PM

always go with science

5:45 PM

the proper scientific method, not ideologys

5:46 PM

racial supremacy hypothesis are all bullshit demonstrably

5:47 PM

Why is intelligence related tho

5:47 PM

It’s dogmatic

5:47 PM

Suffering is about pain and quality of life

5:47 PM

Not anything related to iq or random stuff like height

lol yeah the ice age shrew has potentially maybe more brain mass than us compared to his weight, that's a true exception

5:48 PM

but he ofc doesnt reach our mental capabilities

5:48 PM

Intelligence only gets you abstract thinking

5:49 PM

You cant understand the dignity violation to your species as a pig being (appropriately) kept as farm animal? You have no dignity to be violated. Of course we must prevent animal sufferings and bad conditions

Whales have larger more developed regions for abstract thinking, empathy, and communication than humans

5:49 PM

Nah it sounds like nationalism

5:49 PM

I just don’t want anyone to suffer

you just claim that or you can show that?

5:50 PM

life isn't without suffering, even with our best efforts

5:50 PM

what has it to do with nationalism?

5:51 PM

it's speciism if at all that we give higher rights to humans (and potentially should to apes) and it's unethical how little we care for animals suffering and the overall ecological sustainability of bio diversity, that's clear.

interesting quote but I hope you realize that's not making your point that whales or dolphins are more intelligent (or as intelligent and capable) as humans are (edited)

I don’t have time right now to fully get into this but hopefully you can see that this is about at least part of what I was talking about

5:58 PM

There’s projects of using AI to understand dolphin languages

5:58 PM

Have you seen those?

5:58 PM

I think they said something about dolphin language being far more complex than any human languages

5:59 PM

Also next you can look at the neocortex research too

I noticed you said something like we should give retarded people human rights because intelligent humans are capable of understanding ethics and applying it to them. We can do this to all mammals too or we can separate by individual. But this is all arbitrary. I’m not sure why Intelligence is a factor even. Our ability to understand that we can be nice to others shouldn’t be turned down based on species itself this is just a descriptor we made to organize the science of animal and plant biology so that we can understand things.

Dude you could've won the argument if you were willing to eat retarded people. I think the problem with that is that cannibalism is morally disgusting

Lol

Seriously guys, you need to work on your logic. I did not say "we should give retarded people human rights because intelligent humans are capable of understanding ethics and applying it to them." Never People with mental disabilities are also people just like others, that's why they deserve the human rights like every human. I would have won the argument if I was willing to eat retarded people, what? My argument isn't eating mentally limited animals is okay, my argument is it's okay to eat meat as omnivorous species, for apes, pigs rodents just as for carnivors like cats.

7:50 PM

You must meet your burden of proof to show me why it's unethical to farm and hunt with proper respect for the life of the animals.

You even fall back to the unsubstantiated claim "cannibalism is morally disgusting" although I gave the natural tribe example? "It's not generally unethical to me if humans ate humans. I'm thinking of natural tribes who eat parts of their deceased loved ones to "embody" them ritually. (Maybe weird tradition to us, but hey, other peoples other morals)"

8:08 PM

It's important to distinct between ethics (scientific justice) and socio-cultural morality in the first place.

shut up jordan peterson fan

1

150mg of tramadol and my anhedonia is at least more tolerable. I cannot feel any euphoria tho lol

11:25 PM

I think I could life like this if it would be possible to keep tolerance in check and actually start doing something

@Mods Ehm, such defamations dont get moderated here? mkay

2:05 AM

And Jordan Peterson is the biggest quack doctor I know.

I enjoyed some vids about Nietzsche/existentialists

5:19 AM

well "enjoyed"

5:19 AM

so imo there's bunch of stuff which can be interesting/useful but one has to find it eventually

5:19 AM

when it comes to JP

@Theo Riginal You can pick. Do we we give humans rights because of nothing else besides the classification of being human? Maybe how the word sounds, these sounds elicit importance and mean survival is worthy. Hoooooman. We can solve this injustice by labeling all other species as also human perhaps. If it’s based on the actual characteristic of humans, especially as you regarded intelligence or moral agency, then the humans who lack these should not be given rights that are based upon these traits because they do not have these traits. If it’s based on humanness then we can just start saying pigs are humans too, just a quick annotation of the dictionary.

You dont even answer on the moderation request? And please no human rights violating non sequitors, man. The other said I would have won the argument, if I was for eating mentally ill people and you say now they shouldn't get human rights for not having enough intelligence or moral agency. Cmon guys You show signs of mental illness, I think I need to eat you or revoke your human rights.

1:25 PM

Scientific justice, law philosophy ethics aren't made up of such fallacious conclusions like human rights not applied to animals is injust and that humans who haven't all traits of sane humans aren't humans or wouldn't deserve human rights. (edited)

1:27 PM

Instead, it's the scientific method applied that we search what is natural and not accountable for and make justice for all animals according to the species/individual needs and to prevent harm to themselves or others. Psychology & Law (edited)

Can you explain why you think it’s alright to slaughter animals? This is getting into weird territory now lol

The burden of proof is on you to demonstrate "it's not alright to hunt and farm meat with all awareness for the animals life." We are omnivorous animals as apes, like pigs and rodents eating meat is on our natural diet, as I mentioned several times. @Mods Can you explain why you dont moderate defamations or even answer on requests? (edited)

1

Appeal to nature being omnivorous isn’t that relevant. We can clearly live and thrive on vegan diets. Also it’s your BOP to prove why humans deserve rights

1

https://discordapp.com/channels/307540693826666507/420613019236565003/420676778420338688

4:07 PM

Please be normal @Mods (edited)

" isn’t that relevant"??? I can't thrive maximally without meat. Not up to you to decide what my natural diet desires are. The burden of proof why we deserve rights has been longtime brought, read some secular natural law philosophy. It's poor if you fall back to such relativation of everything out of lack of arguments for your burden of proof. This is apparently no server for me, you have very unscientific epistemology and make unsubstantiated claims without even the willingness to fullfill your burden of proof. Wish you a good life and that you dont mess yourselfs up with more unscientific psychotropic substance DIY psychiatry.

1

Well. I should have known adding this guy would turn out weird

5:49 PM

I was kind of busy driving 5 hours north and back home the last few says

5:49 PM

Days

5:50 PM

If you gave me time I could make an argument (I actually already tried to but the communication seemed unclear)

5:50 PM

Also I am the authorities and I was busy

Well, it was offtopic in public science resources so I moved it to general but I feel it is more appropriate for the channel be normal... or try not to fuck urself up even more than u already are I consider using CBD to upregulate CB1 and CB2, then eventually adding cocoa for anandamide and check out how to slow down its breakdown (I think the enzyme responsible for it was called FAADH?). Gotta check out how to decrease its activity if my memory doesn't fail here. + exercise It is a lil' bit confusing tho since presynaptic CB1 activation reduces glutamate thus normalizes NMDAr hyperfunction, maybe CB1 activation after upregulation of it, will be able to enhance NMDAr function ... aka activation of NMDAr, subsequent MOR enhancement... idk... sounds a lil' bit like fighting these dynorphergic mechanisms using ULDN to sensetize/upregulate MOR at nights maybe it can somehow work out. Also using TRPV1 antagonists to slow down tolerance development to opioid agonists, or sensetizing myself to endogenous endorphins and trying to release em via exercise but well... I am not sure whether NMDAr hypofunctionality due to low glutamate is the case or downregulation of NMDAr/AMPAr lmao. I feel definately worse on lamotrygine which is reducing glutamate. So my bet is that upregulating NMDAr and AMPAr is a better way, yet have no idea whether I'd actually improve on lamotrygine aka if such compenstatory changes take place so I dropped it atm. Piracetam upregulates NMDAr... so it would be maybe worth trying. Then increasing IL-10 to reduce inflammation... Anyone has any info on whether blood levels of cytokines reflect their levels in brain? Well, I will prolly dig into it a lot deeper when I will feel like doing it again lmao cause it sounds pretty fked up. (edited)

@qwerkyscience nerd that tried weed once and got super freaked out by it

9:06 PM

why cant I just be normal

Oh, to hell with your cancer. I’ve been living with cancer for the better part of a year. Right from the start, it’s a death sentence. It’s what they keep telling me. Well, guess what? Every life comes with a death sentence. So every few months, I come in here for my regular scan, knowing full well that one of these times– hell, maybe even today–I’m going to hear some bad news. But until then, who’s in charge? Me. That’s how I live my life.

1

I was anxious as fuck today. I realised what is this whole "game" called life about for me, how did my life look like for the last few years and I was literally feeling sad for the first time in a very long time, like "fuck, now I know why I might've become numb as fuck" (edited)

I’ve been anxious lately too because I need to find housing ASAP

you moved, right?

@qwerkyscience aren't u like a student or something why u moving

to uni iirc

@surajsoib moving to the University :0

@everyone Thoughts? Society has entered a new state of colonialism. Historically, colonialism occurred as geographically contained memes and ideas breached into other areas with alternate ideas via travel. The Internet has brought a new form of virtual travel and eColonialism begins. http://mad.science.blog/2019/08/14/ecolonialism/

theschizotypal

eColonialism

Historically, the mechanism of idea spreading and meming among human groups is through word of mouth. Then eventually the telephone came along and even later the television, both transforming the m…

Geographically contained memes

4:49 PM

ngl, the idea that memes are colonialism too is one I haven't heard of before

4:56 PM

this is new (edited)

New is good

I was worried it wasn’t new enough sorta. But I was also tripping out a bit when I thought that lol

not that I believe in the whole (neo)colonialism thing as being all that relevant to begin with

What do you think about it @Raisin-In-The-Rum ?

that people use it to explain too many things

Oh that’s probably true. I haven’t really researched neocolonialism

8:43 PM

Is it possible that a lot of them fit under some umbrella?

This kinda reminds me of people who do youtube videos /stream. Sometimes they were already quite messed up people, but also the isolating/empty nature of the platforms messes people up. Not sure what definition you're using for colonialism and memes though.

Memes just being ideas that are spreading socially. Very broad

2:43 PM

Culture bits

2:43 PM

Even memes of behavior

2:43 PM

Like whether it’s normal to react angrily or calmly

2:44 PM

But also conscious lingual ideas as well

2:44 PM

Colonialism here is cultural expansion and competition for viralness of mainstream norms

hrm, to be honest, when I think of colonialism it's inherently associated with domination of groups who are weaker, which inevitably leads to exploitation

That is what this will turn into. Certain philosophies will dominate and push out others from the mainstream and become the new normal

If the philosophy is useful/helpful, that's not really an issue though. It's the impact of the dominance, the degree to which people willingly adopt it or feel forced to use it that matters. I'm quite ok with homeopathy/anti-vaccine ideologies being pushed from the mainstream

The marketplace of ideas

key word market place

12:07 PM

money still reigns supreme

Well, currency reigns supreme Although the dominant currency in the marketplace of ideas is memes

anyone here have experience with NAC?

N-acetylcysteine? the medicine?

personally haven't. Heard some anecdotes about people using NAC and SARC for anhedonia but idk anything more about it.

seems like it regulates dopamine and glutamate.

4:35 PM

i’m supposed to be on AP’s, but the side effects are too much for me. i tried seroquel and my body fell asleep two hours before my mind did - i couldn’t tell if i was dead or dreaming

memes are for idiots

5:31 PM

that shit is not funny

But it is disgusting

it shows realms of life

That's the height of human civilization

you watch the animoos ?

I don't

i see, that is unfortunate

robobobo

life ain't mr robot

if one method to cope with stress is moving two fingers together in a specific way eventually neurogenesis or plasticity will allow the fine motor control more ability

4:52 PM

this can also be knocked down when usage discontinue like a few years after stopping violin play or gettin a minor concussion can reduce the fine motor certain drug can enhance the ability to reform ability with practice such as lions mane and psilocin

I increased lamotrigine yesterday and developed some weird headache. Weirdly enough it is specific type of headache I experienced a lot in the past and... benzo always helps with it gotta get into it later and somehow survive this lamo. Guess benzo isn't a good idea to deal with it. Damn, I am able to realize that I have terrible anxiety issues only when I get rid of em. It's some weird pattern, that one (guess it doesn't only apply to me) can notice some issues only when they're actually gone or when something dramatically changes. One isn't even sure what really changed. I guess being trapped in some unusual mindset makes it impossible to even comprehend that it might be different and in fact, it used to be different in the past. (edited)

12:55 PM

Maybe actually glutamate release inhibition leads to such things, whether it is due to sodium channel blockade or it is effect of upregulated mGlur, or dynorphin. Less glutamate-> less GABA lol. Tried taking B6 to enhance GAD but it doesn't seem to be helpful anyway. But I am glad that my benzo tolerance is at least somehow reduced.

12:55 PM

I even feel cognitive enhancement despite being quite pleasantly relaxed, well it's easier to form sentences and express my thoughts for sure.

12:56 PM

Reminded me about probably some autistic traits or some connections between GABA and ability to make pauses (?) between spoken words.

12:57 PM

And it has been like this for a long, long time, even before I started taking gabaergics in the past.

1:00 PM

Maybe it is even related to this delayed GABA switch...

Would make sense that even NMDAr antagonism is blocking GABA release iirc, so NMDAr hypofunction linked to OCD etc, leads to the same effects probably?

I’ve been doing theanine to some decent effect. It’s partial agonist of NMDAr

4:14 PM

It seems kind of similar to your experience

1

In reference to your latest #science-resources post, where can I get me some feminizing effects?

1

I’m not sure lol. Dairy apparently but I suspect if everyone in society is doing it then you won’t necessarily be more feminized than others

That's what I was thinking lol

https://www.youtube.com/watch?v=tDu5e4Rvr3Q

Joey Carbstrong

THE TOUGHEST VEGAN WOMAN ON EARTH | FIONA OAKES | THE CARBSTRONG CAST

@LizardCalledLazarus this is for more casual chat

Okay

4:37 AM

I'm here bro

Ok

You on this video?

Yeah

You'll see you and me walk on the aircraft carrier soon

Are you tripping or something

This is symbolic

Lol

I'm not

4:37 AM

This is synchronicity

4:37 AM

Don't think too much, just pay attention

4:38 AM

I'm here for you man

4:38 AM

Right now

4:38 AM

We're landing safely

4:38 AM

Thinking too much...

1

4:38 AM

Help me...

4:38 AM

Help me.

4:38 AM

Then let's concentrate

4:38 AM

Now get ready!

4:39 AM

Two-seater aircraft

4:39 AM

Now listen carefully and watch like me

4:39 AM

Huh? It stopped

4:39 AM

Someone must have joined

4:40 AM

I'm pressing play

4:40 AM

ignore that guy

4:40 AM

@qwerkyscience Play, yes?

4:41 AM

That aircraft is us going at our goal

4:41 AM

That's us

4:42 AM

Asking from Krishna there

4:42 AM

Then

4:42 AM

They're getting us ready

4:42 AM

Now listen and watch

4:42 AM

cause we're about to launch

4:43 AM

Man this is so intense

1

4:46 AM

Any comments? lol. That was amazing...

4:48 AM

I can also post something that's more amazing after this one

4:48 AM

But I feel ya it's pretty intense man

It’s cool

Good, then I'm gonna select next one

My mind is like crashing today lol

4:49 AM

I listen to tycho

4:49 AM

He’s one of the inspirations for the music I make

Yeah

4:49 AM

I like this very much

4:49 AM

It's... like beyond

I like the new Japan song

transcendental

4:50 AM

There was a video with visuals that I gotta upload

4:50 AM

4 minutes to upload

4:51 AM

meanwhile

4:53 AM

You with me bro?

4:53 AM

4:54 AM

@qwerkyscience

Yea

Yeah, let's get ready for tycho + visuals, lol

4:54 AM

it's going to be so good

4:55 AM

youtube is slow in processing sadly, 50mins

4:55 AM

lemme, OH

4:55 AM

found the next one

4:56 AM

@qwerkyscience Yes or no, continue?

Have you heard Japan

4:56 AM

If not u should play it

I want to do this other thing, I really don't know about it

4:56 AM

Please? I mean this is going to be good too

4:56 AM

Let's take a short break

4:57 AM

I'll check out that song

I have to sleep soon. But you can save it for next time too

Okay but this one for now

1

4:58 AM

Just don't worry

4:58 AM

Listen

4:58 AM

❤

5:00 AM

we have a liftoff

5:00 AM

okay and a joke for last

5:01 AM

Greetings from Pyongyang!

5:01 AM

So beautiful!

5:02 AM

There must be many great people there

This one is good

Got one more

5:02 AM

Which is even more beautiful, not that this isn't this is very

5:04 AM

You wanna continue this? Or go to fireballs

5:05 AM

Shit's getting outta hand xD

5:07 AM

@qwerkyscience You wanna continue? I can pick something more relevant too

5:08 AM

Let's just calm it a little here

I’m just kind of laying here listening lol

Woooaaaa

5:09 AM

So trippy

5:09 AM

5:10 AM

Okay here's the message to us if you are ready @qwerkyscience

5:10 AM

This one has something for us to do

https://youtu.be/X6twHZCfGtQ

Marcelina Urbanska

Moderat - The Mark (Interlude)

That's next sure

5:12 AM

No one's left to scream and shout as the human race is dying except for us

5:12 AM

What a ship of fools!

5:13 AM

Sorry but you gotta hear this

5:16 AM

this one to the end

5:16 AM

come on

5:16 AM

YEH

5:16 AM

LADIES

5:16 AM

AND GENTLEMEN

5:17 AM

WE HAVE A SPECIAL TREAT FOR GAGE FOR TONIGHT

5:18 AM

now listen to the lyrics

5:18 AM

sorry for secretly shamaning you in

5:18 AM

but this is good for you

5:23 AM

Strength!

5:24 AM

Come on! You got this!

5:29 AM

More will come

5:29 AM

Much better to come

5:29 AM

You're almost there.

5:29 AM

@qwerkyscience

5:31 AM

@qwerkyscience You're now invited to my secret discord.

5:33 AM

Morrison is the Shaman now.

5:33 AM

I'm going to dance a little.

be-normal sounded better

join us

5:35 AM

https://togethr.tv/r/lzh64

Togethr.TV

Watch videos together. Enjoy synchronized videos with your friends.

5:35 AM

@Mr Nobody

omw

now

5:36 AM

before it's too late

5:36 AM

we're together now

5:36 AM

the discord

5:36 AM

join

too late to apologizeee

5:36 AM

it's too late

no it's not

5:36 AM

try

loading

just hold on

5:36 AM

next one coming up soon

5:36 AM

we are on the train, riding down the tracks

5:37 AM

say something

the doors are related to psychedelics somehow?

this is

like The doors of perception?

yes

5:38 AM

they are wide open

5:38 AM

open your eyes

5:38 AM

listen and watch yourself

stop paranoing me

5:38 AM

it's not

5:38 AM

it's the opposite

5:38 AM

remember the thing about the paradoxes

5:39 AM

Krishna loves you!

5:42 AM

HERE WE GO!

5:43 AM

WOOPS

5:43 AM

just continue

this music is too noisy for me haha

1

Just listen

5:44 AM

LISTEN

5:44 AM

EVERYTHING

5:44 AM

EVE

5:44 AM

RY

5:44 AM

THING

daaaaaaaaaaamn

WHOOOOOOOOAAAAAAAA!

5:45 AM

it was the end of the son

5:45 AM

g

it stopped playing

5:45 AM

I re-discovered it again yesterday

There we go

https://www.youtube.com/watch?v=4kHl4FoK1Ys

ModernTalkingVEVO

Modern Talking - You're My Heart, You're My Soul (Official Music V...

5:45 AM

@qwerkyscience

5:46 AM

How do you feel?

5:46 AM

heheheh

5:46 AM

❤

5:46 AM

too bad you joined in late

5:46 AM

but that was it

80s' were great

this was a ceremony

5:46 AM

for gage

5:47 AM

he's invited to the discord now

Is it the mechanism behind the brainwashing in religions?

5:47 AM

lol

no

5:48 AM

I need a new room

5:48 AM

leave it

Well, I guess it might be

@qwerkyscience

5:48 AM

This is about us

5:48 AM

getting together

5:48 AM

figuring out

at least when it comes to religions

you need this next one and so does gage

5:48 AM

wait

5:48 AM

can you link this there https://www.youtube.com/watch?v=nNCI5PwCEfE

The Doors - Topic

My Eyes Have Seen You

5:49 AM

play it only on that channel

5:49 AM

press watch

5:49 AM

if no bueno

5:49 AM

then here

Ok, know this one

https://togethr.tv/r/rpg24

Togethr.TV

Watch videos together. Enjoy synchronized videos with your friends.

5:49 AM

click

5:50 AM

this is about the discor

5:50 AM

d

gimme the rights to choose music too

5:52 AM

haha

nope

5:53 AM

listen

5:53 AM

this is a ceremony

5:53 AM

listen to it

5:53 AM

love hides here

I’m going to sleep. To recover from all the sleep deprivation lol

5:53 AM

Goodnight

huh, long one?

5:54 AM

good night

@qwerkyscience You want in on the last piece?

5:54 AM

Just the last one

hahah

I promise

5:54 AM

really

5:54 AM

this time

5:54 AM

https://togethr.tv/r/rpg24

Togethr.TV

Watch videos together. Enjoy synchronized videos with your friends.

5:54 AM

you got 5

LOL

5:55 AM

@Ocelot You sound like a spam bot lol

No

5:56 AM

Don't listen to your thoughts

5:56 AM

Listen

5:56 AM

You're so close

wish I had thoughts in the first place to begin with

Gage just chose sleep out of the 4 there

5:57 AM

It's all fine

5:57 AM

We're continuing here this to the end

5:57 AM

It's gonna be good for us

6:01 AM

Why?

6:01 AM

Get to the end with me and then let's debrief on voice afterwards @Mr Nobody

6:01 AM

Okay you f'd it up

my turn

Sorry man

6:02 AM

I was the shaman here

aaaaaaaaaaaaaaaaaw

I'm on discussion

sup @LizardCalledLazarus aka #Spambot

3:35 PM

?

Just woke up buddies

6:07 PM

Mother called me with this shitty ass 4 hour sleep

6:07 PM

So I suppose I will lead a platoon of 38 with this and test my ming/body to the limits

whaat

6:18 PM

and why r u a robo-dog

6:19 PM

u binged watching

6:19 PM

https://www.youtube.com/watch?v=y8vpeDEOII4

Jedah Dohma

Biker Mice From Mars (Intro TV)

6:19 PM

?

@LizardCalledLazarus https://www.youtube.com/watch?v=yCC_b5WHLX0 "Don't follow any ideas. Follow yourself." (edited)

Roxette

Roxette - Listen To Your Heart (Official Music Video)

12:57 AM

You get it

12:57 AM

@Mr Nobody

"language around that stuff has been deliberately (whether at an individual or memetic level) obfuscated for a while now" I don't know what I was responding to but p sure that was months ago

6:31 PM

nice of discord to remember it for me

6:32 PM

and leave it in my input box in case I come back

Did anybody see Joker?

nope, not me. The only DC/Marvel stuff I liked was Jessica Jones I think

9:39 AM

but it was TV series

3:04 AM

@Ariadne joker is a great model for social defeat theory of schizophrenia

3:05 AM

vegan stigma https://www.psychologytoday.com/us/blog/without-prejudice/201910/prejudice-and-violence-against-vegetarians-and-vegans (edited)

Prejudice and Violence Against Vegetarians and Vegans

Disturbing evidence of pushback against people who do not eat meat

https://youtu.be/I3IyM_kX4hs

YouTube

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

https://www.youtube.com/watch?v=sjc5WTUI3aM lol, I never listened to things like this before

WWRahmania

Times When Dimash Had Fun With His Voice or Forgot That He's Still...

4:28 AM

I wonder if he needs autotune

Ptsd in emotional abusive relationship https://www.ptsdjournal.com/posts/you-can-get-ptsd-from-staying-in-an-emotionally-abusive-relationship/

admin

You Can Get PTSD From Staying In An Emotionally Abusive Relationship

By Jennifer Williams-Fields Stop. Just stop asking why a woman is so stupid and so weak when she stays in an abusive relationship. There’s no answer you can possibly understand. Your judgment only further shames abused women. It shames women like me. There was no punch on t...

https://www.youtube.com/watch?v=SkBpummjR5I&feature=youtu.be Comment below: stvbrsn "Nietzsche got it right. When you gaze into the abyss, the abyss also gazes into you!" @LizardCalledLazarus

(edited)

EVNautilus

Rare Sperm Whale Encounter with ROV | Nautilus Live

4:05 PM

lol. watching some other vid and guy says that clicks they make can vibrate human body to death

Wow

wtf universe https://www.vice.com/en_us/article/zmj7pw/theres-growing-evidence-that-the-universe-is-connected-by-giant-structures

There’s Growing Evidence That the Universe Is Connected by Giant...

Scientists are finding that galaxies can move with each other across huge distances, and against the predictions of basic cosmological models. The reason why could change everything we think we know about the universe.

1

That's really interesting

http://www.purifymind.com/BuddhismAsPsycho.htm

explained theme https://youtu.be/K7kBXKW6Ido

Syre

Vox Explained Main Theme - Extended Mix

qwerky hive meme asking the deep questions

3

1

12:46 AM

Here’s another meme ppl made in a diff chat

hello guys

Hey

Hello

ok boomer

2

what (edited)

I interacted with gwern. He is interesting but he bit me.

5:36 AM

so bipolar is characterized by intelligence deficits despite some genes which are linked to higher intelligence?

6:15 AM

And yet they have higher performance? lol

The problem is probably in the measurement of "intelligence" I mean your standard for intelligence is a little relevant on belief systems and stuff

8:13 AM

2

If you look in Xenotypy I’ve attempted to explain this weird intelligence pattern too

I wish I had more time to read

^^

https://i.imgur.com/NaZr9IK.png

1:33 AM

bro I wnana just lkike fucking dckioll meyself

It was a good year

2

cute!

Can someone tell me what this discord server is about. Don't remember how I got here

@Maravia this server is about floating ideas around, doing explorations in science, often discussing neuroscience. It’s as open as we let it be, but the main actives have been really focused on neuro and philosophy of a particular kind so far. I am a blogger and owner of the server. This was the Qwerky Hive before. My blog is found in #content-stream My posts are very relevant to the explorations here. The studies I’m going thru and collecting are posted in #science-resources and you can contribute with studies in #public-science-resources

1

bloggers have decent personalities but do they know how to truly have fun

3

2:55 AM

not sure

@surajsoib If you mean my personality in this discord, I think it is the nature of the community here. I run a very lively Facebook chat room as well and I’m more humorous and playful there. I try to get them to migrate here but it’s hard lol

3:02 AM

I think another trippy thing is that people keep arriving in the discord and say nothing lol. It’s like an engine that doesn’t start. Maybe if I wiped all the channels :0 wow. Maybe I’ll create fresh channels so that new arrivals just view it as new

1

hmm

3:07 AM

idk tbh

3:07 AM

I am too autistic

I think you got removed from the Facebook group D:

yep

I’ll add u back

idk why, but

3:08 AM

I think I might be too autistic haha

Kettner removes less active people constantly

I find it hard to somehow accomodate (?)

3:09 AM

idk if it is right word

3:09 AM

gotta check translator

You worry too much about that

3:09 AM

There are multiple people with actual autism in the chat

yep, probably

3:09 AM

think it is hard-wired lol

They even got in trouble for hurting others badly

like legal-stuff?

everyone is a little autistic imo

Only a little tho

Autism is reserved for those who have that social pattern to a seriously negative degree

4:11 AM

But the patterns exist on a spectrum ofc

how can you 100% verify if someone's autistic?

6:08 PM

the symptoms aren't all that convincing

You have to define when a set of symptoms becomes autism. But autism is just a set of symptoms

6:16 PM

Those symptoms have to be bad before a person is autism

I am actually also skeptical of autism as a specific condition. The way the definition is widening, there almost doesn’t even need to be any overlap of symptom of maybe even mechanism in varying people. The spectrum has become an all inclusive thing. Although there is at least some major themes that seem popular. Social weirdness, hypersensitivity, and usually decent cognition for high functioning autism. For mute autism, it is more obvious but still might not be a single thing.

6:32 PM

It gets weird if everything can be symptoms of autism

Idk if there’s a single mechanism that causes all autism associated behavior

6:56 PM

Or that unifies most autism symptoms

6:56 PM

It might be a group of factors that cause a single social response

6:56 PM

And that’s what the common pattern is

6:56 PM

But it’s fun to wonder if there is a common pattern at all

Also, you might get into a situation where someone is too high functioning to be considered autistic even if they were tested for whatever reason

12:02 AM

Not like there's a litmus test for autism lol

1:14 AM

autism spectrum is strange it seem to me subjective if the observer believe this person actin weird enough to be autistic but there is a social anxiety removal for autistic adult with mdma therapy so if social weirdness is removed what is left of autism, hypersensisivty?

2

1:15 AM

non verbal communication is big thing of the diagnosis some of the autists dont use non-verbal communication or they broadcast it but cant perceive it in others like 14% of non-verbal compared to a 100% control and this is relative to high functioning autism people not the low functioning autism (edited)

my emotional intelligence is kinda high or i like to think it is so i always rule out im autistic but who knows

Maybe thinking that your emotional intelligence is high is the autistic thing

1

12:56 AM

Jk lol

idk it does worry me

It's ok to be who you are

1

im not im just socially awkward maybd

You aren't who you are?

Quit weed cold turky 6 weeks ago. It's been easy, and easier to let her go. It's not really legal anywhere and if it is there's no real history of exposure so psychiatry is always tip of the tongue

2

I've been self ticklish since a child but only recently diagbosed as schizo, at least I've always been this way

@predictionary.us did you read Illusory Bugs

I saw the post

3:31 AM

Never had the feeling tho

I thought some people on the server might appreciate this(I didn't make it just found it)

3

make sense

2

@here https://www.youtube.com/watch?v=OdGs8XN-59Q

SoupTheory

[Live Map] Coronavirus Global Cases - Doomsday Prep Talk

cdc update coming today at 7pm every monday wednesday and friday they update the numbers on corona virus in usa

When does the zombie gene activate?

35 cases corona virus as of thursday 4pm in united states

6:59 PM

https://www.ncbi.nlm.nih.gov/m/pubmed/13679221/ try salvinorin

Social and environmental enrichment enhances sensitivity to the eff...

Pharmacol Biochem Behav. 2003 Aug;76(1):93-101. Comparative Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Salvinorin is intense. I’m suspicious that it promotes schizo-genesis

@qwerkyscience continual use would lead to the necessary basis for that. it likely would in me

5:57 PM

er idk i've wrote stuff b4 on the dynorphin pathology & schizophrenia. dont mind me

Have you? @Deleted User Have you ever read my dynorphin hypothesis of schizophrenia? Can you link what you’ve written? https://mad.science.blog/2019/12/19/dynorphin-theory/

theschizotypal

Dynorphin Theory

Most of this is taken straight from Psychedelics and Schizophrenia, but without much of the added bulk. The hope is that this can be the landing page for the dynorphin hypothesis of schizophrenia. …

wait you wrote that ^? @qwerkyscience

Yes

neat, read that on reddit a while back

6:44 PM

maybe thats how i ended up here idk

Possibly yeah. Do you know what the other person above has written about dynorphin? I’m curious

im not sure, but ik hes looked into it and read your piece, and is fascinated with the endogenous opioid system

I am as well. I feel it is the value or significance detector in a way, with dopamine too.

i need to look into it more, the dynorphin article was what got me interested in it actually

im posting this in #casual since I don't know how relevant this is. I originally found @qwerkyscience through his Dynorphin Theory article as it talks of schizophrenia, and wanted to mention Deleuze might be someone people would be into. He talks of schizophrenia as a symptom of capitalism (not in a bad way)

I'm writing an essay right now on Deleuze's conception of schizophrenia (even though it's more of a psychoanalytic definition than a modern clinical diagnosis definition) and wanted to include the Dynorphin part in it

@qwerkyscience oh heyyyyyyyyyy

11:40 PM

yoooooo

11:40 PM

that's u

11:40 PM

yes

11:40 PM

ur familiar indeed

11:40 PM

i've checked out ur website n shi a while back haha @qwerkyscience <3.

1

11:43 PM

@qwerkyscience @Deleted User yes i am in fact fascinated by the complexity that is the endogenous opioid system n i've read the studies on the naxolone on schizophrenics n all. i have a schizo friend with extensive trauma and i for one am familiar with the effects of dynorphin (from extensive cell degeneration/death, social shit, depression)

11:47 PM

i posted spinach as an opioid in #science-discussion (edited)

so what i wrote on it was rlly just to that schizo friend of mine (a girl, where i compiled my thoughts on the matter)

1

@ulla I believe I’ve heard of Deleuze a little bit although not extensively. It definitely seems to fit in with the social defeat ideas. Capitalism is like factory farming of the working class, which pushes people to their limits of extracting money without negative consequences. Some amount of people still experience horrific lives and they become the schizophrenics. They are perhaps tributed away as a side effect of capitalism. They are perhaps marginal economic losses that get ignored.

@qwerkyscience for sure! Deleuze also argues that there's a certain freedom and revolutionary potential with (psychoanalytic) schizophrenia - that it's creative and allows for unlimited semiosis. But capitalism is incompatible with them. It reminded me of your comments on D2 receptors (novelty?). I just wanted to point it out since writing the essay reminded me a lot of what I've read on your blog a while ago

1

2

I'd be a willing test-subject for the dynorphin theory of schizophrenia. maybe not rn though, in a few years heh @qwerkyscience

2

In a sense I test the psychedelics aspect on myself but I’m possibly bipolar and so if it’s very different from schizophrenia, then it may mean anything. What do you experience? Are you saying you’ll see if you become schizophrenic or are you already?

@qwerkyscience the former. i already have the glutamatergic and dopaminergic predispositions for it. i get psychotic symptoms sometimes and have had profound delusions. grappled with ocd type stuff before etc. and i feel that every few months i get closer n closer to developing schizophrenia n im not entirely sure why but it's likely the psychoactives i take that are accelerating that. (edited)

6:42 PM

oh is that why its said lsd may cause schizophrenia? er actually. why is it said it may? is it serotogenic, a dopaminergic rewiring, mGlur2 or dynorphin? @qwerkyscience (edited)

6:44 PM

i consider myself to have bipolar2 though ill have or not have a diagnosis soon (i do go hypo/manic though)

I think it isn't backed up by science

6:46 PM

also @qwerkyscience wrote about it https://mad.science.blog/2019/10/12/psychedelics-and-schizophrenia/

theschizotypal

Psychedelics and Schizophrenia

This is a topic I’ve been thinking long and hard about. We often hear rumors about psychedelics worsening schizophrenia or even bringing the disorder on in susceptible individuals. It may be …

6:46 PM

mGlur-5-HT2a schizo connection is well described there

thx

There are some anecdotes about people actually being cured from SZ

yes i get psychotic symptoms from thc

6:49 PM

all that makes great sense ❤️ (edited)

ye, cannabis freakouts are linked to dynorphin

6:51 PM

also CB1 agonism reduces glutamate iirc

6:51 PM

at least presynaptic ones

creatine is quite helpful for reducing glutamate

7:52 PM

i have like every psych disorder, makes for a very interesting system of thinking

7:52 PM

i didnt realize i never learned anything until i was 21

7:53 PM

nootropics made me realize i had made it through life simply memorizing everything but never understanding anything

think I was similar, now it is even worse

(edited)

7:55 PM

I did great in early childhood tho

i was awful in early childhood

8:01 PM

but i was too autistic to notice how autistic i was, which psychologically benefited me

hmm, I was extremely avoidant but there was some quality of inner experience still

then in high school i realized how different i was, and that lead to social isolation, increased delusions, other schizo symptoms (basically all the shit qwerky talks abt in his dynorphin article). then in college i learned how to eliminate the depression, parkinsons motor control symptoms, adhd impulsivity, chronic social anxiety due to autism etc

8:04 PM

i basically isolated myself as a coping mechanism for 7 years straight (edited)

how did u cope with it?

just dissociated myself from reality naturally during that time

8:04 PM

which aspect?

8:04 PM

i fixed the underlying cause

depression, adhd, impulsivity

of basically everything

8:05 PM

poor gut microbiome

wow

8:05 PM

food? or supps?

i fixed my chronic candida yeast overgrowth that i was born with

started drinking lots of kefir recently

repopulated my microbiome w homemade kefir, sauerkraut, and kombucha

maybe that's way to go

"

homemade kefir is top of the line probiotic

but ye, it isn't homemade kefir

8:06 PM

wait, what was kefir made of

?

literally 2 cups of homemade kefir has more probiotics than a full bottle of $50 probiotic supps

8:06 PM

kefir is made from kefir grains

it is milk, right?

8:06 PM

wow

8:06 PM

which are fascinating on there own

8:06 PM

bc they are living things

8:06 PM

and absolutely no one knows where the inital grains came from

got any recipe?

they are self propogating and all the kefir grains in the world came from the initial kefir grains found in the caucus mountains

8:07 PM

i have a link on how to make it in my server

8:07 PM

its very easy actually

8:07 PM

checking this out

just put the grains in milk, let sit for 24 hours, strain (avoid steel strainers), and then blend w berries to make it taste good

8:08 PM

i have a lot of information on how the microbiome influences essentially every psychological disorder on my server

8:09 PM

and my personal experience is proof enough to me anyway, but scientific evidence is def necessary to back up such a strong claim

8:09 PM

i had parkinsons

8:09 PM

i dont anymore

8:09 PM

at least not the symptoms

8:10 PM

at the height of my drug abuse, i had developed what was essentially dementia. my parents said i reminded them of my grandpa with alzheimers

1

^

9:19 PM

i be getting dementia too from this shit

9:19 PM

also cuz i have a cholinergenic issue

9:19 PM

plus neurotoxicity via "toxic encephalopathy" (edited)

9:20 PM

@Deleted User as in i've been so bad b4 to where i couldn't remember even what i'd just said or what i'd been told 2 seconds ago, much less put together a proper sentence with decent wording (my word recall was 0) (edited)

9:21 PM

been there

9:21 PM

candida will exacserbate that tremendously as well

9:21 PM

^this

9:21 PM

i also def have cholinergic issues considering my parkinsonsism

9:22 PM

:/

9:22 PM

also the being to autistic to know ur autistic

9:22 PM

yo, that was me as a kid too (edited)

9:23 PM

yea lmao

Hello

@Deleted User I also get psychotic symptoms off of cannabis. I only use psilocybin now instead of thc lol.

1:24 AM

@rxy hey

welcome

Cannabis can cause me psychotic symptoms w no tolerance, but with a little tolerance it's an effective mild antipsychotic, likely due to the D3 and D4 partial agonism

it is D3/D4 partial agonist?

Yea

1:42 AM

Iirc

hmm, didn't know

The magnitude would likely vary a lot depending on strain

thought it may act as AP due to CBD

It's more than just that

interesting

I wouldnt be surprised if hops also had some similar d3 and d4 partial agonism

1:44 AM

I really like hops

1:44 AM

Trying extract soon

they are gabaergic?

Idk abt that

1:45 AM

Hops have a lot of cannabinoids

1:45 AM

Which is why beer potentiates cannabis

1:45 AM

And why I crave IPAs so much lol

1:45 AM

But hate liquor

hmm, yep, seem to be GABAergic too

1:48 AM

never had hops tho

1:48 AM

just beer

1:48 AM

wine is my fav alc in the end I think

Didnt know hops themselves were gabaergic but it makes sense considering how I'm affected by em

1:49 AM

I prefer beer

1:49 AM

Then wine

wine has GHB

Watt

1:49 AM

Ff

but idk if it is relevant concentration

Fr*

1:49 AM

Weird

1:50 AM

Grapes that have it or what?

1:50 AM

Or does fermenting grapes produce it

1:50 AM

I tried to synth ghb

1:50 AM

Still have all the equipment

hmm, yep, think so. Cannot see any other way for it to get into wine

1:50 AM

or ye, maybe some reaction

I'll just eat grapes with sauerkraut and yeast

1:51 AM

And synth metabolic ghb

I could make like kombucha wine I think

1:51 AM

Already make my own kombucha

1:52 AM

I'd just need to use caffeinated grape juice

hmm

1:53 AM

microbiota high in Bacteroidetes and low in Firmicutes

1:54 AM

how to get such?

Bruh I dont know those words

me neither

And I love microbiomology

1:55 AM

I dont say microbiology bc I only really know microbiome

but generally it seems that aside of keto lactic-acid bacteria produces poly-BHB

What is poly bhb

if it acts in the same way as BHB

1:55 AM

then it is endogenous GHBr agonist

1:56 AM

'J3-hydroxybutyrate, produced during starvation, caloric restriction, fasting, high-intense exercise or by gut microbiota high in Bacteroidetes and low in Firmicutes has been mentioned to suppress sympathetic nervous system activity by reducing histone deacetylases (HDAC) activity and increasing acetylation'

1:57 AM

https://www.ncbi.nlm.nih.gov/pubmed/9503624

Poly-beta-hydroxybutyrate production by lactic acid bacteria. - Pu...

FEMS Microbiol Lett. 1998 Feb 15;159(2):293-7.

1:57 AM

and ye, HDACi

1:57 AM

this other compound, whatever it is

All those strains aside from predicoccus or whatever are predominant in most lactofermented fooda

1:58 AM

Which suggests I could replicate ghb synth w kombucha

ye, but idk if it has GHBr affinity

Hmmm

2:00 AM

How would I know

"The preferred compositions may contain GHB alone, as in a homopolymer (or oligomer) of gamma-hydroxybutyrate, or may comprise GHB in a polymer or oligomer together with other monomers. For example, GHB be copolymerized with β-hydroxybutyrate, as in poly-β-hydroxybutyrate-co-γ-hydroxybutyrate, or copolymerized with two or more different monomers, including other hydroxyalkanoates or hydroxyacids."

2:03 AM

that's where I wish I was better at chemistry

Cbd slowly gives me psychotic effects

2:04 AM

Notably after a couple days I start having formication

I felt literally nothing from CBD

2:05 AM

and I think I dosed some extract for a month or so

I notice a lot from cbd after dosing for a month+

2:11 AM

It's an adaptogen so long term dosing is required for maximum effects

2:11 AM

Only negative I've gotten from it is exacerbating serotonin syndrome due to 5ht1a agonism

2:12 AM

And whenever I have SS, that's the issue; 5ht1a

2:12 AM

Bc it's always w dxm combos

ur microdosing dex?

Ummm

2:13 AM

Macrodosing?

2:13 AM

Lmaooo

daily

?

No matter the dose my cognition improves w my current stack

2:13 AM

Not quite

2:14 AM

But anywhere from 2-7 days a week

I don't even get visuals from dex

Same

2:14 AM

I function better in sigma than sober

2:14 AM

Ask @Deleted User

uhh

They can corroborate my story

My baseline is simply that fucked

2:15 AM

I mean think abt

ye, I get what u mean

2:15 AM

but getting sober is so painful afterwards

I have nearly every psychiatric disorder

2:15 AM

I can type the way I do rn while driving

2:15 AM

Dumb

2:15 AM

But yes

2:15 AM

Case and point

2:16 AM

I live in absolute sensory overload

sober?

2:17 AM

for me it depends, used to have some increased sound sensitivity, touch sensitivity but it is pretty much gone now

Bot quite sober no

2:17 AM

Sober is dangerous for me

same

2:18 AM

cannot call it functioning

Agreef

how did it all started?

2:20 AM

stress?

all of what

ur issues

CBD is sometimes good but I can tell it worsens serotonin problems after it wears off

2:26 AM

Or so I feel

2:26 AM

Also it was linked to worsening addiction unlike other 5HT2ar and 5ht1ar agonists

interesting^

2:29 AM

all my issues started as a result of being born tho

2

2:30 AM

every time ive done a drug, they get better temporarily, unless i overuse that drug, which i usually do

2:30 AM

as is the case w dxm, which ive used a good 450 times or so in the past 2 years

lol. I tend to think the same way

the anti infllamatory effects of dxm help me a lot

2:31 AM

seeing as the root of my problems is inflammation (edited)

was thinking about it recently too

2:32 AM

each time my skin condition got better, my mood improved a lot

yup

2:32 AM

what sucks is i have MTHFR gene mutation which makes me develop tolly and dependence to drugs faster

2:32 AM

so i wd hard

2:33 AM

but before i get to physical dependence i get more benefit from drugs than most

methyl groups supplementation doesn't help?

it does

2:33 AM

but not enough

2:34 AM

NAC and SAMe help a lot

2:34 AM

but ig the problem is deeper than that

ye, I need to get deeper into it

2:34 AM

checked homocysteine once and it was low af

the correlation w MTHFR, poor microbiome and yeast overgrowth is interesting

2:35 AM

but makes logical sense

hmm

when i first started drinking

2:35 AM

my drunk would last a good 8-12 hrs

2:36 AM

bc poor methylation]

2:36 AM

now w my supps its like 6 hrs

2:36 AM

which has goods and bads

2:36 AM

i wd less hard but wd sooner

I have no idea how all of it is connected with each other

i do in my head

2:37 AM

but verbally i couoldnt explain why aside from the fact that they interdependly increase risk for one another

2:37 AM

ig thats sufficient explanation tho

like poor methylation- screwed up synthesis of NTs, glutathione (?)- oxidative stress, inflammatory issues?

2:38 AM

but on the other hand less gene repression?

i dont have an understanding of the complexities that runs that deep

2:39 AM

but glutathione 100%

2:39 AM

poor synth

2:39 AM

and oxidative stress and inflammation

2:39 AM

couldnt tell ya abt gene representation

2:39 AM

or NTs (edited)

2:39 AM

what are NTs

neurotransmitters

o

2:40 AM

lol

2:41 AM

yea that makes sense

2:41 AM

undermethylation + poor metabolisation of amino acids

2:41 AM

leads to poor synth of NTs

2:41 AM

as is often the case w autism

think B9, B6, B12 idk what else has to be converted into methylated forms and they are needed for synthesis

theres a high correlation w autism and MTHFR

2:42 AM

yea i take a b complex specific for mthfr

hmm

I have issues that seem born-with too. Probably adhd bipolar stuff

Cannabis with no tolerance on high dosages is absolutely insane

9:43 PM

Can get stronger than LSD in some aspects

9:47 PM

@qwerkyscience like I got some next level body disassociation today from weed, like it was almost impossible to walk normally, my field of view was just emcompassed in “visuals”, like weed visuals are weird, like feels like my subconscious and consciousness blended together. Felt like a dream and saw shit like 3D shapes, overlay holograms kinda effect around my wrists, looking forward felt weird since everything far was kinda blurry, and it felt as if I was in a cylinder

9:47 PM

I almost greened out as well so I was beyond high

9:47 PM

Some points I felt like I was gonna die

9:47 PM

Like severe ego disillusion

9:48 PM

Even more than LSD

9:48 PM

Closed eye visuals were pretty intense

9:49 PM

Mainly like Mayan art and swirling colors and hyper realistic imagination

9:49 PM

Then here comes the part where I almost shat myself: at one point I swear I started hearing voices

9:49 PM

They were so realistic but I forgot if they said anything

I agree very much. Weed has been consistently crazier than psychedelics for me thus far but I imagine a very high dose of psychedelics to be equally or more intense.

@qwerkyscience personally psychedelics give you more of a helping hand

1:24 PM

While weed is more hazy and confusing, and the body load can be a bit too much at times

1:24 PM

Yesterday basically I fully disassociated from my body

Yes this is my experience as well

Rationalism wont be savior in real world

https://www.nbcnews.com/news/asian-america/asian-americans-report-nearly-500-racist-acts-over-last-week-n1169821

Asian Americans report over 650 racist acts over last week, new dat...

“The deliberate use of terms like ‘Chinese virus’ has definitely fanned the flames of racism toward Asian Americans in this country,” one nonprofit leader said.

1

https://abc7.com/society/amazon-delivery-man-caught-on-video-spitting-on-package-in-la/6056461/

Amazon delivery man caught on video spitting on package in Los Angeles

An Amazon delivery man was caught on video spitting, then smearing the spit with his hand on a package in Hancock Park.

@iggly idk but igglypuff is cute

6:26 PM

there needs to be an uglipuff

6:26 PM

for the uglies

lol

igglypuff is

7:27 PM

a

7:27 PM

shit pokemon

only mewtwo

i caught mewtwo with a fucking pokeball in firered

7:31 PM

go fuck yourself

7:31 PM

only leaf can do that

7:32 PM

idk what firered is

....

7:32 PM

pokemon fire red

never played it

the remodeled version of pokemon red

madness i grew up on fire red

7:33 PM

but i thought you'd prefer leaf green

7:33 PM

not a true vegan imo

i do prefer leaf green hence the name

7:34 PM

but i was only lucky enough to catch mewtwo w a pokeball in firered

nice. yeah pokeball mewtwo is rly rare. on the sp or gameboy advance?

7:34 PM

oh nice

i dont even remember tbh

wish i could have traded with ppl back in the day. was too poor to afford two.gameboys

7:35 PM

amd couldn't get machamp

7:35 PM

gengar

7:35 PM

etc

may have been emulator

7:35 PM

i dont think it was tho

it was a link cable actually

7:35 PM

it was cheap

7:36 PM

i was just unaware at the time and thought of it as some foreign concept

playing pokemon without the ability to fast forward is a tremendous waste of time

plus the people who had the game never had a cable either. it seemed so rare to have

fr

fast forward? like rare candies?

no i mean w emulators

7:37 PM

4x speed shit

7:37 PM

skip through the chit chat

i personally think the great thing about pokemon back in the day was the grind and figuring out ways to make the game easier for yourself.with limitations in place

7:38 PM

like sword and shield is just more fun and easy. no grind in any sense

i havent played any of the new ones

like sure it wasted a lot of time but i wanted my damn lvl 100 blastoise

7:39 PM

oh i see

7:39 PM

yeah if i were to go back, id want an emulator version

diamond and pearl were p much the last ones i spent time on

hated diamond n pearl tbh

7:39 PM

like piplup

7:39 PM

little bich imo.

piplup is a cuck

no doubt, chimchar a beta torchic

yea

I played competitive on x and y

9:36 PM

But it’s been long enough that I don’t remember my strategy so well

my startegy is win

1

Sounds good

https://nypost.com/2020/03/28/los-angeles-coronavirus-crisis-could-reach-nyc-levels-in-five-days/

Los Angeles coronavirus crisis could reach NYC levels in five days

Within five days, Los Angeles could see a surge in the coronavirus just as bad as what an already-overwhelmed New York City has experienced, state and city officials warned. Standing in front of th…

3:49 PM

It’s happening here now. 4 days left

https://amp.theguardian.com/world/2020/mar/28/is-factory-farming-to-blame-for-coronavirus?__twitter_impression=true

Is factory farming to blame for coronavirus? | Coronavirus outbreak...

Scientists are tracing the path of Sars-CoV-2 from a wild animal host – but we also need to look at the part played in the outbreak by industrial food production

https://www.theguardian.com/world/2020/mar/29/china-coronavirus-anti-foreigner-feeling-imported-cases?CMP=fb_gu&utm_medium=Social&utm_source=Facebook#Echobox=1585466260

'They see my blue eyes then jump back' – China sees a new wave of x...

Fears rise that Beijing is stoking mistrust of foreigners as part of the government’s attempt to rebuild a reputation tarnished by the coronavirus crisis

https://www.quantamagazine.org/authors/jordana-cepelewicz/

https://futurism.com/neoscope/half-coronavirus-carriers-no-symptoms

Study: Yes, half of coronavirus carriers show zero symptoms

It's the study everyone will be talking about this week.

This is why I'm not doing instacart right now

4:44 PM

I don't want to risk spreading it without knowing

I think I had it

Although there's a lot of money to be made Really? What makes you think that?

I had lung pain for a few days, possibly fever but I couldnt check, and also chills

4:47 PM

It was harder to breathe too

Sounds like the symptoms

4:49 PM

They are pretty generic symptoms though

People on my campus also had it

Eesh Thankfully, I've been keeping to myself as much as possible

4:50 PM

We only go out to get supplies

I have not left the house in weeks

4:51 PM

because Im quarantining

Good luck to you

4:52 PM

I hope it all turns out all right

I am alright

4:53 PM

I have recovered it seems

That's good

4:54 PM

I guess we'll see how everything else develops

Stay safe on that!

how long do u need to remain quarantined for

I think I might be good to go to the store now but also the city is going to give people citations if they are just out for no good reason.

3:57 PM

I think they say 2 weeks

https://www.pe.com/2020/04/01/was-coronavirus-in-l-a-in-february-researchers-say-probably-yes/?utm_source=facebook.com&utm_campaign=socialflow&utm_medium=social&utm_content=fb-ThePressEnterprise

gqlshare

Was coronavirus in L.A. in February? Researchers say probably yes

Chances are the coronavirus was circulating in Los Angeles weeks before health officials started testing and keeping track of confirmed cases in early March.

https://www.nytimes.com/2020/04/01/health/coronavirus-stroke-seizures-confusion.html?smid=fb-nytimes&smtyp=cur&fbclid=IwAR3sQGDkwBRm9L-eqIEsti6YDVa-JYvi64I7IQgmL9k5EfZHG_f6WsQrMpA

By Roni Caryn Rabin

Some Coronavirus Patients Show Signs of Brain Ailments

Doctors have observed neurological symptoms, including confusion, stroke and seizures, in a small subset of Covid-19 patients.

https://trib.al/ZjoqicS

'Highly-scalable' coronavirus vaccine a few months from human trials

Researchers from the University of Pittsburgh say the new treatment would be delivered through a 'painless jab' similar to the annual flu vaccine.

https://sanfrancisco.cbslocal.com/2020/02/24/san-francisco-police-investigate-racially-charged-attack-recycling-video-can-collector/

davepehlingsf

San Francisco Police Investigate Racially-Charged Attack On Can Col...

Police in San Francisco are investigating an apparent racially fueled attack over the weekend targeting a man collecting cans in Hunters Point that was caught on video, according to authorities.

10:18 PM

So disturbing

10:19 PM

Pandemic Xenophobia is coming to life now

Testing the vaccine in Africa https://www.google.com/amp/s/www.aljazeera.com/amp/news/2020/04/racism-row-french-doctors-suggest-virus-vaccine-test-africa-200404054304466.html

Racism row as French doctors suggest virus vaccine test in Africa

Two doctors spark criticism for discussing in a TV show the idea of testing a vaccine for the coronavirus in Africa.

Well, you gotta test it somewhere

12:10 AM

They can't sue

12:11 AM

You also have absolutely no way of baselining.

7:07 PM

But this is all hypothetic water chumming. A reasonable timeline for a vaccine, best reasonable possible time is a year to a year and a half from first sample to production line

7:08 PM

Which is incredible in and of itself we should live to see such days. Used to be a metric measured by years, or decades.

Omg I'm totally lost

What does Push to Talk mean? For after I mean, listening

u gotta press the button to talk, otherwise ur voice is being detected automatically and u can be heard

I'm off Thank you guys

9:37 PM

Have fun

️

9:38 PM

It's late here hihi Byyyee

Bye

10:54 PM

Thanks for coming!

So this psychonaut thing has really gotten some legs under it. Used to be enthoian review and the hippy stuff Leary spawned.

11:22 PM

Or tom wolfe or hunter thompson. But they really didn't go too much into the science side of things.

11:23 PM

Bob Wilson woulda been blown away to see it make this much progress. He'd had an inkling it might, but he always felt the gov would crush any serious movement that looked large enough.

The internet gives us access to such a great amount of information that we can become increasingly scientific with psychonautics

2

https://www.vice.com/en_us/article/avywv4/my-grandma-the-poisoner-0000474-v21n10

My Grandma the Poisoner

I've come to believe that my grandmother literally poisoned those around her.

@qwerkyscience sure, I was ennoying it, I have taken screenshots and am reading your previous comments now, from above haha

6:24 AM

Good morning, and buh bye :)

@iggly They're offering up to $60 bonuses if you can complete enough orders

would u guys recommend working considering the consistent rise of deaths with covid19

1:24 PM

might need to just do a couple night shifts or something

1:26 PM

@Ariadne what u gonna do

I'm not working, but I'm taking care of my grandma

2:37 PM

If it was just me, I would work instacart

2:37 PM

People still need their groceries

You can wash the groceries too and buy only washable things, packaged food like frozen veggies or canned food

It's if you complete 12 orders in a specific 4 day period

@iggly idk

6:37 PM

my immune system has always been good tbf and im used to nocturnal lifestyle

6:38 PM

id do deliveries tbh but isn't getting a license hard for even instacart how does it run

6:38 PM

uglipuff

6:38 PM

so cute

6:40 PM

im.hot so im immune to the virus

All you need is a car and insurance lol

oh ok

https://abcnews.go.com/Politics/intelligence-report-warned-coronavirus-crisis-early-november-sources/story?id=70031273

Intelligence report warned of coronavirus crisis as early as Novemb...

"Analysts concluded it could be a cataclysmic event," a source says.

https://time.com/5817665/coronavirus-conspiracy-theories-white-supremacist-groups/?utm_source=facebook&utm_medium=social&utm_campaign=editorial&utm_term=u.s._covid-19&linkId=86277354

White Supremacist Groups Are Recruiting With Help From Coronavirus ...

As COVID-19 spreads around the world, white supremacist groups are seizing onto it to recruit and spread misinformation

They've been using this whole political atmosphere to increase their ranks. The fuzz crossover with alt-right works as a functional soft recruitment (edited)

3:33 PM

As someone whos fought them for a..very long time I can at least say that the biggest problem they face is always the same. Membership churn. They have to constantly recruit, as it's also fairly common for membership to age out by no later than 30.

what police crossover with the alt right?

Huh?

man thats some pure distilled boomeritis i just read (edited)

There's some cops associated with groups like proud boys, but they're by and far in the minority

3:37 PM

Well, not sure what to tell you on that count skeeter. I'm not a boomer. Gen X'r.

3:41 PM

ANd TBH i'm still trying to grok out how my synopsis of that political radicalization ecosystem is "boomertitis" at all.

3:42 PM

Because i haven't heard boomers weigh in on neonazis really at all.

@Mr Nobody Oh yeah I talked to one of the researchers who is published in nAch a7 research and I mentioned dynorphin suppression but he stopped responding lol

he stopped responding after u mentioned dynorphin?

11:20 PM

weird

11:20 PM

maybe he didn't know about it

Yes I might ping him

11:24 PM

He didn’t even read the message with the dynorphin thing. I think he forgot and actually so did I until rn

they test binding affinity among schizophrenics?

11:26 PM

or who the patients are?

I think so

https://www.telegraph.co.uk/science/2019/08/12/world-must-prepare-biological-weapons-target-ethnic-groups-based/?fbclid=IwAR0BozqsYya1kVce6Drvn1jokopRNlghD4P86p7ru2UcieQNf5KKT6N3oAA

World must prepare for biological weapons that target ethnic groups...

Biological weapons could be built which target individuals in a specific ethnic group based on their DNA, a report by the University of Cambridge has warned.

https://palladiummag.com/2019/04/01/its-time-to-take-octopus-civilization-seriously/?fbclid=IwAR1bzOpFTuANRwGPoSgksWEKuoePfHsgtq_utSK5gCpypmkfJnipCtRnyIY

Marko Jukic

It’s Time to Take Octopus Civilization Seriously

Forget about AI. There is a much more alarming type of intelligence arising in the oceans beneath us. Most people don’t even know about it. Without a solution, humanity will be overwhelmed.

https://www.scmp.com/news/china/society/article/3079443/coronavirus-could-target-immune-system-targeting-protective

Covid-19 may attack immune system like HIV, doctors fear

Researchers in China and the US find that the virus that causes Covid-19 can destroy the T cells that are supposed to protect the body from harmful invaders.

https://www.latimes.com/science/story/2020-04-10/coronavirus-infection-can-do-lasting-damage-to-the-heart-liver

Coronavirus infection may cause lasting damage throughout the body,...

Some patients who have recovered from coronavirus infection are suffering lasting damage, including liver damage, heart damage and blood clotting problems.

6:25 PM

https://www.koreatimes.co.kr/www/nation/2020/04/119_287752.html

South Korea confirms 111 cases of coronavirus reinfection

https://artbreeder.com/browse

Artbreeder

A collaborative tool for discovering images.

@qwerkyscience Saw this after reading that april fools octopus article... https://blog.therainforestsite.greatergood.com/octopuses-on-shore/

Dozens Of Octopuses Are Walking Up Onto Shore For No Apparent Reason

Even scientists have no idea what is happening or why these creatures are doing this.

1

I actually didn't yet read the octopus article, I didn't realize it was a joke one

12:19 AM

I read some of it though, but it seemed serious

1

https://www.pentadact.com/category/conwaysblog/?K=5&U=8&C0=1&E1=2&C1=6&E2=1&C2=1&C3=3&C4=1&C5=3

Conway's Secret Blog

Gunpoint is a stealth puzzle game for PC that lets you rewire its levels to trick people.

6:06 AM

Mind flayers are real

1

https://www.youtube.com/watch?v=KzxEzf-UGco also wtf synchronsity @Ariadne i was posting about gunpoint yesterday

MindVox

Futurescape - 1hr Ambience, Inspired by Blade Runner & Cyberpunk

8:07 PM

im savin that secret blog that pretty awesome generation from gunpoint

Yea, I love the blog part at the end. I've done full nonviolence before, but I don't think you can true pacifist the whole game

https://www.pentadact.com/category/conwaysblog/?K=2&U=1&C0=3&E1=1&C1=1&E2=1&C2=2&C3=1&C4=1&C5=2 So, if you pacifist everything, the guy at the end won't surrender and has to be punched(I did truth)

Conway's Secret Blog

Gunpoint is a stealth puzzle game for PC that lets you rewire its levels to trick people.

https://www.medrxiv.org/content/10.1101/2020.04.14.20062463v1.full.pdf?fbclid=IwAR01r3pmPUiWtQFXP34pSiy51ampGYY2p4_mt4uxNDqwUc2MzRBSsnVTm_Y

11:52 PM

ITS HAPPENING

@qwerkyscience "These prevalence estimates represent a range between 48,000 and 81,000 people infected in Santa Clara Countyby early April, 50-85-fold more than the number of confirmed cases" Eep.

1

1

@insectodescenso is this disucussion related to amantadine derivatives?

Anandamide is the endogenous cannabinoid! At least one of them

Interesting. A buddy of mine has some delta-8-thc distillate @qwerkyscience

4:40 AM

Causes almost no anxiety/paranoia from my experinece.

I wonder what the pharmacology is

https://www.economist.com/science-and-technology/2020/04/16/acts-of-kindness-prevent-a-downward-spiral-from-solitude-to-loneliness

Acts of kindness prevent a downward spiral from solitude to loneliness

To be alone and to be lonely are not the same thing

i now believe gamedev holds great capacity for AI development when it comes to quantifying creativity in a digital environment like/... how else can you tedach an ai to learn art.. sound... map design.. etc.. working with files and windows interface... deciding what to add next.. when you have 2.5million games who had their entire development process digitally recorded into a measurable way... ai can use that swath of data and start learning something out of it you can teach an ai to paint picasso and stuff but thats based off reference images.. not reference ideas.. not universe lore an ai who learns these advanced creative processes humans possess and robots do not.. an ai who learns this would be able to understand 100% of warhammer 40k lore, from 40,000+ mental perspectives... capable ofr creating ANY kind of art medium... a sound file... a VR game, a painting, a poem, etc of warhammer 40k reference universe. so any creative content generated can be specified into a niche

7:29 PM

here is or a simplified meme of this meme 【ｐｏｓｓｅｓｓ　ｐｒｏｃｅｓｓｅｓ】 (edited)

https://discord.gg/DJtRsk

https://www.cnbc.com/amp/2020/05/06/ny-gov-cuomo-says-its-shocking-most-new-coronavirus-hospitalizations-are-people-staying-home.html

Cuomo says it's 'shocking' most new coronavirus hospitalizations ar...

Early look at data from 100 New York hospitals shows that 66% of new admissions related to the virus are people who were at home, Cuomo said.

https://www.nbcnews.com/news/amp/ncna1201181?__twitter_impression=true&fbclid=IwAR3QtnIBrTo8OO5niPnLrfmfZkaSqnayquPE2GXJjwgyC6QyUA5UXkcYjvQ

Facebook names 20 people to its 'Supreme Court' for content moderation

The list includes nine law professors, a Nobel Peace Prize laureate from Yemen and journalists but no disinformation experts.

http://comfortablyunaware.com/blog/the-world-hunger-food-choice-connection-a-summary/

Comfortably Unaware :: The World Hunger-Food Choice Connection: A S...

@insectodescenso unless AI spontaneously self generates, the chances of us crafting a simulated consciousness remain exactly zero point zero until we can discretely & mathematically describe our own. (edited)

7:41 AM

All a computer can be is a calculator. Sometimes a calculator that builds itself a black box process, but that's a far cry from conscious.

7:46 AM

....And i really wish people would stop cluttering the concept with anthropomorphic overtones, misappropriations, and ad hoc reactionary reflexes.

7:47 AM

It's fetishization borne from ignorance, plain and simple. (edited)

There's maybe half a dozen figures in the exploratory field I would place any stock in whatsoever to give any 'state of the solid state' press releases.

7:56 AM

and NONE of them are rock star scientists, futurists, uber-rich industrialists, defense contractors, politicians, or salesmen/women. (edited)

If you want a REAL goddamn sense of where things are at, and where they're going for the foreseeable future(< 5 years) follow Dr. Ayanna Howard on Twitter. Her opinions on the subject i've grown to trust. (edited)

Dr. Elizabeth Joh is another. Though she's not involved in AI, just in a related field of computational research. (edited)

8:19 AM

And please for the love of all that's holy stop enabling the copypasta scaremongering/fantasy fetishization surrounding the research into the subject. (edited)

Consciousness seems antithetical to solid state to me, but everyone has a different idea of what consciousness entails so it doesn't matter

1

10:47 PM

AI can already break down and recombine ideas, it's called procedural generation

10:47 PM

It doesn't stop the game from feeling derivative though

10:48 PM

The AI has no concept of fun or game design principles

10:48 PM

It doesn't make decisions, it just follows a procedure to generate more content

10:48 PM

Kinda like EA lol

10:50 PM

I'm going to go through the PubMed database on "psychedelics" and on "schizophrenia". I have a nut to crack.

12:15 AM

and an axe to grind

12:18 AM

they think i'm a degenerate.

12:19 AM

I graduated top of my class and have learned more outside of school than I did in class.

12:19 AM

it's going to be messy. Over 150,000 articles to go through

@Beggar Midas do you think concious self awareness, or the mind we have esentially requires quantum states in some way, like photosynthesis does? im a newbie on quantum and maybe a silly question, perhaps literally everything in the reality requires quantum activity to exist

Yes check out the microtubule theory.

3:36 AM

And similarly check out my paper on Alcalculus if you want to see my theories on non-discrete consciousness.

3:37 AM

We move away from assuming infinitesimals are flat / linear. Because I believe after a scale of infinite zoom there remains feature detection through nested similarity.

3:38 AM

It's really fun math and it improves on all of newton's major pieces.

3:39 AM

The same infinitesimal in my math has the same curvature as the original function. So ultimately it's also better math.

3:42 AM

In regards to knowledge not being valuable, private knowledge can be sold at value.

1

yeah exactly i have good private knowledge that can make me a lot of money lol

2

sounds mysteriouuuuuuuuuus

2:34 PM

I want to have this knowledge noooooow

read technical documents

10:49 AM

eventually you'll have searched through everything, or you'll have found something that can't be found

1

@Mr Nobody well i scout

7:03 PM

what i scout is, hmm a sport

7:03 PM

and players who do said sport

1

https://www.the-sun.com/news/901220/george-floyd-protests-minneapolis-police-precinct-fire/?utm_source=facebook&utm_medium=social&utm_campaign=USsunfacebookbreaking

Driver 'ploughs into George Floyd protesters' and police station se...

A DRIVER was filmed speeding into George Floyd protestors in Denver and a Minneapolis police precinct was stormed and set ablaze on a third night of fury across America on Thursday. Shocking video …

https://twitter.com/srslyberserk/status/1266605281728921600

BERSERK‼️ 🏴 (@srslyberserk)

Thoughts and prayers to Trump Tower Chicago. /s https://t.co/x4N8EKh7vM

https://twitter.com/90sskramzband/status/1266616076659392512

pathetic_girl43 (@90sskramzband)

@jimmy_dore Cops arrest peaceful protester with camera for no reason in Rancho Cucamonga protest https://t.co/8tQ7t1wB8x

Retweets

116

Likes

246

I wish mainserin was easier to access

3:35 AM

Besides agomelatine, it's the next most accessible ht2c antag

Why not take agomelatine? I would imagine it’s better tolerated

https://www.reddit.com/r/likeus/comments/gzhxrw/cow_humming_along_with_her_human/

r/likeus - Cow humming along with her human

7,573 votes and 266 comments so far on Reddit

Are stimulants anti-inflammatory? When I take my ritalin my joint pain disappears. Couldn’t find anything about it

Well it increases adrenaline right

True, so it’s like cortisone basically? Would it have the same quick tolerance?

hi

Woah

3:59 PM

https://www.cnn.com/2017/12/22/health/thomas-tank-engine-paw-patrol-fascist-cartoon-strauss/index.html

Why kids love 'fascist' cartoons like 'Paw Patrol' and 'Thomas'

Young children are drawn to worlds in which identities are fixed and transgressions are met with routine punishment.

When they mentioned Buzzfeed, the whole article lost its credibility lmfao

To be honest i didn’t really read this. It’s just a really funny headline

Tbh lmfao

I'd imagine the relationship is more the other way around, TBH.

Didn't you know? Police = fascism

3:43 AM

Is there a qwerky minecraft server

4:41 PM

Im hoping there is

I can invite you to play two player with me

5:58 PM

@insectodescenso

5:58 PM

I was considering streaming here sometime but it’s so different from science or psych lol

I might make a server. That sounds cool. If there are ppl who play mc it will be cool. I have some friends who would probably join.

If you make a server id join

@qwerkyscience I'd be down

Epic

Only if java version

Java version doesn’t play right on my pc

2:33 PM

I have the windows 10 one

It's alright My internet is trash anyway

@Deleted User looking for 5-ht2c antagonist?

@Deleted User yeah, agomelatine is just expensive. Other selective agonists don't have good safety data. The rest tend to also antagonize HT2A as wellz which I don't want.

7:11 AM

Latrepirdine looks kinda interesting. Would be hard to get verified quality without costing a lot though, so probably not a better choice than agomelatine.

I tried agomelatine. It’s interesting and causes a stimulation but also puts you in a trance and I tended to hallucinate or dream awake

Might that be a bipolar-specific thing?

5:06 PM

I don't have bipolar

5:07 PM

It just seems to shut off my cognition until I go to sleep. Not directly sedative, but I find it a lot harder to have fun after I've taken it. Less intelligent thoughts and emotional range.

5:10 PM

I get a similar effect from polygala... And if I can put aside the ease of falling asleep (not to be conflated with sedation)... Low doses of other reuptake inhibitors like methylphenidate and coke also dampen my cognition and emotional range.

5:11 PM

High doses are are a different discussion, signals acting more on post-synaptic receptors

5:12 PM

I figured the commonality is both 5-ht2 antagonists and presynaptic doses of reuptake inhibitors reduce excitatory glutamatergic signalling

5:13 PM

@qwerkyscience

The effects were subtle and it was basically just an easy way to become hypnagogic. The stimulation was noticed as feeling almost like I’m falling asleep from insomnia and also I get these electric shocks in my arm when I take too much stimulants and that occurred. 5HT2c antagonism increases norepinephrine and dopamine tho

That sounds lit

@qwerkyscience were you taking it before sleep?

Yes

Man, I had the trippiedt experience taking a sample dose of Suvorexant

4:07 PM

Reminded me of both certain GABAergics, and Salvia Divinorum

4:07 PM

Very proprioceptive

4:08 PM

Mentally relaxed and physically disabled, yet intense, rapid touch-related geometric folding fuckery

4:09 PM

Lol

That sounds wild. I sometimes experience this 3D fractal effect in hypnogogia

Has anyone here heard of/played Disco Elysium?

Playing it now!

Oof, the writing on that thing

4:38 PM

Very nice

https://www.gamesradar.com/the-making-of-disco-elysium-how-zaum-created-one-of-the-most-original-rpgs-of-the-decade/

The making of Disco Elysium: How ZA/UM created one of the most orig...

Meet the Estonian cultural provocateurs behind hardboiled cop RPG Disco Elysium

4:47 PM

>Estonian cultural provocateurs

4:48 PM

Come on Who can resist?

Yeah the writing is incredible (edited)

I would recommend it to anyone with an interest in poltical philosophy or ethics even without a gaming background

Will agomelatine upregulate 5-ht2c long term?

yes

Do you have link to that @Deleted User

https://pubmed.ncbi.nlm.nih.gov/8840350/

Chronic Citalopram and Fluoxetine Treatments Upregulate 5-HT2c Rece...

The effects of chronic (for 14 days) citalopram and fluoxetine treatments with three doses (2.5, 10, and 20 mg/kg) and withdrawal times (24 hours, 68 hours, and 14 days) on 5-HT2C (formerly 5-HT1C) receptors in the rat brain choroid plexus were studied with quantitative recept...

ssri tend to be strange compared to agonists. Even agonists of 5HT2 receptors are strange and the antagonists seem to often downregulate the receptors unlike other systems.

1

8:35 PM

I am not sure how they are regulated tho and I really wish to know

Shit so not only agomelatine would be bad for you long term but the usual SSRI too?

9:11 PM

But wait isn’t it the whole point that after a few weeks they downregulate and that’s how they work?

5HT2c becomes desensitized but I’m not sure it downregulates. 2c is anxious

a server made for experiential investigation of the nature of self https://discord.gg/3shv2HQ most activity is in voice chat (edited)

11:52 PM

(thanks for letting me post)

2

https://www.forbes.com/sites/parmyolson/2019/01/15/a-shadowy-entrepreneur-claims-his-online-manipulation-business-is-thriving/

For $29, This Man Will Help Manipulate Your Loved Ones With Targete...

In the era of fake news, Elliot Shefler has found a lucrative niche helping people track their loved ones with manipulative ‘ads,’ in much the same way Facebook and Google allow.

1:14 AM

Omg

Wow wonder if this works

I usually just kek at ads like that, but it probably does a lot more for Facebook-only users

https://cdn.discordapp.com/attachments/423220323908059146/730943072149438524/happy_cow.mp4

What effects 5ht2c on heart or cardiovascular system

3

>animal anarchist

Bong masks???

7:54 PM

A true anarchist would include bong masks

Oh yeah

zach hill is not only, say what you will about my opinion, the best musician/lyricist on earth (not rapper), but wackiest visual artist too (check out destroying yourself is too accessible it goes along with an album of his)

https://youtu.be/i1znmh8d7U4

c2chung

cat eyes dilation before striking

Me adjusting the ISO before taking a picture

What would you call this then lol

2:21 AM

https://youtu.be/lws_S_d31Pg

The Adventures of Mojo and Scout

Maine Coon Cat INSANE Chattering & Chirping!!

2:22 AM

Here’s one of the most beautiful techno songs ive heard in a long while

2:22 AM

https://youtu.be/EiXXPXiLmnI

HATE

David Löhlein - Altai II [SNAKE01]

https://soundcloud.com/cosmicrush/the-fall

3:00 AM

So amazing

Oh hey! Lol that is my track yes

4:55 AM

Very funkedelic deadmau5y weird stuff

Altai II was nice

https://www.theguardian.com/us-news/2020/aug/08/california-covid-19-central-valley-essential-workers

'Everyone tested positive': Covid devastates agriculture workers in...

The virus is surging in the Central Valley, where hundreds of thousands labor in the food industry. Workers say companies did little to prevent the spread

11:36 PM

My university is in The Guardian

@qwerkyscience you in Cali? Neat

Yes

3:06 AM

What about you?

Yeah I’m in Cali too

1

Where at

3:57 AM

The onions will be killing us

Are we going to run out of food, or just stop exporting it?

The onions have salmonella

11:49 PM

Oh. We are going to starve to death

11:49 PM

The farmers will hoard the food

11:49 PM

Jk idk tbh

Raid the farmers?

11:52 PM

Pitch forks at the ready

11:52 PM

Kill the alliums

Lol I think killing the farmers exacerbates things

2:39 AM

We should suggest role-reversed feudalism

2:40 AM

Farmer-Kings support service serfs

Conspiracy: chrome mobile wont allow nightmode because they need the white background to scan your favial expression to the content

4:29 AM

Conspiracy 2: they use mask agenda to train face recog ai to read off less data like what you look like behind a mask

This is why you where latex masks of other people

https://www.buzzfeednews.com/article/ryanmac/kenosha-militia-facebook-reported-455-times-moderators

A Kenosha Militia Facebook Event Asking Attendees To Bring Weapons ...

CEO Mark Zuckerberg said that the reason the militia page and an associated event remained online after a shooting that killed two people was due to “an operational mistake.”

https://journal.burningman.org/2020/08/black-rock-city/building-brc/pack-your-virtual-playa-gear-and-get-ready-to-burn-in-the-multiverse/

Kirsten Weisenburger

Pack Your Virtual Playa Gear and Get Ready to Burn in the Multiverse

As Burn Week draws near, many of us are starting to feel the insatiable FOMO one can only get from missing weeks of preparation and anticipation for an imminent and dusty arrival in Black Rock City. While nothing can replace...

4:35 PM

4:36 PM

My sister wanted to run today

4:49 PM

hah

Me too. I was going to go to the mountain omg it’s lame lol

>moderate cannabis use So glad I use it heavily

8:16 PM

2

Yo yo yo

3:53 AM

wassup wassup

Heeey

7:14 AM

1

7:15 AM

And I live in East LA

pretty sun

@qwerkyscience thats a very aesthetically pleasing image

Thanks

i thought it was ugly af

Thank you man

yea man

7:07 PM

love your work tho

2

did you make ur pfp

maybe in another life

7:08 PM

i was lookin for a peacock reminiscent of the one i saw on my dmt trip

7:08 PM

this was best thing i could find

pretty solid

Man I wonder if dehydration was the thing that was always making my comedowns so horrible

Definitely part of it

Ever since I started distance learning again and adopting a heavy water routine, my comedowns have been bareable, hell, I just feel back to baseline, maybe a tad bit more tired, but not like before where I would just go to bed and not even want to get out (edited)

amphs are very taxing on the body

10:58 PM

but they do work

That’s why I make sure to get plenty of protein

10:59 PM

I’m one of the lucky (unlucky for me since I’m a bit on the heavy side) folks that can eat just fine on or off amphs

10:59 PM

After and hour or 2, I can eat normally

11:00 PM

I take my Vyvanse and 6:45 am then a protein-heavy breakfast 30 mins after (before it kicks in), and that does the trick

i usually just eat a bunch of food beforehand

11:00 PM

yeah

11:01 PM

weed is a mixed bag bc it'll let me eat again if i haven't eaten in a while but it could also potentiate it again a ton

Wouldn’t that be counter productive though? But then again, weed seems to help some people with concentration I’ve heard

id say it depends on how much you smoke and your tolerance

True

Weed is just lackluster on stims for me

11:05 PM

Like it feels good initially but it wears off within 45 minutes and I just end up going through way too much weed

I've always found sativas n adderall to be a fantastic combo

11:09 PM

i dont really smoke to get super stoned during the day/by myself (regularly) so i don't usually smoke a ton in a single sitting

Sativa + addy probably would be awesome

11:16 PM

I just am in illegal state and never get sativa doms

my medical card comes in a few days/weeks

11:19 PM

my state just recently got medical but prior i was just lucky to be friends /w the local weed vendors (edited)

wellbutrin day 2 update: when i chew it feels like my skull is pressing down on my brain

how much are you taking?

150mg

11:26 PM

also going through twice as much nicotine as usual

It makes nic feel significantly weaker ime

yup

And eventually cigs stop tasting pleasurable at all for me and I just give up nic completely bc it boring

god i hope!

11:28 PM

i vape though, quit cigarettes a few years ago but can't stop this

I'm just at 0 or 1 cig a day at this point

11:29 PM

Lol

are you still on wellbutrin?

Nah

how much did you use to smoke

Not much except when I was in rehab

11:30 PM

Always been a 1-5 cigs a day kinds guy

Yeah same

11:30 PM

well like 5-7

Only ever use nix when on other substances really

started making my lungs hurt at night

Nic*

so i switched to juul and now i cannot quit!

11:31 PM

cannot seem to

Yea that's why I haven't got a vape

11:31 PM

Bc ik I'll never fully quit

my w/ds are incredibly bad

And just use more nic total

kinda wanna switch back to cigs to force myself off

11:32 PM

yeah better for lungs but bad for nAChRs

have you tried agmatine or NAC?

NAC doesn't do much for me

11:33 PM

agmatine i'm going to try soon

gl

just started wellbutrin so i want to wait for it to really kick in

I love both agmatine and NAC

nac felt great for my body

11:42 PM

how much were you guys taking?

Yea nac is warm

yeah same for me

I take 1200-2400 mg a day bc I benefit significantly from it

it's very mild though

I wish I needed less tho

right now i'm looking for cognitive boosts though i feel stupid all the time

11:56 PM

NAC reduces ocd symptoms/anxiety but is a bit blunting

https://docs.google.com/document/d/1Hq4Gtt07Ash7k7vt3LisImZ-37sCK282TNG8W72hvdo/edit#

Stim Drug List

[Preface] Stimulants are crucial to providing their users with energy, focus, motivation, and increased cognition. However, there are health risks and proper usage to consider. This is an attempt for a comprehensive list of stimulants to offer awareness and more choice in the ...

11:59 PM

i was compiling a list

11:59 PM

Im gonna put rating and do tryptamines after

wow this is helpful

11:59 PM

thank you!

np

https://www.youtube.com/watch?v=G4KdU82otFc

Nerdist

DUNE Official Trailer (2020)

update im not taking wellbutrin anymore

5:29 PM

got three days in, dissociation and suicidal ideation became very strong

5:29 PM

feel ok now

happened to a friend of mine as well

going to try agmatine tomorrow

5:40 PM

tried higher dose NAC today, 1000mg

nice

5:40 PM

the agmatine + nac combo is a staple for me

5:41 PM

but i prefer 250 mg agmatine per dose max

concerned about BBB breakdown but i dont have anyone in my family with alzheimers so i think im ok

2 doses a day usually

@Deleted User you think taking nic patch + mem could be good

7:42 PM

Like I think my mem needs something else cuz I still feel slow

i love the combo personally

7:53 PM

i did that + 10-20 mg amp sometimes

7:53 PM

good synergy imo

@Deleted User what did it help specifically? Cuz I’m looking for something for cum/lag brain

it more helped for my depression tbh

8:21 PM

the cumlag brain would prob be better approached with coluracetam and/or cdp choline

8:21 PM

dexamp, mem, coluracetam, and cdp choline would all go very well together imo and ime

8:22 PM

cordyceps goes great with that too but its more mood and dopamine stuff

8:22 PM

the coluracetam would be verbal fludity help

what is cumlag

brainfog i imagine

8:22 PM

issues with verbal fluidity

ah yeah

turning thoughts into words

8:23 PM

@Silver.

i just tried to make a dr appt and stuttered over all my words

yea in the past whenever i was going into a presentation or an interview or that sort of thing, i would need a script or itd be a disaster

8:23 PM

now w the right stack i can wing shit

8:23 PM

and just convert thoughts to words very effectively

also do you have a mem source lastleaf?

my biggest issue with speaking has always been thought to word conversion

same, yeah

Tbh I’m not sure what it is, just thought using cumlag would be funny It’s like I don’t live in the moment, I’m more distracted by my thoughts to pay attention to what’s being said to me or typed @Deleted User

ahhh yes i think coluracetam would help with that

8:31 PM

colur w dissos seems to decrease feelings of dissociation but increase euphoria and anxiolysis

8:31 PM

make living in the moment much easier ime

@Deleted User opinions on 9-Me-BC for DA pathway regen?

absolutely no idea

8:32 PM

is it similar to bpc 157 at all?

no it's a derivative of beta-carboline

idk anything abt it

prevents oxidation of MPTP to MPP+ in vitro

8:33 PM

https://pubmed.ncbi.nlm.nih.gov/20374418/

The exceptional properties of 9-methyl-beta-carboline: stimulation,...

Beta-carbolines (BCs) are potential endogenous and exogenous neurotoxins that may contribute to the pathogenesis of Parkinson's disease. However, we recently demonstrated protective and stimulatory effects of 9-methyl-BC (9-me-BC) in primary dopaminergic culture. In the presen...

@Deleted User whats the half life on it?

most people take colur once a day iirc

^

8:33 PM

may need 2x a day if you want

8:33 PM

p cheap per dose tho

slightly stimulating though

8:34 PM

similar to oxiracetam or low dose phenylpiracetam

coluracetam is probably my fav racetam

i never noticed much from it

8:34 PM

at least didn't help with dp/dr which was a pretty obscuring issue at the time

it enhances everything i mix it with a lot

it’s kinda crazy you mention it and you were telling me before I might have a cholingeric issue (edited)

yea but that was just spitballing

(all of this is spitballing)

the way i best determined my issues was just by testing dif types of things and seeing how i responded

8:35 PM

good point atom

8:35 PM

lol

btw does it have a tolerance ?

8:36 PM

and how should I take it

sublingual with a smol amt of fat imo is best

volumetric dosing

i notice some tolerance with daily use but i develop tolerance to everything

unless you have an expensive scale

volumetric would be ideal

yeah there’s 20mg pills

start at 10mg

wondering if I should totrate

i dont do pills for anything

8:37 PM

powders absorb so much better

8:37 PM

esp if you have gut issues

yeah true

8:37 PM

still no human studies on coluracetam fwiw

my human form disagrees

8:38 PM

n=1

n=/r/nootropics

jk

8:38 PM

lmao

fuck

don't think it made it past exploratory phase

tbh i get annoyed when ppl on r/noots say its placebo if you notice somn the first time you take a new substance

8:38 PM

bc when you have no tolly to a substance, your most likely to feel somn

not placebo

8:39 PM

but some other phenomena

8:39 PM

not sure theres a term for it

8:39 PM

but often first time use of a drug has diff effects than consecutive

agree

8:39 PM

FOEB

https://link.springer.com/article/10.1007/BF01277590

MKC-231, a choline uptake enhancer, ameliorates working memory defi...

The effects of acute and chronic administration of MKC-231, a new choline uptake enhancer, and two other nootropic agents, linopiridine (Dup 996) and tetrahydroaminoacridine (THA) on working memory deficits and decreased hippocampal acetylcholine (ACh) content were studied in ...

8:39 PM

mice study

is what ima call it

8:40 PM

foreign object exposure breakthrough

8:40 PM

for the substances that have very strong effects from initial dose

8:40 PM

but only w first dose

8:40 PM

FSEB actually

what are foods that enhance choline uptake

8:40 PM

what are foods that enhance choline uptake

sage

8:41 PM

well

8:41 PM

sage is acetylcholinesterase inhibitor

8:41 PM

idk what foods enhance HACU

wait aren’t acetycholinesterase inhibitors big bad?

some are fine

^

depends how potent

sage is fine afaik

8:42 PM

some are fine on occasion but wouldnt want daily use

ACHEIs have medical use also

sage seems fine even for daily use but idk

just lots of side effects

8:42 PM

used to be used for parkinsons iirc

there are some good reports from sage on r/noots

like the herb?

my plant just died so rip

8:43 PM

ya

oh word i have one growing (slowly but surely)

im more doing the herbal noots nowadays

8:43 PM

and some chems to enhance

what do you guys recommend for scales

https://doi.org/10.1254/jjp.76.219 https://doi.org/10.1016/j.euroneuro.2007.02.011 https://doi.org/10.1007/s00702-008-0053-4

Protective Effect of MKC-231, a Novel High Affinity Choline Uptake ...

Japan's largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies

or like measuring utensils

a few more rat studies

8:45 PM

a scale is essential, a measuring utensil is not accurate due to changing densities of powders

8:45 PM

gemini 20 is fine for things with minimum dose > 15mg

8:45 PM

otherwise you're looking to spend ~$200 minimum for 1mg accuracy

8:46 PM

https://web.archive.org/web/20111121081645/http://www.braincellsinc.com/wp-content/uploads/2010/06/BCI-PR-06142010.pdf

yea i use gemini

one human trial on coluracetam w/ no serious side effects. phase 2a which indicates it's safe (but ineffective for depression) short-term. no long-term data exists

coluracetam on its own is mehh

8:47 PM

but w amps or nmda antagonists it really really shines ime

im not sure neurogenic compound + amp is good long term

in reducing negative effects from both and enhancing positve effects from both

amps = amphetamine?

enhance addiction pathways?

8:48 PM

is that why u think bad

8:48 PM

ik noopept + amp is bad

8:48 PM

and ye amp = ampheta

yeah and epigenetic modifications to striatal density

8:48 PM

considering amp reduces striatal density long term

8:48 PM

i imagine neurogenesis + amp = that but worse

8:49 PM

though maybe it'd help recover memory deficits from strial density loss

8:49 PM

striatal

yea your probably right

armchair psychopharmacology ofc

8:49 PM

disclaimer

i notice noopept + stims enhances addiction pathways

yeah and noopept is a weak neurogenic

i dont notice that with any racetams + stims

BDNF and NGF are worthless for the most part

noopept + amp also wrecks my amp tolly for weeks

so atm, I can’t use a scale and everything cuz I live with parents and I don’t want them freaking out

yea unless its in the right place

8:50 PM

which it usually isnt

8:50 PM

lions mane is great for me tho

@Silver. don't touch high-risk research chemicals if you're living at home w/ parents

and seems to be making my thought process more like it was before ever doing drugs

i did the same shit it didn't end well

maybe just try lions mane silver

does lions mane work similar?

not to coluracetam but to noopept yes

mushrooms are geat

i worry about anti-androgenic effect of lions mane though

lions mane, cordyceps and shiitake would probably all benefit you

though nobody has experienced post-finasteride syndrome or an equivalent from reishi yet

I just took a multivitamin and my tummy does not like it

8:52 PM

yea I’m just trying to take everything lowkey, like hiding mem has been tough as it is

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909570/#CR30

Pharmacological and therapeutic potential of Cordyceps with special...

An entomopathogenic fungus, Cordyceps sp. has been known to have numerous pharmacological and therapeutic implications, especially, in terms of human health making it a suitable candidate for ethno-pharmacological use. Main constituent of the extract ...

8:53 PM

cordyceps is good for ur testosterone ❤️

8:53 PM

reishi bad

8:53 PM

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693613/#:~:text=In%20a%20research%20study%20exploring,into%20the%20more%20potent%20DHT.

An Update on Plant Derived Anti-Androgens

Anti-androgens are an assorted group of drugs and compounds that reduce the levels or activity of androgen hormones within the human body. Disease states in which this is relevant include polycystic ovarian syndrome, hirsutism, acne, benign prostatic ...

i dont like reishi and maitake bc IL6

dont't take 5-alpha-reductase inhibitors

8:56 PM

seems lion's mane libido effects are only from water extract not alcohol!

@Deleted User does colouricetam compare to using nicotine?

not really

finally ordered mem :)

@rhiza it’s good for mood regulation and motivation so far

hope so!

9:10 PM

what dose did you start at?

5mg for a week them BID 10mg week 2

sorry what is BID again?

twice a day

ah gotcha

also make sure you do it at specific times

9:11 PM

I recommend downloading Medsafe to keep track of times

1

@qwerkyscience when do i get scientist tag

9:12 PM

do you do morning and afternoon or morning and night?

morning and night

9:13 PM

6:50am and 6:50pm

9:13 PM

give or take 10 mins

why take it at exact times?

9:14 PM

never heard anyone say that before

steady state. Apparently blood brain barrier works better at tight schedules cuz it can regulate stuff. 2nd year end student who used mem for 4 years on a forum for add talked about it extensively

link to forum?

http://www.addforums.com/forums/showthread.php?t=80317

Memantine experience so far.... - ADD Forums - Attention Deficit H...

Memantine experience so far.... General Medication Discussion

9:18 PM

@Deleted User real talk 5 mins in the nico patches seem really good

was for me

@Deleted User you take NAC once or twice a day?

twice

i didn't like it at first but today has been good to me

i have severe drug cravings and addiction problems and it really helps me with that

9:21 PM

which is why i currently take a p large amt

The nico tolerance builds up quickly doesn’t it?

how much?

9:21 PM

The nico tolerance builds up quickly doesn’t it?

@Silver. yes

rip

1200-2400 mg a day usually

9:21 PM

at least lately

1200 is pretty low

9:21 PM

actually both of those are pretty normal

good to hear

9:22 PM

some are very fearful of nac

9:22 PM

im not

1. if you have genetic markers for alzheimer's... stop

9:22 PM

2. don't take it after drinking or you will incur liver damage

9:22 PM

thats it

ye

take it before drinking though and it prevents excitotoxicity ❤️

9:23 PM

and p sure it accelerates metabolism of acetaldehyde but that is just an assumption

heard from one person excitoxicity in high doses could be a problem but havent looked into that

9:23 PM

bc mglur5 iirc

high doses meaning what?

idek

for acetaminophen OD they use 150mg/kg

9:23 PM

or 15g for 100kg

yea

9:24 PM

but thats a one off thing

yeah fair

9:24 PM

can't guarantee linear increase in excitotoxicity with dose i suppose

fuck feeling sleepy on nicotine

9:24 PM

might nap

you took too much

only 7mg patch ://

uhhh that's an enormous amount if you don't have a tolerance

Remove?

yeah if you're feeling lethargic you've already overdone it

9:25 PM

not gonna hurt yourself but it doesn't feel good

9:26 PM

when did you put it on?

10 mins ago

nicotine goes sedative --> stimulant --> sedative

9:26 PM

low dose sedative, normal dose stim, over-dose sedative

double overdose vomiting

yup

9:27 PM

first time i ingested nicotine i had severe nausea for over an hour lol

9:27 PM

vaporized

man I just wanna help my lag brain :/

9:27 PM

I hate being slow

and that was 1.5mg/mL vape juice... i now vape 25mg/mL that's addiction for you

sure is

9:27 PM

day 3 no nic hope i make it

you got it bud

9:28 PM

no dissociation?

nah i barely used much

9:28 PM

just a cig a day past months

i just ran out of my 25mg/mL gonna make a batch of 20 and keep going down week by week

9:28 PM

gonna take 6 months + to taper off without symptoms though probably

9:29 PM

@Silver. how old are you btw?

9:29 PM

only asking for brain purposes, nicotine is harsh on development if <25

yea i was gonna note to try and avoid daily use

even non-daily use

9:31 PM

don't use for nootropic purposes at all IMO. have a cig while ur drunk, whatever.

probably the right call

9:31 PM

im glad i didnt get into nic sooner

w/d is worse than opioids or stims for me

9:32 PM

well kratom w/d i've never been addicted to opiates

im in kratom wd

i don't notice it? at all?

i notice it i just have learned how to negate a lot of the effects

9:32 PM

im very very experienced w wd

9:32 PM

lol

oddly enough, i was going through 4g/day for a month, quit when i moved, forgot about it

yea i end up using a lot more than that unfortunately

9:32 PM

def need to avoid for a long while

9:33 PM

really fucks w gut health

>5g and i feel nauseous

9:33 PM

how so? i'd imagine it'd be good for it

9:33 PM

at least bentaungie

bentaungie maybe

9:33 PM

somn special abt it

might have spelled that wrong

9:33 PM

bentaungie is fermented

yea fuck the sp

9:33 PM

ik

@rhiza 26

but any other krat reduces motility and stomach acid production

@Silver. ah fuck alright i can't tell you anything then

which will cause malabsorption issues long term

9:34 PM

worsen gut permeability

i'm 22 and started at 16 :/

im 22 as well

9:34 PM

i just got my brain damage from pot instead of nicotine until 20

LMAO same

9:35 PM

well both

might go brain damage myself some rn

mostly pot though

bacopa supposedly helpful for weed damafe

9:35 PM

tho i havent rlly looked into it

also stimulates thyroid

9:35 PM

helped my memory long term though

you still take or nah

but if you have trouble eating enough dont do it

9:36 PM

nah, did for 3 months and then stopped when i realized i might be inducing hyperthyroid

bacopa has some feels comparable to cannabis for me

i dont feel anything from it

oh i def do

ashwagandha though feels comparable

initially i felt the apigenin in bacopa a lot

9:36 PM

but frequent use has built tolerance to that aspect

not familiar with apigenin

but i still feel anxiolysis and happiness from it

anyway i need to finish this training for my job so i can start working onsite

gaba agonist also found in chamomile

9:37 PM

gl

my new night shift testing covid samples ❤️

@rhiza What science do you do?

the right kind

@rhiza What science do you do?

@qwerkyscience data entry hun

9:38 PM

they don't respect me enough to hire me for anything else

i work at a smoothie shop lel

but fwiw they don't let undergrads in my lab so i guess thats something

im ready to have my shit together again, be back in school and then have my degree (edited)

it's RT-PCR with a control & covid probe, pretty simple

9:39 PM

im ready to have my shit together again, be back in school and then have my degree

@Deleted User having a degree don't feel that great tbh

9:40 PM

at least right now i can't find work anywhere as an RA

yea but my degree is like guaranteed job

9:40 PM

food science major

9:40 PM

quality assurance job initially is p much a gimme

Oh for what field

ah yeah for sure

want to get into food product research and development after that tho

9:41 PM

i have 80 hrs done already

I will update it I am currently preparing for an exam that’s happening in 2 hours

considering doing my M/S in plant science tbh

9:41 PM

@qwerkyscience get off discord

thatd be cool

9:41 PM

i like plants

9:41 PM

i am one

yeah uni of arizona

9:41 PM

has a plant science MS

im a&m

9:41 PM

just on hiatius

they also do psychedelics research

texas a&m

oh word

9:42 PM

i just grad from brandeis

i did 68 hrs at community college tho

9:42 PM

wish i could just do everything there

9:42 PM

but a&m does have good connections at least

i bet yeah

9:42 PM

brandeis really doesnt do psychiatry or psychopharm

9:42 PM

so i fucked myself

realy wish i didnt waste all my college money on rehab, new car, and arrest tho yiiikes

what'd you get arrested for

dui (on dxm), posession of marijuana (in a terrible county where it wont get dropped, worst place in texas to get arrested for it p much), and felony for posession of etizolam in illegal state reeeeeee

fuuuuck

9:43 PM

that's rough

ya man im pretty good at fucking things up (edited)

eh you'll be fine

9:44 PM

move to california get ur drug felonies smothered and ur set

9:44 PM

my misdemeanor is getting expunged in six months or so ❤️

like ik id be able to go back to school and flourish this spring if my parents would pay for it, but they dont trust me enough to pay for it, understandably, so i just dont want to go back to school while simulatenously working bc i fear ill be setting myself up for failure

yeah fair

9:45 PM

can you save enough to just do part-time at college?

but not being in school is destroying my mental health bc im an addict

or take out loans tbh

im just gonna take out loans

9:45 PM

fuck it

ascent student loans has best rates

i have big plans and im gonna make the money back

not sure about if they wont cosign

ill still need to work to pay for housing and shit tho and thats just new for me

9:46 PM

im already stressing so much abt it just dont want to do it

budget that into loans

even tho theres nothing i want to do more than go back to school at this point

thats what i did

9:46 PM

i took out ~50k

over how long

9:47 PM

idk shit abt loans at all

9:48 PM

im just glad i have pretty much figured out my neurochem and health issues so i should be more effective than ever if i can just not fuck myself over

9:48 PM

ik what to do, its just doing it

whats your stack rn

9:52 PM

also -- apply for FAFSA, get as much as you can out of federal sub/unsub, then the rest: https://ascentstudentloans.com/

Ascent Student Loans | Private Student Loans

Ascent Student Loans provides private student loans. Get the money you need for undergraduate or graduate school with or without a cosigner.

1

9:52 PM

pay $25/month during the rest of college, then you get a 6 month grace period before you start paying real amount. finance for 10 years, you'll fuck yourself if you don't make >$50k on 5-years

my stack is variable tbh

i'm in that boat rn my payments are $400/mo

the constants are cordyceps, lions mane, NAC, 250 mg agmatine 2x a day, 300 mg bacopa, 5 g l glutamine, Na-R-ala

9:54 PM

but i have a bunch of as needed stuff

9:54 PM

ive been doing way too many drugs the past 2 years so im still figuring out what my current baseline is

9:54 PM

and repairing the damage

Yeah that's what I'm working on

Congratulations @rhiza, the illusion I apply to your identity has been updated and I will now stereotype you differently. This is great news! It means my confirmation biases that guide my assumptions of your thinking and behavior are now different

i use racetams as needed, low dose dxm as needed, a variety of herbs and probiotics daily

@qwerkyscience What does any of this mean

it means you have a new role

9:56 PM

lol

Lol yes ^

a lot of akcsphere has a super warped perception of me

Oh you are akcsphwre too

9:56 PM

Who are you then

the guy you're working on upvote academia with

Epic!

WAIT have you not known that this whole time

I didn’t know lol

lmfao

Discord is spooky anonymous

not for you bc your pfp is you

you added me to the server so i assumed you realized

9:57 PM

yeah i don't like to have my pfp on discord

I lose track of the names after a while too

too many drug discords

ya

I will change my name to my SSN

ok

go study for your exam

Yes!

i miss exams

1

you won't soon bud

9:58 PM

shit i need to stop using bud as a term of endearment

ok hun

9:59 PM

stop hun first

9:59 PM

then stop bud

i only used that once

ok but i saw it regardless

look im anonymous on here

9:59 PM

it means exploring self-expression ~~

trueeeeee

yeah sarcastic terms of endearment i need to drop

10:00 PM

agreed

@Deleted User is your second dose of NAC in the afternoon or before bed?

either way really

10:32 PM

i notice when it wears off

ah gotcha

and i take more when it does

how long does it usually take for it to wear off for you?

dose dependent ofc but 1.2 g lasts prolly 8 hrs or so

i dont notice ~much~ from it, though my sober brain is a weird place

10:33 PM

so trying to gauge

10:34 PM

word thanks!

@Deleted User NAC is fantastic actually i change my mind

agree

I am significantly more lucid and cognitively adept than normal

its one of the most consistently helpful things for me

12:34 AM

especially for any drug wd and even killing bad lsd trips

Oh really!

yea i can get the study for the psychedelic weakening effect if you want

12:36 AM

rip cant find it rn

12:36 AM

but it does exist

12:37 AM

also for drug cravings in general after wd ends

12:37 AM

and reducing stim neurotoxicity

Doesn’t nac build up tolerance tho?

Nah

is it good to have a high metabolism

1:49 AM

starting to think this shit is annoying

1:49 AM

every time i finish a meal i basically need to go. sometimes while im still eating

1:50 AM

idk if there's something wrong though, but i do feel good in energy after i eat, shit and exercise

Are you counting your calories from the gram? There’s a chance you’re just having too much fiber and irritating your gut

2:21 AM

Fiber being good for your gut is something that was propagated by the grain industry and some people do fine or even better just eating more energetic foods and maybe fats if they need to help stuff ‘pass through’ easier

Don't listen to borp. He is a paid shill by the carnist industry.

2

Ordered some n-methyl-cyclazodone

10:34 PM

gonna try it tomorrow /w the usual stack

It's as potent as dextroamphetamine @dreamsicle

5:43 AM

Higher doses more onpar with 3-FMA

you've done it before?

Yeah.

was the toxicity noticable?

nice carpet

Thank you. My lamest carpet on my basement.

5:44 AM

Got Saudi Arabian rugs all over.

do you think its a safer/decent alternative to using amph or other stims

Good alternative to amph if used maybe 2 or 3 times a week.

5:47 AM

At most

5:47 AM

Better frankly

5:48 AM

It's a substituted phenethylamine and a conformationaly constrained amphetamine.

5:48 AM

Onpar with the fluoridated amphetamines in higher doses

5:50 AM

P-Cl-Phenylpiracetam is pretty good too @dreamsicle

really? i've usually just stuck with oxyracetam or noopept

i was looking for long duration functional stims mostly

It's onpar with armodafinil and can be empathogenic / psychedelic when larger amounts are snorted.

5:51 AM

Armodafinil then

5:52 AM

N-Methyl-Cyclazodone should do the trick very well at like 5 - 20mg though

i take flmodafinil already

flmodafinil is not even as potent as modafinil

7:20 AM

From my experinece

7:21 AM

Perhaps I was not taking enough. I never really weighed it out.

1

Modafinil felt like micro dosing acid to me. But less good

nmethylcyclazadone is a great success

very sad i couldnt take this everydfay

that description makes me want to try modafinil

10:50 PM

Me trying modafinil first time

that shit make money go ooo ooo (edited)

very very potent

3:10 PM

@dreamsicle

I know memantine is supposed to reduce amphetamine tolerance

6:15 PM

But does it cut the effects for anyone else while they're still on memantine

6:15 PM

I took my normal dose of Vyvanse today and feel, well, really nothing

It cuts certain effects but it can also potentiate

It made amp better for me

10:34 PM

I hate amp on it's own tho

Yeah it reduces the adrenaline and perhaps reward of amphetamines

7:32 AM

I doubt it negatively effects executive function effects

https://www.statnews.com/2020/09/24/crows-possess-higher-intelligence-long-thought-primarily-human/

Sharon Begley

Crows possess higher intelligence long thought primarily human - STAT

A second study looked in unprecedented detail at the brains of pigeons and barn owls, finding hints to the basis of their intelligence.

KAAAAAAAAAAAA

I always knew those crows were plotting. I've seen them play tag, hide and seek etc

memantine has restored my functioning an extraordinary amount in just a few days

8:49 PM

im at a conference and able to focus/be engaged, which i haven't really been able to do in a long time

nice, how much are you using @rhiza

so far only 2.5mg

8:51 PM

will try titrating up next week but i doubt i will need much more at all to reap maximum benefit from it

Science? are you using solution or powder?

Science solution

8:52 PM

I'm really surprised by this, but I don't know its pharmacology too well. Ketamine is only antidepressant for me while i'm still hungover from it

may try it out ty

yeah, would definitely recommend. it will make short-term memory a bit worse though

Wym memantine dosnt effect executive function

1:02 AM

It was drastically different for me i did it once and once only at 5mg my performance in FPS pvp game was abysmal

1:03 AM

It also may cause QT prolongation of heart rhythm

a hammer weights (1 kg and half a hammer) how much does the hammer weigh?

it weighs a hammer

in kgs

yes

@Deleted User hey, what time is it where you are? Im down for a question at some point

@qwerkyscience answer the hammer question first (above)

2:23 AM

1

I don’t understand that question

its a simple math problem so a hammer weighs 1kg and half a hammer

2:27 AM

how many kgs is the hammer?

2:27 AM

@qwerkyscience

2:30 AM

this one is better though: Jake is looking at Bob and Bob is looking at John Jake is married John is single Does a conclusion follow that someone married is guaranteed to be looking at someone single? (edited)

a conclusion follows that someone concluded something i cannot conclude without more conclusive evidence

It does not follow

what are the two possible conditions of Bob... 1) married 2) single consider both of these conditions

You'd be making a huge leap

3:31 AM

At best it's shown in one instance, at worst it's disproved

3:31 AM

Entirely dependent on the condition of Bob

in both cases there is a married person looking at a single

(edited)

...

3:32 AM

2 Bobs

what?

Bob A is single, Bob B is married

there is one bob with an unknown marital status

Bob is being looked at by Jake who is married. If Bob is single, it doesn't matter what John is (edited)

3:34 AM

Right?

the question is

Does a conclusion follow that someone married is guaranteed to be looking at someone single?

In at least one instance, but not guaranteed

is Bob is single the condition is fulfilled. If bob is married then hes looking at john that is single and its also fulfilled

3:37 AM

so its guaranteed

See, I would think guaranteed means as a rule, not true at least once

3:38 AM

That's what I misunderstood

its true in all the possible cases...

If Bob is married, then a married man(Jake) is looking at another married man(Bob) To me that means not guaranteed

the condition of a married looking at a married is irrelevant to the question

We have different meanings of guaranteed in our head

reread the question

3:41 AM

Does a conclusion follow that someone married is guaranteed to be looking at someone single?

if there is at least one married looking at a single in all the possible scenarios then the answer is yes (edited)

I accept your meaning of guaranteed as valid even if I disagree

is there a case where its not true that a married one is looking at a single??

3:43 AM

how are you a philosopher XD ????? (edited)

When married Jake looks at married Bob. Under your definition of guaranteed that's ok, because Bob is still looking at single John. That's valid

it depends on WHAT is being guaranteed

3:44 AM

whats your definition? (edited)

There are no instances where it isn't true

thats exactly the case here, so its guaranteed

3:45 AM

there are no instances of absence of a married looking at a single

That's true, but that wasn't the question

what was the question

Does a conclusion follow that someone married is guaranteed to be looking at someone single? If that someone is Jake and Bob is married, Jake is a married man who isn't looking at a single man

it doesnt say everyone married

3:50 AM

but i see how that could be misinterpreted

I put one case where it is not true. Your guarantee relies on absence, while my guarantee relies on presence of a negative. For me, it is not guaranteed, because it is not true at least once. For you, it is guaranteed, because it is never absent. (edited)

3:51 AM

When I think of it your way, it makes sense

will have to reformulate to at least one

I also haven't done logic in almost 3 years lol

well

3:55 AM

If i changed the statement to: "Does a conclusion follow that at least one married is guaranteed to be looking at someone single?" Does every single need to be looked at at least by one married for the condition to be satisfied? (edited)

No, because the conclusion is linked to the married

its linked to a married-single relationship

True, but the conclusion only says something about the married party. It isn't contingent on anything from the single party

if there is no single party then the conclusion cannot be satisfied, so how is it not contingent on singles??

I suppose they would have to exist

3:58 AM

To be looked at

3:59 AM

Wait

3:59 AM

I got it

4:00 AM

The conclusion that at least one married is looking at a single assumes the existence of at least one single, so the inverse would also have to be true. At least one single would have to be being looked at by at least one married

no shit

This says more about language than anything else though

4:01 AM

Well, that's basically what you asked lol

4:01 AM

If i changed the statement to: "Does a conclusion follow that at least one married is guaranteed to be looking at someone single?" Does every single need to be looked at at least by one married for the condition to be satisfied?

@Deleted User

4:01 AM

No, at least one would have to be

exactly, so why when I apply the term someone to the married it necessitates every married person to be looking at someone single? (edited)

The term guaranteed is what threw me off

"some" by definition is satisfied if it's just a part of "all" (edited)

4:06 AM

also satisfied when its equivalent to all in amount

I didn't have an issue with someone

first definition of "some": an unspecified amount or number of.

Only guaranteed

it still works fine

4:08 AM

an unspecified amount or number of married people guaranteed to be looking at an unspecified amount or number single people (edited)

Does a conclusion follow that someone married is always going to be looking at someone single? This is how my meaning of guaranteed affects the question.

4:10 AM

Which is why we have different conclusions (edited)

and if we take the definition of "some" as "an unspecified amount" then it still works as i said

4:10 AM

which is the common definition

Someone could be anyone. If that someone were Jake and Bob was married, there would be a case where it isn't true and that would mean it isn't always true. Now, it would still be true that someone married is looking at someone single, but someone isn't. This is why our differing ideas of what constitutes a guarantee is giving us different results

4:15 AM

But we're talking in circles

@Ariadne if you were enlightened this would be an easy problem

If someone guaranteed me something and I experienced the situation where the guarantee didn't hold true, I would be peeved. It would still be legal, but I would feel philosophically cheated

4:17 AM

That's my point

4:18 AM

You're right, but it feels wrong to me

4:18 AM

It's not guaranteed, but it is

stop clinging to views bro, they're causing you to suffer

I have few views Guarantees are something I'm very opinionated about

ngl I reread the whole conversation and you're dumb as shit bro

god my fuckin balls HURT

Hi. I'm new here, and I realize that this is a few days old now, but....

@Ariadne is not dumb, @Jazz Muzak. (I was kinda surprised to see insults like that when I came to this server from the main article about mad society, but ok)... Anyways. This is a matter of interpretation. We all approach problems with our own mental toolkit. Both answers could be correct. The question was not phrased sufficiently clearly to prevent gridlocks like this.

9:29 AM

This is how I read it

Does a conclusion follow that someone married is guaranteed to be looking at someone single?

@Deleted User solution #1: yes, because there will be at least one married person looking at one single person. solution #2: no, because each married person is not guaranteed to be looking at a single person. To avoid gridlocks the question needs to be reworded because words like "someone" and "guaranteed" are interpretive. In order for the answer to be unequivocally yes, perhaps "Does it follow that among the three, there is at least one married person looking at one single person?" or something to that effect

9:42 AM

Also I mean like this could become a lateral thinking problem really because married/single is not a logical binary. Bob could be polyamorous or in a relationship or whatever

jazz bullied ariadne out of the server

Ariadne left??

5:46 PM

I’m going to kick jazz

5:48 PM

@desmysticat I do not support how Jazz is behaving but I did hope they could perhaps learn to behave differently with time. That member was here only for a few days. I knew Ariadne in real life so this is a bit frustrating

lmao

weird to get kicked for something that happened days ago, but alright. sorry I was a dick I guess

@Jazz Muzak I didn’t notice but you made my irl friend and supporter of my projects leave. This bothers me. Behave well and pro social or you will be permanently banned.

yes massah

@Deleted User howd you get liver flukes bro

4:02 AM

I remember reading some book from soldiers in vietnam war who said they’d probably get liver flukes from the water they drink and then die from years after

4:03 AM

I think they invented the only medication for em triclabendazole a few decades afterwards

4:03 AM

Actually as late as the early 2000s apparently

4:04 AM

Apparently they increase the risk of gall bladder cancer a fair bit which was like a 1/2 death rate over 5 years

4:05 AM

The funny thing is partly because it’s the only medication that works for em, they’ve been starting to become resistant to it (also overuse in cattle lel)

4:06 AM

Idk man they're not really all that uncommon

4:07 AM

Just usually most ppl dont notice em

Is a fluke a parasite?

Yeah, there’s a few types of flukes

4:14 AM

There’s lung flukes which are like a whole different genus caused in undercooked fish more common in se asia

4:14 AM

Also like intestinal and blood flukes which are treated moderately differently

4:15 AM

I know they’re surprisingly common, because I’ve helped a lot of people mostly over reddit who would be suffering from them for a while and their doctors were confused and whatever lul

4:17 AM

They’re pretty distinctive, almost look like corn kernels or tomato peels.. still wonder why

For me, triclabendazole was useless, although i know it worked for a few ppl who were asking

How do you figure out if you have them

They look exactly like tomato peels

5:31 AM

One time I did nutmeg with hbwr to trip on and ate some raw garlic for vasodilation and ginger for vasoconstriction and nausea and ended up puking up some red liver flukes midway through the trip

5:33 AM

I wonder how potent Hawaiian baby woodrose seeds are as anti parasitics

5:38 AM

ive heard a theory that ayahuasca purges may've helped with the whole tropical parasites out there

5:38 AM

either way that's gross lol

5:39 AM

and if you want to hear something grosser, or yummier, i pretty much just drank a few cups of pee to cure em

Serotonin mediates vomiting generally I think

i was struggling with em for a few months, tried artemesia absinthium (wormwood) tea for a while, then other types of pills, then i got lucky and stumbled across this study that said artemesia annua cures them which thankfully it got nearly all of them, however it was expensive for the extracts and as a broke college student when i noticed they were still around a few weeks later (probably 1/5 of the original) i had some more and it did nothing cuz it needs a high dose

Like if you are sick naturally

honestly i thought i'd be stuck with them for a year or two until i had enough money to pay for another few ounces of sweet annie extract -- i am thankful someone offhandedly mentioned how drinking urine cured their liver flukes lol very effective

5:43 AM

yea serotonin receptors in the intestines as well

5:43 AM

i think it is kind of a mental thing

5:44 AM

like i wonder if some meditation masters are just able to control their stomach real well... then you have to wonder how that could be ethically tested lol

5:47 AM

funny story. that's pretty much how i met my last girlfriend

5:47 AM

is cuz she was struggling with em for a while, doctors were clueless out in the south

5:48 AM

she was pretty skeptical at first, even though i think she had lost a lot of weight from them over a bit i think, either way she definitely struggled through drinking her pee and over the few weeks of talking to her casually she got really into me lol had some fun times with her

5:50 AM

Why does the pee thing work

5:50 AM

i broke up wtih her some time ago cuz of some personal reasons, even though she was obsessed with me, i kind of think she was a little bit impulsive plus i had some other plans that im doing

5:50 AM

i guess the urea or something gets absorbed in the liver

5:50 AM

although i think it works for a lot of the more gut nasties pretty well, definitely causes some intense reaction down there

5:51 AM

whatever the case, it was way easier and more effective than all the herbal remedies and a few pharmaceuticals i tried over a few months

5:52 AM

Ugh I'll probably do that

5:52 AM

lol

5:52 AM

i remember she hated it a lot

5:52 AM

cuz she would drink it a few hrs later and said it tasted horrible

5:53 AM

i thought it tasted fine

5:53 AM

then i figured it was probably from sitting... and yup, that tasted horrible

5:53 AM

I'm gonna start doing it on a day I take amphetamine

1

5:53 AM

lmfap

5:53 AM

oh yeh

5:53 AM

my bro does that

5:54 AM

Make the most of it you know

5:54 AM

If I'm drinking my own piss there better at least be drugs in it

5:54 AM

2 birds 1 stone

Eat amanita muscaria

Not somn I can get atm unfortunately

It’s legal

5:55 AM

Online

5:55 AM

But it’s meh

Yea I think theres better stuff

5:55 AM

Nutmeg alone seems very strong

5:56 AM

So how long did you drink the pee for? @Deleted User

5:56 AM

To eliminate fully

6:00 AM

who knows if it's more effective with a meal.. for real, i'd do like 3 days, maybe even 4, trying to do with the stronk morning stuff.

6:00 AM

Just 1 dose a day?

6:00 AM

i mean like most of em

6:00 AM

i will say though

6:00 AM

gandhi style could be more effective now that you ask

6:01 AM

like just morning for like a week might even be better

6:01 AM

however i think the threshold slightly matters based off my experience with the artemesia annua

6:01 AM

cuz i would also have like some tinctures of those over 2 or 3 days

6:02 AM

Ahh yea

6:02 AM

and the only time it worked was when i had a lot

6:03 AM

heh

6:03 AM

even then there were still stragglers

6:03 AM

So do alongside a parasite cleanse basically

6:04 AM

Multiple times prolly

6:04 AM

i think the urine alone is incredibly effective

6:04 AM

Fuck it I'll drink piss every morning for the rest of my life

6:04 AM

i talked to someone else who was struggling with them for a while, i think he got them while traveling, and he decided to do a parasite cleanse

6:04 AM

For health

6:04 AM

after i had told them that the urine was more than enough

6:04 AM

and i think it was just like, a month more of having em lol

6:05 AM

he kind of went away, even though he was pretty thankful and excited at first that they were finally identified, i think he even wanted to start a facebook group

6:06 AM

the guy i learned that from i think said the rumble in the stomach it causes eased away after a few weeks of drinking it every morning, granted he also does fasting

6:06 AM

My case may be fairly bad

6:06 AM

But improving

6:06 AM

Mine got me anemia

6:06 AM

oh yea, that's like the telltale for em

6:07 AM

I had an intestinal incident a few months ago that exacerbated the issue a lot

6:07 AM

i talked to this other dude who lost like 70 lbs from em over 2 years, was like this tall athletic guy who was confused and depressed why he was becoming skin and bones

6:08 AM

Yea I lost 10 before figuring it out

6:08 AM

the funny thing is that the mod of the /r/parasite sub is a total academia bootlicker, so it can be hard for people to ask questions, and ofc he bans people who'd mention natural remedies

6:08 AM

Gaining it back now slowly, hopefilly

6:09 AM

Rip

6:09 AM

ive seen him gaslight a ton of people who definitely had flukes from photos, until i pretty much shamed him real hard a few months ago and started my own sub lol

6:10 AM

that subs like dead tho now because he makes people do identification based off a textbook i think, which is fair i'll be honest, however it didnt have anything resembling the macroscopic aspect for liver flukes, which i think is why i also got so much of a response when i first explained to them how i cured em

6:11 AM

How big is your sub so far

6:12 AM

i think there's one fluke post on there from like 2 months ago where he started that rule and deleted i think most the old posts, i may have changed his ways slightly cuz i made him look kind of silly over dms lol *(and a few posts publicly) (edited)

6:12 AM

there's like 5 subscribers.. tbh it was pretty much after it was all said and done

6:13 AM

i'd gotten probably like two dozen dms in the months leading up to it, 4/5 i'd say had flukes guaranteed, the rest were likely and more lurkers

6:13 AM

Gotcha

https://youtu.be/gdAEtkjDO3k

The Lincoln Project

REGENERON!

@Jeremy H

I came here to post a meme

6:38 AM

But all this piss talk is a meme on itself thats funny asf

6:39 AM

Shoutout to the biotech industry and if you want to talk biotech hml (hit my line up)

6:39 AM

4

Lmao that meme is hilarious

Benefits from memantine gone >:(

1

memantine works again

Interesting. Tolerance break?

Does memantine have an interaction with magnesium?

Wage slavery

1

They probably enhance each other but I’m not sure if it’s that significant. Taking magnesium will probably only add an effect equal to its own effect. It’s probably slight compared to memantine as memantine is really potent and you’ll probably use doses that produce stronger effects I’m guessing.

@rhiza what is your memantine routine like?

10mg every morning orally

11:40 PM

@qwerkyscience I think sleep is impt to see effects from it, though it seems to help with sleep deprivation

11:41 PM

d2 agonism is GONE when you sleep <6 hours, just like adderall

Wow hmm. I am almost always sleeping less than 6 hours and I get restlessness and ADHD symptoms a lot lol

5

what does that do for you?

Yh insufficient sleep is really impactful when it comes to focus and the efficacy of stims. Maybe has to do with the elevated cortisol or oleamide? Sure there's a study on it somewhere.

If you mean what does sleeping less do for me, nothing. I’m usually kind of hypomanic and insomniac.

https://www.youtube.com/watch?v=ndc3-JMVYAw

Ryan The Leader

Day in the life of a Discord Mod

Please give me mod, I've been grinding this discord every day and i know i would be a great addition to the mod team. I am such a good moderator i own 4 server and i would really like to mod one that has more than 150 members. I am the goodest boy you could ever find. My iq is at least 270. Please if you read this take into consideration if i would be a good mod or not i have pretty good experience sucking dicks as well if thats what you need. No homo tho.

4

2

Please give me mod, I've been grinding this discord every day and i know i would be a great addition to the mod team. I am such a good moderator i own 4 server and i would really like to mod one that has more than 150 members. I am the goodest boy you could ever find. My iq is at least 270. Please if you read this take into consideration if i would be a good mod or not i have pretty good experience sucking dicks as well if thats what you need. No homo tho.

2

Please give me salmon, I've been grinding the high seas since before salt was salty about sand and I know I would be a 150 members. I am a good crab and I have an iq of zoidberg_dance

. Please read this and crab walk with me

2

1

hah I get patron

2

Calling me a psychonaut smh

7:10 AM

Maybe all naturally, or whatever

7:11 AM

I’d say im more of a prophet who is too pussy or uptight or tightlipped or lip flapping to be a psychonaut

7:12 AM

I figured out how to talk with spirits in my dreams using ideas stemming from neuroscience and reading about how many scientists made epihanies via interpreting their dreams.

2

9:57 PM

I wanna be a 'natural philosopher', but that's really just early history of science if you squint a bit.

9:58 PM

does psychonaut include intentionally and unintentionally inducing brain states thru sleep deprivation to induce hypnogogic states?

Yes

Keep having dreams were I'm tripping very hard, and the world is like a cartoon. Then I wake up here. What if I'm still just dreaming.

1

9:58 PM

inception noises

I’ve used fidget spinners to lens my vision and create a strobing effect. This produces psychedelic effects.

9:59 PM

You can feel weird for a while after doing this

1

science in a nutshell. "huh, that feels weird, I wonder if I can do it again" (edited)

Oh that reminds me

10:00 PM

one time I put this vibrating toy in the back of my skull, and it made all text double and wobbly when looking at clocks

1

10:01 PM

vibrating toy

its not what you think

thats because how how the numbers of digital clocks are actually drawn one number at atime but really fast.

10:01 PM

persistance of vision effect gets desroyed when you vibrate your eyes. It's how I figured out that the world wasn't vibrating, but my eyeris were.

I actually have done projects on this flickering/strobing to try to figure out what it all means. There used to be toys that induce psychedelia by strobing

10:03 PM

Soon I may get ketamine and test some of these hypotheses with an eeg!

You can get a good idea on if clocks or LEDs in genearl are pulse-width modulated by just clicking your teeth together rapidly, it also makes digital clocks vibrate.

What the heck heheheh

https://www.reddit.com/r/askscience/comments/qwu9b/why_do_numbers_in_digital_clocks_dancejiggle_when/ covers the science behind the vibrating clocks in more detail.

r/askscience - Why do numbers in digital clocks dance/jiggle when I...

545 votes and 173 comments so far on Reddit

10:07 PM

photostrobe induced epilepsy is interesting. Be careful with that @qwerkyscience

1

10:12 PM

One of my old professors at Vermont tech works at https://leddynamics.com/ that have built things used in airplane cockpits. Dimming an LED using Pulse-Width Modulation is super bad if you are in a plane cockpit at night, but the circuitry to control amperage based dimming is more complex and expensive, so it tends to be avoided entirely in consumer grade hardware. I think the owner of the company has patents on that tech too IIRC. They call it a 'puck' https://leddynamics.com/buckpuck-302xd In the case of digital clocks, its actually a way to avoid having to have multiple drivers for each LED, instead they just use one driver and switch the LED being fired really quickly. It's a cost savings measure to reduce the number of chips needed, or in the case of all-in-one circuits, the cost of fabricating silicon. (edited)

LEDdynamics - Powering LED Lighting Technology Change

Innovative LED products, systems and technologies designed to give LEDdynamics customers a competitive advantage.

BuckPuck 302xD - DC/DC Buck Driver - LEDdynamics

The BuckPuck 302xD - DC/DC Buck Driver boosts a ultra compact size and rich feature set. It can be used for numerous low voltage LED driver requirements.

1

I also have projects where I talk about how psychedelia is almost the same thing as seizure aura

2

Nice! I suspect neuronal signaling issues tied to gaba/glutamate might be seizures. And this came out recently that suggests some of the psychedelic effects are from neuronal circuits over firing. https://quantamagazine.org/a-math-theory-for-why-people-hallucinate-20180730/ with a model that suggests a lot of the effects are how the brain interprets high level noise. Would be interested in seeing the EEG output.

A Math Theory for Why People Hallucinate | Quanta Magazine

Psychedelic drugs can trigger characteristic hallucinations, which have long been thought to hold clues about the brain’s circuitry. After nearly a century of study, a possible explanation is crystallizing.

1

10:17 PM

In M.S. theres a theory that Microglia may act in reverse and add myelin onto a neuronal sheeth if electrical leakage is high. So I try to front load cholesterol in my diet and activate neuron pathways that I suspect are glitching. It seems to be a subset of theories on neural plasticity, so have been looking at psychedelics because they all seem to be serotonin analogs.

10:18 PM

many of the dietary regimines for M.S. involve some kind of psychedelic combined with improved blood flow. Stamet's protocol seems to work for me, but I use serotonin production via gut bacteria instead of a psychoactive component.

10:20 PM

Tl;DR: Kefir good.

1

Do you have that in your blog @qwerkyscience? I'm still new to your work and don't have my bearings yet.

I just realized that if this is happening in my body's nerves, I should be able to use exercise to help remylinate my sciatic nerve.

10:36 PM

pain pain, go away.

Reading any other sources besides the mad.science.blog (edited)

11:08 PM

COPE

1

@Deleted User so, ye like the pee?

Lmfao

12:10 AM

Havent resorted to that yet

It could be a halloween treat

@UltimApe You asked if I have it in my blog. Do you mean the ideas on seizures? I’ve mentioned it a few times. The most clear time I’ve claimed this may be in the Noopept 2D vision article. But I’ve gone really deep into related glutamate/seizure/psychedelia topics like in Cognitive Atomization/Desummation. Also Flicker talks about how strobing is related to psychedelic effects, attempting to explain how fractals, time dilation and other effects work on the chemical level. If you are asking if I talk about myelination and microglial, no unfortunately I haven’t yet.

@qwerkyscience Specifically "I also have projects where I talk about how psychedelia is almost the same thing as seizure aura" I would like to learn more about the projects/talk (edited)

1

Did you fully read the 2-D Noopept article? If you have, I can explain from there

I did, but will read again.

The kindling part, dynorphin parts, and where it describes how visual effects may occur are the important parts

https://www.vice.com/en/article/59nwm5/paranoid-schizophrenia-10-questions?utm_campaign=later-linkinbio-vice&utm_content=later-11252577&utm_medium=social&utm_source=instagram

What Is Paranoid Schizophrenia Actually Like?

The mental illness been wildly misrepresented in popular culture. We spoke to someone who lives with it every day.

The issue is that seeing someone with schizophrenia or even hearing a more detailed explanation of schizophrenia is the trigger for many people.

A Pavlovian response possibly?

I was watching some youtube videos a while back. Most of the behaviors I saw seemed to be side effect of the antipsychotics. I know that I break a little bit when I try to take on the perspective of someone with that state of mind to empathize with them. I have a grounding in rationality that seems to help, but I could see it being a trigger in someone who isn't strongly anchored. (edited)

1

12:19 AM

hmm, I can't find them. I'll ask the person who shared them with me.

12:22 AM

Ah here were go https://www.youtube.com/watch?v=GU8VmJsX6-s

Special Books by Special Kids

Living with Schizoaffective Disorder (Experiencing Psychosis, Paran...

12:23 AM

He's got a bunch of different issues so it's hard to see the underlying schizophrenic problems. There was another interview that didn't have so many compounding factors.

12:24 AM

Seems it was the same channel. https://www.youtube.com/watch?v=7csXfSRXmZ0

Special Books by Special Kids

Cecilia's Life with Schizophrenia (Living with Hallucinations)

12:26 AM

I think this is the same person: https://youtube.com/watch?v=xbagFzcyNiM doing a tedx talk on the subject. (edited)

TEDx Talks

I Am Not A Monster: Schizophrenia | Cecilia McGough | TEDxPSU

I haven't found a good video detailing the paranoid version of it. That seems to be more about distortions in sense of reality. One of my twitter friends has gone off the deep end and thinks that there are people out to get them. They think that the songs playing in grocery stories are being planted on purpose by some entity to taunt them. The problem is they are genuinely like 160+ iq. They're so smart, they can rationalize and come up with plausible reasons why it is true. The trouble seems to be they are unwilling to consider other possibilities. I'm always doubting my own thinking so I don't really feel that, but I can kinda imagine what that might be like. (edited)

12:38 AM

This video discusses that in terms of 'salience' https://www.youtube.com/watch?v=OXsDdY6Xo90 -> abnormally attributing importance to ideas that would otherwise seem disconnected. I feel that way a bit when I drink too much caffine. Things that would normally be benign end up being way more exciting and I obsess on trivial details. I imagine it a bit like that, but around core reasoning facilities.

Memorable Psychiatry and Neurology

What it's like to have schizophrenia

Caffeine is psychomimetic

12:40 AM

It makes nonschizophrenics hallucinate even in doses that are used by normal ppl lol

12:40 AM

But they are subtle hallucinations

12:40 AM

Probably people dismiss them

When I stay up a long time to try and fix my sleep, I start hallucinating and babbling and get very incoherent. Caffeine actually helps when I'm like that. Finding ties between gut microbiota and circadian rhythms that suggest they might be interacting in that space, particularly with how they produce dopamine and serotonin, and help regulate melatonin and cortisol. I find it interesting that many psychotic breaks occur after large bouts of stress, or after an infection. Both of those would disrupt gut microbes in a vary similar manner. Coffee and cigarretes seem to be a a common self-medication, and so i'm looking at choline + vagus nerve as a possible mediator.

12:47 AM

Recent studies indicate that the vagus nerve (which is the longest of the cranial nerves and innervates most of the peripheral organs) can modulate the immune response and control inflammation through a 'nicotinic anti-inflammatory pathway' dependent on the α7-nicotinic acetylcholine receptor (α7nAChR). https://www.nature.com/articles/nrd1797

But people aren't looking at this in a meaningful way right now with microbiome research (at least in schizophrenia) despite the gut-brain axis being fundamentally about vagus nerve signaling. (edited)

The vagus nerve and the nicotinic anti-inflammatory pathway

I believe that nicotine and coffee can be some of the causes

12:49 AM

NAch alpha7 reduces activity of a hallucinogenic system that is central to stress responses

12:50 AM

But nicotine use actually increases this activity and part of the withdrawal symptoms are due to this system. It is the dynorphinergic/kappa opioid system

I'm thinking that there's a homeostatic feedback loop going on that changes the expression of the receptors. So coffee can help it if its low, but too much would drive loss of receptors.

They may both help acutely

I'm still trying to wrap my head around lipid rafts and dimerization of receptor sites.

Dimerization is a topic I like

12:52 AM

Idk about lipid rafts

12:52 AM

Do you know about KOR/dynorphin? It is the salvia system basically

12:53 AM

Nicotine and most stimulants and even most rewarding drugs upregulate it, probably kind of like a homeostatic response

vaguely, but not in enough detail to have a mental model of it.

It seems to usually occur from D1-NMDAr possibly related to dimerized related effect.

12:53 AM

Dynorphin is one of my obsessions

12:54 AM

Dynorphin blocks NMDAr

12:54 AM

And stimulates KOR, like salvia

12:55 AM

Basically it seems if glutamate and dopamine are too stimulated, then dynorphin comes and stops prefrontal cortex function along with maybe other cortical functions. Then the amygdala becomes more stimulated

12:56 AM

It can help stop seizures but it seems to produce psychosis

12:56 AM

It is also one of the key components of operant conditioning. It is “punishment”

12:56 AM

Dysphoria

The amygdala is the location that I think gut microbes are directly communicating with via vagus nerve signals.

Dynorphin is released during inflammation too

12:57 AM

So during sickness it will probably increase, make you anhedonic, dysphoric, and possibly delirious/psychotic

12:57 AM

It also makes you turn hungrier

12:58 AM

So maybe gut bacteria could hijack this

12:58 AM

And make you eat more and turn yourself diabetic or something

Direct modulation of gut microbiota by luminal release of neurotransmitters. In addition to CNS-induced changes in the intestinal microbial environment (e.g. by influencing regional transit and secretions), the host neuroendocrine system can communicate with the microbiota more directly via intraluminal release of host signaling molecules, including but not limited to catecholamines, 5-HT, dynorphin, and cytokines, from neurons, immune cells, and ECCs (151, 152). The CNS likely modulates this process(153-155). Epinephrine and norepinephrine are demonstrated to increase the virulence properties of several enteric pathogens as well as non-pathogenic microbes via stimulation of native quorum sensing mechanisms (156-160). Other gut microbes contain sequences which share 24-42% identity to human genome sequences for the binding sites of melatonin(161), whose gut luminal concentrations have been reported at more than ten-fold serum concentrations in rats and pigs (162, 163). In vitro assays of one such microbe, Enterobacter aerogenes, demonstrate that melatonin not only induces swarming and motility behavior but helps synchronize circadian period and phase across culture plates(161). The gut microbiota exhibit circadian rhythmicity in both abundance and expression in a manner dependent on the host and its behavior, especially feeding timing, and simulated jet-lag shifts composition enhancing dysbiosis (164). https://doi.org/10.1016/j.jcmgh.2018.04.003

(edited)

1

Cytokines and dynorphin are very close

1:00 AM

Dynorphin is the anti opioid

1:00 AM

Regular opioids seem to be very similar to cytokines

Going to have to dig into dynorphin responses of gut microbiota, that does sound like an interesting mechanism.

They are all close to microglial stuff too

Hmm

1:01 AM

Something smells a bit qwerky

1

https://mad.science.blog/2019/12/19/dynorphin-theory/

theschizotypal

Dynorphin Theory

This is the landing page for the dynorphin hypothesis of schizophrenia. Schizophrenia appears to be a condition of extreme stress with issues in stress recovery, leading to an accumulation of negat…

1:01 AM

This gets into dietary factors but not microbiome

1

Any idea if ECGC would effect dynorphin

1:03 AM

It does seem to be very effective for intestinal inflammation and microbiome modulation

It increases serotonin right?

Probably through microbiome modulation

1

1:03 AM

Dont think it directly crosses bbb

I don't have EGCG fresh in my head, but I know i've been taking it to boost microbiota that I suspect produce antiviral compounds.

1:06 AM

azithromycin is derived from an antibacterial that a microbe produces. It seems to also have vague antiviral properties according to some studies.

It has a very potent effect for me w my current gut issues

1:06 AM

And it potentiates the fuck out of my kefir

1

I think it’s a cannabinoid ?

1:07 AM

One of the things in tea is a cannabinoid

Kefir + ecgc feels almost phenibut like

It is a GABA a modulator

1:07 AM

The Wikipedia mentions this

It also makes you turn hungrier

@qwerkyscience Does this mean it doesn't increase when you have a bacterial infection?

1:08 AM

(tangential implication from a different idea)

It might depend, dynorphin probably increases with cytokines during infections

What makes you turn hungrier? Dynorphin?

I don’t think it always induces hunger tho

1:08 AM

It does stimulate eating in animals

Makes sense

so the question is 'when' does it stimulate eating, perhaps

And it’s associated to the orexin system

1:09 AM

I’m guessing there’s other things that stop the stimulation

1:09 AM

Also a lot of people might seek drugs instead of food

1:09 AM

It seems to generally induce craving

1:10 AM

Drug craving is mediated by dynorphin. Stress induced reinstatement of drug seeking is dynorphinerhic

Relatable

Also withdrawals symptoms of drug use fits the dynorphin effects like induced pain, anhedonia, dysphoria, anxiety

1:11 AM

And blocking dynorphin induces euphoria

So would excess dynorphin render nmda antagonists less effective or more

It depends

1:11 AM

It can have dual actions on NMDAr

1:11 AM

It seems to depend on glycine levels

1:12 AM

Also dynorphin can displace glycine from the NMDAr

1:12 AM

When it does this, that’s probably when dynorphin is an agonist

1:12 AM

When it binds to NMDAr main site then it’s probably antagonist

I have too much dynorphin, should I be taking glycine?

Idk maybe that turns it dissociative idk yet lol

1:12 AM

It may be more complicated than this too. You can test it

1:13 AM

Theanine seems to treat withdrawals of opioids

I'll test

1:13 AM

Theanine seems to have gotten more potent for me in my current state

Yes. Theanine sensitivity varies and sometimes Theanine is pretty much psychedelic

1:14 AM

I started getting induced panic attacks a while ago from theanine use so I just got really scared and stopped

1:15 AM

What effects do you get from theanine? Stimulation? Sedation? Visual changes? Migraine?

Sedation and anxiolysis

1:15 AM

Just varying potency

So it sounds like it plays a role in mediating other things more than having direct action. Like a backup system for cytokines.

1:17 AM

Do you know if it plays a role in fight/flight models of stress responses?

1:18 AM

the euphoria/dysphoria is interesting to me. That strikes me as possibly related to anhedonia symptoms in schizophrenia

My suspicion is that it biases us to fear rather than aggression

1:20 AM

Yes, my dynorphin theory post is an argument that dynorphin is linked to the symptoms of schizophrenia. It is also observed to be increased in schizophrenia.

1:20 AM

All systems are probably “indirect” also

1:20 AM

Also dynorphin suppresses dopamine release, potentiates D2 dopamine receptors, blocks NMDAr, reduces glutamate release

1:21 AM

And the dynorphinergic drugs all seem to be hallucinogenic

Looks like thre are a lot of behaviors that might be stemming from homeostasis. Dehydration would bias an animal toward not fighting/running but hiding instead. https://jhu.pure.elsevier.com/en/publications/kappa-opiate-receptors-inhibit-release-of-oxytocin-from-the-magno-4 also stuff about fear memories. https://www.jneurosci.org/content/32/27/9335 I know a bit about fear memory changes thru other pathways, so this looks like an inroad I might be able to use to learn more. Perfect.

Kappa opiate receptors inhibit release of oxytocin from the magnoce...

Dynorphins Regulate Fear Memory: from Mice to Men

Reexposure to trauma reminders is an integral element of trauma-focused cognitive behavioral therapy ([Roberts et al., 2009][1]), but little is known about the physiological processes underlying the therapeutic progress. While it is well established that amygdala, prefrontal c...

1

1:26 AM

I have a suspicion that biasing towad fighting depends on latent levels of oxytocin. If a member of a pack is dehydrated and alone -> hide. If they are happy and among kin -> minor disinhibition of oxytocin would be countered by the oxytocin of having friends around and would join in fighting instead. Its basic risk-reward decision making. Suggests dynorphin, or an analog, would show up in swarming insects.

1

1:27 AM

The actual decision points would be variable depending on signals from gut bacteria, as well as genetic tuning and epigenetic expression. E.g. a predator would have a different bias toward fighting vs a prey animal.

1:28 AM

At least that's what my intuition suggests. Loosely looking it up, it matches that mental model. That it plays a role in opioid system is important too since that seems to be the core of actual behavioral responses to thing like alcohol and eating, with dopamine/serotonin acting less directly.

1:30 AM

@qwerkyscience would it be alright if I quote you on my are.na as a note. This is fantastic.

I would imagine malnutrition would have similar effect to dehydration too

1

1:36 AM

I think fasting causes a larger adrenaline surge

1:36 AM

Which long term caloric reduction causes more cytokines

1:37 AM

In my experience malnutrition causes more lethargy

1:37 AM

Ive gone like 4 full days hard dry btw

1:37 AM

Twice

After 2 days of fasting I seem to get more energy when my body starts using fat (based on breath ketone meter)

1:39 AM

first 2 days suck tho

For me theyre decently chill

Serotonin is involved in insect swarming

1:39 AM

it is also involved in human "swarming" lol

I think ketosis starts entering after about a day

yes, very much. I've read everything I can about swarming behaviors in insects.

1

Definitely ramps up quite a bit by day 2

I really like exploring eusocialism

1:40 AM

Some of my content was about this and comparing humans and eusocial insects/mammals

Eucapitalism chad

1

1:40 AM

Jk

That is my entire jam.

1

And yes! You can cite/quote me on your note. Idk what are.na is

1:41 AM

Eutopia

1:42 AM

Too intense, windback***

1:42 AM

one day

1:43 AM

To be clear, I am against this

1:43 AM

But you can observe xenophobia in the eusocial species as well as possibly "eugenics" in a sense

Dynorphins are a class of chemicals, that makes more sense now. The behavior response may depend on the variation and ratios then.

Endorphins are a class too i think

1:44 AM

and enkephalins

1:44 AM

dynorphins are defined as byproducts of the pro-dynorphin i think

1:45 AM

they are generally all KOR agonists I think

Are.na is a social bookmarking platform. Think del.iou.us meets pinterest. But It has first class storage of markdown.

1:47 AM

I just created a channel in my self research group on dynorphin. one of the blocks is "Dynorphin Q+A with qwerkyscience"

1:47 AM

https://www.are.na/self-exploration/dynorphin

️

Dynorphin — Are.na

Are.na is a platform for connecting ideas and building knowledge.

1:48 AM

No ads, no tracking. I've been using it obessively to store my notes.

I have too much dynorphin, should I be taking glycine?

@Deleted User How can I check this? is it just a blood test, or something else.

Seeing how you interact w stuff and deduction in my case

3:23 AM

Its possible I'm wrong ofc

3:23 AM

But it seems likely

If you are an addict it may be likely lol

i think so personally because i had an unusually good reaction to naltrexone

If dynorphins seem to react like cytokines, presumably the reverse could be true and cytokines could be inducing the same symptoms? if you've got a mast cell problem, it might be tied to that indirectly. Just a thought. Ruling out dynorphin increases would be the first step I think. Tho if it's a brain thing, it may not show up in the blood ,which is why I asked about tests for it.

Naltrexone can be tricky probably. It is anti inflammatory.

3:26 AM

Cytokines do induce the same effects

oh yeh

But it’s not clear if it’s by modulating dynorphin

but i didn't notice anything from 1-5mg naltrexone

3:27 AM

Yea, I also respond very well to ULDN but LDN is useless for me

3:27 AM

yet i noticed a fuckton from 25+mg

Cytokines suppress monoamines and induce “sickness behavior”

I notice most from 100-500 mcg

1

Dynorphin basically does this as well but maybe a bit differently

3:27 AM

Naltrexone scares me

3:28 AM

I feel like it’s similar to tripping sometimes depending on the dose

Its inconsistent for me in effects

I felt like I got hypervigilancw

i feel way more like a person distinct from the rest of my surroundings

3:28 AM

as i increase the dose from 25mg to like 100mg

1

the salvia analog I was trying to get in for a clinical trial is also supposed to be an alternative to Naltrexone

Lions mane with naltrexone is particularly interesting anti addiction combo for me

3:29 AM

With ULDN*

3:29 AM

Far better for drug cravings than 25-100 mg naltrexone alone

emoxypine is anti alcohol

3:29 AM

you alcoholism

im anti alcohol

1

yes Queen

perhaps you should buccal me instead ?

thinking

!thinking

3:31 AM

I have abt 200 50 mg naltrexones so I have to play around w it froghorf

3:31 AM

wow

3:31 AM

thats like infinite dollars of naltrexone

3:32 AM

No, rehab was expensive

3:32 AM

Addiction was ingrained in me from noopept + recreational drugs neurogenesis so it was useless anyways

3:32 AM

Lions mane for a week was more effective lmao

3:32 AM

Addiction was ingrained in me from noopept + recreational drugs neurogenesis

oh i just realized i did this too

lions good, drugs bad

3:33 AM

gotcha

Yea it's easy to ingrain addiction into yourself w some combos

3:33 AM

Noopept + substances methifies em ime

3:33 AM

Does what meth does to your brain but with any drug you mix noopept with, ime

3:34 AM

(Havent done meth)

3:34 AM

when on a stack of 30 powders, including n acetyl semax amidate, i did selegiline + pea combo satou_stare

3:35 AM

well that was a week ago

3:35 AM

i meant the noopept + recreational drugs was my first encounter with powders

The way salvia would work in addiction is a bit complicated. I did notice benefits but the mechanism of withdrawals may overlap with salvia consider. It can stop reinforcement conditioning because it is punishment conditioning

That makes sense based on your view of stuff momi

I am fairly sure you can induce conditioned place aversion to yourself using KOR agonists lol

which view ?

I’m anti alcohol too

3:37 AM

Idk if you meant that you think alcohol sucks but it totally does

Kinda

3:37 AM

The kind of thing/perception that got you demodded in my server lol

1

3:37 AM

I don't think stuff sucks if you can mitigate the brain damage tho

3:37 AM

It's hard to explain

3:38 AM

But noopept+recreational drugs neurogenesis caused similar perspective for me

Why last leaf

The kind of thing/perception that got you demodded in my server lol Patronizing me is another offense worth blocking

I don't mean it in a bad way

Which perspective tho

I just don't know how else to explain it

3:38 AM

Oh, that's unrelated, 1) The noopept was accidentally available from the research chem vendor i used 2) Parents bullied me into trying to kill myself which made me abuse powders for half a year smug

1

3:39 AM

My view never changed that's all

parents gave the epic victory royale seizure

Idk how to explain what I mean

3:39 AM

If anything, it made me spread the word about "your brain already loses neurons by default so if you take drugs you should protect your brain"

3:39 AM

I didnt even notice it happened until I took lions mane and my perspective of life reverted to the way it was before I mixed noopept with recreational drugs

3:40 AM

A reward pathway rewiring, in part

I take lion's mane for insulin management and lipid maintenance.

I wonder which is worse alcohol intake or proccesed foods

1

3:40 AM

So, on that topic...

3:41 AM

I recommend to eat selegiline

3:41 AM

I recommend to never take noopept, at least if you do recreational drugs

3:41 AM

I've seen friends go hardcore addict mode after doing so

3:42 AM

I don't like noopept anyways

3:42 AM

And it happens right after adding in noopept

3:42 AM

Yea I dont either tbh

3:42 AM

Should i not take piracetam then either ?

3:42 AM

Racetams were fine for me

3:42 AM

Noopept fucky tho

3:42 AM

that's curious

3:42 AM

Noopept also causes instant 2 week permatolerance to amphetamine for me if I mix em

3:42 AM

not surprising

3:43 AM

Racetams w amps dont do that sorta thing for me tho

some of the MAO-Is I was looking at are also antibacterial. Was trying to find ways to hack the gut microbiome

Lmk if your successful

3:44 AM

Find a hack for SIBO

Speed run your current iteration, and reincarnate to someone who has some good bacterias

noopept also has neat action on diabetes https://pubmed.ncbi.nlm.nih.gov/23484194/ that I was unable to figure out

Efficiency of noopept in streptozotocin-induced diabetes in rats - ...

We studied the effects of new nootropic and neuroprotective drug Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) in various dosage regimens on the dynamics of glycemia, body weight, and pain sensitivity in rats receiving diabetogenic toxin streptozotocin. In experimental ...

3:45 AM

streptozotocin kills beta cells in the pancreas

3:46 AM

1

My hack for SIBO is red wine, but if your'e sensitive to alcohol, then it prob is a nonstarter

Why would red wine help

in some cases sibo is a result of acid imbalance driven by H pylori infection. Increase acidity and resveratrol can help. It also works because the agent they use to kill the yeast in America to meet alcohol % requirements also helps neuter the gut and give it a chance to regrow in a better pattern. H pylori is common in schizophrenic, autisitc, and diabetic guts.

Explains why I think I have H pylori

3:53 AM

Gut tells me I do

3:53 AM

And past w gastritis

3:53 AM

Gut also been telling me to buy resveratrol

you can probably do something similar without the alcohol content. I have a suspicion that mos of the 'drink apple cider viengar to lose weight" is actually just acting on H pylori and reducing inflammation as a result.

Red wine definitely creates more overgrowth for me. I used oregano and other herbal antimicrobials first. Then after many different herbs, I found the mixture of peppermint leaf, red quebracho, horse chestnut (found in Atrantil) ginger.... also did trial of ld naltrexone.

I drink acv before every meal

3:55 AM

And take betaine hcl w the meal

1

lemon juice is also an effectve sapponins that can disloge h pylori from the crypts they lodg themselves into.

1

And digestive enzymes

1

3:55 AM

And lemon/lime juice before every meal

3:55 AM

Oregano leaf helped my issues in the past

1

3:56 AM

When I was just munching on a bunch of leaf daily

3:56 AM

Havent tried oll of oregano (edited)

3:56 AM

Am responding positively to enteric coated peppermint + ginger + fennel but doubt kts sufficient on its own

Yeah, the fennel was helpful for me too, but not sufficient on its own.

Suppression of Helicobacter pylori Infection by Daily Cranberry Intake: A Double‐Blind, Randomized, Placebo‐Controlled Trials. https://doi.org/10.1111/jgh.15212

that also helps, it impres the development and regrowth, giving other things in the gut a chance to set up shop

Been getting the gut feelin I need cranberry juice lately as well

3:58 AM

Current strongest gut feelings of supps I should buy in order of intensity: oil of oregano, resveratrol, cranberries/cranberry juice

3:59 AM

Think my histamine issue I have band aided rn will go away once sibo is gone

I'm new to histamines, but it sounds like a decent plan in either case. I didn't have healthcare at the time I reset my gut so I never actually confirmed H pylori, but I know my gerd whent away after I did it so I'm happy. There's a bunch of fairly easy tests you can get done. http://mayoclinic.org/diseases-conditions/h-pylori/diagnosis-treatment/drc-20356177

My issues are all interconnected and treating the underlying one should allow the rest to be fairly easily resolved, and I'm fairly certain the underlying one is SIBO (edited)

Trying to cure “being an organism”

4:06 AM

What if living in houses is so bad or something

4:07 AM

But also we do have decent lifespans compared to probably the lifespan of house less humans lol

Cure SIBO -> trigger yeast overgroth -> cure yeast overgrowth -> trigger viralphage proliferation -> cure viralphage proliferation -> get SIBO It's the circle of life!

1

I recently had a fever and I think it’s because I combined algae for a few days with kimchi

From what I can tell, I started w h pylori and maybe sibo too, got MRSA and got a variety of antibiotics for MRSA which caused yeast overgrowth but also may ir may not have killed the sibo

Unless I had Covid and maybe my family is just fine from it or immune from prior infections idk

And became functional for 1.5 years until abusing drugs and health for 2 years and becoming worse off than ever

4:09 AM

So I have knowledge on dealing w all this shit at least

Thinking about it as systems going out of whack is a good way I think, trying to balance the various *iomes so that they all fight each other equally I think is key for a healthy ecosystem.

A yeast overgrowth is ez to handle if that's the only issue anyways

4:10 AM

Yea, candida can be a protective mechanism

4:10 AM

Hydrogen sulfide sibo may as well

4:10 AM

Would like more info on hydrogen sulfide sibo

I sometimes think we should follow instinctive behaviors more but maybe not always

In bees, they self medicate based on sense of smell, but that seems to be what some of the insecticides end up destroying (as well as changing foraging distance)

Like what if when we are sick we are not supposed to eat a lot? What if diabetes from stress/starvation is functional?

Yea I try and listen to my microbiome

1

4:12 AM

Science has fucked w me too much tbh

4:12 AM

Oral antibiotics for mrsa?

4:12 AM

Oral bactrim, butt shot clindamycin and iv vancomycin

Maybe hyperglycemia combined with metabolic changes are to make it so we slowly consume energy sources but then we eat on the clock and experience symptoms

Ah dang

4:13 AM

Yea and all they did was make the infection spread

4:13 AM

I think dry fasting is one of the few things that is real effective for mrsa

4:13 AM

Ouch

4:13 AM

I would only inject antibiotics last resort

Pain induces rapid insulin resistance. What if it’s because injured animals are going to suddenly be starving until they recover?

Manuka honey + turmeric paste was what cured it

4:13 AM

O yeh nice

There are some studies on that that seem to suggest (at least in mice) that it depends on the kind of infection. https://directorsblog.nih.gov/2016/09/13/feed-a-virus-starve-a-bacterium/ (edited)

Dr. Francis Collins

Feed a Virus, Starve a Bacterium?

Yes, the season of colds and flu is coming. You’ve probably heard the old saying “feed a cold and starve a fever.” But is that sound advice? According to new evidence from mouse studies, there real…

Yea I unfortunately was retarded and thought doctors knew there shit back then

4:13 AM

I've since learned

4:14 AM

Not there fault really

Insulin response change when viral or bacterial is fascinating.

My food requirements and hunger got fucked after MRSA

4:15 AM

Breh

4:15 AM

I've since needed to eat every 4-5 hrs to avoid crippling headaches

4:15 AM

How do u get mrsa after stopping prozac hah

4:15 AM

Sounds rough

4:15 AM

Prozac increases antibiotic resistance

4:15 AM

Huh

Huh as well

It’s like mrsa spores just exist right?

4:16 AM

So was ur immune system weakened

4:16 AM

Or maybe open wounds

Listeria acts similarly, it just sits arond waiting for an opportunity to bloom.

I got some gnarly staph in my leg once

4:16 AM

I didnt have an open wound

4:17 AM

Was training out in thailand Tiger Muay Thai

4:17 AM

Just red bump popped up and grew until golf ball size

4:17 AM

Doing like 2 sessions a day for a few weeks

4:17 AM

https://www.google.com/amp/s/www.sciencealert.com/antidepressant-medication-fluoxetine-prozac-may-raise-antibiotic-resistance/amp

One of The Most Widely Used Antidepressants Has Just Been Implicate...

In recent years, bacteria have been growing increasingly resistant to antibiotics – our strongest weapon against them.

4:17 AM

Sorta dehydrated and already pretty skinny

4:17 AM

https://pubmed.ncbi.nlm.nih.gov/30125859/

Antidepressant fluoxetine induces multiple antibiotics resistance i...

Our findings for the first time demonstrated that the exposure to antidepressant fluoxetine induces multiple antibiotic resistance in E. coli via the ROS-mediated mutagenesis.

4:17 AM

Unsure if either mention MRSA actually

4:17 AM

Was also doing the bjj/wrestling classes as well

4:18 AM

Ive heard now that showering right before class cleans off the skins oils/bacteria that makes it more susceptible

4:18 AM

But someone else on here talked abt prozac causing antibiotic resistance and had sources iirc

4:18 AM

Dont feel like digging tho

Oh, prozac is fluxotien? I knew about that

Ya

4:18 AM

More susceptible to ringfungus at least, probs mrsa as well

4:19 AM

Popping that shit was so weird after a few days by the time i got home

4:19 AM

Lot of nazty shit in there

4:19 AM

Shouldve dry fasted in hindsight

4:19 AM

With some slightly salty water

4:20 AM

Salt strong

4:20 AM

Experienced that in an extremely painful way

4:20 AM

I think my mom was mentioning like a manuka honey/turmeric (and maybe garlic) thing working for her when she had staph

4:21 AM

Yea

4:21 AM

She’s an unironically tough lady/anti doctor

4:21 AM

Took like ibuprofen when she got her wisdom teeth removed and then went to work later lul

4:21 AM

Smh ibu is awful tho

4:21 AM

Shoulda used curcumin + piperine + ginger

4:22 AM

Am half joking

4:22 AM

Ibu is awful for gut lining tho

4:22 AM

Idk she has a high pain tolerance

4:22 AM

Alzo if its used occasionally whatever

boosting anadamide via piperine etc would help with pain a bit

Curcumin potent anti inflammatory

4:23 AM

Ginger helps w that too and enhances the other 2

yep, via endocannabinoid system. https://pubmed.ncbi.nlm.nih.gov/22311129/

The CB₁ receptor-mediated endocannabinoid signaling and NGF: the no...

Increasing interest has recently been attracted towards the identification of natural compounds including those with antidepressant properties. Curcumin has shown promising antidepressant effect, however, its molecular target(s) have not been well defined. Based on the interac...

I’ve just eaten piperine and curcumin

Good for mast cell stabilization too

It is CB1 antagonist right

Is it?

Pepper is

4:24 AM

I guess curcumin is an agonist

4:25 AM

Black pepper is used with turmeric to enhance the effect lol

My mom's main problem is a pain disorder. I managed to knock out the pain receptors in my mouth with topical CBG. I could chew on pepper and not feel a thing. TRPV1 is responsible for a lot of inflammatory response from capsacin, and CBG seems to downregulate the receptor.

4:26 AM

I could hardly taste a habanero, it was wild.

What the heck lul

Been trying ot figure out what causes her pain. I think its a mix of overactive TRPV1 receptor creation and activity, combining with low anandamine production (natural anti inflammatory). Curcumin, piperine and a couple others all enhance anandamide (and by association THC) via endocannabinoid system.

Oh is my CBG use a few times why I tolerate cayenne easily now?

4:28 AM

U became part bird

4:28 AM

Cayenne and ginger less spicy

only bird n my mouth, the rest of me felt it :S

1

4:29 AM

My friend is turning it into a suppository tho. and I think I Can target the intestine with a time-release pill form of it.

4:29 AM

1

2

I got a 4mill scovill cayenne pepper concentrate to experiment with once I can get more CBG. That stuff is expensive tho.

4:31 AM

My hope is it will also fix crohn's. There's all sorts of weird findings that crohn's disease may be TRPV1 and helped with capsaicin, but no one manages to get thru the trials becaus it's so f*cking hot.

Interesting

4:31 AM

I prolly have crohn's

4:32 AM

Unspecified IBS atm but it's more IBD than ibs

Theres a bunch of different forms of it. Mine hits my small intestine and my nose. Chronic constipation most of my life.

4:33 AM

then suddenly I am not and its aweful

4:33 AM

large instestine form of it is the kind most people get and leads to IBS related phenomena

4:33 AM

also bird-like :S

4:36 AM

A lot of ancinet cultures used young cannabis sprouts and hemp seeds as analgesics. It's the part of the plant with the most of amount of CBG because at it grows it turns into the other cannabinoids. It's basically the plant's defense mechanism against disease and bacteria in the soil.

I still have 1500 mg cbg

4:36 AM

1:1 cbg cbd full spectrum

4:37 AM

Had tendency to cause orthostatic hypotension tho I think

I only needed 20mg, but it was mixed in something that helps it get hru the membranes in the mouth. I don't know the recepie and the person who made it is hard to contact.

Just get Lazarus naturals tincture imo

Do they have ones without CBD? I'm specifically avoiding that.

I have pure cbd

4:39 AM

I almost took some today but I think I’ll regret it

4:39 AM

Last time I took it daily for a couple days then got formication lol

Ahh ok, no they dont

4:39 AM

They have cbg isolate tho

Like seroquel

Just mix w mct oil

4:40 AM

Qwerky pls stop formicating in #casual, go to #noodles-chat for that.

1

4:40 AM

Told you id be good mod

this is confusing, it says CBG, but the copy says CBD https://www.lazarusnaturals.com/products/tinctures/cbg-isolate-tincture-thc-free-high-potency

CBG Isolate Tincture

CBG (cannabigerol) is one of more than100 non-intoxicating cannabinoids found in hemp plants. CBG, like CBD, offers similar benefits to the mind and body including immune support and relief of muscle soreness. CBG can brighten your mood, promote a healthy inflammation response...

Prob typo

4:42 AM

But yea def confusing and youd think they would have caught that already

4:42 AM

I'd still just get isolate and mix w mct oil anyways

The product actually is THC also

The isolate?

4:44 AM

The full spectrum is

4:44 AM

But the one he linked is isolate

Are you saying https://www.lazarusnaturals.com/products/concentrates-rso/bulk-cbg-isolate-thc-free and mix it?

Bulk CBG Isolate

CBG (cannabigerol) is one of more than 100 non-intoxicating cannabinoids found in hemp plants. CBG, like CBD, offers similar benefits to the mind and body including immune support and relief of muscle soreness. CBG can brighten your mood, promote a healthy inflammation respons...

Ya

4:45 AM

Or just weigh dose on mg scale and toss a tiny drop of mct oil in mouth along w dose and mix orally

that looks pretty good too. The other one I found like like 10lbs worth and it was crazy expensive

I have bulk cbd from em

4:46 AM

May get bulk cbg if you have good results w it for gut stuff

I think the think I used was sunflower lecithin at a particular heat to do something neat with emulsification.

4:47 AM

but mct oil might work the same

Ahh yes sunflower lecithin good emulsifier

Lastleaf I was joking about THC

Idk how youd mix that in w just mct oil + cbg isolate

4:48 AM

Because it would be like how some cbd products were actually just THC except this one is sold as CBG, pics of CBD, and is THC, it would be hilarious lol

Oh lmao

Consult your doctor before use if you have been advised against eating grapefruit.

Nice. I don't see that often. Makes me trust the more.

4:56 AM

If you don't have any issues with IBS/Crohn's would recommend against experimenting too much with CBG. I've been hearing some stories about bowel movements that would kill a horse.

That's exactly what I need

also, as I lost pain sensation in my mouth, I woke up one day with blood and a nasty wound on my tongue. I wanna find a dose that doesn't do that

Well I bit my tongue eating the other day and it hurt despite having gone through 1.5 g cbg in a few months so good news there

4:58 AM

It's specifically sleep that I think does it the most due to weird changes in thermoregulation I experienced. I may be a special snowflake here.

Interesting

The development of antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel as pain therapeutics has revealed that these compounds cause hyperthermia in humans. This undesirable on-target side effect has triggered a surge of interest in the role of TRPV1 in thermoregulation and revived the hypothesis that TRPV1 channels serve as thermosensors. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763780/

knocking out trpv1 seems to get the reverse of this It's partly why my body temp dropped I think.

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregul...

The development of antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel as pain therapeutics has revealed that these compounds cause hyperthermia in humans. This undesirable on-target side effect has triggered a surge of interest ...

5:02 AM

that and CBG is also a TRPM8 antagonist. There are strange interactions between that and TRPV1 that seem to play a role in body temp.

My body temp got low for a while recently

good chance its the CBG

Happened after some cbg use but I have no idea if cbg was involved

5:03 AM

Well that's not good

It lasted 2 weeks for me despite taking oral cayenne tincture daily

5:04 AM

(not the super hot version)

Low body temp will make pathogens more likely to thrive in intestines and gut, wont it?

yeah. The long term goal for me is hibernation, which involves clearing out the gut bacteria entirely to avoid that.

Yea I'm not fucking w cbg again then most likely

5:05 AM

Think I screwed myself up more w it

5:07 AM

Do those little dudes have like an appendix or something to restore their gut bacteria

5:07 AM

Funny stuff

The flip of this is I need to figure out how to reverse it and reactivate TRPV1 receptors. There may be other things that can act against it. I know keto increased my body temp a lot and so does the Cayenne tincture, but that isn't teh same as creating more receptors.

5:10 AM

Bears will eat volcanic soil in the spring that cures them of an helmints the might have during hibernation. I am still exploring ways to restoring the micrbes after. Not sure how the ground squirrels do it. No one seems to be researching it.

5:12 AM

Never thought to explore appendixes during hibernation, that's a good idea. (edited)

Oh cool about the soil

5:14 AM

Yeah bears get a metric fuck load of trichinosis apparently lul

5:14 AM

Gotta cook their meat good

Cayenne should cool your body I think

T gondii too. It messes with their hormones.

Huh

The heat is a sensation but I think it cools u

Wonder where they get each now that i think about it

All sorts of studies on capsaicin/cayenne show it heats you up.

Gondii from venison? River water i guess

5:15 AM

Where they get all that Trich from tho

5:16 AM

Cuz i thinks its different than that weird one raccoons fukkn have that is fine for them but messes up other animals

hmm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843897/

Effect of capsaicin on thermoregulation: an update with new aspects

Capsaicin, a selective activator of the chemo- and heat-sensitive transient receptor potential (TRP) V1 cation channel, has characteristic feature of causing long-term functional and structural impairment of neural elements supplied by TRPV1/capsaicin ...

Like i dont think wild pigs go that far north

5:19 AM

Not common in deer apparently

5:19 AM

Pretty much all the trich cases in US are from undercooked bear

5:19 AM

Since its apparently about all gone from factory pigs

I know that too much activation of TRPV1 can actually down regulate it. Might be seeing different results based on dose?

5:20 AM

https://ncbi.nlm.nih.gov/pmc/articles/PMC6032921/ talks about how it seems to vary

TRPV1 antagonists that cause hypothermia, instead of hyperthermia,...

Thermoregulatory side effects hinder the development of transient receptor potential vanilloid‐1 (1) antagonists as new painkillers. While many antagonists cause hyperthermia, a well‐studied effect, some cause hypothermia. The mechanisms ...

1

5:21 AM

I don't take a lot in my tincture. If I take too much, I start sweating and get cold.

5:22 AM

There might be other things the cayanne tincture is hiting that isn't just TRPV1. I'll have to explore further. Def seems odd

It says it worsens fever after downregulation

anandamide can also downregulate it, so it might be that I'm not making a lot of anandamide and so the effect is more pronounced

1

Interesting

5:27 AM

Dynorphin induces hypothermia also

5:27 AM

MOR opioids induce fever

I am tired. I may be mixing it up in my brain with https://pubmed.ncbi.nlm.nih.gov/11676017/

CH-19 sweet, a non-pungent cultivar of red pepper, increased body t...

We investigated the effect of CH-19 Sweet, a non-pungent cultivar of red pepper, on body temperature and oxygen consumption in humans. CH-19 Sweet was given to 11 healthy volunteers, and core body temperature, body surface temperature and oxygen consumption were measured. The ...

5:29 AM

Or maybe it only does that in diabetics. I'm fairly certain I remember reading TRPV1 increased body temp by a few degrees. It's probably in one of my twitter threads on the topic.

5:30 AM

I should go to bed, ttyl

That first paper you sent suggests it could go either way. Capsaicin may have functional selectivity.

5:36 AM

Or the others may have functional selectivity too

5:36 AM

Goodnight

That lazarus naturals company got back to me in a twitter DM. This is indeed entirely CBG tincture and it was a typo. https://discordapp.com/channels/307540693826666507/593444179749634070/772666529179107348 They also recommended the third party testing they have as the most reliable information.

@UltimApe trpv1 is used for quick signaling of temperature among other things (pain, itchiness, etc)

11:18 PM

there are some defects related to either temperature sensation or regulation

11:18 PM

caused by trpv1 defects

11:18 PM

it's on the trpv1 wiki page

11:19 PM

https://ncbi.nlm.nih.gov/pmc/articles/PMC6032921/ talks about how it seems to vary

@UltimApe probably depends on the activation yeah

TRPV1 antagonists that cause hypothermia, instead of hyperthermia,...

Thermoregulatory side effects hinder the development of transient receptor potential vanilloid‐1 (1) antagonists as new painkillers. While many antagonists cause hyperthermia, a well‐studied effect, some cause hypothermia. The mechanisms ...

11:20 PM

the way piperine or capsaicin work is that they overload trpv1 extremely

11:20 PM

and it down regulates

11:20 PM

you used it all up for a bit of chili, now your head won't hurt

11:22 PM

11:23 PM

I think it also depletes PIP2 which means less signaling

11:23 PM

it's used for more things tho so probably other signaling is affected as well

I took black pepper and turmeric and I think I feel more manic and I’m hot and have higher temperature than usual.

I have drank cayenne pepper tea a number of times.

2:38 AM

It causes a nice warmth throughout the body.

It is nice yes

2:51 AM

I make ghost pepper ramen and sweat intensely it’s like being in a sauna. Feels really good

@qwerkyscience if you eat black pepper you'll also feel hotter

7:14 AM

black pepper got me like GOD DAMN

Yesss I also checked my temp and it was up to 99F

1

That lazarus naturals company got back to me in a twitter DM. This is indeed entirely CBG tincture and it was a typo. https://discordapp.com/channels/307540693826666507/593444179749634070/772666529179107348 They also recommended the third party testing they have as the most reliable information.

@UltimApe Lazarus naturals is a great company.

3

2

10:23 PM

the fuck did i just read

@euh that's like when killer spams links about NAC being neurotoxic

Broccoleaf

When you don't understand xenohormesis.

Dopamine is technically neurotoxic. Water is toxic in enough quantities (unrelated to drowning) I calculated the LD50 of bathwater a while back.

"Water is considered one of the least toxic chemical compounds, with an LD50 of over 90 ml/kg in rats." https://en.wikipedia.org/wiki/Water_intoxication 1 gal is approx. 3790ml average adult rat is 0.227kg 1 gal can kill ~185/2 rats average bath uses ~20 gal of water LD50 of water = 1850 rats per bath.

2:34 AM

Even when not at toxic levels, sudden changes in body salt concentration can induce loss of white brain mater similar to multiple sclerosis.

1

2:34 AM

TL;DR: diarrhea can cause your brain to atrophy via sodium loss. (edited)

1

Yum

I did low sodium for a while and was tripping out

what was that like?

3:04 AM

high sodium seems kind of dank ngl

3:04 AM

https://www.youtube.com/watch?v=mLw-d37LyAw

Mikhaila Peterson

The Mikhaila Peterson Podcast #14 - Cole Robinson: Snake Diet

3:04 AM

this guy says he does like 8 g a day and i believe him

3:05 AM

might be ruff on the veins tho idk he does pair it with fasting and carni

3:09 AM

Low sodium was awful for me

3:09 AM

Just eat more natural salt and more potassium

3:09 AM

My body loves celtic or Himalayan salt

I had orthostatic hypotension mostly. But I also started fasting a lot and got really psychedelic

Similar here but also heart was doing scary shit

3:13 AM

sodium is potassium sparing in high amounts according to him

3:13 AM

so really dont need that much *potassium (edited)

3:13 AM

meanwhile high potassium flushes out sodium

3:13 AM

so the body will retain a lot of water just to hold onto that sodium

3:14 AM

Explains my cravings

3:14 AM

And experience

Was your heart very fast or what

Fast and irregular

I think I had that too but I was also panicking a lot so

3:19 AM

Because I was so psychedelic. Strangely my cognitive ability was fire still though lol. I wrote The Phoenix Effect at that time

Damn lol

3:25 AM

I accidentally did low sodium lmao

3:25 AM

And I ended up also dealing w histamine issues concurrently w the low salt which made my heart super fucky

Me too I wasn’t exactly thinking about it

The sodium brain thing is a short term effect and it's more about rate-of-change of sodium one way or another. "Osmotic Demyelination Syndrome". Tho long term salt weirdness is also problematic. Hyponatremia is a huge problem in older populations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694198/ and may be tied to delerium states https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5273588/ I think kidney failure and congestive heart failure can cause it too.

Hyponatremia in the elderly: challenges and solutions

Decreased serum sodium concentration is a rather frequent electrolyte disorder in the elderly population because of the presence of factors contributing to increased antidiuretic hormone, the frequent prescription of drugs associated with hyponatremia ...

The Association of Hyponatremia, Risk of Confusional State, and Mor...

Hyponatremia and delirium are frequent problems in older hospitalized patients. Although confusional states are considered to be a possible complication of hyponatremia, there has been no systematic study to date of the precise prevalence of delirium ...

6:00 AM

I get really bad leg cramps sometimes. excrutiating. Nothing seemed to help. Once I realized bile is the main way our body uses sodium, and that crohn's (ibs too perhaps) seems to lead to poor bile reabsorption, I started injesting salt when I get bathroom issues. It stopped my leg cramps. No ammount of potassium or other elecrolites seemed to help.

6:01 AM

Not a direct cause of my M.S. symptom, but seemed to be a factor in exacerbating it too.

you'd think elderly people would be getting a lot of salt in their diets

6:01 AM

huh

they're all afraid of heart disease by too much sodium.

"tea and toast syndrome" lawl

6:02 AM

oh yeah and the medications huh

I found a 'low sodium' salt reciently. The other thing to watch out for is iodine deficiency. For many, iodinized salt is the only source we get. Fucks with the thyroid and can make you lose like 10iq points. It doesn't always manifest with a goiter.

6:06 AM

https://www.healthline.com/nutrition/6-dangers-of-sodium-restriction this looks like a good summar

6 Little-Known Dangers of Restricting Sodium Too Much

It's often recommended to reduce sodium to lower blood pressure. Here are 6 reasons why restricting sodium too much can be harmful.

6:07 AM

Fun fact: bees taste salt with their feet. :3

3

I wonder if this is why I like sucking feet

1:53 PM

Umm honey on toes or something (edited)

Yea that's why

https://www.researchgate.net/publication/286654216_Effects_of_rhynchophylline_on_monoamine_transmitter_contents_of_striatum_and_hippocampus_in_cerebral_ischemic_rats

I got embarrassingly engrossed in pcp-2 cells aka Purkinje cells might be close in function...reminds me of the densification between cerebellum sigma and mmda (no not nutmeg nitrogen synthesis) pcp site-2 receptors has got me thinking of ways to upregulate psychedelics trips duration and intensity while reducing the third eye burnout and neuroticism of both. Gaige you should make an article on how kratom and or dissociatives and psychedelics interact, or some articles on serotonin opioid system interaction and something like I'm

1

2:31 AM

Um

2:34 AM

https://amp.reddit.com/r/DrugNerds/comments/iwn6pd/intranasal_administration_of_mesenchymal_stem/

Reddit - DrugNerds - Intranasal administration of mesenchymal stem ...

r/DrugNerds: For the discussion of recreational pharmacology. (r/drugs with longer words)

1

@Athegnawthine Have you read this one before? https://mad.science.blog/2020/06/05/psychedelic-valence/

theschizotypal

Psychedelic Valence

There are two serotonin receptors that seem to play a prominent role in the emotional effects of psychedelics. These two receptors, 5HT2a and 5HT2c, may be able to explain good versus bad trips, at…

I know the author of that one

1

The word "bad trip" should never ever be used.

There are Overly Intense Trips where you can feel like you are going to die, that absolute doom is looming, that the trip will never end, tremendous transpersonal effects; even though you can logically understand that these tremendous transpersonal effects are not real, on a much deeper level this logical knowledge does not matter to you. (edited)

It needs to be understood by all who take hallucinogens that an Overly Intense Trip is absolutely not a "bad trip". That nothing can go wrong except if you want it to go wrong and make it go wrong. The only "wrong" could be if the person tripping is psychotic, thus a "Psychotic Trip"; wanting to harm themselves. It needs to be understood that -if you do not want to harm yourself then nothing could go wrong-

That's not necessarily true but if you think this way it becomes true... So is it true hehehe

qwerky is this in cali?

1:44 PM

this is just beautiful

1:44 PM

today I was looking on google street view

1:45 PM

to find a red district that has a beach side

1:46 PM

there's only one city

1:46 PM

and it's a complete shithole

1:46 PM

city

1:46 PM

that's just in the name

1:46 PM

it's a village

@euh it is Angeles National Forest

3:48 PM

Near LA

Horus, Isha, & Jesus would all look at the what is modern day left calling them far right infact.

@Deleted User What could go wrong on a hallucinogen besides true psychedelic psychosis?

supposedly trauma

And one of my friends had full on psychedelic psychosis or what some would like to call ""excited delirium""; he was suicidal flailing around on the floor babbling nonsense, we ended up bringing him to a hospital because we did not want to risk anything. I was on 230mcg when this happened

12:49 AM

So I am very much aware of what can go wrong and how very badly

12:50 AM

He has not fully recovered years later

12:52 AM

Good point though about trauma.

12:54 AM

But the only asterisk to what I said would be if you are on a hallucinogen around shit that is fucked up, amplifying it though it's independent from the hallucinogen.

12:58 AM

Otherwise the potential trauma is caused by the meme of "bad trips", people's lack of understanding. The Tibetan Book of the Dead adapted by Timothy Leary is marvelously eye opening.

I do think there are right wing authoritarian types who have inhabited the left

I am trying out this new diet 5 days a week. Don't know if this is the right place to share but I am curious if anyone has tried something like this and seen success with psychosis symptoms or otherwise. Goal is to have only 40g carb on those days while still meeting RDAs according to Cronometer

Wake up at 9 am and drink 2 cups water
Breakfast at 10 am
- Shake: 1 tbsp flax seeds, 1 tbsp soaked chia seeds, 30g pea protein powder, 1 cup almond milk, 1 cup spinach, 1 tbsp cocoa powder, 1/4 tsp Terrasoul amla powder, 8 tsp Terrasoul wheatgrass juice powder
- 1 cup water
Snack at 12 pm
- 1 tbsp pumpkin seeds, 1 brazil nut
- 1 cup water
Supplements at 1 PM
- 0.75 g sarcosine/100 XR caffeine
Lunch at 2 pm
- 1 tbsp sunflower seeds, 20 g walnut halves/pieces
- 2 peppercorns/1 turmeric supplement
- 1 cup water
Snack at 4 pm
- 1 tbsp pumpkin seeds
- 1 cup water
Exercise 5 to 6
Dinner at 7 pm
- Salad: 1 avocado, 1 cup spinach, 1 stalk celery, (dressing: 1 tbsp soy sauce, 1 tbsp red wine vinegar), 1 tbsp sunflower seeds
- 2 cups water
Night pills at 8 pm
- Avmacol 1 tablet
- Purity Products Omega 3-6-9 1 softgels
- Solgar, Chelated Zinc 1 tablet 20 mg
- Kirkland super-b complex
- 200 mg NAC
- 50 mg fluvox (reduce to 25 mg in a few weeks) - Night beverage
1 cup almond milk with non caffeinated tea packet
Weekly:
- 10000IU Bronson Certified Organic Vitamin D3

(edited)

If you end up having weird thinking problems with that diet, try some more fats in the morning with the shake. I find that I don't function well even in ketosis if I don't also consume fats in the morning. I've been using ghee, but MCT oil seems to also work.

1

9:56 AM

I also recommend working in oyster mushrooms to get a source of taurine.

9:57 AM

If you start getting diarrhea, watch out for sodium loss.

@UltimApe Are you suggesting to add taurine to diet because of some of the studies you've linked in your page here? https://www.are.na/self-exploration/taurine Specifically, https://www.are.na/block/8232075 and https://www.are.na/block/8108666

️ Taurine — Are.na

Are.na is a platform for connecting ideas and building knowledge.

Taurine Experiment. Exploratory Phase. — Are.na

Are.na is a platform for connecting ideas and building knowledge.

Antidepressant effect of taurine in chronic unpredictable mild stre...

Depression, a psychiatric and dysthymic disorder, severely affects the learning, work and life quality. The main pathogenesis of depression is associated with central nervous system (CNS) dysfunction. Taurine has been demonstrated to exert protective effects on the brain devel...

Are you suggesting to add taurine to diet because of some of the studies you've linked in your page here?

@Lavencia Mostly that vegetarian diets are low in taurine and that coincides with weird problems in heart health. I think that is still approximately true, but don't think the mechanism is as direct as people let on (which is why I'm exploring taurine there). I mostly did a quick look at the ingredients and didn't see much in the way of things to produce bile acid for processing the fats. Was thinking about these https://www.are.na/self-exploration/bile-salts-bile-acid which is upstream of taurine by way of https://en.wikipedia.org/wiki/Bile_acid#Structure_and_synthesis Tho it's possible I overlooked other ways of making bile that might be covered.

12:22 PM

Was cue'ing off the b complex + NAC as you looking out for liver problems. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974141/

The effect of N-acetyl-l-cysteine (NAC) on liver toxicity and clini...

Busulphan (Bu) is a myeloablative drug used for conditioning prior to hematopoietic stem cell transplantation. Bu is predominantly metabolized through glutathione conjugation, a reaction that consumes the hepatic glutathione. N-acetyl-l-cysteine (NAC) ...

12:23 PM

NAC is all over the place on it's impact, but most of the time it's for protecting liver and kidney function. https://webmd.com/vitamins-and-supplements/n-acetyl-cysteine-uses-and-risks and the B vitamins are also a major player in liver processes.

N-Acetyl Cysteine (NAC): Uses and Risks

WebMD explains the uses and risks of the supplement N-acetyl cysteine (NAC).

12:29 PM

Assumption is you're aiming for a vegetarian keto. That's what it looks like to me. I know a bunch of people who's psychosis symptoms have improved with that style, but normally its geared for carnivore. Been trying to find good examples of vegetarian options and bile production is one of the factors I try to pay attention to when judging.

Biochemical and physiological evidence in favor of a GI etiology for psychiatric illness has been accumulating more or less continuously since 1860 [32–35]. Such investigations included those of Herter (1907), who found indication of low stomach acid in patients with mental illness, along with bacterial putrefaction of various amino acids including tryptophan. One function of gastric juices is to maintain a proteolytic environment to enzymatically control proliferation of anaerobic bacteria to the small intestine and prevent the absorption of toxins. Herter’s findings have interesting physiological ramifications given that tryptophan and the other aromatic amino acids phenylalanine and tyrosine are precursors of schizophrenia-relevant neurotransmitters including serotonin, dopamine, epinephrine, and norepinephrine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437570/

Gastroenterology issues in schizophrenia: why the gut matters

Genetic and environmental studies implicate immune pathologies in schizophrenia. The body’s largest immune organ is the gastrointestinal (GI) tract. Historical associations of GI conditions with mental illnesses predate the introduction of antipsychotics. ...

@Lavencia low calories might be an issue. I didn’t count here but it looks like it could be low calorie. Being low calorie can enhance KYNA synthesis over serotonin.

@UltimApe and @qwerkyscience thank you for the pointers on including enough taurine/increasing calories. I have now modified it to be about 1300 calories but now has about 58g carbs In addition, as there are no oyster mushrooms available for delivery near me, I am going to use Swanson-Spectrum-Mushroom-Complex-Capsules https://www.amazon.com/Swanson-Spectrum-Mushroom-Complex-Capsules/dp/B07359J4MR/ref=sr_1_2_sspa?dchild=1&keywords=Full+Spectrum+14+Mushroom+Complex&qid=1604879342&sr=8-2-spons&psc=1&spLa=ZW5jcnlwdGVkUXVhbGlmaWVyPUE5MDZMR1ZHTVVVN1QmZW5jcnlwdGVkSWQ9QTA1NjM2ODEyUDJKQUQ1Qk9HQlJIJmVuY3J5cHRlZEFkSWQ9QTAyODY3NjEyTFhVWkVNTFEyTkRFJndpZGdldE5hbWU9c3BfYXRmJmFjdGlvbj1jbGlja1JlZGlyZWN0JmRvTm90TG9nQ2xpY2s9dHJ1ZQ== (edited)

1:05 AM

That mushroom blend has lions mane, which is good for blood sugar regulation, and a bunch of other lipid adjusting things in it. I would expect that to help a lot there. I can't speak to everyone's luck with lion's mane, but noticed I can get a lot more carbs before my breath ketone meter shows me being out of ketosis. I am already a bit of an outlier there tho, so YMMV. Cronometer is such a great tool!

1

@Lavencia on 1300 calories I got trippy. 1800 is where I felt pretty good.

1

who are these people

10:04 PM

stims have never made me horny

take garlic w em then

Stims on selegiline and pramipexole tho Smug3_ATWE

12:08 AM

Different story indeed...

@Deleted User Dipropylphenethylamine and stims

‍

(edited)

3:28 AM

DPP specifically significantly increases the monoamines released from synapses firing. (edited)

3:32 AM

3:34 AM

It was considered the magnum opus of the inventors of Deprenyl / Selegiline. It has zero maoi activity.

What articles are you working on atm? (edited)

11:46 PM

I have over 148,000 views on my site and have room for advertising, if you want I can put some free links up to your site if you'd like. Just temporarily, I don't have any paid for ads on the platform yet. But cost per click with google is like $2, and on my site it's 0.1 cents, so if you want to pay for it later it's at a very competitive price.

My psychiatrist saw my website and put in the notes that it's thought disorder

11:57 PM

It's pure science, 99.9% of posts have a DOI

11:59 PM

She told me one of my delusions was that I thought I was internet famous, but I dodged that bullet when I started getting immense followers and recommendations from people, I deleted the account. But now 150k views has to account for something

12:01 AM

In the past I've managed to discredit every single delusion they thought I had, and proved the truthfulness of my claims, and they still kept me on a treatment order (forced treatment) despite getting it all wrong. The only way I can get out of the forced treatment is commit to being treated without the order. It's a catch-22 for sure. (edited)

12:02 AM

Every post gets an ad on the righthandside

12:04 AM

So far I have the mdma testkits from the quentin experiment, the psychedelic salon, and my own other website as ads. Feel free to check out jackdonmclovin.com too, i have a lot of philosophy type posts, a letter to a consciousness and so forth

Are you in the US?

Nope, AUS

12:52 AM

I've been a longtime follower of qwerky

12:53 AM

He theorizes like I do

Ah, alright. Ive sort of heard stories of that out here, might vary by state but i think its a tragedy that people can do that to each other

Forced treatment sounds like you need to run away

7:16 AM

Thats imprisonment or poisoning

7:19 AM

Anyway i got some centrum pfizer multi vitamins and decided to investigate the wikipedia article on it. The entire debate is on whether it reduces cancer or cardiovascular moralities or not. Meanwhile im going into the search with a different frame

7:20 AM

Im trying to figure out whether taking these multivitamins is going to cause an increase in cancer, or other disorder in the long term, so that pfizer can give me treatment using one of their new therapeutics. Create the disease and profit from treating it

1

7:23 AM

Im really conflicted though because food has a huge concoction of vitamins. But when it comes to drugs, mixing two or more can create unprecedented negative effects and harm user when the drugs on their own would not. So why would i want to take 15 difterent types of vitamins at once even if all of them are healthy dosage?

I am sketched about supplements but I use some in small doses

one thing with supplements is so much stuff tends to deplete or rely on other stuff

6:19 PM

easy to fuck up equilibrium

Yes

https://www.eurekalert.org/pub_releases/2020-11/udg-lba111320.php

Link between Alzheimer's disease and gut microbiota is confirmed

In recent years, the scientific community has suspected that the gut microbiota plays a role in the development of the disease. A team from the University and the Hospital of Geneva the National Research and, University and IRCCS SDN Research Center of Naples, confirm the corr...

@rhiza Just ate 1.5 grams of Colorata

What is the taste? Some of them are fishy and some are yummy

Capsules

6:41 PM

Colorata not Amanita

Oh is colorata a different thing altogether? I assumed it was a specific strain like how there are Washington amanitas versus other kinds.

psychotria colorata

8:44 PM

active component being hodgkinsine

Ooh! It is a dissociative I’ve heard.

The active alkaloids are Hodgkinsine and Psychotidrine @rhiza @qwerkyscience (edited)

11:15 PM

It's a dissociative used natively in South America known as Humo or Kumikeetoo. (edited)

11:16 PM

Hodgkinsine is an opioid agonist / nmda antagonist and Psychotidrine is an nmda antagonist

Psychotidrine

11:24 PM

Hodgkinsine

11:25 PM

They are both alphamethyltryptamines bound together. It did have possibly a tryptamine feeling. But a lot of things feel a bit like mushrooms. (edited)

I think opioids can mildly resemble some of the shroom effects

1

I thought I read somewhere that a small amount of Hodgkinsine breaks down into amt though.

1

For whatever reason cannabis always induced a psychotic episode in me, and I never understood why. Recently I got my genetic information and saw this.

2:38 PM

1

2:38 PM

Didn't even know this was a thing associated with genetics at all

2:39 PM

Only have one risk allele but enough for it to cause quite traumatic experiences.

1

2:41 PM

Of course there are many other factors but this bit is interesting

I wonder if I have such genes as well

euh

Click to see attachment 🖼️

I have the same polymorphism.

1

@euh where did you get genetic testing? (edited)

This person is now @moomin64

1

Lavencia

@euh where did you get genetic testing? (edited)

Hey I got it done through 23andme since the holiday sales. Went with the cheapest option. It provides the raw data still and then ran it through some raw data tools to see the interesting bits.

1

AncestryDNA is the same, just get whatever is cheaper, only need raw data.

2

3

https://www.dea.gov/press-releases/2020/10/27/dea-and-usps-unveil-drug-free-usa-forever-stamp

DEA and USPS unveil Drug Free USA Forever stamp

hmm drug dealers should mail lsd out in those

1

Hmmm seems smart

1

What if it’s a trap

DEA and USPS secret plot to turn everyone into girls EXPOSED. It seems the two agencies planned on rolling out postage stamps laced with HRT to turn everyone into a trap. (edited)

3

@qwerkyscience I sometimes talk to the guy who did that Symmetric Vision thing you posted

2

7:13 AM

He has a discord for visual art stuff

Send the link here

same

5:13 PM

send plox

https://www.youtube.com/watch?v=ajgeaOt_HTQ

Eric Faw

Age of Aquarius - The 5th Dimension (lyrics) HD

Was thinking about living ethically, and why is that not a standard?

Because the norm is not to care about ethics or morals. The norm is to care about getting money, and providing for a family. Living ethically is only seen as a privileged for some.

I was thinking about how you should only eat meat you have hunted (or family/straight from hunter) for it to be ethical, and realized that basically means just going back to ancient times. I don't even want to start to think about how many other places it applies to

I just dont eat meat simple.

I just stab my meat with a form before eating it...

Well you gotta make sure its dead

1:17 AM

Just because its been boiled and cooked doesnt meant it can't act up and do something.

@Deleted User How do body work?

8:58 PM

8:59 PM

@Deleted User it's very tempting to stay on this place

6:29 PM

you should

@Deleted User I can't. I have to move on

6:39 PM

Goodbye old friend.

6:39 PM

you were good to me. (edited)

6:39 PM

goodbye friend, good luck out there in the real world

2

exactly

I'm making a meme and checking it twice. It seems a bit naughty, but think it's kinda nice. https://gist.github.com/ultimape/253221a3a42acefbef8839f61c8e6ae8

It's a big fungus lord. A parody lyrics and homage to CG5's "Big Ch...

It's a big fungus lord. A parody lyrics and homage to CG5's "Big Chungus" https://soundcloud.com/cg5-beats/big-chungus - big-fungus.md

Nice poem. Is it somehow sexual

Not at all. Someone is psychologically projecting their horny.

2

12:30 AM

sexual? hmm

12:47 AM

the large mushroom being a phallic symbol, I can see that.

I apologize for my projection

Jk tho. I’m not actually right now

https://www.sciencedaily.com/releases/2020/01/200114101724.htm?fbclid=IwAR1Z6nslCE1wLt_F_WNyXOo1pwX-HvGFnmszAKYjJ7_YI_ubhorusDf3oNw

Flame retardants and pesticides overtake heavy metals as biggest co...

Adverse outcomes from childhood exposures to lead and mercury are on the decline in the United States, likely due to decades of restrictions on the use of heavy metals, a new study finds.

2:05 AM

I’ve been saying cholinergics are bad and induce schizophrenic type effects fwiw

valued each lost IQ point at $22,268

12:13 AM

im becoming more and more retarded yet i still havent seen a dime of that money

solipsism rising https://www.scientificamerican.com/article/how-do-i-know-im-not-the-only-conscious-being-in-the-universe/ (edited)

How Do I Know I’m Not the Only Conscious Being in the Universe?

The solipsism problem, also called the problem of other minds, lurks at the heart of science, philosophy, religion, the arts and the human condition

solipsism only has virtue because it's the last philisophical entry about something like theory of self on wikipedia lol, on a lighter note though, i think there will be a point in this universes cycle where we will see that we are all the same being

2

lol that thing about pythagoras you mentioned for beans reminds me of this

4:22 AM

https://existentialcomics.com/comic/189

The Pythagoreans

A philosophy webcomic about the inevitable anguish of living a brief life in an absurd world. Also Jokes

4:22 AM

>They supposedly believed a bunch of weird stuff, like the musical scales having mystic properties, and not being able to eat beans (with a wide variety of reasons given by different accounts, even stuff like that you would lose part of your soul when you farted).

.5+(5^.5)*.5=phi

UltimApe

yeah. The long term goal for me is hibernation, which involves clearing out the gut bacteria entirely to avoid that.

Been kinda distant lately because of the winter messing me up. But I come bearing a weird idea. Anyone wanna try to get gut bacteria in the small intestine to produce B12? If so, when paired with liver production of glutathione, we might be able to avoid the need to eat vitamin C https://www.are.na/block/10088029 by mirroring what I think bears are doing to up-regulate Vitamin C during hibernation. B12 problems are all over the map when it comes to mental & health issues. So this might be worth trying even if not aiming for vitamin C recycling. So far the only thing I have on my radar is a weird tradition among some people from India consuming cow urine. I'd rather not. Sharing this in a couple of my chats to see if any one has ideas. (edited)

Going without Vitamin C — Are.na

Are.na is a platform for connecting ideas and building knowledge.

I’ve been feeling weird too

5:31 PM

I got possibly eczema but I got paranoia about it

I get weird rashes sometims. I think it's a mast cell issue.

10:45 PM

Winter makes everything about my biology go wonky.

I liked winter

3

UltimApe

Been kinda distant lately because of the winter messing me up. But I come bearing a weird idea. Anyone wanna try to get gut bacteria in the small intestine to produce B12? If so, when paired with liver production of glutathione, we might be able to avoid the need to eat vitamin C https://www.are.na/block/10088029 by mirroring what I think bears are doing to up-regulate Vitamin C during hibernation. B12 problems are all over the map when it comes to mental & health issues. So this might be worth trying even if not aiming for vitamin C recycling. So far the only thing I have on my radar is a weird tradition among some people from India consuming cow urine. I'd rather not. Sharing this in a couple of my chats to see if any one has ideas. (edited)

Is the goal of trying to generate B12 without Vitamin C for an experimental reason or is there a health benefit to avoiding ingesting Vitamin C and letting the body convert the oxidizied form to Vitamin C, as you mentioned?

I mean an application would be if someone had a severe oxalate problem perhaps? Considering excess vit c is converted to oxalic acid

10:47 PM

I dont recall if that's for any form vit c or just ascorbic acid

Ascorbic acid wrecks me. Whole food vitamin C helps me manage seasonal sinusitis.

Im guessing you take like a whole 1/2 g pill of vitamin c and it tears up your stomach? Ive noticed when i try even have small bits of it under the tongue occasionally to spread out the dose it can really burn the tissue lul. Meanwhile whole foods are full of plant compounds that spread out the duration and increase how effective it is

Lavencia

Is the goal of trying to generate B12 without Vitamin C for an experimental reason or is there a health benefit to avoiding ingesting Vitamin C and letting the body convert the oxidizied form to Vitamin C, as you mentioned?

I'm actually thinking that there is something related to this process in the space of autism / ehler-danlos that is tied to mitochondrial function and want to explore it more directly. B12 being low in many neurodegenerative disorders that manifest with collagen problems and bone problems, as well as generalized fatigue has me interested in the space around glutathione (kideny function) & vitamin C.

Alex Swoleman

Ascorbic acid wrecks me. Whole food vitamin C helps me manage seasonal sinusitis.

Someone I was talking to seems to think that kind kind of vitamin C matters and so I need to learn more about this.

1

ph neutral vitamin c like calcium ascorbate maybe

5:47 PM

from what i hear from someone at least

UltimApe

I'm actually thinking that there is something related to this process in the space of autism / ehler-danlos that is tied to mitochondrial function and want to explore it more directly. B12 being low in many neurodegenerative disorders that manifest with collagen problems and bone problems, as well as generalized fatigue has me interested in the space around glutathione (kideny function) & vitamin C.

Are there any other co-occurring symptoms with your fatigue? Like disorganized thinking? musical hallucinations? physical anxiety symptoms?

Lavencia

Are there any other co-occurring symptoms with your fatigue? Like disorganized thinking? musical hallucinations? physical anxiety symptoms?

not consistantly correlated with the fatigue, but I do experience these aside from the musical hallucinations.

UltimApe

Someone I was talking to seems to think that kind kind of vitamin C matters and so I need to learn more about this.

Ascorbic acid is stripped of other naturally occurring co factors like copper

https://www.psypost.org/2021/01/heightened-anxiety-linked-to-an-impaired-ability-to-simulate-alternative-versions-of-past-events-59089?fbclid=IwAR2y8UYt--qcrK1th7ObuBnjzHhZGZZI0l38RS3ZP78CAqZWX_NcUU2DEOI

1

Amanita pantherina

Ooo let me know how that goes

1

https://midov.pl/_matrix/media/r0/download/matrix.org/KXtyaaozwZDavyrKjnnddHbe

@Deleted User noise. amanitamuscariashop.com I assume by the package?

10:40 AM

@qwerkyscience The neurotoxicity of Amanita scares me the most. Especially Pantherina. Paul Stamets says Pantherina should not be eaten. (edited)

Oh no

@ZPM115 https://pubmed.ncbi.nlm.nih.gov/31325463/

Effects of Amanita muscaria extract on different in vitro neurotoxi...

Muscimol is the main compound found in Amanita muscaria. Several studies have proven that muscimol has suppressive effects on essential tremor, without impairing speech and coordination. The effects of muscimol in Parkinson-affected patients is also described in a number of studies. These studies de …

1

ZPM115

@Deleted User noise. amanitamuscariashop.com I assume by the package?

amanita.lt (edited)

12:36 AM

@Deleted User That is not a pure Muscimol extract. Those are dry Amanita Pantherina mushrooms which contain high levels of Ibotenic Acid even when decarboxylated properly which is quite neurotoxic.

12:37 AM

Pantherina contains much higher levels of Ibotenic Acid than Muscaria does.

12:41 AM

Ibotenic Acid is decarboxylated into Muscimol which is awesome stuff. However even with Muscaria which has much lower levels it is basically impossible to decarb all of the Ibotenic Acid into Muscimol without lab equipment to create a true distillate.

ZPM115

@Deleted User That is not a pure Muscimol extract. Those are dry Amanita Pantherina mushrooms which contain high levels of Ibotenic Acid even when decarboxylated properly which is quite neurotoxic.

yeah but it also has equally higher levels of muscimol, its just more potent meaning you take less. Otherwise there is no evidence that the relevant levels of ibotenic acid are neurotoxic when orally ingested. (edited)

12:44 AM

Im getting 100g of muscaria for 30 euros btw. Gonna microdose

12:45 AM

what are the capsules? this looks crazy https://abload.de/img/psychotria-colorata5nkj9.jpg

Those are Psychotria Colorata aka Humo. A dissociative opioid used natively in South America. It contains Hodgkinsine an nmda antagonist and U-opioid agonist as well as Psychotidrine an nmda antagonist. I'm just making sure you know about Ibotenic Acid. You're almost certainly not going to cause any significant or noticeable damage if even any damage at all from taking it multiple times.

ZPM115

Those are Psychotria Colorata aka Humo. A dissociative opioid used natively in South America. It contains Hodgkinsine an nmda antagonist and U-opioid agonist as well as Psychotidrine an nmda antagonist. I'm just making sure you know about Ibotenic Acid. You're almost certainly not going to cause any significant or noticeable damage if even any damage at all from taking it multiple times.

Doubt it'd cause any damage taking it many times as well. What do you take it for?

Dissociative and opiate effects

12:54 AM

Hodgkinsine and Psychotidrine are alphamethyltryptamines bound together.

you use it recreationally? (edited)

I'm not sure what you're getting at?

I mean for fun or for practical purposes

12:55 AM

like what is the context of ingestion of this plant usually for you (edited)

I am what they call a reluctant psychonaut I suppose. Though I do enjoy them as well.

12:58 AM

Colorata is an extremely rare experience

Look up the Ambrosia society for amanita

@qwerkyscience https://twitter.com/ck_eternity_/status/1351567855863607297

CK Eternity (@ck_eternity_)

One of the hardest things to come to terms with when I started to realize I was malnourished was that just because my diet made me feel more spiritual, didn't mean it was healthy There are many nutrient deficiencies that inadvertently open you up to energy/emotion around you

Likes

174

5:01 PM

feel like most even well constructed vegan diets lead to a lightheadedness that may feel pleasurable but at the same time make you susceptible to say psychotic symptoms (edited)

5:01 PM

like when you talk about withdrawals from l theanine and such

5:03 PM

while I can take 2mg of clonazepam daily for two weeks and have close to no withdrawals besides mild sleep disturbance

5:05 PM

also things like cold tolerance and such

5:06 PM

many factors there, like low cholesterol being associated with psychiatric disorders, protein amounts etc (edited)

5:07 PM

like these trends are clearly there with people I know that are vegan vs animal based (edited)

5:08 PM

also whats interesting is that vegan diets are very prevalent in a certain category of spiritual people

5:09 PM

and I wouldn't say that its purely ideology based, as it does change the way they feel and everyone reports similar changes

5:11 PM

but when you go further in the 'spiritual path' (very loaded bullshit terms xd) people tend to shift towards meat

5:13 PM

generally spirituals with 'sensitive self' values are vegan

5:13 PM

(the map is a meme but works)

I think you shouldn’t immediately pin it to my diet but it could be a factor

5:27 PM

I cannot take clonazepam once without extreme anxiety. That happened to me before I tried veganism. It was when I was paleo even. Also phenibut was bad when I was paleo too. I couldn’t even drink half a beer without feeling like my anxiety is worse for weeks. Now, I will say this wasn’t really present when I first tried alcohol or phenibut. But after using phenibut more and using tianeptine a lot, now I seem to more quickly reach negative comedowns. (edited)

5:28 PM

Also the bulk of my most extreme schizo-like symptoms were before I was vegan. Mostly in middle school more than 14 years ago or something like that

5:29 PM

The sort of issues I face now days is frustration. I feel bothered by society, by the way status hierarchies work, by bullies, unfairness, abusive people and so on.

Deleted User

also whats interesting is that vegan diets are very prevalent in a certain category of spiritual people

Have you read what I’ve written today about this

5:32 PM

You may also wonder why there are alt right shamans. You shouldn’t conclude that psychedelics make everyone believe in alt right ideologies. The reality is that deviating from social conventions will tend to cluster together. Those who are willing to break social rules are, well, willing to break social rules. This could mean being outcast, it could mean being a sociopath, it means spooky ideas like flat earth, alt right, drug use, and any other form of rule breaking will cluster together because the precursor is the willingness to deviate from social norms

5:34 PM

And my diet doesn’t make me feel spiritual. My inclination towards this diet is because I don’t wish for animals to be harmed unnecessarily and also I wish to reduce the load on the environment.

5:35 PM

Maybe I’ll talk about all this in a podcast episode soon

vegetarianism for ethical reasons is cool.

10:47 PM

it seems like ldl/saturated fats could be decent for heart disease. at least the evidence seems a bit varied but id be open to seeing other reviews

10:47 PM

https://www.youtube.com/watch?v=sNz2gWqL0Ng&list=TLPQMTkwMTIwMjEh3k1ttct-WQ&index=4

Low Carb Down Under

Dr. Paul Mason - 'Are you smarter than a Doctor? What your doctor d...

Deleted User

what are the capsules? this looks crazy https://abload.de/img/psychotria-colorata5nkj9.jpg

source?

Athegnawthine

source?

reverse google image search it

qwerkyscience

The sort of issues I face now days is frustration. I feel bothered by society, by the way status hierarchies work, by bullies, unfairness, abusive people and so on.

You're not getting the status you think you should be?

2:03 PM

And what's your conclusion on tianeptine? I've been experimenting with it quite a bit and the second cycle was the best I've ever felt. Gives the cognitive flexibility similar to psilocybin but in a more controlled and functional way, making it easy to change patterns.

Deleted User

You're not getting the status you think you should be?

It is more complicated than that. I just got banned from r/Psychonaut. I think I’m recently bothered by this. Trying to think of how this person who banned me is thinking. Also there’s many other frustrating events that happened but it’s not entirely status related. It just stuff that makes the world seem like it’s deeply broken

Deleted User

And what's your conclusion on tianeptine? I've been experimenting with it quite a bit and the second cycle was the best I've ever felt. Gives the cognitive flexibility similar to psilocybin but in a more controlled and functional way, making it easy to change patterns.

Tianeptine was useful but it gets sketchy at some point. I don’t use it anymore. You can experience pretty intense withdrawals from it but sometimes that doesn’t happen the first times using it.

qwerkyscience

It is more complicated than that. I just got banned from r/Psychonaut. I think I’m recently bothered by this. Trying to think of how this person who banned me is thinking. Also there’s many other frustrating events that happened but it’s not entirely status related. It just stuff that makes the world seem like it’s deeply broken

What did you post before getting banned?

qwerkyscience

It is more complicated than that. I just got banned from r/Psychonaut. I think I’m recently bothered by this. Trying to think of how this person who banned me is thinking. Also there’s many other frustrating events that happened but it’s not entirely status related. It just stuff that makes the world seem like it’s deeply broken

It is more like I am angered by observing people use their status so irrationally. I was talking to a scientist who’s not seen my writing before and I think he dismisses my points and doesn’t give me room to speak on why his theory is incomplete. I feel he is just operating on weird delusions.

Otherwise yes, people have different value systems and different levels of maturity. While you're engaged in one game they perceive you through the prism of their value system projecting their game onto you, which you're not consciously playing. Thus the surprise when you get punished according to rules of their game. (edited)

1

Deleted User

What did you post before getting banned?

I hadn’t posted in over a week. But it was a post with only 2 upvotes about evolution of death and psychedelics

3:18 PM

It is frustrating that I’m basically living in a world operated by gatekeepers and it feels as if many of these gatekeepers aren’t truly experts on the sort of things they are gate keeping.

3:18 PM

But I don’t wish to express this frustration too much. It is not really a constant issue

3:19 PM

Sometimes I feel like knowledge is a hopeless goal too. It seems like answers to various curiosities are in an unreachable realm.

I mean bureaucratic institutions, yeah

The frustrating part is sometimes I got 400-700 upvotes in psychonaut

3:29 PM

I can’t even tell the people who read it that I’m gone forever lol

1

3:30 PM

And since I post in such a sporadic way, sometimes a month or more in between, people won’t be surprised if a month passes. Then probably people will forget

The issue of status isn’t just that I want to have it. It is that I feel too many people are focused on making judgments based on perceived status. I dislike the idea that people mostly believe people based on authority and not through some kind of understanding. I don’t think there’s a way out of that currently though.

yeah dude i hate reddit

2:05 AM

started using it like a decade ago

2:05 AM

i've seen how the people who sort by new will gatekeep what garbage vs what stuff filters to the top

2:07 AM

ive seen legit experts in a specific field who have genuine cutting edge stuff get dismissed by mid-smaller sized community because it goes against their bias

2:07 AM

pretty easy for people to have a cult of a subreddit without realizing how much stuff gets removed and curated by moderators

2:10 AM

the 'cutting edge' stuff i think of is kind of funny because it has a beautiful amount of simplicity and genius behind their framework, with some evidence, and people will just downvote and dismiss it because it makes them uncomfortable and that there 'isnt enough competitive' evidence for it yet

2:11 AM

even people who are pretty darn knowledgeable about the topic are dismissive of it, and i think a large reason for it is because the simplicity and effectiveness of these guys' other framework is enough to make their jobs a lot harder, and beginners would be able to learn in ways more independently of their instruction, so they sort of intentionally dismiss it out of realization...

1

The internet as a whole has gone to shit over the past 20 years. At some point there's not going to be a place for freedom of expression. It'll be a huge echo chamber or immediate ban.

3:31 AM

Traffic is overly concentrated among a few top sites, allowing for control at top levels.

web 3.0 should be pretty censorship resistant

3:53 AM

im excited for it

3:54 AM

it would take more work in some ways. setting your own filters and algorithms etc. Having more control would be kinda nice in some ways and who knows maybe it would make people more responsible over who they allow to control their flow of information. I see a rise in stronger tightly knit communities that still have room for anonymity

as im typing the sounds of the keyboard are forming into the beat of the song i heard earlier

9:39 AM

whats web 3.0 about? i heard of new socila media that is decentralized open source and you can hose your own shards or server instanes of it so there is no top down authoritarian control

it's just about decentralization yea and in turn accessible APIs

9:55 AM

i havent really kept up with websites or anything in specific because i assume it'll change a good bit in the coming years anyways, plus i plan on working on some myself

9:57 AM

but in some sense it could be as simple as a blog post that has specific and extra tags sent out that people can subscribe to easier and not be dependent on any one hosting provider

9:59 AM

the aspect im more interested in is just the modularity of it, and maybe being able to create convenient ways to filter and aggregate lots of the internet into a more navigable space. finely tuned.

@qwerkyscience @Deleted User Tianeptine sulfate is the only viable one imo. And a lot of the Tianeptine out there has specific impurities that are known to cause problems.

ZPM115

@qwerkyscience @Deleted User Tianeptine sulfate is the only viable one imo. And a lot of the Tianeptine out there has specific impurities that are known to cause problems.

I used sodium, why?

And a lot of the Tianeptine out there has specific impurities that are known to cause problems.

source?

https://www.bocsci.com/tianeptine-and-impurities-list-1873.html

6:03 PM

Tianeptine sodium is crap. It only lasts like 3 hours at most and is not as euphoric.

6:03 PM

Sulfate will last all day long which means it very likely has less addiction potential and it has been shown to cause long lasting antidepressant effects similar to mdma with only one or a few doses. Although I have only used the Sulfate and Free Acid versions myself. (edited)

6:04 PM

@Deleted User

ZPM115

Tianeptine sodium is crap. It only lasts like 3 hours at most and is not as euphoric.

idk it worked pretty well, didnt feel the sulfate version at all

Doses for an opiate effect from the Sulfate version are like minimum 100mg up to like 500 or more milligrams.

7:09 PM

But if you have a low opioid tolerance this can be much lower.

ZPM115

Doses for an opiate effect from the Sulfate version are like minimum 100mg up to like 500 or more milligrams.

and how much for sodium

7:11 PM

I felt 10mg

I have never tried Sodium. I have heard that many places sell low quality Tianeptine though.

https://www.marketwatch.com/press-release/the-next-leg-in-the-bull-market-for-psychedelic-stocks-2020-12-21

The Next Leg in the Bull Market for Psychedelic Stocks

ATLANTA, Dec 21, 2020 (GLOBE NEWSWIRE via COMTEX) -- ATLANTA, Dec. 21, 2020 (GLOBE NEWSWIRE) -- Santa Claus came early this year as shares in psychedelic...

9:21 AM

https://en.wikipedia.org/wiki/18-Methoxycoronaridine

18-Methoxycoronaridine

18-Methoxycoronaridine (18-MC) is a derivative of ibogaine invented in 1996 by the research team around the pharmacologist Stanley D. Glick from the Albany Medical College and the chemist Martin E. Kuehne from the University of Vermont. In animal studies it has proved to be effective at reducing self-administration of morphine, cocaine, methamph...

9:21 AM

In animal studies it has proved to be effective at reducing self-administration of morphine, cocaine, methamphetamine, nicotine and sucrose.[

ZPM115

Tianeptine sodium is crap. It only lasts like 3 hours at most and is not as euphoric.

I preferred this one. I felt the withdrawals were much crazier with the long lasting forms sometimes

qwerkyscience

I preferred this one. I felt the withdrawals were much crazier with the long lasting forms sometimes

How much were you taking and what were the withdrawals like?

100mg a day or so of sodium. I don’t know how much for the other forms. Probably a similar range or slightly more.

6:11 PM

Withdrawals induce pain, depression, emotionality, colorful perception, and panic

@qwerkyscience @Deleted User Interesting. From my experience and from what I have read/ heard from the online drugs community is that Sulfate is the best form of Tianeptine; with Sodium being second & Free Acid being third (though by far the cheapest) of the commonly found forms of Tianeptine.

9:36 PM

Though for some reason I personally find opioids to be only slightly addictive if at all.

9:39 PM

However I have had rather bad Xanax addictions a few times which took greatly extreme mental & physical strength to break on my own. So I am not talking nonsense when I say that I do find opioids to really even be mildly addictive; including opioids like Oxy/Hydrocodone, Tramadol, & Codeine. (edited)

Opioid addiction is more about dosing to get rid of physical withdrawal symptoms that last from few days to months. (edited)

1

9:47 PM

Very unpleasant physiological state after a certain point. (edited)

Oxycodone & Hydrocodone as well as some Codeine were my main drugs for a whole semester of College about 2 - 3.5 years ago. (edited)

9:52 PM

I purchased a bulk amount from a very reputable prescription pill dealer.

9:58 PM

A minimal week of that semester would be taking around 15 - 25mg of Hydrocodone three or four days of the week roughly at the least.

Coming closer to the end of that semester I ran out of Oxycodone & began to run low on Hydrocodone (saving enough of both for very infrequent occasions each year for many..); nearing semester's end I was using up the last bit of Codeine. Around finishing semester with a much smaller purchase of Codeine alongwith a bite of Hydrocodone too which finished off my trial of opioids with from what I recall no noticeable cravings/ addiction; without any sort of intentional tapering. (edited)

Hey guys, I'm currently looking for work. I'm a Senior Full Stack Software Engineer, with Biomedical Engineering (hons. AI) training, and am studying a Doctor of Law in Intellectual Property. Let me know if you know of anything that could help. (edited)

1

@qwerkyscience Dude, I love your blog!

I think that antipsychotics are the worst drugs for one's physical health there are. Couple of day ago I got driven over by a truck called Zyprexa aka. Olanzapine. It felt exactly what one would expect after taking a look it's binding affinities. I took relatively low dose of 5mg and I can only imagine what the full dose would feel like :/

8:19 PM

It blocks everything

1

Not to mention it's horrible for weight gain and things like diabetes. After experimenting with all kinds of drugs, and medications I ultimately think that we've largely got psychiatry wrong in most cases thinking people should take something every single day to feel better without looking at the long-term effects. A lot of these medications are addictive and have rebound therefore making it really hard to imagine coming off of. I think they should all be utilized as powerful tools with a strong case-management system for identifying triggers and relapses in problems. So, when I see that you're considering IV ketamine I think that is much more of a viable treatment option and something to keep up with.

Studied mice, who were exposed to a wider number of different opportunistic bacteria, were somewhat more adept at deciding whether to allow possible pathogens to cross the BBB. Some were held in captivity in a close-to-sterile environment and were not incubated / bathed in the vaginal secretions of their mother just after birth, so their microbiome (in nose, mouth, other mucosa and stomach/offal) comprised of fewer opportunistic (often gram-negative bacilliform) bacteria. Banks, A. W: The blood-brain barrier as a regulatory interface in the gut-brain axes (Behavioural Physiology, 2006).

@ZPM115 I'm curious (hopefully this isn't considered sourcing, because it's legal), where'd you get Psychotria Colorata? Also, could you share more about that experience?

I just woke up from Olanzapine coma and I got an uncontrollable urge to eat. Eating urges come from H1 inverse agonism and 5-ht2c inverse agonism. Olanzapine is one of those drugs of doom but I feel like I must take it, because otherwise I feel like I'm about to implode. The problem is that I feel shitty and I know very well what recreational drugs would instantly cure that. But, I also know that brain's negative feedback loops would upregulate causing drug addiction and even shittier feelings. I feel so crippled and weak. No action I take makes any difference, there is only negative reinforcement. I can only avoid things that I know are harmful. Back to Olanzapine, It has no significant alpha adnergic affinity, hence one of the best anti psychotic. I get significant dysphoria from risperidone, quetiapine, levomephromazine, and perphenazine. They are potent alpha 1 antagonists. Alpha 1 antagonists expand blood vessels in nose, causing inability breath through nose. It is the most horrible feeling ever forced to be a mouthbreather.

Sorry to hear, I have felt pretty horrible/had no energy/worsened cognition when taking risperdone--and quetiapine made me not able to breathe. Maybe I am repeating something already known but have you thought about mimicking the effects of clozapine? https://slatestarcodex.com/2017/07/27/why-is-clozapine-so-great/ by taking NMDA agonists. "If this really was the source of clozapine’s special powers, it would be a really important big breakthrough. All through residency, I kept hearing “nobody really knows why clozapine is so great” or “it probably has something to do with its weak D2 binding affinity or something”. If we knew it was just because clozapine was an antipsychotic plus glycine, we could just give people an antipsychotic plus glycine, and avoid the agranulocytosis, metabolic syndrome, seizures, myocarditis, eosinophilia, etc. This theory isn’t ready for prime time yet; it’s still not really proven that the NMDA agonists work for schizophrenia at all. And it probably never will be – it’s hard to patent these chemicals, meaning that it would take extreme creativity to jump the bureaucratic hurdles necessary to get them into the pharmacopoeia. Until that happens, using these chemicals will remain experimental, and replacing clozapine with them downright irresponsible. Still, it’ll be hard to watch treatment-refractory schizophrenia patients get their agranulocytosis, metabolic syndrome, seizures, myocarditis, eosinophilia, etc without wondering whether another way is possible." (edited)

Scott Alexander

Why Is Clozapine So Great?

[Epistemic status: Very speculative; I don’t fully understand a lot of the studies involved] Clozapine is an antipsychotic drug sometimes used to treat schizophrenia. Like most antipsychotics…

2:18 AM

EPS = extrapyramidal side-effects; sedaatio = sedation/fatigue; hypotensions = abnormally low blood-pressure; prolaktiini = abnormally high plasma levels of prolactin & subsequent gynacomastia; painonnousu = increase in weight; diabetes = risk of developing type 2 diabetes; rasva-arvot = blood lipid levels; antikolinergiset haitat = anticholinergic complications/side-effects such as dry mouth

Lavencia

Sorry to hear, I have felt pretty horrible/had no energy/worsened cognition when taking risperdone--and quetiapine made me not able to breathe. Maybe I am repeating something already known but have you thought about mimicking the effects of clozapine? https://slatestarcodex.com/2017/07/27/why-is-clozapine-so-great/ by taking NMDA agonists. "If this really was the source of clozapine’s special powers, it would be a really important big breakthrough. All through residency, I kept hearing “nobody really knows why clozapine is so great” or “it probably has something to do with its weak D2 binding affinity or something”. If we knew it was just because clozapine was an antipsychotic plus glycine, we could just give people an antipsychotic plus glycine, and avoid the agranulocytosis, metabolic syndrome, seizures, myocarditis, eosinophilia, etc. This theory isn’t ready for prime time yet; it’s still not really proven that the NMDA agonists work for schizophrenia at all. And it probably never will be – it’s hard to patent these chemicals, meaning that it would take extreme creativity to jump the bureaucratic hurdles necessary to get them into the pharmacopoeia. Until that happens, using these chemicals will remain experimental, and replacing clozapine with them downright irresponsible. Still, it’ll be hard to watch treatment-refractory schizophrenia patients get their agranulocytosis, metabolic syndrome, seizures, myocarditis, eosinophilia, etc without wondering whether another way is possible." (edited)

The thing is, I don't have schizophrenia. In finland antipsychotics are used off label for everything, including anxiety. Qwerky science blog explains how dynorphin can unite all theories of schizophrenia. Dynorphin is nmdar antagonist and that's why nmda activation helps with schizophrenia.

Wait, so you're taking olanzapine for anxiety?

niquil

Wait, so you're taking olanzapine for anxiety?

Yeah it's prescribed for that but I am not going to take it anymore because of the horrible side effects.

oh dear god, yes. Stop it now.

3:22 AM

3:22 AM

Can't you take like gabapentin?

3:23 AM

And maybe propranolol? That stuff has like no side effects.

I used to take pregabalin but I had to stop taking it because of bad rebound anxiety.

I could give you some horrible advice and tell you to try phenibut. But someone is going to argue with me. Heh.

3:25 AM

Uhm... pregabalin is wonderful too, but it does have the rebound. It's gotta stay rather constant. Like if you were to do it again you really need to be careful with it. Gabapentin seems to have less of this action, I switch between all of the meds I'm mentioning.

Phenibut is a big Not Available here in Finland :/

Social or general anxiety? Anxiety attacks?

Not actually anxiety nor depression, just dysphoria and inability get pleasure. Just horrible feeling most of the time.

Anhedonia. Hrm. Did you say you're doing recreational or illicit stuff too? opiates/benzos? (edited)

Just dxm but had to stop that because I cannot tolerate anti abuse incredients anymore. There is only one dxm syrup available here.

Sounds like you need a ketamine infusion

do they have those there?

3:34 AM

Also, if clozapine isn't viable there's memantine which I won't dare take because it gave me aphasia for like a week. But there's options. It sucks they ruined your dxm, be careful. I hate it when I see brilliant people get caught up this stuff like my best friend who was going towards his Ph.D. in neuroscience @ UCI and ended up dying from inhalents because he had to stop drinking.

Yes, I'm pushing doctors for that. Dxm is orders of magnitude better anti depressant than any official treatment.

So, you were regularly taking DXM like daily? What did it do for you? Just make things ... less intense, like more disassociated where you could just focus on what you wanted to and dull the things you didn't?

I took it once per week. It allowed me to hallucinate, relax, be happy, get interested in new stuff, enjoy novelty. It calmed my thought storms and it allowed me to reach meditative states.

3:43 AM

If the official psychiatric system can't or doesn't want to help me, then fuck them. I'll start my psychonaut carreer and to live with my own rules.

Deleted User

Yes, I'm pushing doctors for that. Dxm is orders of magnitude better anti depressant than any official treatment.

So your issue is anxiety? I would try to get some Etifoxine from CosmicNootropic or RUPharma. They should ship to Finland.

Deleted User

The thing is, I don't have schizophrenia. In finland antipsychotics are used off label for everything, including anxiety. Qwerky science blog explains how dynorphin can unite all theories of schizophrenia. Dynorphin is nmdar antagonist and that's why nmda activation helps with schizophrenia.

Although there might be things we label as schizophrenia that have different mechanisms fwiw. I argue that dynorphin helps to explain many links to schizo

qwerkyscience

Although there might be things we label as schizophrenia that have different mechanisms fwiw. I argue that dynorphin helps to explain many links to schizo

I'm pretty sure my anhedonia, depersonalization and dysphoria are caused by dynorphin. Dynorphin neatly unites everything.

Deleted User

I'm pretty sure my anhedonia, depersonalization and dysphoria are caused by dynorphin. Dynorphin neatly unites everything.

What are you gonna do?

le_drig

What are you gonna do?

Nothing. I'll accept my fate and I'll swallow all the bullshit life brings.

Yeah but if dynorphin is the problem, can't you do something against it?

le_drig

Yeah but if dynorphin is the problem, can't you do something against it?

Without breaking any laws, my hands are tied. (edited)

What about Kratom?

6:28 PM

It's a recommendation as of last result because it can be addictive, but its typically legal and manageable. Just you will not have a fun time discontinuing it. If it is illegal, stay the hell away from it. But like I can order a kilo of it for ~$100 in the States.

6:31 PM

There's also tianepetine which I wouldn't dare try because I know I would end up in a fate worse than death, but if it were prescribed and taken as prescribed would be ideal. Anything above prescribed and you're in something well beyond hell. That's the problem with drugs, even pharmaceutical ones, they all have limits and aren't carefully followed and respected as the deadly things they are will ruin your life. My hat's off to you if you can do it without all of them which besides buprenorphine is what I do now. I tend to do a lot of meditation, try to eat and drink healthier, exercise... All of the stuff your typical health class would tell you to do but I refused to do for a long time. Or if I wanted to be more practical, buproprion (wellbutrin) is a decent one to give a shot. Just that olanzapine was totally wrong in your case IMO. (edited)

Thanks for input. My pursuit for legal iv ketamine is advancing. I know the risks of self medication and that is reserved only for situations if nothing dr prescribed helps.

Ahh, god damn I love DMT. off-topic

niquil

Ahh, god damn I love DMT. off-topic

I would love to try psychedelics. Atypical antipsychotics are 5-ht2a antagonists or inverse agonists and they are not helping, they are making things worse, so trying opposite action would be very interesting.

I got really emotional over something that happened tonight, and I thought my DMT pipe was empty long ago and quickly ended up in hyperspace with some new knowledge that pulled me out of it.

@niquil as for legal opioids there's also Akuamma seed powder which has stronger visual effects and physical effects onpar with Kratom. Black Caraway feels like a light dose of Codeine or Tianeptine.

11:03 AM

They sell both on amazon.com

...visual effects? what?

You don't get closed eye visuals/ hypnogogic imagery from opioids?

No...

11:04 AM

Not that I've ever noticed. I see more on seroquel.

Some people only gets visual effects from psychedelic hallucinogens. I get them from many things from dissociative hallucinogens to most stronger stimulants as well as opioids. Not necessarily very strong visual effects though.

The closest I've seen to that is on a low dose of hydrocodone or codeine. And it's minimal. Kinda reminds me of spacing out like nutmeg.

11:06 AM

Which would be of a hypnogogic type of hallucination.

How much hydro? Like I'd expect to get visuals around 20 - 30mg+

20, yup

11:07 AM

Like back when I first started, before I ever touched oxy or heroin.

11:07 AM

I've never heard of those two you mentioned that are on amazon and I'm usually up to date on this stuff or so I thought.

11:09 AM

I'm looking at the alkaloids for Akuamma and noticed one is a mu agonist, Pericine.

11:10 AM

That would be fun to extract and test, there's such little information on it.

I know of even rarer opioids.

11:13 AM

I have Psychotria Colorata which is a dissociative and an opioid used natively in South America known as Humo.

11:13 AM

I'm currently writing the second ever report of it online

11:14 AM

That is one pretty plant too

Probably the second or third rarest drug in my collection

11:17 AM

Do you think I should take Memantine or DXM now?

I have no desire to ever touch Memantine ever again. Go for the DXM.

Why do you not like Memantine?

Elisabetsky, E., Amador, T. A., Albuquerque, R. R., Nunes, D. S., & Carvalho, A. do C. T. (1995). Analgesic activity of Psychotria colorata (Willd. ex R. & S.) Muell. Arg. alkaloids. Journal of Ethnopharmacology, 48(2), 77–83. doi:10.1016/0378-8741(95)01287-n covers how well you can make an extract from that too, results look nice.

11:19 AM

It gives me such bad aphasia I cannot speak for over a week from one dose.

11:19 AM

I stutter so bad that it's not even worth trying to talk.

Damn. It's not something you want to really be taking on SSRI's and other meds.

Zip, no other meds.

11:20 AM

It's a rare <5% side-effect

Sorry to hear that. I enjoy Memantine very much.

Must be genetic too, my dad says he has something similar happen.

11:21 AM

It's okay, I get rx'd ketamine 100mg x 30

11:21 AM

Capsules too.

dayum

Wow, you can't buy Psychotria colorata anywhere can you?

11:23 AM

except pinterest it looks like lol

I'm probably one of the very few people in North America who has Colorata.

(which leads to etsy, which leads to nowhere)

11:25 AM

https://botanicfarms.net/products/psychotria-colorata-leaves

Dried Psychotria Colorata Leaf

Alkaloids obtained from colorata leaf and flowers of this species showed a marked dose-dependent naloxone-reversible analgesic activity, therefore suggesting an opioid-like pharmacological profile. it is one of the best pain killers, it has the ability to combat chronic pains to make you feel cool and good relaxation. Psychotria Viridis: Effects...

11:25 AM

best I can find, but that looks ugly.

11:27 AM

"To further understand the mechanism of analgesic activity and structural requirements of pyrrolidinoindoline alkaloids identified in Psychotria colorata, we here report the analgesic activity of the trimer hodgkinsine on thermal and chemical models of analgesia. Results show that hodgkinsine produces a dose-dependent naloxone reversible analgesic effect in thermal models of nociception, suggesting that activation of opioid receptors participates in hodgkinsine's mode of action. Hodgkinsine shows a potent dose-dependent analgesic activity against capsaicin-induced pain, indicating the participation of NMDA receptors in hodgkinsine-induced analgesia. Such a dual mechanism of action may be of interest for developing innovative analgesics." Interesting.

I bet it's much better than Kratom

Yeah.

Hrm. Maybe in a month or two I'll have to give it a go.

11:29 AM

I've been wanting to try something different from Kratom sometime. Plus I may want to drop the buprenorphine.

What's the dosage like and the duration?

11:30 AM

I'm assuming that's pure leaf crushed up

6 - 8 hours

11:31 AM

0.75 grams - 5 grams I have tried

Sedative or stimulating?

Only a single report of it online at 1 gram. Was very close to my experience.

11:31 AM

It's an opioid and an nmda antagonist/ dissociative

11:31 AM

So sedative

Sounds like something I would totally pick up.

The alkaloids are alphamethyltryptamines bound together

mu and not kappa too, right?

Yeah

Yeah, that's like my ideal kratom.

11:33 AM

Now don't tell anyone else :p needs to stay this channel's secret forever.

It's in the same family of Psychotria plants as Psychotria Viridis which is traditionally the dmt plant in Ayawaska.

11:34 AM

It contains chimonanthine too which is broken down into micro dose or light dose amounts of alphamethyltryptamines

11:34 AM

Hodgkinsine and Psychotidrine are the primary alkaloids though

I've wanted to try ayahuasca but I'm worried it's absolutely nothing like the 6+ hour version of DMT I wish it would be.

11:35 AM

I've considered taking an maoi with dmt but I believe that's exactly what makes ayahausca what it is,

If you took a Peak dose of Ayawaska you'd be in internal hallucination tryptamine land for a few hours.

The 3x15 minutes of very low-dose DMT I had earlier tonight was just a teaser. (edited)

Rick Strassman is mapping the dmt realm with intravenous dmt in the UK.

11:40 AM

At the London College if I can remember properly

So I've heard. That sounds nuts.

11:41 AM

DMT is just so strong and so unique that it's hard to conceive of it as only a hallucination.

11:41 AM

Like I truly want to believe there is an ecosystem of beings in my brain that it somehow opens the pathway to communicate with.

Not really though. LSD is far more potent than DMT by weight. With smoked DMT the duration is very short so it's much easier to take an extreme dose.

11:42 AM

If you took 1mg of lsd...

Okay, potency sure. But strong as in the quality of the hallucination rather than by weight.

11:43 AM

Although, that can be debated too.

11:43 AM

It is definitely unique thouhg.

It's the prototypical tryptamine for sure

11:44 AM

Entities are the strongest on tryptamines

I've done a few tryptamines and never had anything like this but I don't doubt a lot of the TiHKALesque ones would touch on it.

11:44 AM

Like, it's amazing how different 5-MeO-DMT is. (edited)

Peak Unity and Interconnectedness versus Peak Internal Hallucinations.

1

I wonder if there's a certain point we can see under fMRI they're interacting differently. There's a theory that a lot of these things can be triggered with TCMS, like that guy trying to recreate NDE's with one.

Did you watch Hamilton's Pharmacopeia this week?

12:02 PM

The bonding of lsd to the 5HT2A receptor has been fully elucidated.

12:03 PM

Which means we know what makes 5HT2A receptor antagonists non active versus psychedelic.

12:04 PM

So we can prepare for a wave of thousands of new 100% legal psychedelics.

Godspeed

oh wow

https://www.vice.com/en/article/93wmxv/can-a-company-patent-the-basic-components-of-psychedelic-therapy?fbclid=IwAR1K-p8QR37GFyqLY4A89n6wnmLeUFPsMO-wj2TUMtwSyg2AHxZEuy6F01k

Can a Company Patent the Basic Components of Psychedelic Therapy?

Compass Pathways, a Peter Thiel-backed psychedelic mental health company, has made patent application claims on aspects of psilocybin-assisted therapy as basic as using soft furniture and holding hands.

https://youtu.be/ilZ_-bSWvsc

What I've Learned

Why the ridiculous Red Light wellness trend just might work

https://youtu.be/5I33GJh6ZBQ

Attar

Retard Day Traders III | The Downfall of Diamond Hands

https://youtu.be/MPiQ8c_qTz8

The Energy Blueprint

4 Amazing Health Benefits Of Spirulina by Alex Leaf, M S

https://isochroma.wordpress.com/2009/06/13/rape-of-children/

isochroma

Rape of Children

people just want to be happy but i am here to tell them that they aren’t going to be happy i am here to tell them that the world’s gonna be a shithole real soon they will be homeless, j…

https://youtu.be/-O8YutN_VbU

Boost Your Biology

Have You Tried These To Upgrade Your Sleep? (Biohacking Sleep)

https://youtu.be/OaNXiEUrpIc

RUN-DMC

The Role of MCAS in Long Covid | With World Leading Specialist Dr L...

https://twitter.com/basicmorality/status/1363923692426645507?s=21

qwerky science (@BasicMorality)

Your existence is anecdotal. I’m agnostic about whether you are real.

1

9:26 PM

A new poll plz answer

https://youtu.be/dEYlGEvqb-0

slmrcs

psychiatric intake with depressed, bi-polar, schizophrenic with Opp...

https://www.jackdonmclovin.com/Hello/specifics/45/

2

https://www.theatlantic.com/magazine/archive/2017/06/when-your-child-is-a-psychopath/524502/

When Your Child Is a Psychopath

The condition has long been considered untreatable. Experts can spot it in a child as young as 3 or 4. But a new clinical approach offers hope.

1

https://youtu.be/thJzw5Go14Q

High Intensity Health

Blood Sugar Wrecked if You Don’t Move

Seeing you write on substack got me curious about the platform: https://jackdonmclovin.substack.com/p/unwritten-works

Unwritten Works

And written works, if that's what you're into

2

@UltimApe dm

https://youtu.be/BJwsT3jg9G4

Chris Masterjohn, PhD

How to feel great on a poor night’s sleep?

https://www.psypost.org/2021/03/new-research-provides-evidence-that-a-single-dose-of-psilocybin-can-boost-brain-connections-60095?fbclid=IwAR1nNUG1Pla9LN-tBlk6dhhfbigrmOVbNGXyCNLn_CajKf7YR7uJEfpsO5g

New research provides evidence that a single dose of psilocybin can...

Scientists in Denmark believe the psychedelic substance psilocybin might produce rapid and lasting antidepressant effects in part because it enhances ...

ZPM115

@UltimApe dm

huh?

http://cepuk.org/unrecognised-facts/myth-of-the-chemical-imbalance/

Myth of the chemical imbalance -

I took 2mg haloperidol. Let's see if it helps with nervousness.

You should try out Fluorophenibut sometime @Deleted User

@ZPM115 Do you take it?

꧅ ꧅ ꧅ ꧅ does anyone else see the blue / red opitcal ollision on the columns?

Maybe slightly warmer on the right half? @insectodescenso

1:31 AM

Yeah very faintly

1:31 AM

Possibly making myself see it tho

Mainly on PC not mobile

1:55 AM

I dont see it very well on phone because the unicode id bit different

1:55 AM

@slipperysalamander love your avatar

1

https://www.bloomberg.com/news/articles/2021-03-23/microsoft-said-to-be-in-talks-to-buy-discord-for-more-than-10b

Microsoft in Talks to Buy Discord for More Than $10 Billion

Microsoft Corp. is in talks to acquire Discord Inc., a video-game chat community, for more than $10 billion, according to people familiar with the matter.

1

https://youtu.be/y9vQ-bebJwA

AsapSCIENCE

Why Penises Are Shrinking Across the World

1

https://www.youtube.com/watch?v=nEnklxGAmak

Stanford

24. Schizophrenia

1

seen it

3:37 AM

it's about taking things too literally. Which I just thought was called having a sense of humor

https://en.wikipedia.org/wiki/Jerusalem_syndrome psychonauts should travel to Jerusalem

Jerusalem syndrome

Jerusalem syndrome is a group of mental phenomena involving the presence of religiously-themed obsessive ideas, delusions, or other psychosis-like experiences that are triggered by a visit to the city of Jerusalem. It is not endemic to one single religion or denomination but has affected Jews, Christians, and Muslims of many different background...

https://youtu.be/ihByfIEDLXQ

Hans Amato

Problems with the carnivore diet (calcium, potassium and more)

1

Just took ~60mg of HA-966 if anyone wants to ask some questions about it later.

Im currently on 1000mg acetaminophen and amoxicillian825mg clavolunate125mg with 2 ear infections, and tonsillitis infection

Oh no. Why do u have infections? Or is it just something that happened? Did you ever have Covid before?

if i had corona virus it was never tested for or confirmed but i dont know why im getting infection but this is the first time taking antibiotics and having an issue like this

10:21 PM

vitals are good no worry

7:46 AM

bweakfest

@zorpborp is that raw ground beef?

yummy

i think im gonna do like , maybe 2 lbs a day cuz im starting to enjoy it lately more

https://www.vice.com/en/article/akggdz/people-eat-raw-meat-high

11:59 PM

been doing this since december and have noticed benefits

the grossest part about that is them fermenting it in plastic

2:20 AM

instead of like a glass jar or ceramic

2:26 AM

lol

2:26 AM

nice image from there

2:26 AM

seems like a pretty hot ferment

2:26 AM

fats taste pretty bad too fermented

2:27 AM

https://www.youtube.com/watch?v=prwCMLg49yY

Geoff B

Aajonus Vonderplanitz on Ripley's Believe It Or Not in 2002

https://youtu.be/w7vbTc-X6Xc

Hans Amato

For high testosterone, eat these foods! (the absolute foundation fo...

maybe ergot related kind of thing in rotten meat

its da jenkem

3:33 PM

gettin him litty! yuh

this pixel art is giving me optical illusions

I need a hug

2

went first therapy session today, was good

3

7:23 PM

my homework is to try and iteratively improve maintaining eye contact, get some external reminder to help form a routine among other things

7:24 PM

The eye contact one is soooo difficult

7:24 PM

Like, once upon a time, I had no issue

7:24 PM

then a couple months of isolation back in 2015-16

7:24 PM

and bam, I suddenly can't

7:25 PM

I feel like when I maintain eye-contact for more than 2 seconds, I'm mentally violating the other person. It just feels so.... rude (edited)

@lov same here it used to be physically painful for me to look ppl in the eyes now i dont really do it idk prolly good to get in the habit of it

11:08 PM

some people say its a sign of disrespect to not look them in the eyes

My rehab counselor thought it was due to inferiority complex

psychiatrists told me it was due to autism

Yea that's what I told myself

https://youtu.be/YjldfvsDSxU

Hans Amato

Perfect health trilogy for reducing stress, lowering cortisol and i...

https://www.reddit.com/r/Pikabu/comments/naitcu/%D0%BF%D1%80%D0%B8%D0%B2%D0%B5%D1%82_%D1%81_%D0%BA%D0%B8%D1%80%D0%BF%D0%B8%D1%87%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B2%D0%BE%D0%B4%D0%B0/

r/Pikabu - Привет с кирпичного завода

163 votes and 34 comments so far on Reddit

https://youtube.com/watch?v=ocQ6PDiP014 (edited)

Uxküll

Berserk Opening HD

zorpborp

https://youtube.com/watch?v=ocQ6PDiP014 (edited)

Hey its my channel

1

5:50 PM

#ThankYouMiura

I guess thats the problem with starting an insurmountably tough and aesthetic story where victory seems hopeless. May he rest in peace

Agreed

5:13 AM

Also sleep deprivation induced thought disorder and dementia qualities

5:14 AM

We stayed awake for 48 hours while driving 24 hours consecutively (edited)

zorpborp

I guess thats the problem with starting an insurmountably tough and aesthetic story where victory seems hopeless. May he rest in peace

yh idk, in Japan you have mandatory annual health checkups so I'm surprised his cardiac issues werent diagnosed and treated. Really sad,

the deer fly may use some neurotoxin like deliriant or dissociative when it bites human for blood because i got bit by a blood sucking fly once and it had subtle after affects shifting my conciousness for a few hours (edited)

5:30 AM

https://www.youtube.com/watch?v=i7VMcMJBjD4 11:20 watch a man inject himself with mandaratoxin giant hornet sting and record the reaction

Brave Wilderness

STUNG by a GIANT HORNET!

I got bit by a fire ant and I had an effect also. I got sleepy and napped suddenly

https://youtu.be/va_3mcTeb1E

Hans Amato

Exercise, stress metabolism, and low testosterone

https://nootropicsdepot.com/summer-sale-2021/

https://youtu.be/q-3GmgWO03k

Michael Lustgarten, Ph.D.

Are There Foods That Can Increase NAD? (Part II)

Yea I can ban em as they come, but they still keep coming so idrk what to do, banned like 40 today

3 months free nitro: https://www.epicgames.com/store/en-US/p/discord--discord-nitro

Discord Nitro for Free - Epic Games Store

Download and play Discord Nitro for FREE at the Epic Games Store. Check for platform availability and play today!

1

The high priest of carnivore has admitted defeat.

7:56 PM

1

um

7:15 PM

I wonder how bad pregabalin + tramadol overuse over the course of 2021 is?

7:15 PM

so, here's my thoughts

7:15 PM

pregabalin prevents excitatory synapses from forming while active (edited)

7:16 PM

and k-opioid activity of tramadol synergizes to wreck havoc

7:16 PM

but the counter to this is

7:18 PM

tramadol activity is too low a dose, where the pro-plastic activity of the serotonin reuptake overshadows the k-opioid activity still (depends on individual metabolism i guess) (edited)

7:19 PM

and the blockage of excitatory synapses only really hurts learning and re-learning some aspects of memories that were activated

7:19 PM

so, all in all, not too bad I reckon

7:21 PM

I guess the only way to know the extent is to measure some phenotype

7:21 PM

and do a before and after

7:22 PM

~~then capture some children to run the placebo half of the experiment (with both or just one of each placebo)~~ (edited)

This brand was already not great but now it will likely get worse: https://www.reddit.com/r/Supplements/comments/nzty08/nestlé_expands_in_vitamins_with_575_billion/

r/Supplements - Nestlé Expands in Vitamins With $5.75 Billion Natur...

44 votes and 21 comments so far on Reddit

New video: https://www.youtube.com/watch?v=48lEscOZVuI

Flat Earth SubGenius Society

Flat Earth SubGenius Red Pill Talk w/ Alison Wonderland Live on the...

Deleted User

Im getting 100g of muscaria for 30 euros btw. Gonna microdose

How such good deal? Said 40 for 30g

Atheengnawklimb/banfoetime

How such good deal? Said 40 for 30g

got a secret source

https://youtu.be/QQsPQQzSYqU

PsychedSubstance

KRATOM LEAD ME TO INJECT... | Vital Educational Content

𝖀𝖝𝖐𝖚𝖊𝖑𝖑

https://youtu.be/QQsPQQzSYqU

I don't have any doubts. He's going to really enjoy TRT though lol

https://www.youtube.com/watch?v=XIYk3FVepjQ

Collectif AlienCorp

Avalmatek - Mushrooms From Space (Acid Tekno)

1

https://play.google.com/store/apps/details?id=com.buildloop.drugbiblefree

Drug Bible Free: A Complete Drug Guide (RX & OTC) - Apps on Google ...

Consumer, Clinical, and Research Information on 100,000+ drugs

https://youtu.be/6vE8zvXwIN4

Boost Your Biology

Reversing Cannabis/Marijuana Brain Damage: How To Protect The Brain...

𝖀𝖝𝖐𝖚𝖊𝖑𝖑

https://youtu.be/6vE8zvXwIN4

I decided to subscribe to this guy actually

1

He is in the server!

1

Adam

I decided to subscribe to this guy actually

Me too he is actually one of the best YouTubers in that field I've seen so far

https://podcasts.apple.com/au/podcast/boost-your-biology-with-lucas-aoun/id1520485498#episodeGuid=d5a71c78-1d88-4cb2-81d6-7437d9ee64d4

‎Boost Your Biology with Lucas Aoun on Apple Podcasts

‎Health & Fitness · 2021

6:27 PM

Here is the time we did a collaboration. I meant to cross post it on our podcast here too but didn’t do this yet.

1

6:28 PM

I plan to have him as a guest at some point too.

https://abc7news.com/covid-long-hauler-symptoms-term-side-effects-of/10897908/

EXCLUSIVE: Lab discovers root cause of confusion, fatigue experienc...

A Bay Area virologist appears to have discovered the root cause of COVID-19 long haulers -- symptoms that include fatigue and confusion that can last for months -- leading to better treatment and an end to suffering

@Deleted User pm

https://www.youtube.com/watch?v=a9QqF9tgL0M

Analyze & Optimize

Honey: More Than Just Sugar

https://nkalex.medium.com/long-covid-dysfunction-not-damage-theory-and-treatment-concepts-853ae4e22f1a

Long Covid: Dysfunction, Not Damage — Theory and Treatment Concepts

While Long Covid brings about a lot of bad news, the good news is that there is not a single type of organic damage found across all Long…

1

try cold shower while doing shamanic throat singing chants

Confirmed that this works, super easy and free to try right now: https://www.youtube.com/watch?v=1FNpyDxZA3I

VigorousSteve

Icing Your Balls | Optimizing Testosterone | Novel Ergogenics | Pod...

Palms are sweaty hands spagehtti anxiety already 3 espresso beans is one too many!!

1

LOL

What's you guys' thoughts on Terrence McKenna? I'd been familiar with him for a little under a decade now but never really took him on because I just chalked it up to woo stuff. I've been listening to recorded talks and conversations of him to sleep for a month thus far. (I usually listen to random podcasts or lectures to fall asleep to) I realized something, I love this guy. I don't care about his justifications for his experiences that breeds the ideas whatsoever. What I love is the willingness to throw out some out-there ideas and perspectives, it's quite entertaining I'd found. I always loved those sorts of, faux explanations to theories people had. Added an atmosphere of mystery and wonder to it. I might be even considering his ideas sincerely, I think part of me want to take a chance and just say screw articulate empirical logic. He's articulate, he isn't very empirical, but he is logical a lot of the times for his out there premises. But not always logical from what I'd heard, but no one ever is. I like ballsy theorists. Makes for entertaining thought experiments and consumption on my part. (edited)

@lov I think he is legendary but many of the things he said were incorrect or even potentially dangerous.

9:31 PM

For example he did not consider phenethylamines to be psychedelic...

I like Terrance McKenna as well. I was worried he was insane at first but I think he’s not too crazy. He’s very poetic. Some stuff is possibly just wrong. I think he is pretty good tho

10:10 PM

I’ve used one of his speeches at the end of one of my podcasts about schizophrenia. About how they are basically outcast people

He really kinda went insane tho with his timewave 'theory'

Did you also see Rupert sheldrake lol

@qwerkyscience

I think it’s true that it goes both ways

7:01 AM

Not sure about viruses as warfare. Have you read any of my evolution posts? @Deleted User

qwerkyscience

Not sure about viruses as warfare. Have you read any of my evolution posts? @Deleted User

No, am quite busy but what was the consensus?

qwerkyscience

Not sure about viruses as warfare. Have you read any of my evolution posts? @Deleted User

Btw operation seaspray

Deleted User

No, am quite busy but what was the consensus?

What if the propensity to unleash pandemics upon other overly ‘monocropped’ species has evolved like the way flammability has evolved? It has been said recently that humans pushing onto nature is a contributing factor for the ongoing pandemic. Perhaps when species like bats harbor various dangerous contagious pathogens it may help to maintain ecosystems from total collapse by annihilating some of the species that has become too prevalent. This could be a kind of anti-homogenization mechanism for ecosystems, much like the role of fires. Such systems like this would certainly outlive a system without such mechanics. By hosting contagions, an organism can weed out invasive species that are colonizing the ecosystem. In the case of the ongoing pandemic, it has been argued that human farming and land use has increased the risks of exposure to pandemic contagions like we face today. This idea isn’t new, as it has been argued that the loss of biodiversity should give rise to zoonotic diseases even 6 years earlier (Morand et al 2014). It could be that zoonotic illness leads to increased biodiversity and helps check overpopulating species that further induce a loss of biodiversity. In this case, ecosystems that have zoonotic illnesses may outlive ecosystems without such illnesses. As one redditer put it: in the same way the body produces antibodies to fight off infections, the ecosystems produce viruses to fight off overgrowths of species that become too prevalent. Could a Gaia immune system have evolved?

1

Deleted User

Btw operation seaspray

Sorry, I read your original statement to mean that viruses evolved to control human behavior as a means of competing or going to war with other viruses. Idk why lol

1:39 PM

@Deleted User The above is the part about the evolution of pandemics as a means for increased biodiversity.

I'm gonna make like every human before me when a disaster is present and say this whole human problem will solve itself

I wrote this somewhere else but I was sort of sleepy when I did. Was curious about any thoughts on it

Look in front of you. In those separate objects, you see features. The edges of one object contrasting the next object. Distance, shadows, colour, edges etc. You can maybe feel the texture of one object in your view. Another separation from those previous features. It may also make a sound upon striking it. Yet another feature. Now, imagine your entire perspective was a blocked by a huge flat red that surrounded your entire field of view. No shadows or depth either. There are no discernable objects within the red. That's what reality is, there are no boundaries between any feature, there isn't even change. It's all the same thing. Not connected, because to separate isn't even something possible outside your hallucination. No single entity is permanent, but it is all permanent if that even makes sense. The unreal is impermanent, your experience is impermanent because it is unreal. In the real, the "sound" is no different from the "shadow" to the "smell". The "feature" is empty, has no essence. That is what is there.

1

6:34 AM

The thing is, I don't actually think of things like "reality", rather it's more just another existence. We are what we are, it isn't untrue, just a variation. Sometimes I wonder if there really is only these 2. (edited)

6:36 AM

Thinking about all this too deeply may lead one to solipsism, so better to tread lightly.

1

@lov what are the problems with considering solipsism? Also do you mean solipsism as skepticism or as a belief that everyone/everything else is not real? We cannot conclude that we are the only thing real. We can be agnostic though. And I very much am agnostic in this sense

I think a deep belief and preoccupation with the idea might eventually lead people to some distasteful behaviour

yeah it's definitely in the rulebook for mental illness (schizo) to believe in solipsism (edited)

11:14 PM

equivalent to paranoia

11:14 PM

paranoid that nobody else exists. but seeing is believing so gfys

Some psychs seem to clear our conditioned recognition of things cleanly while others seem to put them into overdrive until it breaks

6:36 AM

I don't know how people enjoy the latter, it's so disorienting and reminiscent of ptsd flashbacks almost, just more immersed in the present (edited)

6:38 AM

The ego seems to be of the same nature as entities almost, but co-opted by our culture

6:39 AM

While "we're" more like our cells, we don't actively make them multiply etc, same idea. We just happen, the illusion of something in control might be created by our culture.

6:40 AM

But... maybe this ego actually provides us with something approximating control. May or may not be for our betterment individually, I think it might be in service of the hive mind of the information age.

6:42 AM

I shouldn't anthropomorphise it and assign motivations, it just does things, and it may benefitting one "body" more than the rest in the entirety of its interactions. (edited)

6:46 AM

There's the "empty dynamic" and the "self-sustaining structures" at play here, abstractly speaking.

6:47 AM

The latter manifests "meaning" in the former.

6:48 AM

I think all these entities are manifestations of "minds" imbedded in extremely compressed forms in our genetic code and our culture is the environment that allows the ones that are here, like egos, to emerge.

6:49 AM

And psychedelics allows us to tap into ones that could emerge instead or together with egos in differing environments.

6:51 AM

Those entities must've been beneficial to humanity at some points in our evolution, getting stored genetically in very concrete, rigid forms. (edited)

6:52 AM

https://www.cell.com/current-biology/pdf/S0960-9822(08)01051-8.pdf

1

6:54 AM

I'm just bored and playing with ideas btw, unsure if I even believe any of this. Well, my belief in ideas is of no concern, ideas are fun to explore in themselves.

6:55 AM

https://docdro.id/bGzwzV3

Developmental genetics and psychopathology Some new feathers.pdf

Development and Psychopathology 24 (2012), 1165-1177 © Cambridge University Press 2012 doi: 10.1017/S0954579412000624. Developmental genetics and psychopathology: Some new feathers for a fine old hat. WENDY JOHNSON University of Edinburgh and University of Minnesota-Twin Cities. Abstract Without ...

6:55 AM

@qwerkyscience These 2 papers will be of interest (unless I've already rec'ed them lol)

lov

Some psychs seem to clear our conditioned recognition of things cleanly while others seem to put them into overdrive until it breaks

I think this might basically depend on where our attention goes. Attending to usual things might lead to observing amplification and hyper focus on those recognized things. You can also pay attention to reality without automatically recognizing things. It’s almost like breaking the addiction to the ways we usually process reality. Here’s from a post about attention and mechanisms of psychedelics: In recent posts, I’ve posited that (serotonergic) psychedelics may work by deconditioning our attention, freeing us so that we can attend to things in abnormal ways, including memories, perceptions, and the way we filter our reality based on prior experiences. The way we perceive reality may depend heavily on conditioned use of attention to memories, external stimuli, and beliefs about reality. The psychedelic drugs might disrupt recall of conditioned responses which allows these radically different ways of perceiving the world. This can be very useful to show people the ways that they have been dissociated and also show us that we can perceive reality in numerous alternative ways just by paying attention to the details of reality differently. Our ordinary perception of the world is like a connect-the-dots game in which we learned which dots to pay attention to and specific ways of connecting the dots. Psychedelics essentially allow us to pay attention to dots without our usual priority, allowing new ways of building a reality perception to emerge. https://mad.science.blog/2021/09/16/attention-as-the-mechanism-of-dissociation/

theschizotypal

Attention as the Mechanism of Dissociation

We often view dissociation as a sort of state in which we lose connection to things we are usually aware of. Dissociation could be defined as subtraction of subjective experience (or potentially al…

3:32 PM

If you look at this post, consider the section about dissociative drugs and how immersion plays into their mechanisms. I think psychedelics similarly allow immersion into aspects of reality in novel ways. Like you can dissociate from the ego by paying attention to sensory perception in an immensely immersive way.

lov

I shouldn't anthropomorphise it and assign motivations, it just does things, and it may benefitting one "body" more than the rest in the entirety of its interactions. (edited)

Be careful about anthropomorphizing humans

lov

Those entities must've been beneficial to humanity at some points in our evolution, getting stored genetically in very concrete, rigid forms. (edited)

I suspect there could be many consciousnesses inside of our brain. Split brain might reveal that. I think some part of our brain speaks and we assume this part is us. I think it’s possible there are other separate consciousnesses. Maybe there are also nonconscious aspects too.

qwerkyscience

Be careful about anthropomorphizing humans

To use a metaphor, I was viewing the ego as a puppet to a greater system with very specific and intense effect on it. So anthropomorphizing it would be wrong since its intent is being controlled by something distinctly non-human. But upon reflection, it's probably a bidirectional relationship, where it affects the system as well, influencing its relationship to it in very human ways, so anthropomorphising it would not be an issue. But all this is just me trying to reason out a sort of internal simulation of how it would work, I can't say anything too much about the real. (edited)

qwerkyscience

I suspect there could be many consciousnesses inside of our brain. Split brain might reveal that. I think some part of our brain speaks and we assume this part is us. I think it’s possible there are other separate consciousnesses. Maybe there are also nonconscious aspects too.

Same, I think the one we actually are might be positioned within the brainstem, while others are part of the more recent parts of our brain.

I have a theory of what a "reward" is to a human. It's some form of being closer to breaking down subjective boundaries (in the more abstract sense) Now this part of the theory is a little out there, it's on the level of the subjective, the biological co-opted the direction of entropy on that level to self-sustain on the biological level. (edited)

11:03 PM

One way to short circuit this is via extremely intense pain in a helpless state where the subject accepts and allows the pain.

11:03 PM

One of the most intense forms of boundary dissolution manifests this way imo

11:04 PM

Because during almost torturous pain, and knowing how to let go from psychedelic use, I experienced one more intense than smoked 5-meo-dmt could provide (not to say that this isn't extremely intense)

11:07 PM

Although... while maintaining a separate existence once on 5-meo, I was able to articulate what I was experiencing to myself, witnessing everything, which took on the shape of a concaved cylinder I think (edited)

11:10 PM

Actually, during both experiences I was able to be massive existences, 5-meo focused more on earthly existences while during the pain, it was more on galactic sizes, and comets etc

11:10 PM

There was no "will" to impose change

11:11 PM

simply being it as it did its thing as it was supposed to

11:11 PM

I'm going off on a tangent

11:12 PM

Reward = subjective boundary dissolution, different boundaries depending on the context

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Among my random theorizing, I actually feel a little confident in this being true

11:25 PM

not the entropy part, just the reward being that

lov

One way to short circuit this is via extremely intense pain in a helpless state where the subject accepts and allows the pain.

https://en.wikipedia.org/wiki/Limit-experience

Limit-experience

A limit-experience (French: expérience limite) is a type of action or experience which approaches the edge of living in terms of its intensity and its seeming impossibility. This approach has led to the seeking of limit experiences as a sort of dark mysticism. A limit experience breaks the subject from itself. The idea is associated with writ...

1

Are there any sources of analysis related to the cases of drug induced synaesthesia in the form of sound to vision?

8:42 PM

And I'm thinking specifically, language to non-symbolic visual representations

8:43 PM

I've been thinking of trying my hand at recreating something similar, although it being non-symbolic isn't really possible imo, but something approximating it can... sort of

8:44 PM

The visual representations were never just simulations of what the language encoded, it was... well if you've experienced it, you should get the gist

What is the cognitive foundations of semantics?

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On a separate note

9:26 AM

I wonder if schizophrenia is like, the stressed mind with a diminished "self" to centre it. Think of it like a sleep deprived adhd person.

Yes

9:38 AM

I’m writing a paper called stress induced hallucinogenesis

9:44 AM

I just woke up in the middle of the night so I can’t say much more lol

speaking of sleep deprived!!!

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10:58 AM

lol

Doing fasting/keto/ calorie restriction. Feeling pretty "based". Very stimulated but in a way that is not manic or euphoric. I gotta loose lots of weight and fasting/keto is the easiest route.

I'm in a problematic situation, I don't want any/much catabolism of fat or muscle, but also want a more active lifestyle whilst doing calorie restriction

4:40 PM

I can't win here

I’m doing high carb and exercise sometimes

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https://repository.arizona.edu/bitstream/handle/10150/641705/azu_etd_17781_sip1_m.pdf?sequence=1

5:20 PM

at page 121 talks about intermittent fasting for increasing opioid analgesic efficacy, ofc there are other pros

5:20 PM

the rest of the thesis is interesting as well

I got methylphenidate prescription. Now I feel like normal and all anti social thoughts are gone. @qwerkyscience

The best effect is that I feel like I'm part of the society again.

Deleted User

I got methylphenidate prescription. Now I feel like normal and all anti social thoughts are gone. @qwerkyscience

That’s interesting. I wonder if it would also help me.

qwerkyscience

That’s interesting. I wonder if it would also help me.

I feel like Methylphenidate has lifted my dopamine back to normal but it doesn't go above the roof of maximum effect. I feel very normal and adult. I don't get any mania, euphoria or other "fun" stuff. It's a very good substance to make people behave like real civilized adults. It has some drawbacks but I'll explain them later.

@qwerkyscience The side effects are easy, increased hearth rate and drier mouth. But the drawbacks are reduced creativity, narrower focus and decreased thoughts. You have to force new ideas by talking alout to yourself and then you can come up with new goals. You really need to have a to do list or list of tasks in your mind becuse without goals you'll get stuck to stupid things. It might be impossible for the brain to be super productive and spontaniously creative at the same time thingering

what are people's recommended devices for administering flicker 40-60 hz?

Deleted User

I got methylphenidate prescription. Now I feel like normal and all anti social thoughts are gone. @qwerkyscience

It helped me so much for the first year I was on it, then I got off it for 6 months and when I started using it again it had a bunch of new horrible side effects like being constantly agitated (frustrated over nothing) and made my sleep issues even worse. Didn’t really have any side effects at first.

Deleted User

It helped me so much for the first year I was on it, then I got off it for 6 months and when I started using it again it had a bunch of new horrible side effects like being constantly agitated (frustrated over nothing) and made my sleep issues even worse. Didn’t really have any side effects at first.

I'll try to use MPH as a sling shot towards better life. I hope healthier body helps with anhedonia.

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12:45 AM

Had a very strange nightmare last night that reminded me of this

12:48 AM

Felt like the front of my face was caved in from the pressure of witnessing a white hole or something and I felt the immense and intense pressure of the void flooding in and holding my mind down and empty, like only the tiniest light of an observer remaining, like witnessing a type of dramatization of an ego death. It was sort of an ego death as I felt my thoughts, my mind, my being desecrated and hallowed out. It was really intense and in some ways agony, but also something about giving and being held down also felt really good in a sex kinda way lol. (edited)

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12:49 AM

There was some demon tortmenting me in my old highschool bedroom, they kept sending me into further bouts of insanity each time I tried to find someone to sit through the nightmare with me. I remember sitting there with a friend looking down at my pitiful state, worried for me, me not knowing if I could trust they were real. I had a nightmare I went crazy!!!! (edited)

12:53 AM

I think the reason I dreampt it was because I have an exam today and I’m really stressed, so I woke up in the middle of the night and responded to a friends message on discord which involved some discussion of managing ego. Then I went immediately to sleep and had some crazy af dreams. There was a lot more to the dream, like how the situation of my mind imploding on itself even came to be (something about accidentally uniting these ancient Christian artifacts and being abducted by someone in search of them), as well as I had a bunch of other delusions like the house full of people screaming and yelling it was not the greatest dream. Glad it happened tho, very interesting!!!! The demon I’ve seen in a dream before, they’re the one pulling the strings behind all the bad whenever things keep going wrong. Remind me of a Skyrim daedra how they play with the mortals. (edited)

https://en.wikipedia.org/wiki/Exploding_head_syndrome

Exploding head syndrome

Exploding head syndrome (EHS) is an abnormal sensory perception during sleep in which a person experiences unreal noises that are loud and of short duration when falling asleep or waking up. The noise may be frightening, typically occurs only occasionally, and is not a serious health concern. People may also experience a flash of light. Pain is ...

1:02 AM

Reminds me of how I imagined exploding head syndrome (although reading this article now, it looks like their heads don’t literally explode the way mine did, not implode more accurately) (edited)

1:03 AM

I felt like I was on the childhood perception of what drugs were, crazy delusions and stuff, not a drug I’ve ever been on but it was wierd af

1:05 AM

1:06 AM

Imma decide to try binding them to this drawing I made a while back, associate them with the symbol for manipulation purposes or whatever

1:07 AM

since Ive seen this tormenter behind the curtain before in dreams, like a re-occurring dream but only a motif from it

... last time I saw them (the same demon), it was in another dream from a few months ago, they'd put me in a lord of the flies type situation with some imaginary kids who they'd drove mad and let destroy each other ... I think Id come across some youth utopia in the woods behind the neighborhood after having moved to a new house, some pools in the middle of nowhere full of kids hidden away from the adult world, but then they'd found something just a little deeper into those woods .. ... I think that dream ended with a scorched wasteland, giant lovecraftian monsters roaming the valley, lighting across the sky, the ground being turned into mountainous piles of runestones (and I had to search through them like Sisyphus for the right one to end the chaos and save this alien ice girl Id done things earlier in the pool with), and the kids gone mad turned against eachother and armed with alien weapons and artifacts - the demon only confronted us as the perpetrator of the chaos and I'd had to negotiate with them to return things to normal .. which they did, while few were left, the land was as if nothing had happened .. though there was a shed full of artifacts we had to agree never to touch (which most of the kids must have went and grabbed from as soon as we left since I went back to check later and they were all gone except a paper dragon which I took to help me cook at the family restaurant which would've been the next part of the dream if I hadnt woke up lol) (edited)

1:14 AM

Sorry to spam chat aaaaaa

Deleted User

Felt like the front of my face was caved in from the pressure of witnessing a white hole or something and I felt the immense and intense pressure of the void flooding in and holding my mind down and empty, like only the tiniest light of an observer remaining, like witnessing a type of dramatization of an ego death. It was sort of an ego death as I felt my thoughts, my mind, my being desecrated and hallowed out. It was really intense and in some ways agony, but also something about giving and being held down also felt really good in a sex kinda way lol. (edited)

It reminds me of little nightmares 2

2:05 AM

My dream from last night: There was a chase scene involving tunnels and a giant worm. One part of the tunnel had other people and a car. At some earlier point I think Mario and Luigi were here. They became generic people later. Another part of the tunnel led into a mall. Or at least staircases based on malls. There were glass panels coming up between every few stairs, as if the stairs were closed off. We had to jump over these. At some point we lost the worm in the part of the tunnel with the car. Previously, I had run this worm chase many times and didn’t realize we could lose the worm this way. Some nude girl was with us. She threw pots onto the stairs to draw the attention of the worm. The music from Little Nightmares 2 would play when the worm got closer. The dream felt physically exhausting. Before this worm chase, there was some television show that had comedians. On this show, a giant dog monster burst through the walls. Even before this part, I remember a forestry field area that seemed connected with buildings. The song that played was the part starting at 2 mins https://open.spotify.com/track/6irSpAUxidGr63f9M0dI4o?si=GiS0wkA5SYSUjnWWoCPmqQ (edited)

@Deleted User @qwerkyscience Asenapine has so far been the best substance for inducing nightmares for me. The feeling of head exploding and small black holes tearing me apart is quaranteed with Asenapine. 2.5mg is the best dose for this purpose, anything higher blocks too much dopamine. 5hta2 and 5ht2c antagonism seem to contribute to higher dream intensity. 5-ht6 and D3 antagonism disinhibits acetylcholine, which is required for dreaming. Quetiapine blocks mAchr1,3,5 and it reduces dreaming providing deeper sleep.

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Deleted User

Click to see attachment 🖼️

That was spooky as shit

anyone ever get a sleep study done?

Yes

Deleted User

anyone ever get a sleep study done?

I have

12:51 AM

I've done a couple tests in lab and have done a couple at-home tests too.

testing123

I have

oh cool, did you find it useful at all?

Deleted User

oh cool, did you find it useful at all?

Yes, I ended up being diagnosed with idiopathic hypersomnia and sleep apnea

1:18 AM

Treating the sleep apnea with PAP therapy has helped me need less sleep, though I still need an afternoon nap to feel my best, but I don't feel as terrible and tired all the time

testing123

Yes, I ended up being diagnosed with idiopathic hypersomnia and sleep apnea

oh i see, that's good to hear the PAP has helped

1:20 AM

i struggle with hypersomnia as well

1:20 AM

need usually about 12 hours to feel rested

Getting a study can maybe show what's up, and if it ends up not showing anything, it is still helpful for getting prescribed different stimulants if they can be helpful

1:22 AM

Do you get 12 hours in one long chunk? Or do you have a lot of awakenings? I had a lot of awakenings, especially in the morning, and I think it must have been me being disturbed by breathing issues, especially during REM in the second half of sleep

sometimes i can get 12 hours in one stretch yeah,

4:42 AM

will post my results once i get them

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does anyone know how to find the mapping between where the brightness slider is and what the nit value is on an ipad pro?

I'm really interested now about nuclear weapons and why INF treaty was so important, along with START treaties

11:53 PM

I get these "interesting" moments sometimes

It's so fun to go down the research rabbithole. I'm reading about international nuclear treaties and nuclear tests. Why? I dunno, but it intersts me now.

You are making me feel I should try concerta again

@qwerkyscience Concerta = concentration

But you need to be interested into stuff already and then the drug just provides fuel for that activity. One of my friend lacks enthusiasm for new stuff that he hasn't done already so Methylphenidate does't help that much. Lisdexamphetamine(Vyvanse, Elvanse) works better for him but even that isn't quite enough. Perhaps good old D-amph would help him but that was made unavailable as soon as the more expensive, patented Lisdexamph got its lisence.

https://youtu.be/QUjYy4Ksy1E

HealthyGamerGG

Why Gifted Kids Are Actually Special Needs

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++

1:31 AM

i've seen this for a while.

How has everyone been recently?

Stress, happy, sad, mad all of the things

12:55 AM

How about you

qwerkyscience

Stress, happy, sad, mad all of the things

so many emotions

1:17 AM

I am okie

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https://images-ext-1.discordapp.net/external/VgT5k3Qkc7Xiucjg2i5Ih_3CBu65X5KLaX7-8yuzqQA/https/media.discordapp.net/attachments/614194132751220736/918831673725038613/unknown.png

4:53 PM

Any thoughts on the phenomena of knowing when to “hang up the the phone” as Alan Watts called it?

4:56 PM

Why is it that all my trips seem to go poorly nowadays, whereas when I was 18 I could do 5 tabs and pretend to be sober in front of my mom???? Is it simply the increase of stress in my life -I don’t even know if I can tell it’s that much more stressful the times I tried tripping (in the summer when I had no responsibilities)

4:57 PM

I mean, shulgin was able to trip way into his old age, so it doesn’t seem like there should be a natural limit (atleast not for everyone)

5:00 PM

But I find the last 6-7 times I’ve tripped I find I keep repeating ‘I’ll never take LSD’ over and over again. Very little visuals as well, but that could just be because I’ve gone for mostly lower dose trips since they’ve gotten spook

Deleted User

Why is it that all my trips seem to go poorly nowadays, whereas when I was 18 I could do 5 tabs and pretend to be sober in front of my mom???? Is it simply the increase of stress in my life -I don’t even know if I can tell it’s that much more stressful the times I tried tripping (in the summer when I had no responsibilities)

What if we develop a diff relationship with the drug too? Like novelty must fade somewhat. Maybe we develop fears associated to the drug too

8:56 PM

Also tolerance and other factors

8:56 PM

Novelty might boost the positive emotion of the experience too

8:56 PM

It’s like “omg wow this is so mind blowing!!!”

hot take: psychedelics trigger memory consolidation, removing access to priors

11:02 PM

and depending on the dose, has after effects of having your past timeline become more salient

11:02 PM

making you feel more complete

11:04 PM

but fades over time due to internal mechanisms that inhibit useless memories to your person's success, something evolutionarily preferred by our ancestor's environments

11:07 PM

I suspect it's making episodic memory more salient at the expense of semantic memory

11:07 PM

perhaps there's an internal contradiction between the 2 and a certain balance is coded as baseline

lov

hot take: psychedelics trigger memory consolidation, removing access to priors

I like it! Have you read my Phoenix effect post? It is about the hypothesis that psychedelics induce something similar to the childhood critical periods

qwerkyscience

I like it! Have you read my Phoenix effect post? It is about the hypothesis that psychedelics induce something similar to the childhood critical periods

yep, it's even something that I can remember as well, the experience back then and psychedelic effects now

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I just revisited your remeron post

1:27 AM

and it reminds me of 2 things wrt its effect on waking experience, my experience with quetiapine and agomelatine

1:28 AM

although, quetiapine effects may have been something specific to me for a period of time, because ever since, it never creates those feelings again, it's quite uncomfortable now

1:28 AM

Agomelatine is extremely fascinating for its waking effects, I was in love with it

1:29 AM

But maybe that also was time specific because I never got my hands on it since

1:30 AM

Agomelatine's waking effects is what I thought psychedelics would be like before I tried them. Was wayy off the mark.

1:30 AM

Agomelatine's waking effects were closer to codeine's waking effects (no tolerance) than anything. I don't mean like an opioid, specifically my experience with codeine.

1:33 AM

I'd be fascinated to combo agomelatine and gaboxadol

lov

Agomelatine's waking effects is what I thought psychedelics would be like before I tried them. Was wayy off the mark.

Tell me more

It feels like you're dreaming. I'd argue that my dreaming mind and waking mind are quite different. And it'd activate that version of me, and that subjective feeling I get when looking at things in a dream emerge. irl, most things are ignored in my home, my eyes just move over them without my attention. During a psychedelic trip, these things look like it's the first time I'm seeing everything. On agomelatine, it feels like neither, it feels like the subjective feeling of a dream. My "dream mind" is similar to my mind on codeine when out in public, and on agomelatine, it's like that. Although, much more lucid. Depends if it makes me sleepy or not. If I use it closer to a bedtime I have been sticking to previously, it'll make it less lucid and more like the former "minds".

I havent read your latest article, but its title reminds me of these videos: https://youtu.be/eSbaqqDfGxU https://www.youtube.com/watch?v=wTSMGPW5owY

Weltgeist

SCHOPENHAUER: Being Alone (How to Deal With Society)

Skeptical Waves

Why Nerds are Unpopular - Paul Graham

12:23 AM

(id watch the second on 2x speed or 1.5 atleast)

12:26 AM

As a kid Id stay up at night unable to sleep, unable to turn my brain off, thinking about problems like "would I trade a second of unimaginable pain for a lifetime of equivalent pleasure?" .... idk, kinda irrelevant, but it reminds me of that

On the sociopathy post, I think intentional covert sadism is something endogenous to everyone from a certain perspective. More, it seems like a lack of capacity for empathy wrt the other's position. I mean for "obviously" absurd hysteria and reactions to the most benign things, and us thinking they are overly sensitive and have thin skin. People crying over religious tales, and getting offended by attacks on their legitimacy directed at them. Even things like scientology perhaps. Anything really. All our lack of empathy for their positions where they truly believe in them, so it makes you wonder, what is justified and what is not? Either way, the other person is still hurt. Sometime, the covert sadism might be part of this https://www.degruyter.com/view/journals/lpp/4/2/article-p241.xml?tab_body=abstract (edited)

No Aggression, Only Teasing: The Pragmatics of Teasing and Banter

No Aggression, Only Teasing: The Pragmatics of Teasing and Banter A bone of contention among researchers is whether the primary function of humour is the expression of aggression against the hearer or the promotion of solidarity between the interlocutors. It is commonly averred that teasing boasts a dichotomous nature, i.e. malignant and benevol...

10:17 PM

Just a funny take, take some ghb and you might be capable to feel empathy towards even the most absurd sensitivities.

10:18 PM

Consider, if I were to reciprocate the aggression by trying to trigger both of these individuals in an equivalently emotionally arousing way, I would likely seem like an asshole to the group, particularly if I trigger them by using commonly held triggers that are ubiquitous among the others in the chat. This is because the others in the group will empathize and relate to being triggered in those ways and not empathize or relate to being triggered via exposure to subtler reminders of animal harm.

10:19 PM

there's a way to do it so that you don't come off as an asshole a lot of the time ime, but it requires us to laugh off their comment and then phrase your attack in a way that it's delivered to the person in question wrapped up in a way that the surrounding people likely don't catch on to its true harshness except for the recipient.

10:20 PM

I prefer the self-isolating until finding the right group of people where you can be emotionally honest with.

10:26 PM

Their behaviours may be culturally sanctioned, but always remember,

“Homo sum, humani nihil a me alienum puto. I am human, and think nothing human alien to me.”

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10:27 PM

In the grand scheme, we're all so, so similar, just societally asymmetrically arranged.

10:33 PM

Man, I see so many people who don't identify as sadistic often display such sentiments or enjoy cheering on such things being carried out.

10:39 PM

It's also unfortunate personally that I have had perpetual sadistic instincts, also innocent playful teasing which I try to use as the main outlet as an adult occasionally. But it was never someone getting justified punishment, but rather a thrill in making someone feel pain, among other emotions. I felt bad about it and tried to repress it because I felt bad when it turned out making them feel worse than I expected. There's a spectrum and mine has a cut-off where I feel instinctively that it's an allowable amount of pain to inflict that'll lack long term negative consequences. Sometimes it was done because I wanted to expose them to it in a controlled environment and desensitize them to it in the wild. But I'd let them in on it after the fact. There's constant sadistic things I wish to tell people just to see if I can hurt them, but I hold it back all the time. Yet, I know it still slips out in impulsive moments occasionally.

10:42 PM

And... it seems pain is one of the few things I've noticed that reliably gives me sexual arousal. Not even if it's inflicted by me, just pain irl. Not in videos though. I like lover-dovey videos. I wish it was the reverse :

lov

Man, I see so many people who don't identify as sadistic often display such sentiments or enjoy cheering on such things being carried out.

I don't even understand why I see people doing it out of curiosity and fun, not as bad as I see those doing it as social punishment. They're those types who think themselves righteous in that regard ignoring their euphoria based attraction to those things.

10:48 PM

I also liked to make my close friends giving me shit for my veganism watch https://vimeo.com/209647801 to fuck with them and their emotions.

10:51 PM

oh, trigger warning for this video above I guess (edited)

10:51 PM

It features animal abuse

10:53 PM

I used to be incapable of seeing any animal abuse at first, it was alarmingly triggering. Then on dmaa, I laughed at some things in that documentary. Swear it's a psychopathy inducing drug. Anyway, nowadays, I don't like the abuse, but I can watch those videos and images without much/any emotions emerging.

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10:54 PM

It's crazy how much horrible things one can get desensitized to.

lov

It's crazy how much horrible things one can get desensitized to.

the more we face up to it the quicker we evolve

lov

Man, I see so many people who don't identify as sadistic often display such sentiments or enjoy cheering on such things being carried out.

Yess very much! I think what I’m describing is somewhat universal but the Reddit polarization is likely due to bringing up veganism and also using sensitive terms like sadism and sociopathy. People want to believe they are so in alignment with their utopian values and neglect that they can become angry lol.

lov

And... it seems pain is one of the few things I've noticed that reliably gives me sexual arousal. Not even if it's inflicted by me, just pain irl. Not in videos though. I like lover-dovey videos. I wish it was the reverse :

I relate to this somewhat but it’s usually not physical pain for me. I actually didn’t realize that pain was an element of the things I was interested in until recently when I started to kind of psychoanalyze myself.

lov

I also liked to make my close friends giving me shit for my veganism watch https://vimeo.com/209647801 to fuck with them and their emotions.

I used to also do this! Lol. I’ve also become desensitized as well and sometimes I end up curiously watching disturbing content repeatedly just to observe the feelings that do arise.

@Deleted User I also had a family most of whom seemed sadistic, although I'd argue theirs weren't as deeply ingrained into them as mine is, but theirs were expressed more in the bullying sense, oh lucky me being the youngest haha (edited)

7:10 AM

They really made sure the trust issues flourished

qwerkyscience

I relate to this somewhat but it’s usually not physical pain for me. I actually didn’t realize that pain was an element of the things I was interested in until recently when I started to kind of psychoanalyze myself.

It doesn't actually matter what causes their reaction tbh, it's only the reaction that elicits it. Even if they fake it. hmm, I never thought of this, maybe I should try roleplay of sadistic fantasies without any real pain whenever I ever get the opportunity.

7:18 AM

And when I want to inflict it, it's usually just to show off the cleverness in how I'm pulling it off rather than caring about the reaction in itself, just the level of reaction is a gauge to how effective it was. I avoid the ones that are over the line from my perspective, when I see someone genuinely disturbed, it makes me feel bad. It's easy to dehumanize them and not feel bad, but I rarely ever do that. I'd feel like shit for my worst enemy. I am conflicted whether this is a good thing or not. Because it had caused me a lot of pain from helping horrible people, but also is an important part in the mechanism for not hurting my friends. (edited)

7:22 AM

I don't think I ever told anyone this before

7:22 AM

don't think I would if I wasn't smashed

7:22 AM

I dehumanized my dad a lot when he died to avoid the physical reaction, and over-nostalgic thinking (edited)

7:22 AM

and it worked like a charm

7:24 AM

except the sometimes random nostalgic memories, I think nostalgia is a bad thing so I try to avoid it

7:24 AM

but sometimes I'd still mindlessly indulge them

Not dehumanized, but rationalized actually

7:54 AM

that his absence is better for the earth

in your opinion, what's the validity of insight gained through drug-induced altered states

I think people who experience a “wholeness with the universe” are really just experiencing synesthesia of their identity with their conceptual construction of the universe.

5:33 PM

Don’t think it’s actually transcendent in that sense unfortunately

5:34 PM

“It's All In Your Head ... You Just Have No Idea How Big Your Head Is”

So, imo, if there’s some insight to be gained - it’s that perhaps we have some peripheral sense of the universe. That we build some model of our environment. And perhaps, that we’re capable of blending that sense with that of our self.

I like that stance a lot

9:49 PM

Started reading it thinking this person is ignorant

9:49 PM

But no you turned that into something really understandable

Basically, I think it can tell us a lot about the brain, but not as much about transcendental metaphysics (as it’s often toted to). Though maybe it can, it’s just that what a lot of what people mistake as “leaving your body” still takes place in your head (imo). (edited)

insectodescenso

in your opinion, what's the validity of insight gained through drug-induced altered states

We should view scientists like drug users in this regard if we are to learn from the replication crisis

1:07 AM

The validity of science gained insights should be highly questioned

1:07 AM

I’m jk mostly

insectodescenso

in your opinion, what's the validity of insight gained through drug-induced altered states

Normally I think we obsessively focus on a set of thoughts or ideas and are kind of confined to them. Psychedelics might cause us to think about different things and thus lead to new thoughts because we are finally thinking in new territory. But humans are not good at thinking themselves into truths. We can observe that scientists fail all the time and they dedicate their lives to finding truths and even learn strategies for doing so. Humans on psychedelics are not necessarily granted sudden access to cultural knowledge about critical thought or the scientific method. So the ideas will likely not be very high quality unless a person is very well trained. It’s also possible that psychedelics would cause us to leave behind trained methods of insight.

1

https://youtu.be/pEnjM1jC1Rw

Eckhart Tolle

Dissolving the Ego | Eckhart Tolle Teachings

5:47 AM

So what is ego? Is it just the pattern of behaviors we've dedicated alot of mental resources to - grey matter allocated to processing - that we get energy conservant (defendant) about? Think about the study where they took scans of london taxi cab drivers brains - and they found that they all had similar changes in neural configuration .... if I were to threaten the value of their job, I am to threaten the time and energy put into their maps. "It cant be all for nothing" im sure the brain screams each time the ego is under attack .... The term ego is kinda archaic in that it refers to both the structures it identifies with (the networks representing the map of london, their shopping habits, or what contrived pathologies/set-of-behaviours we're capable of developing) AND the phenomena of it under attack. The term was invented before we really understood the deeper mechanics at play, as it really labels two things as one. Took a while to understand the ego cause of that. (edited)

5:52 AM

.... (my writing gets kinda disorganized after this point, sorry rip) Ego death is a momentary thing, not really a persistent state lest your a monk who literally does nothing their entire life. Anytime you learn anything or develop any kind of muscle memory - you've built ego. Ego death can be a 15 minute event (wile with DMT), or perhaps even as a waning thing, like the slow disappearance of the moon that can take place over the course of a month (maybe like learning meditation). I actually vaguely remember Jung talking about the importance of the ego. There's a time and a place for its death, but it absolutely exists for a reason. You can kill your ego, trim off the edges of the network for playing guitar, then relearn it better (cause it never fully died). Through relearning, you are given a chance to do things better. Like a phoenix reborn!!! You go through many moments of ego death - when your told your bad at something and scrap it to begin anew. Cycles of reincarnation, like the phoenix!!! Ego is identifying with something - with your habits, like your fondness of playing guitar - or of your property (like a waif lool) Is identifying with something - is it the assignment of your brain deciding it needs to try and keep that habit relevant? Where as if you no longer identify with something, the networks dedicate to it will wither (I bet) kinda fell apart near the end rip (edited)

.... I think I have this fear that what I'll be best at is that which I dedicated time to learning in childhood. That if let go of the habits I made in childhood, Ill never be that good at anything again. Or that maybe it is the foundation for everything else in my life, the backbone or something (like how paul stamets knows about alot of different fields, but its their interest in mushrooms that tie it all together)? I fear some consequence to forgetting childhood pathologies. Maybe seeing god in all can be a replacement for seeing that childhood self in everything. .... religion will save me from my trauma .. .for my childhood self is encompassed in god, which I view as the model for the sum of all This last paragraph I am very uncertain of compared to the rest of what I was saying, which I think has some truth, that I just struggle to articulate what it is (edited)

https://en.wikipedia.org/wiki/Cortical_remapping

Cortical remapping

Cortical remapping, also referred to as cortical reorganization, is the process by which an existing cortical map is affected by a stimulus resulting in the creating of a 'new' cortical map. Every part of the body is connected to a corresponding area in the brain which creates a cortical map. When something happens to disrupt the cortical maps...

6:32 AM

In 1968, Merzenich and two neurosurgeons, Ron Paul and Herbert Goodman, conducted an experiment to determine effects on the brain after a large bundle of peripheral nerves in adolescent monkeys' hands were cut and began to regenerate again.[3][4][5] They knew that the peripheral nervous system could regenerate itself and sometimes during that process the neurons would 'rewire' themselves by accident. These 'wires' would accidentally connect to a different axon, stimulating the wrong nerve. This resulted in a "false localization" sensation; when the patient was touched on a specific area of the body, that touch was actually felt on a different part of the body than expected.

I wonder if psychedelics help amputees suffering from phantom pain..?

Deleted User

In 1968, Merzenich and two neurosurgeons, Ron Paul and Herbert Goodman, conducted an experiment to determine effects on the brain after a large bundle of peripheral nerves in adolescent monkeys' hands were cut and began to regenerate again.[3][4][5] They knew that the peripheral nervous system could regenerate itself and sometimes during that process the neurons would 'rewire' themselves by accident. These 'wires' would accidentally connect to a different axon, stimulating the wrong nerve. This resulted in a "false localization" sensation; when the patient was touched on a specific area of the body, that touch was actually felt on a different part of the body than expected.

I wonder if psychedelics help amputees suffering from phantom pain..?

I imagine so, Hypnosis can too

https://www.reddit.com/r/Nootropics/comments/4a5fg9/ashkenazi_mimetics/

r/Nootropics - Ashkenazi mimetics

72 votes and 50 comments so far on Reddit

10:34 AM

it would be cool to see an article on sphingolipids! could even give some nootropic opinions on sphingolipidase inhibitors like people have asked

10:35 AM

https://medicalxpress.com/news/2020-04-schizophrenia-abnormal-fatty-metabolism-brain.html

Schizophrenia related to abnormal fatty metabolism in the brain

Researchers at the RIKEN Center for Brian Science (CBS) in Japan have discovered a deficiency in the brains of people with schizophrenia that could lead to the development of new drug therapies. A postmortem comparison published in Schizophrenia Bulletin revealed that schizophrenia was associated with lower than normal levels of S1P, a type of f...

@qwerkyscience how’s Xenoblade 2?? hehe

I think people are more effected by negative (fitness effecting or population controlling) memes in isolation cause they can’t dissipate the seriousness of it onto other people. Can’t joke about it with others, or talk to people who’ll re-assure them it’s all just bs. Everything becomes serious, especially in a situation where there’s millions of others exposed to the same thing in isolation. If you have friends, you can joke about how garbage what they’re teaching you in school is. If you don’t, your left to deal with that internally. Idk. (edited)

2

@Qwerky Hive , anyone here play video games? Or board games? Make music?

I play a couple games (edited)

Only made a couple of tracks for a game project, ambiance type music

1

Life

10:07 PM

I play that game

zza

Only made a couple of tracks for a game project, ambiance type music

Have you seen @qwerkyscience 's music? I think it could be really cool for a game project toooo. Do you make games @zza ?

10:10 PM

Where can we listen to your tracks?

I've heard some of it. Well, trying to make games with a buddy. Simple ones, still WIP

Oooo what're you using?

Old snippets for 1 game, it's in space

10:13 PM

Unity haha

zza

Old snippets for 1 game, it's in space

Ooo weird I feel like I'm kinda going between environments here

10:14 PM

Like it's starry and windy but also underwater

10:14 PM

Andd then as it continues feels like I'm approaching something over the horizon

10:14 PM

And then like I'm sort of about to drift

zza

Click to see attachment 🖼️

This one kinda sounds like I'm walking through a space building and there's some kinda anticipation that something could be JUST around the corner

I’m playin some games

Nice, it is meant to be a bit mysterious, space and all

1

Shh

Question

5:45 PM

If I am not sure if I have an Iron deficiency now but had one in the past

5:45 PM

Is it okay if I just randomly take iron supplements?

The answer

6:05 PM

Is no

Can you try and eat more alternatively

Blargh, I feel like I’m eating enough

6:06 PM

Lots of eggs, spinach, chicken, beef

I think iron is something you really want to get from diet

Salmon

Yea so your probably fine

Empress of Cheer

Is it okay if I just randomly take iron supplements?

I wouldn't

7:45 PM

Why is my name red? I'm not a threat!

There ya go

Empress of Cheer

There ya go

THANK YOU!!!!!!!!

almost 400mg of tramadol with alcohol is not the behaviour of an intellectual here, yet

10:42 AM

If i can type must mean it's been pretty safe

10:42 AM

but I couldn't fill vape juice cuz it's like parkinson's

10:43 AM

and at a moment, my entire existence sparked when I almost fell asleep

10:43 AM

figure that was a near seizure

10:43 AM

god, I hope I'm not causing any brain damage, i'd hate that

10:44 AM

I remember back in the day staying up with people doing things like this in harm reduction places to ensure they were okay

10:45 AM

and giving them a nice talk to help encourage them to change some decisions they're making after they sober up

10:45 AM

the irony now

10:45 AM

the alcohol was maybe right after the tram peak so not both at the same time

10:46 AM

liver is going to be mad later

I've been typing well I think for this

10:57 AM

I took the alcohol to the end of the peak of the tram high

10:57 AM

stomach hurts like hell though, ulcers be gone damn it

It sounds not worth it @lov

ulcers

it def wasn't, time for another couple months off alcohol

Empress of Cheer

If I am not sure if I have an Iron deficiency now but had one in the past

You can check if you're deficient in iron from the desire for lemons

Deleted User

You can check if you're deficient in iron from the desire for lemons

I mostly crave tomato

Empress of Cheer

I mostly crave tomato

And biohacking tehe Fried tomatoes are a biohack ainy they? I think theyre more antiocidant when fried.

Deleted User

And biohacking tehe Fried tomatoes are a biohack ainy they? I think theyre more antiocidant when fried.

Whaaaa that's awesome

I’d like to fight with someone over something meaningful where I can prepare sources and citations

9:37 PM

Or at least be in the vicinity of such conversations

Why animals should have wings

9:40 PM

All animals

If autists are low in oxytocin the that mean they aren’t as tribal and are less biased, right?

8:31 AM

But at the same time you need to make those strong social connections from having a common outgroup in order to succeed in this nepotistically dominated world - little room succeed solely due to lack of bias.

8:31 AM

Also, In another chat some one told me neuroticism was more associated with tribalism and dogmatism than autism was (not certain about that one but sounds probable) -what’s the association of oxytocin and neuroticism in that case then? (edited)

1

@Empress of Cheer why'd you delete it

Deleted User

@Empress of Cheer why'd you delete it

It was too late in day for me to enjoy arguing and I didn’t want people’s feelings to be hurt

I bit my fork today and I've been sad about it ever since

1

10:49 PM

Like a thread in the Universe was supposed to be lightly pulled but some idiot came and yanked it thru

@Empress of Cheer Hello, I am inquiring about my ban from your discord server. You see, really I am a good guy, and I promise I had no ill intentions. If you would like to reinstate me, I swear I will live up to your expectations and never break the rules again. Patiently awaiting your response, Sirsadalot.

1

Deleted User

@Empress of Cheer Hello, I am inquiring about my ban from your discord server. You see, really I am a good guy, and I promise I had no ill intentions. If you would like to reinstate me, I swear I will live up to your expectations and never break the rules again. Patiently awaiting your response, Sirsadalot.

You know exactly why you were banned from my server

You even tried to tell me you did it to make the community more united.

Empress of Cheer

You know exactly why you were banned from my server

You even tried to tell me you did it to make the community more united.

I was banned for being too seggsy

1

How common do you think it is for schizos to also be autistic? If social isolation can cause all the symptoms of schizophrenia, maybe so can autism if its severe enough???!

9:11 AM

a thought

I just realized something. Ive always thought of a core part of my childhood as being unable to fall asleep - cause Id spend so much time day dreaming and just thinking about weird scenarios rather than fall asleep. I always had alot of anger towards my parents for not listening to my complaints of being unable to fall asleep at night - my whole childhood is marked by the memories of hours of sleepless nights, sitting in bed alone waiiting to go unconscious ...... spending so many hours in social isolation mightve left me kinda schizo tbh! Insomnia + parental neglect = schizo symptoms? (edited)

1:17 PM

Id tell myself things like Id never forgive them, that Id never forget the injustice done to me, that Id never become like the adults who've forgotten the pains and injustices kids are subjected to.

Familiar faces all up in this server

2

I dont know if IM schizo btw I used to be this before mushrooms: https://en.wikipedia.org/wiki/Schizoid_personality_disorder but im way different now

Schizoid personality disorder

Schizoid personality disorder (, often abbreviated as SPD or SzPD) is a personality disorder characterized by a lack of interest in social relationships, a tendency toward a solitary or sheltered lifestyle, secretiveness, emotional coldness, detachment and apathy. Affected individuals may be unable to form intimate attachments to others and simu...

Deleted User

I dont know if IM schizo btw I used to be this before mushrooms: https://en.wikipedia.org/wiki/Schizoid_personality_disorder but im way different now

Bro I was looking into this the other week and wondering if it was me kek

Empress of Cheer

I’d like to fight with someone over something meaningful where I can prepare sources and citations

Alrighty, I beleive aliens have landed and pyramids are a source of power.

1

Empress of Cheer

I’d like to fight with someone over something meaningful where I can prepare sources and citations

Y'all this wasn't like a challenge or anything

5:36 PM

I was just venting

5:37 PM

Empress of Cheer

Y'all this wasn't like a challenge or anything

Well thats a shame because its already happened heheheh

12:53 PM

Pyramids can grow tomato plants by 100% extra

1

society is so odd

12:37 AM

like, so many things happen in it that are so blatantly hypocritical and delusional with lots of people taking some sort of moral high-ground

12:37 AM

or laughing at the stupidity of belief in one thing, then using the same underlying principle of general belief in that thing on another thing, viewing it as an obvious truth (edited)

12:38 AM

I'm missing examples ofc

12:38 AM

I'm just ranting more or less

12:39 AM

I've noticed self-segregation happening a lot among groups

12:39 AM

I don't participate in this

12:39 AM

so I might be labelled odd by a friend or 2

12:40 AM

but the others they'd do the same for avoids them for another group etc

12:41 AM

so I'm thinking odd ones similar to me (i'm guessing a few of you here) aren't really that specifically odd, just the others that'd be deemed as such by those people aren't around for comparison

12:41 AM

But for me, almost everyone else, literally 99% of people, are so so fucking odd

12:41 AM

there were some quiet ones who I thought differently of

12:42 AM

but once i'd experienced their thoughts in-depth enough times, I realize how... scarily shallow it usually is (edited)

12:44 AM

Around 90% of people lack what I thought was the threshold for human self-awareness, they can at least recognize themselves in a mirror so that's good (edited)

12:46 AM

You'd think I'm exaggerating as a literary device here, tfw

12:47 AM

I don't know if I have free will

12:47 AM

maybe I do, maybe I don't

12:47 AM

whatever "free-will" means on a technical level (edited)

12:48 AM

but I'm sure even if I did, only a small percentage of humanity would, I actually have some theorize about this

12:48 AM

It's those who are capable of simulating others in their minds (edited)

12:49 AM

their thought processes etc

lov

or laughing at the stupidity of belief in one thing, then using the same underlying principle of general belief in that thing on another thing, viewing it as an obvious truth (edited)

A lot of my posts are actually about this kind of dynamic

6:20 AM

I’m thinking of making it a whole category type on my site.

6:20 AM

A lot of cluster b traits are basically this.

6:21 AM

https://mad.science.blog/2021/02/27/the-polarized-mind/

theschizotypal

The Polarized Mind

Polarization seems to play an underestimated role in the psychological processes underlying cluster B personality traits, such as narcissism and psychopathy, and also appears to promote delusional …

6:21 AM

This is basically about your rant

6:21 AM

We are resonating in synchronicity now

lov

But for me, almost everyone else, literally 99% of people, are so so fucking odd

I think this kind of idea very often and feel distress from loneliness kinda

lov

but once i'd experienced their thoughts in-depth enough times, I realize how... scarily shallow it usually is (edited)

Hmm words can be pretty shallow inherently. I don’t tend to look at people like this as much anymore. Maybe some part of my mind does. But I am also having maybe a selection filter for the people I’m around too. I think humans are very similar to animals in their motivations and focuses tho. Like many political issues are like complex manifestations of territorialism kinda. (edited)

qwerkyscience

https://mad.science.blog/2021/02/27/the-polarized-mind/

I need to study this like the bible when I go visit my parents in February lol

1

lov

but once i'd experienced their thoughts in-depth enough times, I realize how... scarily shallow it usually is (edited)

Yea I feel fairly shallow nowadays than before uni. Feel like I had to give up my cohesive worldview I was building for this segmented scramble to manage all these barely related subjects.

1:35 PM

Hopefully when I’ve got more free time I can piece myself back together

1:37 PM

Idk if we’re talking about exactly the same thing, but I atleast don’t have the free space in my head rn to to think about societal problems and solve them on a personal level (like solving the polarization of my own parents) when school requires so much of my capacity. Who has time to fulfill community roles when we live in such a large world full of so many people we’re subject to. I could be missing the mark with that last bit... (edited)

lov

It's those who are capable of simulating others in their minds (edited)

I was putting some active thought into this the other day while writing hypnosis scripts. If you imagine somebody, and then imagine them feeling a certain way - with them exhibiting traits of that feeling - you end up feeling that way. I think, in totality, taking the perspective of others (such as how someone feels) requires us to recreate the feeling, and then attribute the feeling to something external. This may also explain why people's heart rates and breathing sync up as they bond together. (edited)

qwerkyscience

I think this kind of idea very often and feel distress from loneliness kinda

https://en.wikipedia.org/wiki/Social_loafing You take on more accountability alone

Social loafing

In social psychology, social loafing is the phenomenon of a person exerting less effort to achieve a goal when they work in a group than when working alone. It is seen as one of the main reasons groups are sometimes less productive than the combined performance of their members working as individuals. Research on social loafing began with rope p...

10:32 PM

the whole weight of the world when isolated enough okay

Deleted User

Pyramids can grow tomato plants by 100% extra

maybe this is the ancient tech the egyptions used to promote crop yield

lov

or laughing at the stupidity of belief in one thing, then using the same underlying principle of general belief in that thing on another thing, viewing it as an obvious truth (edited)

bayesian analysis is nice skill to learn for problem solving and views of the world in my opinion

lov

like, so many things happen in it that are so blatantly hypocritical and delusional with lots of people taking some sort of moral high-ground

like people who brag about being high are no "better" then people who brag about being sober

i made the 20 amino acids in latex

2:27 AM

surprisingly easy and hard at the same time

2:28 AM

also not sure if this is how a pro would even draw it

can you link it, what TeX editor to you use?

I'm using vscode. I can share the file

3:27 AM

hmm discord doesn't like tex files (edited)

3:28 AM

here's it renamed to txt

aminoacids.txt

4.11 KB

3:28 AM

just change to tex

visual studio does tex? news to me

5:01 AM

how do i convert it back to tex

adenofthieves

how do i convert it back to tex

save the file as .tex

vscode has a tex package that's decent but honestly I mostly use emacs w/ AucTeX because it has a lot of nice macros and inline previewing of greek symbols

cool feature in the vscode tex extension. hover over math shows a preview

When meditating, I've noticed to get into a really deep state I've developed a tendency to try tune in on this strange perception basically Ill move my head side to side - and try and to infinitely slow that movement down till the point it feels like my heads like locked in on one axis and making really greased / lubricated movements Really weird, dont know to describe it any better

9:37 AM

Its like, my head starts to move insanely fluidly, like the degree of control I have becomes insanely narrow. Instead of existing in a space where my head turning range is 62 degrees wide and 16 positions within that space - my head turning range becomes only a few degrees and the positions I can place my head scaled down inside that. Moving in such a tiny space feels crazy fluid. Also I try to think back to how I felt on mushrooms - thats super useful, when combined with weed it can actually start make me tripping and seeing stuff like Im actually on mushrooms!! -Just by thinking about mushrooms!!

9:37 AM

The fluidness is kinda drunken in feeling - wobbly sorta loose feeling

9:38 AM

When I start to do this meditation while singing - my singing gets really good too - I think micro movements are more important for the song I like (edited)

9:40 AM

I dont usually continue to move my head and instead just focus on the feeling it produces separately instead. Though sometimes I move it again for some feedback if going deeper.

9:45 AM

I used the neck as an example cause its the easiest for me to notice first and tune into - but I end up feeling my whole body this way as I then begin to feel a sort of acceleration.

https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2869.2002.00297.x

10:13 AM

Why is sleeping with your head back associated with hallucinations? Is it true that blood flows to the back of the brain and increases activity occipital lobe? What is the evolutionary reason people bow down to pray? Does this form of mediation increase blood flow to the PFC - is god associated with priorities and executive function?

10:13 AM

10:14 AM

10:16 AM

its kind of a submissively pose - slaving to your brain as Ive seen people in adhd communities call it (having properly functioning executive function and sufficiently high trait conscientiousness)

10:18 AM

yea - its quite a stretch I realize

is god associated with priorities and executive function?

my opinion is that a main message of most of the major world religions is sitting on your ass is a big no no

3:40 PM

but I guess that's based on passages of various texts where primarily the issue is that God predestines something to happen and the person don't wanna do it

3:41 PM

in which case the voices from god would actually be likely due to low PFC activation (correlate of psychosis) but presumably doing an activity requires executive function so god will leave you alone

I feel like god is a motivational thing. Purpose and meaning. Meaning and priorities in life.

5:14 PM

Not that I’m very godly, I’m raised atheist actually.

@Deleted User https://direct.mit.edu/jocn/article/29/10/1633/28714/Predicting-Motivation-Computational-Models-of-PFC

5:30 PM

... We propose that MPFC activity reflects monitoring of motivationally relevant variables (such as effort and reward), by coding expectations and discrepancies from such expectations. Moreover, we derive behavioral and neural model-based predictions for healthy controls and clinical populations with impairments of motivation. Second, we illustrate the possible translation to effort-based behavior of the HER model, an extended version of PRO model based on hierarchical error prediction, developed to explain MPFC–DLPFC interactions. We derive behavioral predictions that describe how effort and reward information is coded in PFC and how changing the configuration of such environmental information might affect decision-making and task performance involving motivation.

Deleted User

Not that I’m very godly, I’m raised atheist actually.

I was raised as a God and my children are atheist so I can relate

I think its not uncommon for Christians to turn their head down in prayer either actually (the maoirty) I think people look upwards to the heavens when desperate enough to actually see visions tho (the minority)

7:25 PM

ill try meditating with my head down for homework and head up for artistic endeavors

Slowly losing consciousness is quite similar to a runner's high and I'd argue it's also one form of a "religious experience"

12:20 AM

Honestly, my fav of my personal religious experiences wasn't changes in states of consciousness

12:20 AM

rather just pondering at the night's sky in nature

12:21 AM

It's not something other's would describe as that but growing up, that's what felt closest to it for me

lov

It's not something other's would describe as that but growing up, that's what felt closest to it for me

I’d lay in bed at night wondering the universe, life and death, and nature of existence as a kid. It was pretty religious I guess

birth as a very long drawn out death process

Birth is death XR

8:32 PM

Or death is birth XR

8:32 PM

Idk can I speak to a pharmacist?

4

Deleted User

the whole weight of the world when isolated enough okay

I feel that brother

What topics have been interesting you lately?

The whole weight of the universe

12:01 PM

That's beautiful angst there

12:02 PM

I'm melancholic for the first time in some long time

1

12:02 PM

Which is somewhat welcomed since it feels like this run of shit in my life is over with the army

1

12:02 PM

I really hate myself for everything it stood for

12:03 PM

It's just a goddamn 2 day long existential crisis trying to see things like I used to before

Are people mean, rude, aggravating, and aggressive because they don't know how to get attention any better way? They dont have the social strategies like wit and humour to get attention and all they know is how to anger and troll people?

Deleted User

Are people mean, rude, aggravating, and aggressive because they don't know how to get attention any better way? They dont have the social strategies like wit and humour to get attention and all they know is how to anger and troll people?

Need more specifics

Deleted User

Are people mean, rude, aggravating, and aggressive because they don't know how to get attention any better way? They dont have the social strategies like wit and humour to get attention and all they know is how to anger and troll people?

Not necessarily, some people believe behaving this way gives them a strategic advantage in social and professional environments

Hawkins

It's just a goddamn 2 day long existential crisis trying to see things like I used to before

That stressful, I’m glad you’re making progress back to the way you used to. I hope you don’t put too much pressure on yourself to get there though. Maybe you brain doesn’t have to be the way the army programmed it to be OR the way it used to be. Maybe it can be better.

qwerkyscience

Need more specifics

ah actually nvm I probably shouldnt sorry nvm mb (edited)

https://en.wikipedia.org/wiki/Paris_syndrome

Paris syndrome

Paris syndrome (French: syndrome de Paris, Japanese: パリ症候群, Pari shōkōgun) is a sense of disappointment exhibited by some individuals when visiting Paris, who feel that the city was not what they had expected. The condition is commonly viewed as a severe form of culture shock. The syndrome is characterized by a number of psychiatric symptoms suc...

6:26 AM

it'd be cool if people reacted to placebos with extreme disappointment istead of deluding themselves into thinking it worked

6:26 AM

hope you guys dont mind me posting the most barely realted random wiki articles in here aa

This is for off topic content right?

10:46 PM

Idk is it okay for me to post a pic of me in a Harley Quinn wig?

10:46 PM

Or does that go in #qwerky-memes ? I donut know

10:49 PM

I will post anyways and just remove if not okay

10:49 PM

Here's my Harley wig

10:49 PM

1

10:49 PM

Gonna wear it for my next stream since I've been playing Batman

10:49 PM

And when I play Xenoblade Chronicles I'ma wear my purple haired anime girl wig

1

10:49 PM

It’s okay to post

1

https://emulatorgames.online/games/

Games Tags (Game Genres & Game Series) – Emulator Games Online

Choose your favorite retro games by Game Genres, Consoles or Game Series

https://www.twitch.tv/empressofcheer

7:40 PM

I'm on

7:40 PM

Not doing anything in particular

1

Hi everyone

Hi

Good morning.

Hello!

9:16 PM

Lesser seen psychonaut among the neuroscientists PrettyPog

Omg good morning everyone!!

4:49 PM

I can't believe I missed out on this!

4:49 PM

I'm working on a lil meme today

4:49 PM

Like using reference pics to create the sketch but it was inspired by this server

4:49 PM

1

Empress of Cheer

Click to see attachment 🖼️

You're a bit of a cheeky one slyly aren't you?

5:42 PM

@William Anderson

2

What kind of music do you guys listen to

i make music, https://www.jackdonmclovin.com, youtube and spotify

nice

all improv

3:01 AM

i just play and record everything that come out. one take only.

3:02 AM

otherwise: https://www.youtube.com/watch?v=08uEjxRPSdc

Alan Gogoll

Relaxing Acoustic Music - peaceful instrumental guitar for study, s...

3:03 AM

what i'm listening to right now

Any1 know why the after effects of cholinergcs/anticholinergics seem to induce a weird dissociative episode for hours after they've worn off for me?

9:12 PM

Is it just whacky dysregulated choline orrr?

9:12 PM

There's one paper on it I found, but no abstract that I can see

9:13 PM

and the article might not even be what im looking for, the title is just the closest thing to the question im asking

9:13 PM

https://pubmed.ncbi.nlm.nih.gov/5335793/

[Analysis of "dissociation" between the effect of anticholinergic d...

[Analysis of "dissociation" between the effect of anticholinergic drugs on behavior and the electrical activity of the brain]

I feel like choline has a role in awareness anyway

9:13 PM

So ya

9:14 PM

Its a lot of overlap when it comes to what systems and chemicals do what tho

Yea, for sure. But it only really happens when I take anything that effects choline levels, so that's kinda why I assumed it could've been a direct correlation to it.

Youve never even had lingering disso from dxm?

Not really, if you mean after coming down?

9:16 PM

Maybe if I smoked weed afterwrds

Yeah

it'd bring back the effects a little

9:16 PM

But that happens with most drugs for me, dxm, psychs, etc

9:16 PM

Weed just likes to bring back their effects

I mean yeah its just a whole lot of complicated systems I really wish i could understand them all and tell you

theron (he/himemantine started a thread. 2/16/2022 9:20 PM

💊 Peaches&Amphetamines💊

Any1 know why the after effects of cholinergcs/anticholinergics seem to induce a weird dissociative episode for hours after they've worn off for me?

I experience this with cholinergics too. I’ve basically had psychotic effects after cytisine wears off. It’s a bit relieving to know it happens to others too. Though I’m sorry that you face an annoyance.

4:24 AM

This is why I’ve been proposing that nicotine’s connection to schizophrenia is not necessarily pure self-medication but also amplifying of the symptoms. Not too different from benzodiazepines being self-medication and simultaneously eventually resulting in serious amplification of symptoms

4:25 AM

It’s curious that you notice this from anticholinergics as well. I’d like to hear more about this. I avoid those types of drugs because I’ve had gross lasting changes to my psych from relatively mild experiences.

I smoke with skittles (schizo) what should i notice

Hmm I’m not sure you’d really notice something in particular now except that it probably would seem to be beneficial acutely.

7:26 PM

I think it would be similar to how some users of stimulants become tired a lot despite the taking stimulants daily. I think this sort of thing happens with most repeated drug use.

7:27 PM

Idk it’s hard for me to assess what is really beneficial or not when it comes to drugs. Partly because it takes a long time before issues arise and the benefits still seem to exist when those problems arise but it might just be a the contrast from the peak of the dose to the crash.

7:28 PM

How long have you used nicotine? How frequently do you dose? How long has it been since you’ve had more significant symptoms?

7:32 PM

https://www.reddit.com/r/funny/comments/sul52t/its_not_about_the_money/?utm_medium=android_app&utm_source=share

My nicotine use was basically vaping constantly when I was awake so that had to go for me personally

qwerkyscience

It’s curious that you notice this from anticholinergics as well. I’d like to hear more about this. I avoid those types of drugs because I’ve had gross lasting changes to my psych from relatively mild experiences.

I'm not sure, it was odd. I had taken 25mg of DPH to ease anxiety when I was on Cyclazodone because that's all Cyclaz seemed to do to me lol.

10:56 PM

Did that twice, both on the comedown-ish of the Cyclazodone, and both times it induced a dissociative/derealization episode

10:57 PM

Nothing looked real, life felt like a movie, almost cartoon like but not cartoon like

damn would benztropine do that if I took enough

Idek what that is lol

it's an anticholinergic med that I have (edited)

1:02 AM

https://recoveryfirst.org/prescription-abuse/cogentin-benztropine-mesylate/

Does Cogentin (Benztropine Mesylate) Get You High? - Recovery First...

Cogentin can create a number of effects that are termed overdose in medical terms but may be sought after by recreational users and experienced as a “high.”

1:02 AM

American Addiction Centers has taught me so many different ways to abuse drugs

1

1:03 AM

mmm and it has a dopamine reuptake component

1:04 AM

this seems remarkably dangerous though so I'm good

1:04 AM

will get me 2d vision somewhere else

My 2d vision wasn’t pleasurable it freaked me out

1:17 AM

It’s cool when that’s what you’re going for ig lmao

i miss acid. made things 3d

1:18 AM

and a bit cartoonish

That does sound cool lol

1:19 AM

Acid was one that was so intense for me, definitely left this world a few times (edited)

god i love acid

What's your trip count?

i dunno 20 times or so, 1 time over 1000ug

1:30 AM

microdosing that is not a placebo

huh I did like 15-20 trips in a 2-3 year period not that high though

1:30 AM

highest was 600 ug IIRC

Jesus

1:30 AM

I’ve never done above 200 lol (edited)

1k is dope af

1:31 AM

you may as well be god

Aren’t higher doses like that comparable to ayahuasca

what ever you think, happens

1:31 AM

yeah i reckon

using it therapeutically though seems pretty hard bc you need high enough dose for 5-ht2a downregulation and it has to be done every few weeks for that effect

i got caught with 1kg of Huperzine A, my family thought it was coke

1:33 AM

that shit has the same biological effect but no trip

1:33 AM

and it's strong too

1:33 AM

i'm talking neural regrowth

1:33 AM

quick turnaround on learning

is it legal?

1:34 AM

oh shit it is

1:35 AM

I wouldn't say it has the same effect as LSD but it might help with neuroplasticity

1:37 AM

overnight delivery here we go

Huperzine scares me a little lol

3:16 PM

Good luck

3:17 PM

Just don’t do too much. I think higher doses feel psychotic. But low doses can feel sharpening and clarifying

But the man said no trip

4:21 PM

I spent way too much money on cannabis

4:21 PM

Now we’ll just have to see how long it’ll last me

4:22 PM

But I learned to buy the bulk brand not the premium brand

4:22 PM

Even though they’re literally the same company

1

The company is vertically integrated to the nine

5:18 PM

it's insane

5:19 PM

and they accept debit card at their stores even tho cannabis businesses are cash only because they just operate an ATM at each of their registers

5:19 PM

legal gymnastics that you kinda need scale to do

Do autists get more endorphins from from self harm? I feel like always corrupt people’s dogs training lol. They’re always so well trained not to put any pressure at all in their bites but I actually kinda like a bit of pressure. I’m maybe evolved to train the dog to protect

(edited)

he protecc

1:39 AM

he attacc (edited)

He really do attacc!!!!!

There are two types of memory retrieval’s - recall and recognition. Are people better at recall more assertive, capable of steering the conversation, better at holding frame, and overall generally more dominant?

Deleted User

There are two types of memory retrieval’s - recall and recognition. Are people better at recall more assertive, capable of steering the conversation, better at holding frame, and overall generally more dominant?

Nah it’s probably more than that

got a pax now don't gotta smoke the herb

12:51 AM

can vape it now so much cleaner

I smoke blunts

damn

12:55 AM

i quit the nic

I smoke cigarettes in between. I can’t quit the Nic, i get too anxious and hyperactive, start wiggin out

i mean I did it with 300 mg of wellbutrin daily

12:57 AM

definitely much harder w/o meds

My mate tried that and failed

gotta get yourself off the cigs and onto pure nicotine first

I can’t. Don’t like the vape

12:58 AM

Nor patches

12:58 AM

Nor gum or inhaler

12:59 AM

But it doesn’t cost me much. About $30 a week

i mean it's killing you

Not really. You have to smoke 1 pack a day to show up as a cancer risk. I smoke 1 pack a week. Also you need 10 pack years, which is a pack a day for 10 years before it shows up doing damage. I’ve been smoking 1 pack a week for 10 years which means i have 60 years left. I don’t get a cough from it, and my lungs remain infection free

interesting

1:03 AM

reminds me of this student film https://www.youtube.com/watch?v=q4MnrGjGt-0

Fire Escape Films

Smoke For Thought (2003)

1

1:04 AM

I cannot control my nicotine intake so it's best for me to quit

I did a presentation on how smoking was curtailed by the wider economy and how good it can be for you. And ultimately you need to control your minds attraction to the placebo

adenofthieves

But it doesn’t cost me much. About $30 a week

wait what

2:31 AM

how are you spending 30$ a week

2:31 AM

but only smoking 1 pack a week

2:32 AM

what 30$ pack of cigs are you smoking

50g in Australia

2:36 AM

it's expensive here

Jeez

most people pay $100, but i have a hookup

Man i wish i could quit cigarettes, i started smoking this year, did really enjoy the nootropic effect of nicotine but my consumption did scarily ramp up went from few cigs a week to a pack/day

that's how it goes

insilico

Man i wish i could quit cigarettes, i started smoking this year, did really enjoy the nootropic effect of nicotine but my consumption did scarily ramp up went from few cigs a week to a pack/day

Try titrating down

5:26 PM

There are also medications that will remove the addictive feature of cigarettes

varenicline and wellbutrin in the US

Bupropion

5:28 PM

More info: https://www.cancer.org/healthy/stay-away-from-tobacco/guide-quitting-smoking/prescription-drugs-to-help-you-quit-smoking.html

Quit Tobacco Prescription | Smoking Cessation Drugs

wellbutrin is bupropion

5:33 PM

varenicline is more effective

theron (he/himemantine

wellbutrin is bupropion

Ye but might be helpful to know what Wellbutrin specifically is when asking doc

https://en.wikipedia.org/wiki/Cortical_remapping I need to find a better article on this to share to people when I want to get the concept across Any suggestions?

Cortical remapping

Cortical remapping, also referred to as cortical reorganization, is the process by which an existing cortical map is affected by a stimulus resulting in the creating of a 'new' cortical map. Every part of the body is connected to a corresponding area in the brain which creates a cortical map. When something happens to disrupt the cortical maps...

https://youtu.be/If61baWF4GE

RealLifeLore

Why Russia is Invading Ukraine

1

1

Deleted User

https://en.wikipedia.org/wiki/Cortical_remapping I need to find a better article on this to share to people when I want to get the concept across Any suggestions?

It's a generalization but https://en.wikipedia.org/wiki/Neuroplasticity is rated a B-class article

Neuroplasticity

Neuroplasticity, also known as neural plasticity, or brain plasticity, is the ability of neural networks in the brain to change through growth and reorganization. These changes range from individual neuron pathways making new connections, to systematic adjustments like cortical remapping. Examples of neuroplasticity include circuit and network c...

2

theron (he/himemantine

It's a generalization but https://en.wikipedia.org/wiki/Neuroplasticity is rated a B-class article

yea its a pretty good article, theyve updated it alot since I first read it!

What is something that would really help you out right now? Help finding a therapist? A room to rent? A room mate? Help learning a skill? Something bigger that I'm not aware of? Need a couple bucks? Job referral? In the same vein, is there anything you're really good at and would like to teach others? Help you can offer? @here (edited)

1

A job. If you like you can write positive feedback for my website

2

adenofthieves

A job. If you like you can write positive feedback for my website

link!!

melon

link!!

Then i could visit US, live in Thailand. babylonpolice.com

1

adenofthieves

A job. If you like you can write positive feedback for my website

what kinda job

Software Engineer, unless I could get something in Biomedical Engineering Product Design

adenofthieves

Software Engineer, unless I could get something in Biomedical Engineering Product Design

Ooooo well you’ve got a portfolio right? Resume? Sounds like you just need to make sure your resume is optimized and then network

Yeah I’m failing on the networking. I deleted Twitter when i started getting popular. And deleted Facebook way way way before the peak. I now have both but they’re essentially dead. Once i get a job i can pay for advertising for my website and then do that as a side gig.

adenofthieves

Yeah I’m failing on the networking. I deleted Twitter when i started getting popular. And deleted Facebook way way way before the peak. I now have both but they’re essentially dead. Once i get a job i can pay for advertising for my website and then do that as a side gig.

For networking it doesn’t have to be like you’re a public figure blah blah blah

adenofthieves

Yeah I’m failing on the networking. I deleted Twitter when i started getting popular. And deleted Facebook way way way before the peak. I now have both but they’re essentially dead. Once i get a job i can pay for advertising for my website and then do that as a side gig.

You said you’re based in Thailand right now?

linkedin?

7:05 AM

i think people mentioned going to conferences for networking (edited)

7:06 AM

btw, i think your site needs to look prettier xddd Bartleby

but thats just my personal preference

I’m in Australia, Melbourne. I got banned off linked in and they won’t say why. I’m a Snowden Assange advocate from way back that used to believe truth was light. Now I believe truth is dark, so I don’t stick well on public forums. I’m trying again fr on reddit based off of my proven persona in discord

1

woah

I intentionally made it boring so you could attach more So to the knowledge contained within

hm

7:08 AM

its informative from the get-go, but the way its structured makes me feel a little lost

7:09 AM

paradox of choice kinda feeling but not exactly

7:09 AM

it could both be nice to look at and improve user experience (edited)

I think you should try to pick your battles more and not advocate for everything you believe in on autistic websites without taking any actual concrete action

2

melon

its informative from the get-go, but the way its structured makes me feel a little lost

and thats understandable because the community is still small so you want the new users to be informed from the very beginning

Like the name comedown kid

1

might not be useful but if i could reorganize your site, I'd simplify and categorize the information even more...

adenofthieves

Like the name comedown kid

Thanku :D

btw thank you @Empress of Cheer for asking that..made me reflect on some things

Empress of Cheer

What is something that would really help you out right now? Help finding a therapist? A room to rent? A room mate? Help learning a skill? Something bigger that I'm not aware of? Need a couple bucks? Job referral? In the same vein, is there anything you're really good at and would like to teach others? Help you can offer? @here (edited)

Social confidence I think

7:19 AM

On tramadol, and for several weeks after the second time that I took memantine I had great social skills and confidence

7:19 AM

I think they were related

7:20 AM

But when I feel tired during the day I can’t do this

7:20 AM

I am trying to not be tired during the day anymore

You should come to the nootropics discord

Lmao no

7:21 AM

I dislike the nootropics community

Fairo fairo

I was trying to fix my sleep schedule

I don’t believe in it

឵ComedownKid

I was trying to fix my sleep schedule

and your methods were?

Siesta. Before I had little consistency but I was more or less already doing this

7:22 AM

Just not well

7:22 AM

But I’m doing the siesta extended sleep schedule

7:23 AM

I mean super extended really. Extended is 6h night sleep and I do 6h 30m typically

7:23 AM

And I don’t even wake up at the right time like this

7:23 AM

And sometimes I don’t wake up after the siesta on time

you struggle with staying awake?

Its supposed to be 1:30 and today I slept more like 2:30… with an alarm

melon

you struggle with staying awake?

Its not that, I’m sleepy all day :(

1

I used to be that way...

7:25 AM

but It's gotten really good after i started taking a short walk to absorb sunlight in the day time.

So even with super fucking extended biphasic sleep, 8h TOTAL when normally it should be like 6h total on siesta, I need to sleep longer I guess

1

7:26 AM

So idk what to do and I’m getting really frustrated thinking about it rn

the more regular your schedule the better it is

7:26 AM

hmm

7:26 AM

idk if this helps, this is my routine:

7:30 AM

-wake -protein shake (maintain low blood glucose) -if i can fit it in, exercise (promote orexin a) -prepare a light meal -take all my vit, supplements and noots -sit in silence for a bit -work … -lunch during late noon -take a walk (get sunlight to moderate melatonin for better sleep) (edited)

7:30 AM

@឵ComedownKid

7:30 AM

i did read about high blood glucose making people sleepier, so dietary changes can make a big difference

7:33 AM

i add l-tyrosine to my coffee, after an hour or more from waking up

I don’t even bother with nutrition beyond the stuff everybody can agree on because its totally polluted with ideology and groups

7:40 AM

And since I still have some room for improvement with the basic stuff

yeah vit and suppl can be kinda sus

I’m considering fladrafinil because of its serenic effect. It’ll be a problem if it prevents my nap tjough

1

what about flmodafinil?

Not serenic

could add something like bacopa or l theanine i think

7:42 AM

i like how flmodafinil sounds would really wanna try it someday

melon

could add something like bacopa or l theanine i think

For what?

i think they were anxiolytics

7:44 AM

at least i assumed that might have been what u were looking for (serene effect)

Reduce irritability

flmodafinil reduces irritability iirc

No

flmodafinil successfully reduced aggression in rats’ studies. It worked as an inhibitor that calms you when you feel agitated.

7:47 AM

not sure if thats the affect you’re looking for

Thats sketchy

7:48 AM

I already have fladrafinile

1

perhaps, might be unreliable

I’ve been reluctant to consider this but maybe caffeine would work

caffeine makes me kinda jittery but it helps with getting more motivated smh

melon

perhaps, might be unreliable

Yeha its only been shown in rodent study lol but serenics are few and far between, and this seems to have the least severe side effects of them

this as in fladrafinil?

And also could fix my problem of sleepiness

1

melon

this as in fladrafinil?

Yeah

1

lol thats kinda funny how many people who use this server are just the nootropics community rejects And not because this is the server for a blog about social rejection theories of schizophrenia either - but just because it happens to be the next best pharmacology place xdd (edited)

1

oh really

quite!

not been in the community ling enough to know

7:54 AM

but kinda homey here

7:55 AM

they like to argue a lot on other servers

yea it does have quite the particular vibe doesnt it (edited)

1

have yet to chime into the show and tell questionablescience initiated

7:56 AM

but it makes happy Smugonomics

Since I couldn’t bring myself to tell my friends anything

1

7:58 AM

really wanna make a permanent switch to freelance/working on projects alone. Picking up on C++ on my own and it would be dope if I get good enough to make games, apps, and the sort.

7:58 AM

just feel like im not really built for teamwork, and being in constant contact with people

1

7:59 AM

if theres anything i might be good at..helping people order their thoughts/rational

8:00 AM

anyway gn all

gn!!!!!!!

8:01 AM

Deleted User

lol thats kinda funny how many people who use this server are just the nootropics community rejects And not because this is the server for a blog about social rejection theories of schizophrenia either - but just because it happens to be the next best pharmacology place xdd (edited)

Nootropics community is like THE worst place to learn about pharmacology

3:03 PM

They jump to conclusions a lot and make claims with extremely little evidence

melon

really wanna make a permanent switch to freelance/working on projects alone. Picking up on C++ on my own and it would be dope if I get good enough to make games, apps, and the sort.

you could start off making game assets and selling those in the unity community

1

឵ComedownKid

Social confidence I think

What about social confidence in particular do you struggle with?

Like I described in the following messages up there

adenofthieves

I’m in Australia, Melbourne. I got banned off linked in and they won’t say why. I’m a Snowden Assange advocate from way back that used to believe truth was light. Now I believe truth is dark, so I don’t stick well on public forums. I’m trying again fr on reddit based off of my proven persona in discord

Since those platforms aren’t a good fit for you, try just joining networking specific facebook groups and joining meet ups on sites like meetup.com

1

឵ComedownKid

Like I described in the following messages up there

oh so just lack of energy

឵ComedownKid

Nootropics community is like THE worst place to learn about pharmacology

Depends on the community, the subreddit? Awful place. Nootopics? Awful place. But some of them actually do the work and verify their claims (edited)

3:10 PM

nootropics are literally the only reason i got into pharmacology lol

Empress of Cheer

oh so just lack of energy

Its not as much social confidence as it is an ease of socializing and a strong ability to do it well (that I think comes from the ease of socializing). The tiredness just makes it harder

💊 Peaches&Amphetamines💊

Depends on the community, the subreddit? Awful place. Nootopics? Awful place. But some of them actually do the work and verify their claims (edited)

Which?

឵ComedownKid

Its not as much social confidence as it is an ease of socializing and a strong ability to do it well (that I think comes from the ease of socializing). The tiredness just makes it harder

And you’re working on your sleep hygiene already?

Not specifying a community there, moreso some people ive met in the awful communities

Vitamin D is supposed to be really good for energy

Just saying you cant fit everyone that participates in those communities as not making legit claims

Maybe try 2000ug of Vitamin D every day for a bit

vitamins have done and never will do anything for me lol

3:14 PM

i get no noticeable difference

Empress of Cheer

you could start off making game assets and selling those in the unity community

@Empress of Cheer thank you so much GREAT IDEA

1

2

melon

just feel like im not really built for teamwork, and being in constant contact with people

You can hire me to do a lot of talking to your clients while you get the actual coding done

1

woahhh

3:16 PM

if I ever get to that point!

melon

if I ever get to that point!

what point are you at rn? where are you based?

1

I’m a complete amateur learning on my own

3:18 PM

no affilition or external help

melon

I’m a complete amateur learning on my own

that’s fine

1

3:22 PM

Like what coding do you know already

I’m in the process of learning C++

Oooooo it’s your first language

1

and fiddled around with python a little when making discord bots

1

melon

and fiddled around with python a little when making discord bots

You can sell discord bots on Fiverr

1

C++ is kinda easier to grasp

1

Empress of Cheer

You can sell discord bots on Fiverr

i did think about it!

3:23 PM

didnt think there would be a market for it

3:23 PM

thank you

melon

C++ is kinda easier to grasp

I heard C++ was harder!!

aaaaaa thank youuuuu

3:23 PM

ehhh

melon

didnt think there would be a market for it

I saw a few on there and I was about to commission someone to help me set up my discord and build bots for me before my bf was like “yeah why don’t i just teach you”

1

m…maybe cuz I jumped to c++ right after some acclimatizing from python and didnt learnt the full extent of python yet (edited)

1

Empress of Cheer

I saw a few on there and I was about to commission someone to help me set up my discord and build bots for me before my bf was like “yeah why don’t i just teach you”

woahh

I love my server profile here cause it’s like

3:25 PM

Dramatic face ✨

1

3:25 PM

Right next to “questionable science”

3:25 PM

Idk LOL

Anyway I’m glad you were able to get some halps

1

3:26 PM

Lmk if you have any other freelancing questions

1

3:27 PM

If you end up wanting to build Wordpress sites for $$$ lmk too

3:27 PM

I can make it extra easy for you LOL

oohh

We just have to figure out pricing

do you run a website builing business? (edited)

3:28 PM

ah right or maybe your bf used to do it

nope that was me

3:28 PM

just a smoll one to help me whenever i was unemployed LOL

1

oh!

3:30 PM

do you enjoy being employed more than being a freelancer? @Empress of Cheer

melon

do you enjoy being employed more than being a freelancer? @Empress of Cheer

It’s a little more stressful as a freelancer because I don’t like charging people more than they can afford but I also like working with small businesses and also if someone leaves because I charge so little it feels like a scramble to find someone new

oh…

But with the right team I could prolly charge more

1

yeah that’s understandable

I was only charging $800/mo per client for a website and light SEO

1

i also did skim over some quora answers amd they said the biggest competition are from the third world

3:33 PM

sorry if that sounds rude

3:34 PM

they’d be willing to work for less

Empress of Cheer

And you’re working on your sleep hygiene already?

Ya

Empress of Cheer

Vitamin D is supposed to be really good for energy

Send citation lol

឵ComedownKid

Send citation lol

never

5:50 PM

I’m questionable science

melon

sorry if that sounds rude

It’s not

1

melon

i also did skim over some quora answers amd they said the biggest competition are from the third world

But we also have various advantages over them

1

឵ComedownKid

Send citation lol

something something melatonin

1

5:52 PM

@qwerkyscience for real science

឵ComedownKid

They jump to conclusions a lot and make claims with extremely little evidence

Me lol (rip)

melon

really wanna make a permanent switch to freelance/working on projects alone. Picking up on C++ on my own and it would be dope if I get good enough to make games, apps, and the sort.

Making games seems really cool

qwerkyscience

Making games seems really cool

it does!! but the market is really saturated so I must compromise a little.

and appeal to popular tastes

1

melon

it does!! but the market is really saturated so I must compromise a little.

and appeal to popular tastes

Or you can be like Tolkien and say fuck it to what’s being made and create something else entirely

1

4:14 PM

Something new and brave and beautiful

2

python is practically pseudocode

7:46 AM

doesnt get much easier

Empress of Cheer

Or you can be like Tolkien and say fuck it to what’s being made and create something else entirely

how is tolkien a canonical example of this

Lovetron 9000

how is tolkien a canonical example of this

I’ve been told he basically invented Orcs and the like

Aesthetically orcs kinda reminiscent of tortured souls from hell with seared misshapen skin Conceptually alot like homunculi or fallen angels (warped elves/angels) (edited)

1

@Deleted User Tolkein's orcs are corrupted elves

yea

perhaps more punishing social defeat response encourages higher competence

https://youtu.be/GlOQdr4S95c

Prof. Edward Dutton: The Jolly Heretic

What is the Psychology of Bronies; of Grown Men Who Love My Little ...

5:56 AM

autism lol

6:01 AM

Most bronies Ive met have all been fun characters - eccentrics and weirdos Got to know the guy who ran the conventions for a bit, spent 24 hours a day in VRchat lol (seems to pay well) -taught me a thing or two about how to rig anime girls in unity (edited)

yea they are cringe and the idea of a bronie is putrid but I can relate considering transgenderisms just an autistic fixation of a sort too tho (edited)

9:53 AM

same thing with furries, theyve been pretty smart people the ones Ive met

9:54 AM

Ive met some awful furries tho and atleast one absolutely evil brony

9:55 AM

it was very surprising tho to find out that all these people Id been crossdressing with as anime girls in VR were what they were tho shouldnt have been too surprised i guess lol

Empress of Cheer

Vitamin D is supposed to be really good for energy

update after investigating this: It seems like the results are mixed. There's plenty of studies showing correlation with VidD deficiency, but I don't really consider that sufficient evidence to support supplementation. This one is my favorite, because it has a large sample size, and includes healthy people, and people with only daytime sleepiness and no other sleep disorders. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666927/

High-dose Vitamin D Supplementation and Improvement in Cognitive Ab...

Vitamin D may affect the modulation of signaling pathways in the central nervous system. We aimed to evaluate the effect of high-dose vitamin D supplementation on neuropsychological functions in female adolescents.We studied the effects of 9 weeks of ...

6:53 PM

it found a significant improvement in sleepiness but not a large one

6:54 PM

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912284/

Vitamin D Supplementation and Sleep: A Systematic Review and Meta-A...

Background: Vitamin D deficiency is associated with sleep disorders and poor sleep quality. Whether vitamin D supplementation (VDS) helps resolve these problems remains unclear. Objective: To systematically review the effect of VDS on sleep quantity, ...

1

6:55 PM

here's a review if anybody wants to look into more studies on this

7:01 PM

https://pubmed.ncbi.nlm.nih.gov/34881361/

No improvement of sleep from vitamin D supplementation: insights fr...

We were not able to demonstrate a significant effect of vitamin D supplementation on sleep in this vitamin D insufficient population.

7:01 PM

this one found no difference in anything but the sample size was much smaller

7:02 PM

and surpisingly, it actually says they only used vitamin D "insufficient" participants

It can impact stuff like magnesium. This could be one factor here. I think calcium may also be related to gabaergic signaling if I remember.

9:40 PM

But for me, vitamin d gives me insomnia pretty easily too

it increased sleeping time in one paper iirc

12:02 AM

so thats bropaply not a common effect

12:04 AM

Chewing gum seems to have a lot of beneficial effects, specifically on stress

1

12:04 AM

it increases arousal (not sexual) but I'm not sure how well-studied its effects on sleepiness are

12:06 AM

https://pubmed.ncbi.nlm.nih.gov/22123610/

The contrasting physiological and subjective effects of chewing gum...

Uncertainty exists with respect to the extent to which chewing gum may attenuate stress-induced rises in cortisol secretion (Johnson, Jenks, Miles, Albert, & Cox, 2011; Scholey et al., 2009; Smith, 2010). The present study used the Trier Social Stress Task (TSST: Kirschbaum, Pirke, & Hellham …

12:06 AM

⬇️ perceived social stress ⬆️ cortisol

12:07 AM

https://pubmed.ncbi.nlm.nih.gov/26090381/

Chew the Pain Away: Oral Habits to Cope with Pain and Stress and to...

The acute effects of chewing gum on cognitive performance, stress, and pain have been intensively studied in the last decade. The results have been contradicting, and replication studies proved challenging. Here, we review some of the recent findings of this topic and explore possible explanations f …

12:07 AM

review

Stimulates vagus nerve too

@Calico lol thought I recognized your name from somewhere

12:09 AM

check mutual servers

https://pubmed.ncbi.nlm.nih.gov/22061430/

The effect of chewing gum on physiological and self-rated measures ...

The proposition that chewing gum can improve alertness was investigated via both physiological and self-rated measures. The Pupillographic Sleepiness Test (PST) provided a measure of pupillary unrest (PUI); a physiological index of daytime sleepiness. Chewing gum reduced the extent of sleepiness as …

1:40 AM

n=30

Mint may have additional benefits but both unflavored and flavored gum are beneficial in something

5:48 AM

I think it was anxiety

Question

6:18 AM

Do HDAC inhibitors increase the activity of ligands to nuclear receptors?

Also

7:47 AM

Does anyone know what some good upregulators/activators of SIRT1, SIRT6 and SIRT7 proteins are?

henlo folks

3:40 AM

Oh

lov

Do HDAC inhibitors increase the activity of ligands to nuclear receptors?

@Scientists

3:41 AM

Maybe @Psychonauts

what if i lean extra hard into my kawaii persona

Sure lol

What’s it like?

qwerkyscience

Sure lol

What’s it like?

Nyaa~~

2

8:20 PM

LOL

oh god

3:17 AM

I hate how much I love those personas when talking to someone

1

3:18 AM

like actually speaking

3:19 AM

When I see it in text, I immediately think it's a young teenage boy who's "transitioning".... or femboy or whatever the correct term is

3:20 AM

Don't ask me why, maybe enough time on discord has influenced that stereotype forming in my mind

3:20 AM

I swear to god

3:21 AM

Close human contact like hugs etc is evil

1

3:21 AM

I was good before its influence (edited)

3:21 AM

now like a drug, I crave it in its absence

3:22 AM

And it feels worse without it, incentivizing me to seek it out

3:22 AM

But I won't bend to the inclination to reproduce with extra steps

3:24 AM

Steadfast, until an appropriate alternative, cure, prophylactic or too perfect a mate is found.

1

3:25 AM

The latter is difficult, very difficult, because the mind will create false memories, false everything to convince the more independent parts of the mind to go along with it, that that mate is perfect when they're not. Just to reproduce, god damn balls.

1

Empress of Cheer

what if i lean extra hard into my kawaii persona

What if

1

Any women @here with PCOS?

I'm male, but predicted PCOS genes and have done extensive reserach as my ex-wife of 10 years and current GF have it.

1

UltimApe

I'm male, but predicted PCOS genes and have done extensive reserach as my ex-wife of 10 years and current GF have it.

Do you know what's worked for them?

8:08 PM

I finally got my diagnosis

8:08 PM

And like

8:08 PM

I'm just so thrilled

I fixed current GF's menstural cycle timing by acting on gut bacteria related to inflammation and lipid function.

1

8:10 PM

she was at 3 months and now is down to monthly. I have no idea what I'm doing, but you may wanna look into the Mediterranean diet. People with PCOS genes who eat a healthy one seem to not have fertility symptoms. I think It's driven by stuff like butyrate/propinate/acetate in the gut.

8:10 PM

I'll find the study.

UltimApe

she was at 3 months and now is down to monthly. I have no idea what I'm doing, but you may wanna look into the Mediterranean diet. People with PCOS genes who eat a healthy one seem to not have fertility symptoms. I think It's driven by stuff like butyrate/propinate/acetate in the gut.

I love fish

8:11 PM

I don't eat it as much w my bf being allergic to shrimp and me only liking a few kinds

This one looks like a good review https://pubmed.ncbi.nlm.nih.gov/31547562/

Adherence to the Mediterranean Diet, Dietary Patterns and Body Comp...

Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder and is characterized by chronic anovulation, hyperandrogenism, and polycystic ovaries. Obesity, low-grade chronic inflammatory status, and insulin-resistance (IR) often coexist in PCOS. The Mediterranean diet (MD) is an an …

8:12 PM

A gotcha is that poor people tend to eat more carbs & less fresh food, and have worse outcomes. https://pubmed.ncbi.nlm.nih.gov/35334895/

Low Adherence to the Mediterranean Diet Is Associated with Poor Soc...

The Mediterranean diet (MD) is recognized as one of the healthiest dietary patterns as it has been consistently associated with several beneficial health outcomes. Adherence to the MD pattern has been decreasing in southern European countries for the last decades, especially among low socioeconomic …

8:13 PM

My ex's menstural pain lowered significantly when she cut out her daily soda and started walking to the bus.

8:16 PM

I've heard good things about inulin (a sort of fiber that is sweet) and myo-inositol, but the kind matters a lot. The idea seems to be it hits follicle stimulating hormone which impacts ovaries. I've been going via gut bacteria because it's my main obsession. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757431/

Intersection of Polycystic Ovary Syndrome and the Gut Microbiome

The etiology of polycystic ovary syndrome (PCOS) remains unclear, although studies indicate that both genetic and environmental factors contribute to the syndrome. In 2012, Tremellen and Pearce proposed the idea that dysbiosis of the intestinal (gut) ...

UltimApe

A gotcha is that poor people tend to eat more carbs & less fresh food, and have worse outcomes. https://pubmed.ncbi.nlm.nih.gov/35334895/

Yep that's what happened basically when I started trying to save money

UltimApe

I've heard good things about inulin (a sort of fiber that is sweet) and myo-inositol, but the kind matters a lot. The idea seems to be it hits follicle stimulating hormone which impacts ovaries. I've been going via gut bacteria because it's my main obsession. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757431/

I wonder if that's in sweet potatoes? Maybe that's why I like sweet potatoes lol

UltimApe

My ex's menstural pain lowered significantly when she cut out her daily soda and started walking to the bus.

I don't even do daily soda but I haven't been drinking as much coffee

8:19 PM

I usually don't even eat much sugar but since getting off my birth control, I'm less swollen but craving so much sugar lately

sweet potatoes are on my list of good foods for my GF. She's got type II diabetes associated with the PCOS and sweet potatoes are great here.

1

UltimApe

sweet potatoes are on my list of good foods for my GF. She's got type II diabetes associated with the PCOS and sweet potatoes are great here.

My dad had high blood sugar and my mom had low blood sugar so I'm like

8:20 PM

Why didn't the doctors catch this fucking sooner dude

hemoglobin A1C levels, the defacto measure, is a measure of levels over time - a sort of average that can be gleaned from acumulation of sugars on the heme (blood cells). its a shitty measurement if the problem is variability. High one moment and then low in the next would average out to "Normal". There is also a gene mutation tied to gout (uric acid) that makes high uric acid production even when A1C levels are "normal" and cause all the same kind of inflammation. Its really maddening. We can't get a real-time blood glucose meter to track this stuff for my GF until she gets to the point that she needs to take insulin.. but by that point her beta cells are already dead.

8:25 PM

Another fun one is that those finger tip SPO2 meters are known to fail with type II diabetics because the skin is thicker for some reason. So of course when the GF goes in to get a lung test, the lung specialist sees fine SPO2 and we can't convince them to order a blood O2 test. I've given up on doctors.

8:28 PM

They just follow procedure and best practice that is drilled into them. Nurses follow check lists. GF had a case of thrush in her troat recinetly. but she didn't have pain in it, so no one bothered to look and gave her meds that make thrush worse. The irony is she went to the ER specifically because of an asthma medication that causes thrush. told them she was having trouble breathing and her throat was closing up. They never even looked! I hate it.

8:29 PM

They miss things they don't look for. It took me litterally 2 seconds to shine a light in her mouth and see the fungal infection.

8:30 PM

They also recently tried to put her on an asthma medication that can cause schizophrenia. I've been trying to tell them she has odd dopamine genes and is at risk for schiz due to her diabetes, but they won't listen to me. So now she's at risk of being medically non-compliant.

8:31 PM

sorry, i'm sensitive right now. this has been causing a lot of stress for me.

Empress of Cheer

Do you know what's worked for them?

You may appreciate the collection on PCOS I keep here https://www.are.na/self-exploration/pcos-polycystic-ovarian-syndrome

PCOS - PolyCystic Ovarian Syndrome — Are.na

Are.na is a platform for connecting ideas and building knowledge.

1

If you like cooking, reddit has some good subreddits on meal prep, it seems to be an easy to way to stay on a meal plan. We're planning to move to a place where we can cook soon, so it's been on my mind lately. https://www.reddit.com/r/MealPrepSunday/ https://www.reddit.com/r/KetoMealPrep/ We're going to go keto for a bit and monitor blood sugar with a standard prick test and measure ketosis with urine test strips.

r/MealPrepSunday

r/KetoMealPrep

8:42 PM

Currently we're experimenting with https://huel.com/products/huel-hot-savoury which is an easy way to get fiber in and it seems to combat her drive to eat tons of sugar. Makes it possible to do without reliable access to amenities. IIRC it's custom designed by nutritionist to help with diabetes / insulin management. Seems fairly good. Tho it makes me gassy.

Huel Hot & Savory

Brand new! The delicious new Huel Hot & Savory is a nutritionally complete vegan meal packed with rice, quinoa, vegetables, herbs and spices. It’s ready in under 5 minutes and it contains a balance of carbs, protein, fats, fiber and all 27 essential vitamins and minerals. First time ordering Huel? Claim your FREE Huel T-shirt at checkout. All fi...

1

UltimApe

Currently we're experimenting with https://huel.com/products/huel-hot-savoury which is an easy way to get fiber in and it seems to combat her drive to eat tons of sugar. Makes it possible to do without reliable access to amenities. IIRC it's custom designed by nutritionist to help with diabetes / insulin management. Seems fairly good. Tho it makes me gassy.

Omg that's so sweet that you're sharing in her diet

8:43 PM

I've heard great things about huel

8:43 PM

I've been taking metamucil for fiber

I was doing th powder meal myself before, but stopped since they introduced the probiotics. they specifically compete with the ones I was trying to promote.

8:44 PM

The soups don't have it (yet), so that's nice.

8:45 PM

fiber type matters a lot as different bacteria turn them into different things. We focus on butyrate as it's the main anti-inflammtory.

1

UltimApe

They also recently tried to put her on an asthma medication that can cause schizophrenia. I've been trying to tell them she has odd dopamine genes and is at risk for schiz due to her diabetes, but they won't listen to me. So now she's at risk of being medically non-compliant.

Ahhh, I need someone like you in my life to look out for me

8:54 PM

My dad has some kind of schizo symptoms

8:58 PM

They told me to take chromium supplements

I'm not a doctor, so grain of salt. But I did notice an improvement when supplimenting chromium. It seems to be only needed if in a deficit tho.

1

9:03 PM

GF had been taking a pack of vitamins meant for diabetics. It also included silicon and a bunch of other things. We can't find it anymore tho, sadly.

1

I think I'm also going to do a sleep study

9:04 PM

I have low SHBG which apparently can be impacted by metabolic issues, sleep apnea, hypothyroidism

1

9:04 PM

My whole family snores like bears

9:04 PM

And since sleep apnea is associated with poor attention span??

9:05 PM

Yeah

In the future, more research is needed to explore the relationship between SHBG and PCOS, evaluate the effects of different interventions on SHBG levels and their therapeutic effects on PCOS. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818772/

huh, I guess there isn't much research on gut bacteria's impact on that.

Effect of Sex Hormone-Binding Globulin on Polycystic Ovary Syndrome...

Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases causing infertility in women of childbearing age. It is characterized by hyperandrogenemia (HA), chronic anovulation, and polycystic ovary morphology (PCOM). Most women with ...

1

9:09 PM

Study from feb 2022

Empress of Cheer

I have low SHBG which apparently can be impacted by metabolic issues, sleep apnea, hypothyroidism

What is the connection with SHBG and snoring? I figured the GFs was just the diabetes type II.

UltimApe

What is the connection with SHBG and snoring? I figured the GFs was just the diabetes type II.

Snoring is associated with sleep apnea which is associated with low SHBG

I love learning new things, then finding a recent study that is like "we don't know why this happens".

Although these studies suggest that hyperandrogenism is correlated with metabolic dysregulation, it is not understood why women with PCOS become insulin resistant and why they have a higher incidence of insulin resistance than predicted by their body mass index. Insulin resistance and hyperinsulinemia may contribute to metabolic dysregulation by upregulating ovarian androgen production and increasing androgen bioactivity through decreased sex hormone-binding globulin production https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309599/

Sex, Microbes, and Polycystic Ovary Syndrome

Recent studies have shown that sex and sex steroids influence the composition of the gut microbiome. These studies also indicate that steroid regulation of the gut microbiome may play a role in pathological situations of hormonal excess, such as PCOS. ...

1

I hate PCOS

9:16 PM

PCOS is a POS

lmao look at this wiki I found https://wiki.chadnet.org/

Library of Chadnet

The greatest website on the interwebz!

what if instead of saying “kyaaa~” I said “kyãã”

mispelling is cuute i think shows vunerable!! like you need taken care of!!

https://www.ewg.org/foodnews/summary.php

EWG’s 2022 Shopper’s Guide to Pesticides in Produce™

EWG's Shopper’s Guide to Pesticides in Produce™

What do you guys think about this mans claims? https://youtu.be/VzGKem6wp8s

sv3rige

Seeds: Why Most People Are Mentally Ill

1

Deleted User

What do you guys think about this mans claims? https://youtu.be/VzGKem6wp8s

vegetable oils are very damaging but its not the only issue.

Deleted User

What do you guys think about this mans claims? https://youtu.be/VzGKem6wp8s

This particular YouTuber is a bit weird. He suggests staring at the sun and stuff like that (edited)

6:05 AM

I wouldn’t recommend his content but he might say occasional true things

6:05 AM

He also definitely says sketchy things

he does seem kinda sour!

6:13 AM

he has a bit of the "holier than thou" atheism thing going on lol

Anyone @here have any favorite debate streamers / youtubers?

Educational channels??

imagin posting sverige non ironically

1

hmm i like distributist, whatifalthist, contrapoints, not just bikes, practical engineering, geography now, jreg, mental outlaw

1

1:05 PM

numberphile, sixty symbols

1

1:06 PM

and theres a lot more but thats just some of the top of some of my main favorite topic categories

1

1:08 PM

distributist is like one of the only religious conservative youtubers i really respect

1

1:09 PM

geopop is good source of content about geopolitics but it isnt original content

bleet

hmm i like distributist, whatifalthist, contrapoints, not just bikes, practical engineering, geography now, jreg, mental outlaw

Jreg, zased!!!

Ahhh heck I need to write all these down, those are quite a lot (edited)

oh technology connections is actually really good and actually practically useful

7:52 PM

he does like 40 minute videos about dishwashers or AC systems

7:52 PM

and they are actually not super boring

7:53 PM

i dont have a lot of reapect for ‘debaters’ i general - i think debate is a waste of time, it’s like watching sports more than it is like dialogue

Empress of Cheer

Any women @here with PCOS?

Here, will check through this later

1

Empress of Cheer

Any women @here with PCOS?

I have been diagnosed with cysts, but I still don't know if I have the typical PCOSyndrome But my ovaries don't work properly that's a fact. Because of that i have never had normal cycles/regular cycles and my hormones were dysbalanced. Childhood prepuberty was messed up in some ways which makes me believe it's not just the ovaries (tbf pcos is a neurological syndrome anyways) and then puberty kicked in and it got really bad.

I was forced to wait it out (my parents didn't let me get help) , but it didn't get better and I didn't know back then what to do about it besides that you should probably go to a doctor. So I just did other things like all kinds of diets (low calorie, Mediterranean, low fat, low sugar, high veggie and fruits/high fiber, unprocessed, glutenfree, lactosefree etc) sleep cycles (sleep withdrawal, polyphasic sleep) There are different things that help imo and you just have to try. A lot of women do say that carbohydrates cause issues and I agree, i do best on a ketogenic or even better carnivore diet. But there's also some women who do best on a mixed diet and need carbs, complex ones and also in a balance. Sleep matters too. Stress and a bad sleep schedule will screw up all hormones. If you have those basics down you can go on further because pcos can be so severe it requires strong medicational therapy in some cases. But again, everyone is different. For some women controlling their insulin resistance with diet and exercise fixes everything. I'm a really bad case, I probably still have cysts/will always have them In my case diet, sleep (sleeping too much is bad for me so i prefer to sleep too little and catch up some days) and avoiding stress are absolutely necessary basics.

For my androgen problems Dutasteride helps but for a lot spironolactone or other antiandrogens help. I personally am profiting from testosterone, but dihydrotestosterone is bad for me. Since diet, avoidance of stress and proper sleep all contribute to better insulin resistance and help pcos that way too, inositol, specifically myoinositol can help. But also other compounds as well... I am skimming through what others wrote, they kinda stated all that already. About diet, if you have for instance estrogen dominance or even actual excess, then soy can make it worse too. On the other hand it can make it better if you're low on both progesterone and estrogen and androgens are high, trial and error I guess, although you should always first get blood levels tested multiple times (the time of day matters as well as month of course, or time of months if you don't have a regular cycle) so you know what you start out with.

9:33 AM

Also not just soy but other phytoestrogens can be absorbed through skin like through bodylotions. BPA from plastic is bad in general, it causes metabolic and hormonal dysbalance, the more you consume the worse. In pregnant women it alters the fetus' health forever, but I am not sure how longterm the impact is on adults if they stop it, I would have to look it up.

UltimApe

I've heard good things about inulin (a sort of fiber that is sweet) and myo-inositol, but the kind matters a lot. The idea seems to be it hits follicle stimulating hormone which impacts ovaries. I've been going via gut bacteria because it's my main obsession. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757431/

this is great!

9:40 AM

regular bowel movements are important too because constipation can also cause one to reabsorb estrogen more? At least that is a theory but I don't know exactly. Hormonal dysbalance affects bowel movements of course too. This article has nice info on it: https://centrespringmd.com/estrogen-metabolism-detoxification-reduce-breast-cancer-risk-with-healthy-estrogen-levels/

CentreSpringMD

Estrogen Metabolism + Detoxification: Reduce Breast Cancer Risk wit...

Do you have a family history of breast cancer? Do you have difficulty sleeping or experience hot flashes? If so, it may be because your estrogen levels are out of balance. Estrogen metabolism and detoxification is the process by which the body breaks down estrogens to prevent leftover estrogen metabolites causing problematic side effects and […]

UltimApe

hemoglobin A1C levels, the defacto measure, is a measure of levels over time - a sort of average that can be gleaned from acumulation of sugars on the heme (blood cells). its a shitty measurement if the problem is variability. High one moment and then low in the next would average out to "Normal". There is also a gene mutation tied to gout (uric acid) that makes high uric acid production even when A1C levels are "normal" and cause all the same kind of inflammation. Its really maddening. We can't get a real-time blood glucose meter to track this stuff for my GF until she gets to the point that she needs to take insulin.. but by that point her beta cells are already dead.

oh yes and about gout: it's best not to start and stop severely low carb diets because it can cause release of uric acid and cause acute inflammation. That's why better go slow and also stick with it long enough instead of yoyoing back and forth, and if introducing carbs, starting low.

hey @Sirsadalot

Empress of Cheer

Anyone @here have any favorite debate streamers / youtubers?

Educational channels??

@Empress of Cheer Destiny and MrGirl and Brittney Simon

bleet

hmm i like distributist, whatifalthist, contrapoints, not just bikes, practical engineering, geography now, jreg, mental outlaw

I would consider Contrapoints more of an entertainer than anything else

bleet

oh technology connections is actually really good and actually practically useful

agree

UltimApe

They just follow procedure and best practice that is drilled into them. Nurses follow check lists. GF had a case of thrush in her troat recinetly. but she didn't have pain in it, so no one bothered to look and gave her meds that make thrush worse. The irony is she went to the ER specifically because of an asthma medication that causes thrush. told them she was having trouble breathing and her throat was closing up. They never even looked! I hate it.

oral thrush? that was the next thing I wanted to mention Candida can be a major problem and link between all these issues as well. First of all one can be susceptible to candida overgrowth just like that, genetically, or through an acquired immune deficiency like after receiving antibiotics and wrecking the gut biome or taking medications like corticosteroids that can facilitate the growth of candida, but there's more. Estrogen facilitates the growth of it too, which is why estrogen dominance is another factor to consider. Additionally candida overgrowth itself can shift the body into estrogen dominance. And insulin resistance can of course contribute to that. High blood sugar levels feed candida more, high carb diets as well. but even on a lowcarb diet or zerocarb there can still be systemic overgrowth. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360257/ same article 2 different sites: https://www.sciencedirect.com/science/article/pii/S2211124721016831 and https://www.biorxiv.org/content/10.1101/2020.07.22.207191v1.full Another issue why Candida but also other metabolism issues are linked to PCOS or generally ovarian cysts is Acetaldehyde: https://www.biorxiv.org/content/10.1101/143495v1.full https://pubmed.ncbi.nlm.nih.gov/22909057/#:~:text=Conclusions%3A%20Candida%20albicans%20isolated%20from,upregulation%20of%20candidal%20acetaldehyde%20metabolism. Candida produces acetaldehyde, especially during die off. Mine was so bad I had extremely high inflammatory levels, in the blood and in stool. My doctors thought I had IBD for a while... Molybdenum Glycinate binds with acetaldehyde and prevents its toxic effects on the body, so a longterm supplementation but especially during times you induce die off like through antifungals is important.

Cellular and Molecular Biology of Candida albicans Estrogen Response

Candida albicans is the most common etiological agent of vaginal candidiasis. Elevated host estrogen levels and the incidence of vaginal candidiasis are positively associated. Elevated estrogen levels may affect host and/or fungal cells. This study investigates ...

Oestrogen promotes innate immune evasion of Candida albicans throug...

Gender is a risk factor for several infections that, for many pathogens, has been linked to sex hormones impacting host immunity and directly affecting microbial virulence. Candida albicans is a commensal of the urogenital tract and the predominant cause of vulvovaginal candidiasis (VVC). Factors that increase circulatory oestrogen levels like p...

Polycystic Ovary Syndrome as an Endogenous Alcoholic Polycystic Ova...

Polycystic ovary syndrome (PCOS) is a growing worldwide public health problem that affects millions of women in their reproductive age. Despite being a very common disorder among women, there are still gaps regarding knowledge of disease mechanisms. In this respect, it was recently reported that acetaldehyde (ACD) is endogenously formed during n...

Production of carcinogenic acetaldehyde by Candida albicans from pa...

Candida albicans isolated from potentially carcinogenic oral diseases can produce mutagenic amounts of acetaldehyde. Cigarette smoking and alcohol consumption may favour adaptational changes resulting in the upregulation of candidal acetaldehyde metabolism.

2

Totouroboros Totouboros

oral thrush? that was the next thing I wanted to mention Candida can be a major problem and link between all these issues as well. First of all one can be susceptible to candida overgrowth just like that, genetically, or through an acquired immune deficiency like after receiving antibiotics and wrecking the gut biome or taking medications like corticosteroids that can facilitate the growth of candida, but there's more. Estrogen facilitates the growth of it too, which is why estrogen dominance is another factor to consider. Additionally candida overgrowth itself can shift the body into estrogen dominance. And insulin resistance can of course contribute to that. High blood sugar levels feed candida more, high carb diets as well. but even on a lowcarb diet or zerocarb there can still be systemic overgrowth. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360257/ same article 2 different sites: https://www.sciencedirect.com/science/article/pii/S2211124721016831 and https://www.biorxiv.org/content/10.1101/2020.07.22.207191v1.full Another issue why Candida but also other metabolism issues are linked to PCOS or generally ovarian cysts is Acetaldehyde: https://www.biorxiv.org/content/10.1101/143495v1.full https://pubmed.ncbi.nlm.nih.gov/22909057/#:~:text=Conclusions%3A%20Candida%20albicans%20isolated%20from,upregulation%20of%20candidal%20acetaldehyde%20metabolism. Candida produces acetaldehyde, especially during die off. Mine was so bad I had extremely high inflammatory levels, in the blood and in stool. My doctors thought I had IBD for a while... Molybdenum Glycinate binds with acetaldehyde and prevents its toxic effects on the body, so a longterm supplementation but especially during times you induce die off like through antifungals is important.

Molybdenum you say? "Revisit gut microbiota and its impact on human health and disease" [JUL 2019] from 'Journal of Food and Drug Analysis' highlights some additional insights to the Molybdenum/bacteria related inflammation processes aside from butyrate/propionate levels. https://doi.org/10.1016/j.jfda.2018.12.012

https://www.youtube.com/watch?v=RWkv9ad7zvc

MedCram - Medical Lectures Explained CLEARLY

Sauna Benefits Deep Dive and Optimal Use with Dr. Rhonda Patrick & ...

thought patterns

11:24 PM

I never heard them cut out

11:24 PM

I only heard qs cut a tiny bit

https://theswaddle.com/regular-blood-donations-can-reduce-toxic-forever-chemicals-in-the-bloodstream-study/

Regular Blood Donations Can Reduce Toxic Forever Chemicals in the B...

"While both interventions are effective at reducing PFAS levels, plasma donations were more effective and corresponded to a 30 percent decrease."

I chose clothing for Empress of Cheer today

6:16 AM

1

https://www.reddit.com/r/Nootropics/comments/kzhg6d/i_consumed_large_amounts_of_semax_selank_and_p21/ kids are way smarter than we give them credit

r/Nootropics - I consumed large amounts of Semax, Selank, and P21 i...

10 votes and 31 comments so far on Reddit

Empress of Cheer

Click to see attachment 🖼️

@utheraptor i been posting this kinda stuff for a while now lololol

Why couldn't gare post this tho laserlol

7:06 PM

I post aesthetic girly things to my friends too

i only post manly things like sewer pipes

4

7:06 PM

utheraptor

I post aesthetic girly things to my friends too

BUT why would he be posting EMPRESS OF CHEER STUFF lolol

bleet

Click to see attachment 🖼️

so manly

7:07 PM

(I am just shitposting, I trust that you are not the same person lol)

1

I’ll find something girly in my camera roll

1

7:11 PM

i think the math is wrong in some ways

1

7:11 PM

I feel like discord somehow makes colors look more washed out in my photos

1

qwerkyscience

Click to see attachment 🖼️

so delicate and sweet

1

Anyone here want to debate with David Weiss about the shape of the earth? No anti flat earthers allowed. Don't bother if you are. I'll know. It will be live streamed on Syncretism Society's youtube channel. Lmk asap. DM me. https://www.youtube.com/channel/UCpDrSOtQ552LXmdRVYvTLyQ/featured

Syncretism Society

We greatly appreciate your donations! To continue to support the Grand Rise of the Syncretism Academy please use our new PayPal, https://www.paypal.com/paypalme/SyncretismSociety?locale.x=en_US If possible when making your donation please send it via “Friends and Family” not “Goods and Services”. Join us on Instagram for daily updates on ...

egg!!!

Empress of Cheer

Anyone @here have any favorite debate streamers / youtubers?

Educational channels??

I'm a fan of the following youtube channels. I don't use twitch. I used it when it used to be justin tv, but only when it would stream nature documentaries on loop, shit was lit. There were vg streamers, irl streamers and a couple other genres in the early days too, but even when twitch blew up, those more rare genres took a while to grow. Youtube: Casually Explained, Jay Foreman, The Drug Classroom, Max Planck Institute for Intelligent Systems, francischeefilms, Fundamentals of Biochemistry, Psychopharmacology Institute, Daniel Sýkora, Bryan Maltais, Kyle Sullivan, OverClocked ReMix: Video Game Music Community, Matthewmatosis, Murmus CTF, Internet Storm Center Stormcast, cybercdh, GynvaelEN, Ninh Ly, VoxDev, PBS ReInventors, Quanta Magazine, Infinite Backlog, Black Hills Information Security, Charles Lumpkin, GeoWizard, PBS Infinite Series, Internet Historian, Abandonia, Mark Johnson, James Tanton, Shut Up & Sit Down, Psychopathology and Phenomenology, 4096, Sacha Epskamp, Psychofarm, Stillpoint, Jonas Čeika - CCK Philosophy, Shaybs, Institute for Advanced Study, Caribou-kun, geoffmackley, F. Perry Wilson MD, PilotRedSun, Lawrence Krauss, Incognito Mode, PBS Space Time (edited)

12:53 PM

A few of these are entertainment channels

lol

2

@qwerkyscience

the desire to be futuristic

1

lov

I'm a fan of the following youtube channels. I don't use twitch. I used it when it used to be justin tv, but only when it would stream nature documentaries on loop, shit was lit. There were vg streamers, irl streamers and a couple other genres in the early days too, but even when twitch blew up, those more rare genres took a while to grow. Youtube: Casually Explained, Jay Foreman, The Drug Classroom, Max Planck Institute for Intelligent Systems, francischeefilms, Fundamentals of Biochemistry, Psychopharmacology Institute, Daniel Sýkora, Bryan Maltais, Kyle Sullivan, OverClocked ReMix: Video Game Music Community, Matthewmatosis, Murmus CTF, Internet Storm Center Stormcast, cybercdh, GynvaelEN, Ninh Ly, VoxDev, PBS ReInventors, Quanta Magazine, Infinite Backlog, Black Hills Information Security, Charles Lumpkin, GeoWizard, PBS Infinite Series, Internet Historian, Abandonia, Mark Johnson, James Tanton, Shut Up & Sit Down, Psychopathology and Phenomenology, 4096, Sacha Epskamp, Psychofarm, Stillpoint, Jonas Čeika - CCK Philosophy, Shaybs, Institute for Advanced Study, Caribou-kun, geoffmackley, F. Perry Wilson MD, PilotRedSun, Lawrence Krauss, Incognito Mode, PBS Space Time (edited)

SO MANYYY and I haven't heard of most of these

bleet

i think the math is wrong in some ways

idek what the math is solving for lol

bleet

Click to see attachment 🖼️

Those aren’t sewer pipes though

i know

hi

12:44 AM

have you fulfilled your daily quota of sleepies and nutritions?

maybe

1

1:26 PM

lol what fine advice (edited)

1:26 PM

cool etymology tho

It an actual problem I have. I recently brought this up that my downside is indecisiveness and the upside is openness/also indecisiveness

1

qwerkyscience

It an actual problem I have. I recently brought this up that my downside is indecisiveness and the upside is openness/also indecisiveness

I mean it's just a matter of knowing what you want and prioritizing that

Yess

3:42 PM

For me it’s the knowing what I want part that’s hard

qwerkyscience

For me it’s the knowing what I want part that’s hard

In what sense? Like can I have an example?

Hmm I want a lot of things but it’s hard to decide one single goal

4:28 PM

Not sure about specifics. I want to go deeper into academia but I also want to leave academia and do full on YouTube stuff. And I want to pull off science outside of academia

Deleted User

Click to see attachment 🖼️

i call doing this preference for fast choice of a heuristic that doesn’t have super glaringly obvious issues over optimization

6:29 PM

and usually afterwards i dont regret it because i dont usually rhink about the past much

qwerkyscience

Not sure about specifics. I want to go deeper into academia but I also want to leave academia and do full on YouTube stuff. And I want to pull off science outside of academia

why do you wanna go deeper

Because I’m not done learning and it gives more time to write and think about the world

qwerkyscience

It an actual problem I have. I recently brought this up that my downside is indecisiveness and the upside is openness/also indecisiveness

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083454/

Beta-Blocker Propranolol Modulates Decision Urgency During Sequenti...

Arbitrating between timely choice and extended information gathering is critical for effective decision making. Aberrant information gathering behavior is thought to be a feature of psychiatric disorders such as schizophrenia and obsessive-compulsive ...

1

10:43 PM

might be of interest

https://youtu.be/IkY2s1I5gfs

Analyze & Optimize

Why Fluoride is in the Water | The Shocking History of Water Fluori...

𝖀𝖝𝖐𝖚𝖊𝖑𝖑

https://youtu.be/IkY2s1I5gfs

cause they caught onto why the bromide was being put in it (edited)

damn i got banned from sirsads server

8:54 AM

for saying that if youve got no social life irl and spend all day on discord that at that point alcohols worth a try

8:55 AM

Tbh our generation drinks far less than any generation before us and struggles with far more mental health issues, specifically loneliness, isolation, and lack of community (edited)

8:56 AM

I do genuinely think not only our culture, but even potentially our biology's evolved in such a way to be adapted and dependent on it to a degree

8:57 AM

You can see it in populations that have drank for hundreds of years in the differences in enzyme expression But could a shift in one chain of the pathways not possibly shift expression in all the rest? (edited)

8:57 AM

I dont know, but it certainly sounds possible

8:59 AM

I was even advocating stuff like setting strict predetermined limits, I personally never use alcohol unless its a social situation My point was that you'd atleast ought to suggest some alternatives rather than just push the hard puritan message of it as evil (edited)

that's why i hang out with stoners and go from stoner to stoner

9:01 AM

but i do drink too

adenofthieves

that's why i hang out with stoners and go from stoner to stoner

ya they are not a fan of weed either

9:04 AM

the one time I mentioned it I got treated pretty holier than thou by the person I was talking to (edited)

damn

9:08 AM

missin out

I wanna find the discord where all the Wikipedia editors hang out

12:31 PM

Omg can you imagine the conversations with those people!?? Xddd

12:31 PM

I’ve met one and they reply crazy long responses

Deleted User

for saying that if youve got no social life irl and spend all day on discord that at that point alcohols worth a try

Can you not see how your wording could come off as condescending and as tho you’re advocating for alcoholism at a glance tho

Empress of Cheer

Can you not see how your wording could come off as condescending and as tho you’re advocating for alcoholism at a glance tho

Ya rip I came back to delete this regret writing it now But to be fair I didn’t start with that point but ended with it, it was just the last straw Reading what I wrote backwards gives a better of the context aaaa (edited)

1

Deleted User

I do genuinely think not only our culture, but even potentially our biology's evolved in such a way to be adapted and dependent on it to a degree

It’s the plastic isn’t it

1:54 AM

lost my drawing tablet pen so all i can do is doodle stuff that doenst need to be perfect in every stroke (no anime girls rip) (edited)

1:56 AM

would be cool to add a person laying across it when Ive got a finer tool to draw it tho (edited)

Original message was deleted or could not be loaded.

I kinda like it tho

2:18 AM

Reminds me of like a psychedelics coloring book

Deleted User

Click to see attachment 🖼️

what program u use for that?

Rancicl

what program u use for that?

Mspaint lol

https://lizardlabs.eu/retailers/ anyone know which of these send to UK ?

Lulz

Let's oversimplify complx science:

Seeking pleasure will always cause a dysphoric kickback.
- Challenging yourself through unpleasant experiences (like: exercise, cold shover, long term goal commitment) will feel good on the long term after the challenge and it builds up your character.

8:39 PM

Would it even be possible to achieve a robust resistance for all discomfort? Even with an access for all substances in the world, with infinite supply, would you be able to eliminita all human suffering and achieve an endless gold mine of reward?

--- Basically: -D-amphetamine + Oxymorphone -Ketamine for tolerance reduction

Pregabalin for suffering reduction
kor antagonist Nor-BNI to combat dysphoria
Stress free environment in your drug den bunker and no caffeine because it is stressfull
Keto diet with optimal amount of daily exercise
All minerals and supplement in perfect order. I think this would keep you happy quite long

8:51 PM

--- I am sure that you cannot just force the feeling of wellbeing only with drugs. I can confirm myself that unhealthy life and obesity makes all drugs just stall.

8:56 PM

--- I am also sure that drugs become pointless if one's basic needs are fullfilled. Not even opioids are cure for everything. Buprenorphine was quite nice for sure, but I wasn't able to play videogames because I felt just too slow. I remember when I was young, video game flow state felt better than any drug ever.

Jyhoman

Would it even be possible to achieve a robust resistance for all discomfort? Even with an access for all substances in the world, with infinite supply, would you be able to eliminita all human suffering and achieve an endless gold mine of reward?

Not with chemicals in the equation no

Jyhoman

Would it even be possible to achieve a robust resistance for all discomfort? Even with an access for all substances in the world, with infinite supply, would you be able to eliminita all human suffering and achieve an endless gold mine of reward?

Kind of, that is the goal of old school buddhist monks and Sadhus from Hinduism, those guys live through pretty hard living conditions most often and they will report bliss as they grow old (edited)

11:11 AM

I think using substances to acheive such a goal is total dead end though

11:13 AM

what you describe sounds like descending into hell honestly

11:14 AM

so let's have an amphetamine addiction, an opiate addiction, a gabbaergic addiction and a ketamine addiction YAY all those finally stop working as intended and I don´t think I have to explain what it's like to withdraw from opiates or gabbaergic drugs

11:14 AM

Stick to the old school meditating for ten years and smoking hash in a shillum

‍♀️

Jyhoman

Would it even be possible to achieve a robust resistance for all discomfort? Even with an access for all substances in the world, with infinite supply, would you be able to eliminita all human suffering and achieve an endless gold mine of reward?

You could probably sacrafice accomplishing things in life like creating art and family to avoid discomfort (edited)

I was writing about this jn somewhere else. Delusions of grandiosity and projection are 2 tools that give you robust resistance to most discomfort. As long as you feel in control, your ability to tolerate is endless. Speaking as someone who used to self-administer electrocution, you're invincible if you're in control. The thing is many don't feel in control even when they are. Projection works when facing someone who is the cause of your discomfort, mike tyson spoke about how he'd use this in his fights.

1

4:45 PM

Certain drugs provides this

4:45 PM

but their temporary nature is the issue

Jyhoman

--- Basically: -D-amphetamine + Oxymorphone -Ketamine for tolerance reduction

Pregabalin for suffering reduction
kor antagonist Nor-BNI to combat dysphoria
Stress free environment in your drug den bunker and no caffeine because it is stressfull
Keto diet with optimal amount of daily exercise
All minerals and supplement in perfect order. I think this would keep you happy quite long

also, keto is dangerous for intense exercise afaik because using fatty acids as an energy source requires more oxygen and if the heart isn't getting enough, it could result in heart damage. Insulin resistant people and those with clogged arteries face this problem. Both being the possibility of insufficient oxygen but for different reasons.

Jyhoman

--- Basically: -D-amphetamine + Oxymorphone -Ketamine for tolerance reduction

Pregabalin for suffering reduction
kor antagonist Nor-BNI to combat dysphoria
Stress free environment in your drug den bunker and no caffeine because it is stressfull
Keto diet with optimal amount of daily exercise
All minerals and supplement in perfect order. I think this would keep you happy quite long

I've done both stimulant + opioid for an extended period as well as pregabalin + opioid for an extended period. One of the biggest issue with this is while it works near perfectly for discomfort resistance and a small amount of well-being. But it doesn't work well ime for motivation. In fact, it kills it. Imagine hanging right before the bottom of the barrel, unable to reach it, when you reach it, you usually start fighting for improvement. A mildly happy life free of discomfort isn't all that it's cracked up to be without substance and meaning, and these methods don't help with seeking meaning. Worst of all, I for example knew/knows what to do, but yet couldn't do much. Same for others I know who've used these methods. And worst of all, it's killed our abilities to tolerate discomfort sober, and sobriety has become near intolerable. I personally have issues that can make my sober life a living hell, but before the drugs, I figured out a way to tolerate it, now those methods aren't enough. It's harder knowing there's a superior solution. But I'm not as smart as I naturally am like this. Nor were those I know who did this.

4:58 PM

It may seem idiotic that I still think there are drugs that work, but I do

4:58 PM

Well, they did work long ago

4:58 PM

Although my health isn't the best rn, so doubt I can use it the same until I improve it

4:59 PM

DMAA works well to motivate you to move and do physical stuff. Chores, exercise, cleaning etc

5:00 PM

Lorazepam works well for the comedown.

5:00 PM

GHB works well for something in the evening/night to do, something to look forward to doing later in the day. (edited)

5:01 PM

All 3 worked for me near daily for a year or 2 without issue. Made me successful at all my endeavours and life great.

5:02 PM

When I needed to actually do thinky work, nothing beats sobriety.

5:03 PM

Creativity....nothing beats low dose combo of: pregabalin, tramadol & sulpiride (all without tolerance)

5:03 PM

This is a magical combo for creativity.

5:04 PM

Tramadol's ability to lower gaba release is helpful here imo

5:05 PM

Sulpiride's ability to release dopamine (even in the pfc) is useful here as well as it's stimulation of the ghb receptor.

5:06 PM

Both of these help to offset pregabalin's effects on the pfc and return you to your smarter baseline. But retaining the properties outside here that improves creativity.

5:06 PM

I am transparent in everything I do, but sometimes I feel like I shouldn't share my creativity combo since I can probab use this to my advantage lol, but fuck it.

Neti

You could probably sacrafice accomplishing things in life like creating art and family to avoid discomfort (edited)

You need to live a very special type of life for this to work. Being near nature, meditating, living a simple life, living a life of giving whilst under the belief that you have nothing of value to give, taking part in the lives of the less fortunate in a detached way where you have no stakes in the outcome. This allows you to continually do your work without breaking, remaining objective and able to help to the best of your ability.

5:11 PM

Without some special life, this eventually leaves an existential discomfort.

5:11 PM

Oh, another way is to isolate yourself from humanity for extended periods of time. This works, but it....does things to your mind.

lov

I was writing about this jn somewhere else. Delusions of grandiosity and projection are 2 tools that give you robust resistance to most discomfort. As long as you feel in control, your ability to tolerate is endless. Speaking as someone who used to self-administer electrocution, you're invincible if you're in control. The thing is many don't feel in control even when they are. Projection works when facing someone who is the cause of your discomfort, mike tyson spoke about how he'd use this in his fights.

I have some stuff written up about projection on r/defining concepts

Jyhoman

--- Basically: -D-amphetamine + Oxymorphone -Ketamine for tolerance reduction

Pregabalin for suffering reduction
kor antagonist Nor-BNI to combat dysphoria
Stress free environment in your drug den bunker and no caffeine because it is stressfull
Keto diet with optimal amount of daily exercise
All minerals and supplement in perfect order. I think this would keep you happy quite long

bro why dont I see psychedelics in here

lov

This is a magical combo for creativity.

doubt

Neti

You could probably sacrafice accomplishing things in life like creating art and family to avoid discomfort (edited)

wtf why are you trying to avoid discomfort

Where do you get norbni

lov

Creativity....nothing beats low dose combo of: pregabalin, tramadol & sulpiride (all without tolerance)

I’ve been trying to figure out what exactly makes Tramadol so unique and magical compared to everything else I’ve tried. The “first” high that comes before the opiate high (which usually begins ~4hrs in) feels like increased creativity, motivation, focus, and insanely reduced friction for initiating actions, and the craziest thing is there’s absolutely no comedown.

4:45 AM

Another thing I would add, I used to take 50-100mg of tramadol but now I feel like I get 80% of the effect (esp the opiate part) with just 20mg (a fifth of a 100mg pill) and even that sometimes has me nodding in the evening

Deleted User

I’ve been trying to figure out what exactly makes Tramadol so unique and magical compared to everything else I’ve tried. The “first” high that comes before the opiate high (which usually begins ~4hrs in) feels like increased creativity, motivation, focus, and insanely reduced friction for initiating actions, and the craziest thing is there’s absolutely no comedown.

When I take serotonergic psychedelics I get these effects with reduced friction for initiating actions. It’s one of their main utilities for me. Tramadol is serotonergic also

Lovetron 9000

doubt

no u

9:09 PM

Are there any nootropics that can offset some of the more noisy aspects of such a psychedelic so you can utilize it at a low yet active dose, for the purpose of generating ideas in a more controlled manner

9:09 PM

I am thinking things like guanfacine or low dose sulpiride might work

9:10 PM

It doesn't seem to me like stimulants would work due to outside effects from the ones you want actually making it worse

9:10 PM

You want something concentrated enough to the pfc in desirable activity vs negative outside effects (edited)

9:11 PM

There are probab a few normal nootropics that work, just I'm not familiar enough with them anymore to speak about their utility here

lov

Are there any nootropics that can offset some of the more noisy aspects of such a psychedelic so you can utilize it at a low yet active dose, for the purpose of generating ideas in a more controlled manner

noisy? wdym?

qwerkyscience

When I take serotonergic psychedelics I get these effects with reduced friction for initiating actions. It’s one of their main utilities for me. Tramadol is serotonergic also

Interesting. Lately on serotonergic hallucinogens (like half the time) I find myself having the hardest time initiating (physical) action, having to think through every aspect of the action to make sure it’s “valid”

1

11:55 PM

An example that comes to mind from a recent trip is one where I couldn’t get up at all because every time I tried to I felt like I had my phone (or something valuable) in my lap that would fall and break, so I had to make sure I could “safely” get up, which was something that took forever while in that tripping state

11:56 PM

Probably wasted half that trip trying to figure out whether or not I could get up LOL

It took me like 10 minutes to check my email when I was peaking

10:14 PM

I need to trip again so I can try to induce synesthesia

Deleted User

I’ve been trying to figure out what exactly makes Tramadol so unique and magical compared to everything else I’ve tried. The “first” high that comes before the opiate high (which usually begins ~4hrs in) feels like increased creativity, motivation, focus, and insanely reduced friction for initiating actions, and the craziest thing is there’s absolutely no comedown.

well when you have an opiate that also have potent serotoningeric activity no doubt if you like serotinin drugs it feels like heaven also it keeps you a. bit stimulated while you're just a slug on most opioids

6:51 PM

it's like both endorphin and serotonin overload it made me feel at the top of the world too

6:52 PM

I still don’t understand why It's a medication, the serotoninergic effects do nothing to kill the pain and is actually dangerous is abused or mixed with other drugs wile there areway safer opioids

tramadol lowers gaba release a bit, don't recall where in the brain this is most active though

lov

tramadol lowers gaba release a bit, don't recall where in the brain this is most active though

opioid and serotinin systems?

7:30 PM

The R- and S- enantiomers of tramadol act on different receptors in a complimentary manner. The R- enantiomer is a selective agonist of the mu receptors and inhibits serotonin reuptake while the S- enantiomer inhibits noradrenaline reuptake. Tramadol acts as an opioid receptor agonist,[11][12] serotonin releasing agent,[12][4][13][14] norepinephrine reuptake inhibitor,[12] NMDA receptor antagonist,[15] 5-HT2C receptor antagonist,[16] (α7)5 nicotinic acetylcholine receptor antagonist,[16] and M1 and M3 muscarinic acetylcholine receptor antagonist.[17][18]

7:31 PM

on noradrelaline reputake, nmda antagonist lol wild

Deleted User

well when you have an opiate that also have potent serotoningeric activity no doubt if you like serotinin drugs it feels like heaven also it keeps you a. bit stimulated while you're just a slug on most opioids

I loved Tramadol. Also, interestingly, I reacted to the euphoria of opiates in such a way that they were quite stimulating for me: I was writing reams and reams of poems, going out meeting more people than I ever had done before, was obsessed about becoming a polymath like da Vinci. My mind opened up. This was just with codeine.

haha reminds me of a friend who writes and sings rap music

7:32 PM

one of his stances was like funny how I write easy fucked up on tramal

Deleted User

The R- and S- enantiomers of tramadol act on different receptors in a complimentary manner. The R- enantiomer is a selective agonist of the mu receptors and inhibits serotonin reuptake while the S- enantiomer inhibits noradrenaline reuptake. Tramadol acts as an opioid receptor agonist,[11][12] serotonin releasing agent,[12][4][13][14] norepinephrine reuptake inhibitor,[12] NMDA receptor antagonist,[15] 5-HT2C receptor antagonist,[16] (α7)5 nicotinic acetylcholine receptor antagonist,[16] and M1 and M3 muscarinic acetylcholine receptor antagonist.[17][18]

Ok so tramadol and what for dopamine

7:46 PM

Oh it’s an opiate that is beat (edited)

to me it looks like it was designed to be the most recreational opioid not the most painkilling at all this pharmacology bugs m as hell haha (edited)

It cures my ibs along with pregabalin

1:37 AM

Cures, not helps

1:37 AM

Or removes for the rest of the day that it otherwise would act up for (edited)

1:37 AM

not cures haha

1:39 AM

Shit feels like getting kicked in the nuts, these drugs were a miracle for that. I've lost the euphoria that I can identify, although it does seem to do something, it's pain killing properties are there without the euphoria

1:39 AM

Ignoring the pharmacology, wrt direct experience, it works for certain types of pain

Deleted User

it's like both endorphin and serotonin overload it made me feel at the top of the world too

Yeah, it’s an amazing combo in a single substance. The most interesting part of it for me is that the opiate effects really only kick in (noticeably) for me a few hours after taking it (it’s quite noticeable too since I begin to itch on even low opiate doses) and it kicks in right around when I feel I’m coming down off the initial stimulation high (which is most pronounced for the first few hours after taking it). The stim + opiate combo is actually one I’ve really enjoyed with other substances (for example, amphetamine then kratom on the comedown) since it allows me to keep my productivity going after the stim comedown, and most importantly makes me feel good about the work I did while stimmed (a lot of times even when I get a lot of work done on stims, the comedown makes me question whether the work I did was worth it at all, since in that state it’s hard to get excited for the future rewards that I’ve gotten closer to reaching) (edited)

@lov To help me answer your question about reducing the 'noisy' aspect of psychedelic hallucinogens; are you specifically referring to tryptamines, phenethylamines, or both?

11:35 PM

Tryptamines have a liquid-esque flow (which can be difficult to define/put your finger on exactly what it is, esoteric), felt throughout the bodies nerve-system; whereas phenethylamines have an electric tingling pins&needles(in a good way) felt throughout the bodies nerve-system, that is well defined/determinable. (edited)

11:37 PM

So do you define 'noise' as difficulty understanding the effects/high; or do you define 'noise' being well defined electric tingling? (edited)

Tryptamines. Cognitively, bringing up information from the unconscious into the conscious without being in control of it. This may be specific to certain types of people though, so you might not necessarily know this effect, the same as I probab not knowing certain effects it may have in others with certain differences.

10:16 PM

I mean noisy because my working memory can't maintain information for long, so often it'd feel noisy as the information would be broken up and sometimes in nonsensical orders

10:18 PM

Phenethylamines aren't particularly noisy, more that it fucks with my attention, not my ability to pay attention, just that I end up paying attention to all sorts of nonsense rather than what I wanted to focus on prior

10:19 PM

I've mentioned it before, but some property and differences with 5-meo-dmt causes it to lack noisy features. Well, smoked or insufflated specifically. Plugged, I am pretty sure some of it gets converted to another psychedelic.

10:20 PM

Man, it's so "clean"

10:21 PM

I know clean and dirty tend to be terms reserved for other classes of drugs, but to me, I think some psychedelics are dirty and some clean, might just be my preference, who knows

10:22 PM

iirc, terence mckenna didn't care for it, how he described it came across to me as it being too clean lmao

10:22 PM

He likes lots of differentiation, a jungle, an ecology of form

10:23 PM

I prefer things chill

Never tried Mescaline or Peyote but besides those all Phenethylamines I tried felt shitty and toxic, lack of headspace to me

3:58 PM

And same with the 5 MEO substituted typtamines they feel pretty bad to me the 5 meo dmt is interesting but I think this substitution makes the effects way more toxic on the heart and generally less psychedelic

3:58 PM

juste compare 4 ho dmt (psilocin) and 5 meo dmt one is cleaner than the other xD

3:59 PM

or 4 ho mipt and 5 meo mipt

3:59 PM

5 meo tryptramines : junk drugs

I think it just releases more adrenaline, and the "heavy bodyload" isn't really heavy as rather its anaesthetic, dissociative effects makes it seem that way at first before taking full effect. I take propranolol or atenolol whenever I use it now and it's very gentle physically. (edited)

@lov I'm sorry I'm very interested, do you use propranolol or atenolol before your psychedelic trips ? Which molecules ? Did not you notice any adviserse reaction from mixing those

I've only done it with 5-meo, um, I think. Probably. It creates a big difference, makes it easier to dive deep

7:25 AM

But I kind of dislike it for that reason, I liked a slightly more grounded trips

7:25 AM

There's something to the initial discomfort followed by that release

7:26 AM

It's the premature ejaculation of trips

7:26 AM

heh

7:26 AM

But yea, it makes it extremely easier for myself to delve into some deep trippy stuff

7:26 AM

I speak more of propranolol

7:27 AM

Atenolol being mostly peripherally is in-between the 2 versions.

Sup psychonauts

Anyway, I came here to ask, what depths and understanding has any of you taken away from analysing your salvia trips? I don't mean like your life stuff, specifically curious if any of you developed any theories about some aspect of the mind from looking at your salvia trip(s)

Deleted User

And same with the 5 MEO substituted typtamines they feel pretty bad to me the 5 meo dmt is interesting but I think this substitution makes the effects way more toxic on the heart and generally less psychedelic

I have looked into the pharmacology of psychs it seems that among the available drugs DMT is the cleanest, most 5ht2a binding over the dirty targets

VeganPermanently

I have looked into the pharmacology of psychs it seems that among the available drugs DMT is the cleanest, most 5ht2a binding over the dirty targets

NBOME is iirc

7:31 AM

Very selective

7:31 AM

Used in studies for that

Neti

NBOME is iirc

Full agonism is toxic

Depends on one's definition of dirty, also he's right, well not nbome but those sorts of drugs are, or rather was

Discard that start again

7:32 AM

Spice is the cream

I think it’s 5HT2c you don’t want mostly since it’s what causes the vasoconstriction and therefor killer body load in some people

1

1

Heart out of chest too

There are a new class of beta-carboline based psychedelics with a higher affinity for 5-ht2a currently being researched, I believe it might be based on one of the alkaloids from harmala, not the main ones we know. I am unsure whether this has been published yet though

Neti

I think it’s 5HT2c you don’t want mostly since it’s what causes the vasoconstriction and therefor killer body load in some people

5ht1a and the adrenergic receptors too

VeganPermanently

Full agonism is toxic

I know people who go through grams of the stuff like its nothing

It's an entire new structural class of classic psychedelics

7:34 AM

Now!

7:34 AM

imagine that

7:35 AM

Dennis Mckenna's people discovered it

1

Inb4 dna damage

dirty delete

7:36 AM

cool

Shneaky

VeganPermanently

Inb4 dna damage

inb4 flashbacks from stretching

Beta Carboline psych

7:37 AM

On an unrelated tone

Anyone dabbled with benzydamine

There they are, the beta cabrolines (edited)

A small part of me always wonders if strong psychedelic using peeps have a higher rate of brain cancers or heart valve damage, well we know of the latter's effect which can be prevented, but the former, I mean i'm willing to take that risk if true, it's purely just a guess of mines for a while

lov

A small part of me always wonders if strong psychedelic using peeps have a higher rate of brain cancers or heart valve damage, well we know of the latter's effect which can be prevented, but the former, I mean i'm willing to take that risk if true, it's purely just a guess of mines for a while

Tumour maxxing bigbrain

7:38 AM

Most excellent

7:38 AM

They’re usually benign anyways

7:38 AM

Harmless lil helpful fellas

7:38 AM

Just contributing more gray mass

7:39 AM

Extra lumpy lump

Neti

Tumour maxxing bigbrain

I've found a way to use chemotherapy preventatively without detriment

7:41 AM

as Pax would say 'there is no clinical usecase'

I think I have some sort of psychosis related risk factor genes, and another from the other parent, genetic disposition for later stomach ulceration, I think these 2 things lowers my risk of cancer dramatically. iirc, machine learning experiments with predicting psychosis genetic risk showed that this group have lower risks of cancer. And separately, iirc, schizophrenia presents a lowered risk for certain types of cancers. The ulcer thing is my guess that my body is shit at fast division of cells.

7:42 AM

ie stomach lining

I have no cancer in my lineage

same

7:43 AM

wait no

7:43 AM

my aunt had breast cancer

but I have Alzheimer's, whole load of heart disease

same

7:43 AM

diabetes a little on one side

I pray to God I share most genes with my granddad

parkinson's too

7:43 AM

also, schizophrenia

dude is disease free at 80 still

7:44 AM

running around the house every morning

jfc, my mother's side of the family is just fucked brain-wise

building new structures

lov

jfc, my mother's side of the family is just fucked brain-wise

My maternal grandfather died of vascular dementia

7:44 AM

Too much lard and bacon

dementia is evil

7:45 AM

yea my grandmother was the same

7:45 AM

eating lard out the fridge

7:45 AM

yuck

Same with hurricanes, I understand when people say we must respect hurricanes wrt not playing around and taking it seriously, but some also say we should respect them as great forces of nature

7:46 AM

I disagree, they take human lives, leave people homless and diseased from a lot of the fallout

7:46 AM

evil

no respect should ever be given to agents of death

7:47 AM

they're enemies

Perfect answer

7:47 AM

I was semi-joking in what I wrote

wanna join an immortalist server?

I like to write that in response to things like x is evil because people give a free pass when it comes to things from nature, so I like to say that to see how they'll rationalize their way out. But you answered in a way that's got my respect

VeganPermanently

wanna join an immortalist server?

nah, I doubt I'd participate, I'm very selective about the servers I join because it often ends up being forgotten and causing clutter

7:50 AM

So unless there's a hook that's obvious to me, I refrain

lov

Anyway, I came here to ask, what depths and understanding has any of you taken away from analysing your salvia trips? I don't mean like your life stuff, specifically curious if any of you developed any theories about some aspect of the mind from looking at your salvia trip(s)

Also, hope someone has an answer to this or a link to people answering it in a tripreport or something (edited)

lov

So unless there's a hook that's obvious to me, I refrain

the promise of immortal life and heaven on Earth

7:51 AM

I've taken salvia once

7:51 AM

it was interesting

7:52 AM

but I forgot the lessons

7:52 AM

next time I'm dosing galantamine concurrently for this reason

VeganPermanently

the promise of immortal life and heaven on Earth

Righteousness beyond my instinctual traits is no longer something I try too hard to cultivate. Everytime I do, the world just proves that it can't be better, or a classic quote that may be another way I sometimes look at it,

The optimist proclaims that we live in the best of all possible worlds; and the pessimist fears this is true

VeganPermanently

next time I'm dosing galantamine concurrently for this reason

ohh, this is what I've been thinking people need to do more

7:55 AM

Nice idea

lov

Righteousness beyond my instinctual traits is no longer something I try too hard to cultivate. Everytime I do, the world just proves that it can't be better, or a classic quote that may be another way I sometimes look at it,

The optimist proclaims that we live in the best of all possible worlds; and the pessimist fears this is true

I have disconnected the connection between affect and life outlook

7:56 AM

I have extreme negative affect and I'm also extremely optimist at the same time

7:56 AM

I believe this is the perfect state because it protects against delusion yet allows motivation

I'm no pessimist, when I'm in a low mood sober, it usually makes me more cynical, logical and all around sharp. When I'm in a sober high spirit, it usually makes me more optimistic, and feeling like despite the difficulty, I am capable of finding a brilliant outcome to whatever situation presenting itself.

7:59 AM

Due to heightened creativity

do u smoke cannabis?

7:59 AM

have u ever read this wiki?

Not really, not my thing, but I smoked today at my friend's bd party for the first time in many months It was offered, can't say no

https://en.wikipedia.org/wiki/Negative_affectivity

Negative affectivity

Negative affectivity (NA), or negative affect, is a personality variable that involves the experience of negative emotions and poor self-concept. Negative affectivity subsumes a variety of negative emotions, including anger, contempt, disgust, guilt, fear, and nervousness. Low negative affectivity is characterized by frequent states of calmness ...

lov

I'm no pessimist, when I'm in a low mood sober, it usually makes me more cynical, logical and all around sharp. When I'm in a sober high spirit, it usually makes me more optimistic, and feeling like despite the difficulty, I am capable of finding a brilliant outcome to whatever situation presenting itself.

r u high IQ

8:00 AM

like >130

yea

how yung r u

25 going on 26 in december

cool

8:01 AM

I'm 27

nice nice

I have had fluctuating emotions myself my whole life, it has calmed down in the past year

Emotions beyond highs and lows?

I can't say if my brain matured or it's the drugs I'm taking

haha

8:03 AM

SAME

8:03 AM

It went away right around the time before my more consistent drug use, leading to daily use

what r u f with

sorry?

what r u using

ah, um, I feel kinda silly cuz I have said it so many times here already. Hopefully not annoying for anyone backreading this. Pregabalin and tramadol is what I used past 2 years daily except for 2-3 months at some point (edited)

that's reckless

8:06 AM

not judging or anything just saying

Unfortunate circumstances, I used to be someone who never cared to get intoxicated much, it was purely about diverse experiences, then throwing the substance away when I've explored it sufficiently, usually not too long

8:08 AM

But, you know, life and shit

well

8:09 AM

I hope you'll pull up the beetroot

8:10 AM

I was prescribed tramadol and benzos a few times

8:10 AM

never took it

8:11 AM

always looked at the doc with a judging stare and maintaining silence for a min or two

8:11 AM

they're retards

8:11 AM

one doc came back with another doc to mock me

8:12 AM

'look at this guy. coming to a hospital and refusing to take the meds'

8:12 AM

I said observe me fool

8:13 AM

2 hours later he was impressed I pulled the weeds and presented a clean yard

I should probab quit again. I can't properly quit without using my psychedelic, I experience terrible withdrawals and after that, fucking scary depression. Like torment, like a bad trip became my baseline. I think the psychedelic helps mess with the serotonin receptors to not make that aspect of the withdrawal difficult, helps a little with the opioid aspect too. Pregabalin tolerance and withdrawal, while bad, goes away amazingly quickly, in a week it's almost reset perfectly from use going into the grams within a day sometimes. So, after the psychedelic, things becomes easy, but there's this weird fear with the psychedelic, like I'll realize how useless some of the things I'm researching is for my life and how much it's hurting me. I'm scared to let go of this little weird situation with plans not helpful for my life circumstances right now. Not scared scared, rather stubborn is the better word.

lov

I should probab quit again. I can't properly quit without using my psychedelic, I experience terrible withdrawals and after that, fucking scary depression. Like torment, like a bad trip became my baseline. I think the psychedelic helps mess with the serotonin receptors to not make that aspect of the withdrawal difficult, helps a little with the opioid aspect too. Pregabalin tolerance and withdrawal, while bad, goes away amazingly quickly, in a week it's almost reset perfectly from use going into the grams within a day sometimes. So, after the psychedelic, things becomes easy, but there's this weird fear with the psychedelic, like I'll realize how useless some of the things I'm researching is for my life and how much it's hurting me. I'm scared to let go of this little weird situation with plans not helpful for my life circumstances right now. Not scared scared, rather stubborn is the better word.

u need to take care of pregabalin use first. quitting can kill u

8:15 AM

u need to taper very slowly

8:15 AM

also do u know about my addiction set

8:15 AM

Memantine, NAC, Naltrexone

Tram withdrawals are horrific

8:15 AM

Worse than heroin

Deleted User

Tram withdrawals are horrific

can't kill u tho

VeganPermanently

can't kill u tho

No but you'll wish it would

Deleted User

No but you'll wish it would

Zeno of Citium will take care of this

VeganPermanently

u need to take care of pregabalin use first. quitting can kill u

It's not that bad, as long as I take care of my cardiovascular system with something compensating for any potential little damage it poses. It doesn't feel like withdrawal from gabanergics though. I doubt any neurotoxicity is that bad, the biggest issue with it is its fucked up relationship to angiotensin. (edited)

Deleted User

Worse than heroin

Given what I've seen with friends withdrawing from H, most definitely agree

lov

It's not that bad, as long as I take care of my cardiovascular system with something compensating for any potential little damage it poses. It doesn't feel like withdrawal from gabanergics though. I doubt any neurotoxicity is that bad, the biggest issue with it is its fucked up relationship to angiotensin. (edited)

still, inhibitory neurotransmission deficit ensues. Memantine can help with that. Also a lot of endurance exercise

They say venlafaxine is the worst antidepressant withdrawal, tramadol seems to overlap in activity with it except for the prominent opioid effect.

8:19 AM

It's built to be hellish

8:20 AM

But also miraculous, a silver bullet for certain hells

u sound 5ht1a dominant

8:21 AM

VeganPermanently

still, inhibitory neurotransmission deficit ensues. Memantine can help with that. Also a lot of endurance exercise

I don't think it works that way, I haven't studied it in a while, but it seems to decrease the physical movement of neurotransmitters in certain areas of the brain, rather than dealing with ion channels

8:22 AM

Oh, preg and tram have shut down my sperm production, it's kinda cool, the pharmacology of why

lov

Oh, preg and tram have shut down my sperm production, it's kinda cool, the pharmacology of why

sperm loads correlate with cognitive function

VeganPermanently

Click to see attachment 🖼️

interesting

I believe this is due to the fact they're both dependent on vesicular loading

8:23 AM

recycling, function in general

Pregabalin withdrawal is mostly low D1, high acetylcholine + norepinephrine

VeganPermanently

sperm loads correlate with cognitive function

huh, I do forget shit from the day before, usually every day is almost like a genuinely new day

8:25 AM

I posted here on reddit how pregabalin probab stops sperm production

8:25 AM

https://www.reddit.com/r/DrugNerds/comments/nxl6wh/does_pregabalin_use_negatively_affect_male/

r/DrugNerds - Does pregabalin use negatively affect male fertility,...

33 votes and 30 comments so far on Reddit

all of this is dependent on mitochondrial function as well, opioid notorious for nooking it

Its withdrawal is amazing, in that, well I am...feels weird to say, but probab on the spectrum, but not what's normally considered autistic. I think it's an autism that is very much in the same league as those clinical but not problematic in our society so doesn't get attention. (edited)

8:26 AM

point being

8:26 AM

I have an extremely heightened sense of smell (edited)

8:27 AM

And I can smell what I presume to be the concentrated release of pheremones

Modafinil really helps me control autistic vulnerabilities to sensory inputs

VeganPermanently

all of this is dependent on mitochondrial function as well, opioid notorious for nooking it

crap

8:28 AM

I want a NET inhibitor instead, amitriptyline helps when its metabolite takes hold

8:28 AM

It makes me angry-ish

https://www.pnas.org/doi/10.1073/pnas.0705087104

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.

but I kinda enjoy the feeling

8:29 AM

I found isopropylphenidate to lower my ability to think

phenidates suck

8:29 AM

as amphetamines

8:29 AM

as tropane alkaloids

8:29 AM

they work by reversing the function of presynaptic transporters instead of inhibiting them and improving vesicular function

8:30 AM

Modafinil indeed inhibits DAT and improves vesicular release

8:31 AM

which is why it works best when u sprint

8:31 AM

it's dependent on mitochondrial function while the classical release agents are not

8:31 AM

because of this MoA it's an intraneuron antioxidant while the other release agents increase oxidative load

VeganPermanently

https://www.pnas.org/doi/10.1073/pnas.0705087104

ahh, my understanding of electrical fields in the brain and the rhythms etc is poor, shit makes me sad that I can't even begin to deconstruct these papers

8:33 AM

monoamines have a weird relationship with oxidation beyond their known metabolic pathways I believe, I think they indirectly affect some high-level control of something involving a lot of oxidative stress somehow (edited)

lov

monoamines have a weird relationship with oxidation beyond their known metabolic pathways I believe, I think they indirectly affect some high-level control of something involving a lot of oxidative stress somehow (edited)

it's a bimodal effect

monoamines are way too complex to cell biology

this is because natural release is dependent on vesicular content which is dependent on VMAT2 function which is dependent on mitochondrial health

8:35 AM

in a high oxidative load environment mitochondria burn out over time

8:35 AM

but without oxidative load altogether they just stop producing cellular energy

8:36 AM

low grade intermittent oxidation bursts stimulate mitochondrial biogenesis

8:37 AM

which is why 10 minutes of red light therapy / day help monoamine function

8:37 AM

but if you exposed your brain to red light all day it would cause Parkinson's

8:38 AM

the neurons rust to death starting from the mitochondria

It's more than that, there's something happening that isn't scientifically recorded afaik, I've looked around a ton

8:46 AM

Look at selegiline and, BPAP (similar monoamine enhancing activity without inhibiting mao)

8:47 AM

these affect the oxidative stress in single non-brain cells a weirdly strong amount

BPAP is a vesicular release agent as well

8:47 AM

whenever u see 'electrically evoked release' that means vesicular release

I think low-dose dnp, (at a does where it actually has an opposite effect in most cells causing an increase in useful work) causes an interesting effect on mitochondrial health (edited)

again same effect

8:49 AM

increase in mitochondrial function > increase in ATP production > increase in VMAT2 function

huhhh

8:50 AM

Do you think

vesicles are everything

8:50 AM

as Neti would say

increased VMAT2 function can trigger RLS?

eggs within eggs

1

lov

increased VMAT2 function can trigger RLS?

no

Because I know of some interesting experiments which had what I assume is an enormous increase in mitochondrial function in the brain but also caused RLS. The RLS can be a side-effect from other stuff the treatment messes with ofc

8:52 AM

but the idea that it could be this seems interesting

but it does increase risk for schizo and bipolar again depending on mitochondrial function, I believe the transporter conformation can reverse if the electrical input is high yet there is a cellular energy deficiency (edited)

ohh

8:54 AM

makes sense

8:54 AM

negative feedback to prevent crazy stuff from ion imbalances

8:54 AM

https://en.wikipedia.org/wiki/Valbenazine#Pharmacology

Valbenazine

Valbenazine, sold under the trade name Ingrezza, is a medication used to treat tardive dyskinesia. It acts as a vesicular monoamine transporter 2 (VMAT2) inhibitor.

8:55 AM

I think it's reasonable to guess that increased VMAT2 can cause RLS

ADHD is the same thing but it doesn't implicate VMAT but DAT and NET

Been thinking

lov

https://en.wikipedia.org/wiki/Valbenazine#Pharmacology

poison

this would be quite the interesting combination

8:55 AM

selegiline + PEA + clonidine

8:56 AM

specifically slow-release PEA

psychosis inducing concoction

8:57 AM

I wanted to synth a TAAR1 partial agonist that displaces PEA from the receptor

8:58 AM

PEA overload may be causative for psychosis

probab easy for a mistake which can cause that easily, but otherwise, speaking ideally, I think a goldilocks zone exists where it would work well enough for what I think it can do

in the meantime I found a better way to treat psychosis, directly modulating receptor activity

hm...I am at psychosis risk, probab shouldn't play with that combo

oxytocin metabolite analogs

9:01 AM

deficiency of which may also be causative for psychosis

or

high PEA + brain oxytocin metabolism dysfunction (edited)

9:02 AM

remove any one and psychosis is blocked

there's a vasopressin antagonist which increases oxytocin activity iirc

the former modulates monoamine release while the latter modulates receptor function

also 5-ht1a ofc

the issue is not oxytocin receptor activity

9:03 AM

but it's metabolism

what effects comes after it's metabolism's outcome

9:03 AM

but before psychosis

9:03 AM

does it directly modulate pea

9:04 AM

or simply, whatever receptor function

9:04 AM

I'm guessing monoamine function, that'd make more sense lol (edited)

lov

or simply, whatever receptor function

dopamine receptors

9:05 AM

but the metabolite doesn't block them, but modulates them

conformational changes

9:05 AM

I imagine

9:05 AM

I'd guess not all receptors but specific spots in certain heterodimers

which cancels tardive dyskinesia of antipsychotics for example

9:06 AM

but it's antipsychotic on it's own so you don't need concurrent treatment at all

9:06 AM

I'd imagine TAAR1 partial agonist + DAR modulator would be most potent

9:07 AM

then some Modafinil and a shizoid person is suddenly a golden brick in the wall

do you know what's so special about dxm that sets it apart as I hear people claim, I believe them but it is something that produces an extremely unique effect or simply modulates the normal dissociative holes or whatever

lov

do you know what's so special about dxm that sets it apart as I hear people claim, I believe them but it is something that produces an extremely unique effect or simply modulates the normal dissociative holes or whatever

the red dye

1

9:09 AM

on a serious note, it's possible it changes the conformation of SERT

9:09 AM

so it's more like MDMA and less so like SSRIs

but I doubt that's the cause of the so called entities and other effects it produces

Oh I meant you asked why it's so addictive

no no

9:11 AM

I'm curious about the drugs at the edge that seem to be doing something special

9:12 AM

amanita, iboga, dxm, salvia to name a few stand out from my readings

9:12 AM

Not that they are deeper or do anything more amazing

maybe the muscarinic antagonist effect contributes to the delirium

just I don't understand them well yet

much like scopolamine

VeganPermanently

maybe the muscarinic antagonist effect contributes to the delirium

hm, that could be something, but they remember too much for it to be like that

9:13 AM

especially with nmda antagonism too

this will also produce addictive effects esp combined with sigma agonism, NMDA antagonism and SERT agonism

9:14 AM

btw just to clarify when I say SERT agonist I mean it changes the conformation to release instead of uptake

lov

hm, that could be something, but they remember too much for it to be like that

sigma agonism improves recall

9:15 AM

also I know people who describe their datura trips in detail

9:15 AM

it's funny how these people talk about it

9:16 AM

'so I was talking to my washing machine as my mom came in...'

9:16 AM

roflmao

VeganPermanently

I have looked into the pharmacology of psychs it seems that among the available drugs DMT is the cleanest, most 5ht2a binding over the dirty targets

that rings true if I compare to my subjective experience : DMT has virtually NO bodyload or any feeling of toxicity to the body or heart rythm increase, I've had none of that with DMT, but with the new synthetic tryptamines , a lot to a freaky extent (edited)

DXM does a lot. I think it’s nmdar antagonism isn’t even it’s most potent effect. It’s serotonin effects might be. I think SSRI can be trippy too but most people wouldn’t on normal doses

qwerkyscience

DXM does a lot. I think it’s nmdar antagonism isn’t even it’s most potent effect. It’s serotonin effects might be. I think SSRI can be trippy too but most people wouldn’t on normal doses

https://jeccr.biomedcentral.com/articles/10.1186/s13046-021-02109-z

Targeting INMT and interrupting its methylation pathway for the tre...

Background Castration-resistant prostate cancer (CRPC) is associated with a very poor prognosis, and the treatment of which remains a serious clinical challenge. Methods RNA-seq, qPCR, western blot and immunohistochemistry were employed to identify and confirm the high expression of indolethylamine N-methyltransferase (INMT) in CRPC and the clin...

1:43 PM

DMT against prostate cancer

1

1:43 PM

1

VeganPermanently

Click to see attachment 🖼️

For political activism in the drug war

1

VeganPermanently

no respect should ever be given to agents of death

I am maybe death worshipper I like big beautiful cliffs and forests full of beasts

11:52 PM

:/

11:52 PM

Death has its utility

11:53 PM

Even it’s own beauty

11:53 PM

There is no rebirth, no growth or development without it

11:54 PM

If we want to abolish death we have to inherit its responsibilities and learn to take over its functions without it (edited)

11:54 PM

To kill death necessitates becoming of death

lov

interesting

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/

Serotonin and brain function: a tale of two receptors

Previous attempts to identify a unified theory of brain serotonin function have largely failed to achieve consensus. In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the ...

Neti

There is no rebirth, no growth or development without it

Classic deathist fallacious thinking

VeganPermanently

Classic deathist fallacious thinking

Do deathists or immortalizts make better music ?

VeganPermanently

Classic deathist fallacious thinking

the beauty of the eggshell must one day hatch and fall apart:(

7:21 AM

Egg!!!!!!!

Neti

Do deathists or immortalizts make better music ?

there is a very small amount of immortalists in the world today, but they're damn good artists

VeganPermanently

there is a very small amount of immortalists in the world today, but they're damn good artists

okay I choose them

Everyone chooses immortal life when given the opportunity. Not a single person will tell God to erase them at the gates of heaven. The problem is that people know death is the hardest problem of existence so they don't bother and cope instead. 5HT2A activation and lots of questioning leads one to shred off the deathist ideologies imposed by society. The end of death is the end of suffering, but not the end of evolution and development. The world will only grow. Humans consume such miniscule amounts of energy when compared to the amount the sun produces that it's ridiculous that we need to die.

VeganPermanently

which is why 10 minutes of red light therapy / day help monoamine function

What about sleeping with a lil red led?

Neti

What about sleeping with a lil red led?

a lil bit of dmg/time

7:29 AM

rip

I have a few photons coming through my blinds I'll block them but I'm unsure how to ventilate the space

7:30 AM

air becomes dense when the windows aren't open

7:30 AM

and it's not a small room either

7:30 AM

looks like I breathe a ton

VeganPermanently

but if you exposed your brain to red light all day it would cause Parkinson's

Oh lol rip

7:31 AM

Wry next sentence despair

7:31 AM

xdddd

Neti

Wry next sentence despair

it's either Pax DFO camp or VP's caveman camp

7:36 AM

TH+ neuron cell death depends on light exposure and Fe availability

VeganPermanently

but it does increase risk for schizo and bipolar again depending on mitochondrial function, I believe the transporter conformation can reverse if the electrical input is high yet there is a cellular energy deficiency (edited)

Do you have any suggestions for a basic beginners mitochondria stack.?

Neti

Do you have any suggestions for a basic beginners mitochondria stack.?

yeah lots of endurance exercise

7:37 AM

I’ve actually been exercising everyday!!!

gz

I took up mountain biking!!!

7:37 AM

There’s no where flat around where I live for distance biking unfortunately

High dose B vitamin organized according to absorption and circadian modulation

I live on a hill

like B6/9/12

7:38 AM

B1/5

I biked till dark today

etc

Neti

There’s no where flat around where I live for distance biking unfortunately

that's just extra effort

It’s actually become my favourite part of the day I even llook forward to

but you probably need bigger gears in the back

7:39 AM

7:40 AM

so it's B6/9/12, in the morning a few hours later B1/B5, B2/B3 before sleep

1

@Neti show me your cassette

7:43 AM

prutty deadwood

VeganPermanently

@Neti show me your cassette

La casette..?

Neti

La casette..?

La mandala

7:46 AM

I have to bike up this mountain eventually

VeganPermanently

La mandala

Oh the spinny

7:47 AM

I got three mega gear shifts on one side and 10 minis on the other (edited)

Neti

Oh the spinny

essentially the bigger the gear is the easier it is to climb with it

7:47 AM

the number of gears doesn't matter but the size of the biggest one

VeganPermanently

essentially the bigger the gear is the easier it is to climb with it

Oh ya I’m well familiar with gears Lotta climbing to be done constantly !!!!!

I have to change my cassette I ruined it

I'm an idiot always so lazy to clean it

7:48 AM

so I need to change it every few months

My back brake is broken which is kinda dangerous

7:49 AM

Only front break works lol

Neti

My back brake is broken which is kinda dangerous

u used it too much

It’s an old bike, wasn’t used for years

I have to spit about 200 usd on my bike total

7:50 AM

everything is edgy

7:50 AM

but everything works

7:50 AM

and as my doctor says

7:50 AM

as long as it works

7:50 AM

don't fix it

7:50 AM

7:51 AM

200 USD is a lot of Kanna

7:51 AM

I only plan on spending money on drug

(edited)

Neti

I only plan on spending money on drug

(edited)

I have a few more low hanging fruit on my list

7:52 AM

I wanna trial DNP

7:53 AM

vanillin as well

7:53 AM

cheap drugs but kinda hard to source weirdly enough

Fixing gluten sensitivity has probably been such a low hanging fruit in terms of fixing my fatigue Kinda mad I haven’t seriously thought about fixing it sooner

7:54 AM

I bought a gluten free bread

7:54 AM

Was absurdly tasty

7:54 AM

Expensive tho

7:54 AM

I should learn how to make my own

I stopped eating bread

7:54 AM

2 months ago

Bread is so gooooood tho D:

7:54 AM

I couldn’t

my cuisine is so good

7:55 AM

I can throw out anything and it will still be a level above fine dining

7:56 AM

I used to think that I need certain preparation teks

7:56 AM

but I put that to a test and I was so damn wrong

7:57 AM

now it feels stupid to burn food

What were you guys saying about monamine content. I probably have alotta gunk floating around in me from leaky gut syndrome L

Neti

What were you guys saying about monamine content. I probably have alotta gunk floating around in me from leaky gut syndrome L

I found ways to really modulate the shit out of monoamines, like put a person in a very stable and sustainable state of permahypomania

7:59 AM

while being resistant to dysfunctional mania and psychosis

8:00 AM

but it requires advanced custom synth, it will cost a lot

8:00 AM

fucking nameless chemicals

Random nameless research chemicals despair

8:00 AM

always so expensive

Neti

always so expensive

dose is 100 mcg tho'

8:05 AM

and from the looks of it you don't need to use it all the time, just a few day cycle every once in a while

8:06 AM

has potential to treat bipolar, autism, shizophrenia, depression, Parkinson's

lov

what effects comes after it's metabolism's outcome

Oxytocin’s metabolite MIF1 also inhibits the ACTH receptor (by blocking its ligands). (edited)

yoyoyoyo

9:43 PM

This week is nuts. Trying to get my ruined car fixed

9:43 PM

I didn't work on a video yet because of that. Made a bunch of AI art tho

You should add your servers discord address to your very best pieces for advertising!!!!!

12:04 AM

Or advertise your articles in your art even somehow

12:05 AM

Few key lines to hook the person to read more

12:05 AM

Like a brief quote or line of poetic prose to suggest the topic in your discord/articles

12:06 AM

I’m in a discord that formed their community by just making a buncha art and spreading it onto the internet and letting it circulate

12:06 AM

Sometimes you see discord links at the end of videos/memes (edited)

12:07 AM

The art you’d use to advertise with would need to reflect/appeal to the type of person you want to draw in tho -has to somehow demonstrate that it’s about psychology/pharmacology (edited)

12:08 AM

Maybe photoshop some select molecules of interest over your art

qwerkyscience

I didn't work on a video yet because of that. Made a bunch of AI art tho

Quality > quantity imo!!!

1

12:34 AM

Taro and Nells house. Where Riyon first comes into contact with the legendary psychedelic type drug zaza.

12:35 AM

They use salvaged technology in a post apocalyptic slums

12:35 AM

12:36 AM

Colony 25 from the outside. The colony where Taro and Nell live.

12:36 AM

12:37 AM

The underworld meadow. An underground place of many flowers, trees, lakes, mushrooms, and grass. The air is filled with zaza from the flowers. Just being here intoxicates you.

12:38 AM

qwerkyscience

Click to see attachment 🖼️

I love this one, it brings back sensations and memories of a time I've long past

1

qwerkyscience

The underworld meadow. An underground place of many flowers, trees, lakes, mushrooms, and grass. The air is filled with zaza from the flowers. Just being here intoxicates you.

shrooooooooms ❤️ I want to find the f ing time to read you neat lore (edited)

1

@VeganPermanently Have you heard of HA-966?

S-(−)-HA-966 has been described as a "γ-hydroxybutyric acid (GHB)-like agent"[7] and a "potent y-butyrolactone-like sedative",[5] but it shows no affinity for the GABAB receptor (GABABR).[7] I don´ñt understand how it can be a GHB like agent with no Gabba B ction but I fucking want some !!!!!

Akaçía

S-(−)-HA-966 has been described as a "γ-hydroxybutyric acid (GHB)-like agent"[7] and a "potent y-butyrolactone-like sedative",[5] but it shows no affinity for the GABAB receptor (GABABR).[7] I don´ñt understand how it can be a GHB like agent with no Gabba B ction but I fucking want some !!!!!

the structure resembles GHB

qwerkyscience

Click to see attachment 🖼️

Then the pumpkin eats you and shits you out on the ground for the bears to eat

Brethren-men bill

Then the pumpkin eats you and shits you out on the ground for the bears to eat

Scared

3:33 PM

True cosmic horror

yooo everyone it's me gmerch

3:17 PM

Yo

7:36 PM

Who are you, gmerch? Please introduce

yo it's me gmerch

kuzweil's books have influenced me more than almost anything else that i know of...i believe within ~20 years a superintelligence will emerge that will gain a decisive strategic advantage over all other competitors and wipe them out, it may be the first human to connect their brain to a computer in a useful way, or it may be a new artificial lifeform created by a human, either way it will be a new paradigm: the first time in history when a single individual will be significantly more capable at achieving his goals than all of his peers combined...i'm not sure how meaningful it is but i scored 145iq on a supervised mensa australia test

7:50 PM

and i like dmt

7:51 PM

hey gmerch

1:53 AM

Yes I think there's a relatively high probability of a scenario like the one you're describing

1:55 AM

I don't think most super-empowered humans would default to destroying all possible competitors. I think we've learned enough about empathy, joint success and possibly even about oneness of consciousness, that in the human-computer scenario, humanity stands a chance. In a simple AGI scenario though, our odds might be significantly lower

nateTheGreat

I don't think most super-empowered humans would default to destroying all possible competitors. I think we've learned enough about empathy, joint success and possibly even about oneness of consciousness, that in the human-computer scenario, humanity stands a chance. In a simple AGI scenario though, our odds might be significantly lower

I think even a basic understanding shows that we only have empathy because we are just tools that our genes use to reproduce themselves...right now our genes are more capable of achieving their goals than we are, but if we overcome our genetic slavery and become the dominant ones in the relationship, we wouldn't be bound by such things as empathy... But also it only takes 1 player to not have such weak thoughts, and that player will win...i think you project what you hope would happen to you rather than what would really happen, but even if you became superintelligent first and decided not to use your advantage, it would only take 1 other mind catching up to you that had the will to achieve its goals, to take you out, and then your dreams of peace would be shown to be nothing more than a delusion But yeah, the one possible scenario i can see where 1 mind wouldn't destroy all others, is if many minds simultaneously accelerated to superintelligence and all hit physical universal limits at the same time...in that case there would be a rough equilibrium of many similarly-capable minds like we have now...but that seems very unlikely (edited)

dre🅰m

I think even a basic understanding shows that we only have empathy because we are just tools that our genes use to reproduce themselves...right now our genes are more capable of achieving their goals than we are, but if we overcome our genetic slavery and become the dominant ones in the relationship, we wouldn't be bound by such things as empathy... But also it only takes 1 player to not have such weak thoughts, and that player will win...i think you project what you hope would happen to you rather than what would really happen, but even if you became superintelligent first and decided not to use your advantage, it would only take 1 other mind catching up to you that had the will to achieve its goals, to take you out, and then your dreams of peace would be shown to be nothing more than a delusion But yeah, the one possible scenario i can see where 1 mind wouldn't destroy all others, is if many minds simultaneously accelerated to superintelligence and all hit physical universal limits at the same time...in that case there would be a rough equilibrium of many similarly-capable minds like we have now...but that seems very unlikely (edited)

Why should we escape evolved interests or "genetic slavery"? Everything we care about and think is a product of how we evolved. What is the point of creating new interests outside of evolved interests? The only reason you'd even want to escape genetic slavery is because you evolved to want that somehow. Which means you can never escape it because escaping is part of the thing being escaped.

4:51 PM

The only way I can see creating new interests as valuable is if we set the bar for feeling happy very low. Like we become euphoric simply every breathe we take for no reason. Then we can all live in paradise by doing nothing but breathing. I am not sure I'd even want that though but I guess if we changed what I want, then I would, so it makes no difference.

As we increase the horizons of our intelligence, we also increase the horizons of our goals and motivations...most humans are not concerned with gathering all the matter in the universe to make a bigger brain & body, or with finding a way to escape the universe before it runs out of energy

8:22 PM

Likewise, a superintelligent mind with a brain made with all the matter and energy from 1000 galaxies will not be concerned with how to make a good resume for a job application

8:25 PM

If you think a superintelligent mind will still be concerned with human-level goals then you are anthropomorphizing it too much

8:26 PM

Human-level goals will be lost long before then, while it is still on Earth (edited)

dre🅰m

Likewise, a superintelligent mind with a brain made with all the matter and energy from 1000 galaxies will not be concerned with how to make a good resume for a job application

The concern to make a resume for a job application is actually about sex and the fear of death or even broadly the fear of losing what we have, which probably also stems from things like sex and fear of death

8:58 PM

Humans don't actually care about job applications. Those are merely a tool to achieve sex and survival

9:03 PM

This is a fun topic

We have those motivations now because our genes have wired us that way...if we achieve our own goals, even just survival, that is only subordinate to our genes' survival

9:05 PM

We're limited right now by the way we are hard-wired...if we remove those limitations our goals will change

9:07 PM

Removing our limitations or creating a new lifeform without those limitations isn't much different...but if the way we create a new lifeform that becomes a superintelligence is to just let it loose and let it grow on its own, then we would have less influence on its development

dre🅰m

We have those motivations now because our genes have wired us that way...if we achieve our own goals, even just survival, that is only subordinate to our genes' survival

If you want anything else, it is also because you are wired that way. If you try to escape your wiring, it is actually a product of your wiring causing you to try to escape. What motive do you have?

9:08 PM

Why should we create that new lifeform? Just because? Should we make humans value counting every grain of sand and build a society that only ever counts grains of sand?

qwerkyscience

Why should we create that new lifeform? Just because? Should we make humans value counting every grain of sand and build a society that only ever counts grains of sand?

Life is in competition, and we don't wipe each other out because we can't, because we're all so similar...there's some variation but no one has a decisive advantage...creating a superintelligence (or upgrading oneself to be superintelligent first) could allow someone to gain that advantage and eliminate all competition, that's why people have that goal

What is your goal

Our goals have been influenced by our genes, and they still dominate our behavior and existance now, but soon we will be more capable...yes they influenced us, but we also had influence from the rest of the universe

qwerkyscience

What is your goal

I'd like to escape the universe before it runs out of energy

9:16 PM

But i also want to expand my mind, and i expect my goals will change when i do

dre🅰m

I'd like to escape the universe before it runs out of energy

Do you acknowledge this is because you evolved to do so?

dre🅰m

But i also want to expand my mind, and i expect my goals will change when i do

What kind of goals do you think drive this? I think an expanded mind provides more access to rewards and more ability to attain security from death. Maybe more ways to reach all of our other goals. I don't think that mind expansion itself is the real goal. Instead, we use an expanded mind as a way to better solve all of our fears and desires.

9:20 PM

I think our fears and desires can be boiled down into something extract. Maybe we can even simply just say we have fear and desire and that is basically it. The complicated theories and belief systems surrounding our fears and desires are like an analysis for the best ways to control our emotions. It all comes down to controlling a feeling inside of us. That is all we are

dre🅰m

I'd like to escape the universe before it runs out of energy

what's your plan for immortality so far

I have a friend who aims to achieve immortality within his life

ugh

6:35 AM

There truly, truly are few people you can trust

6:35 AM

therefore

6:36 AM

You should avoid as much as possible placing yourself in a position where you need to

1

6:37 AM

I figured out how to quit my drugs sucessfully (edited)

6:38 AM

Prednisolone helped keep the withdrawal effects within reason, although they still sucked, even after tapering

6:38 AM

Tramadol withdrawal makes you sad

6:38 AM

like a baby :p

6:39 AM

Pregabalin withdrawal puts you in hell, literally, the anxiogenic effects somehow manifest visually in an utterly terrifying manner

6:40 AM

And now, I have none of these types of drugs on me for the first time in a long time

6:40 AM

And some girl from long ago thinks it time to reopen a scar

6:41 AM

Took atenolol, my heart was ready to explode, still is a mess but less.

6:41 AM

Took desvenlafaxine prior to all this

6:42 AM

I haven't used it in a million years. Poor timing again, I recall it made me more sensitive to my emotions. If there ever was a time for me to be my usual unfeeling self, god damn it.

6:43 AM

I guess I can maybe utilize this unpleasant feeling to do something. I want to throw up

6:44 AM

It even interrupted some research I was doing, maybe someone here would be interested

6:45 AM

https://www.nature.com/articles/s41467-020-17312-3

Multivariate genomic scan implicates novel loci and haem metabolism...

Nature Communications - Ageing phenotypes are of great interest but are difficult to study genetically, partly due to the sample sizes required. Here, the authors present a multivariate framework...

qwerkyscience

I have a friend who aims to achieve immortality within his life

is that me?

I meant someone else but you can be another one too lol

lov

You should avoid as much as possible placing yourself in a position where you need to

I feel for you with this. Hang in there. After withdrawals it will be better. People can suck. Sometimes I convince myself it’s all miscommunications and differences of belief, rather than corruption or evil.

1

Half the people in these alchemy circles have probably tried for immortality some time or another (edited)

2:30 AM

I’m pretty young still so I haven’t looked into much beyond a few minor potions of longevity I take for now (edited)

Neti

Half the people in these alchemy circles have probably tried for immortality some time or another (edited)

My friend is a successful biologist

oh I just meant in the sense jack is talking about

1

https://reichandlowentherapy.org/Content/Lifestyle/shame.html

I 100% disagree with that article on both counts

adenofthieves

I 100% disagree with that article on both counts

Anything in particular?

9:37 PM

I feel it points out an interesting connection between feeling blamed and feeling imperfect

9:38 PM

The weight of the sin of fault

Just the definitions at the start. It’s implying a whole lot about knowing the cause and effect of blame and shame, and characterises it in a way that is complete incongruous with my experiences.

I just watched Haibane Renmei

11:38 PM

Very sad show about guilt, sin, flaw, and forgiveness (edited)

Neti

https://reichandlowentherapy.org/Content/Lifestyle/shame.html

Kept thinking about this non stop and how it connected a lot of the behaviours the characters were showing like inability to ask for help and such

I wonder if we'll ever see media produced like that show again

3:58 AM

At least the artistic aspect of it

https://en.m.wikipedia.org/wiki/Donald_Triplett this man is the prototypical original autist

Donald Triplett

Donald Gray Triplett (born September 8, 1933) is an American man known for being the first person diagnosed with autism. He was first diagnosed by Leo Kanner, and was labeled as "Case 1". Triplett was noted for his savant abilities, particularly the ability to name musical notes played on a piano, and the ability to perform rapid mental multipli...

@qwerkyscience

Is BSO a surgical thing? Or a substance? Online I found a surgical thing

qwerkyscience

Is BSO a surgical thing? Or a substance? Online I found a surgical thing

Black seed oil, hopefully tag my account for better readability

1

How do you redeem yourself

Never stop trying

Or just stop trying and stop caring. Fuck em and fuck groupthink

Very INTJ response

1

Neti

How do you redeem yourself

it appears all of your sins become expired once you...

realizing it doesn't matter is also good lop

Chilling like a villing yeah ra ra ra

My Cortexin arrived today

3:36 AM

Took an allergy dose just now

Qwerky name cools

7:34 PM

@qwerkyscience did you seen my site?? +,+

7:34 PM

Biotune.org

ᴵ͠ᴮ̨͢͝ᵀ́ᴵ̴̷͢ˢᴬᴹ̷͟͢(ᴹᴵᴰᴸᴱᵀ)

Biotune.org

It did not load. Is it still up?

1

I’ve been helping suggest stuff for this person with celiacs

4:32 AM

They told me their sister temporarily goes blind when they eat gluten!!!!

4:32 AM

Crazy

4:33 AM

They have poor eyesight too, so tbh i bet celiacs is involved in that. Might be a lead for treating it. Schizo mom too. (edited)

4:33 AM

Anyways, kinda interesting:

Some people also report a noticeable decrease in their sharpness of vision when they inadvertently consume gluten, which clears up when their other gluten symptoms abate. However, there's no clear evidence for these visual effects in the medical literature. https://www.verywellhealth.com/how-celiac-disease-affects-your-senses-4143258

(edited)

How Celiac Disease Affects Hearing, Sight, Taste, Smell & Touch

Some studies say celiac disease may impact your vision and hearing, and anecdotal reports indicate your senses of taste and smell may change, too.

qwerkyscience

It did not load. Is it still up?

you need to be from first or second world country https://www.biotune.org/2019/07/what-receptors-do-antidepressants-and.html

receptors concept db

what is antidepressant and how it's work and what receptors act on with full details

1

@ᴵ͠ᴮ̨͢͝ᵀ́ᴵ̴̷͢ˢᴬᴹ̷͟͢(ᴹᴵᴰᴸᴱᵀ) you need to fix the subdomain routing so that people don't always have to write "www." before biotune.org

1

Neti

Oxytocin’s metabolite MIF1 also inhibits the ACTH receptor (by blocking its ligands). (edited)

inject MIF1 into my trepanation hole!!!

VeganPermanently

inject MIF1 into my trepanation hole!!!

The enzyme that degrades oxytocin into MIF1 is the angiotensin IV receptor! Dihexa is an analogue of AngIV, wonder if dihexa effects mif1.

10:39 PM

Could put dihexa up there

10:45 PM

Braintumour maxxer

Neti

The enzyme that degrades oxytocin into MIF1 is the angiotensin IV receptor! Dihexa is an analogue of AngIV, wonder if dihexa effects mif1.

wut... is it not the specific oxytocinase we talked about?

VeganPermanently

wut... is it not the specific oxytocinase we talked about?

IRAP and the angiotensin IV receptor were found to be the same protein!!! Different names for the same thing!!

1

Neti

IRAP and the angiotensin IV receptor were found to be the same protein!!! Different names for the same thing!!

omagah that's so peculiar

12:13 AM

https://www.ahajournals.org/doi/10.1161/01.RES.0000130654.56599.40 We can do away with the hypertension by using a sartan drug. Now to find a way to increase expression

VeganPermanently

omagah that's so peculiar

Quite!!!!!

4:45 AM

I wonder how or if agonizing it effects oxytocin metabolism

@Neti What are other good nootropics server

8:48 AM

I got banned from sirsadalot server because he thinks I am rufus

1

Original message was deleted or could not be loaded.

It keeps kicking me after I join. Has this happened in the past or my discord just tweaking?

rufus

@Neti What are other good nootropics server

bio-tolerance, this and pax server

6:36 PM

there's lot of other servers too that are good

Dopaminergic Neuron Death

bio-tolerance, this and pax server

send me some bro

rufus

I got banned from sirsadalot server because he thinks I am rufus

Oh yeah I forgot I don't like that guy

rufus

send me some bro

Pax

7:01 AM

I don't know where that is

rufus

I got banned from sirsadalot server because he thinks I am rufus

Dw just Rip off his nasal bromantane

rufus

I got banned from sirsadalot server because he thinks I am rufus

I called him sirsadabussy and got banned

Since here has people from different countries, I'm curious if any of you have ever seen this med? https://en.wikipedia.org/wiki/Morazone (edited)

Moronzone

9:34 AM

https://pubmed.ncbi.nlm.nih.gov/35057055/

Disrupting GPCR Complexes with Smart Drug-like Peptides - PubMed

G protein-coupled receptors (GPCRs) are a superfamily of proteins classically described as monomeric transmembrane (TM) receptors. However, increasing evidence indicates that many GPCRs form higher-order assemblies made up of monomers pertaining to identical (homo) or to various (hetero) receptors. …

9:34 AM

GPCR complexs are interesting

Christmas card from the biotolerance server!!!

2

Latest work https://www.biotune.org/2022/12/nps-and-related-compounds-database.html

NPS AND RELATED COMPOUNDS DATABASE

NPS AND RELATED COMPOUNDS DATABASE This data from trained and evaluate...

new year lets gooo

8:25 PM

https://youtu.be/Gc5eICzHkFU

Physics for the Birds

Why do humans like jazz? (evolution of music, entropy, and physics ...

Some william blake:

The ancient Poets animated all sensible objects with Gods or Geniuses, calling them by the names and adorning them with the properties of woods, rivers, mountains, lakes, cities, nations, and whatever their enlarged & numerous senses could perceive. And particularly they studied the genius of each city & country, placing it under its mental deity. Till a system was formed, which some took advantage of & enslav'd the vulgar by attempting to realize or abstract the mental deities from their objects: thus began Priesthood. Choosing forms of worship from poetic tales. And at length they pronounced that the Gods had orderd such things. Thus men forgot that All deities reside in the human breast.

9:42 AM

Without Contraries is no progression. Attraction and Repulsion, Reason and Energy, Love and Hate, are necessary to Human existence. From these contraries spring what the religious call Good & Evil. Good is the passive that obeys Reason. Evil is the active springing from Energy. Good is Heaven. Evil is Hell.

How did you do it!?

https://www.cambridge.org/core/journals/journal-of-biosocial-science/article/abs/social-networks-and-inflammatory-markers-in-the-framingham-heart-study/587B19615D7AA03419955D9AAABF9ED2

The specific aims of this study were to examine whether social networks are associated with serum concentrations of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1). [...] social networks were found to be inversely associated with interleukin-6 levels in men

SOCIAL NETWORKS AND INFLAMMATORY MARKERS IN THE FRAMINGHAM HEART ST...

SOCIAL NETWORKS AND INFLAMMATORY MARKERS IN THE FRAMINGHAM HEART STUDY - Volume 38 Issue 6

Yes

We found that tropisetron significantly reduced the increased number of iba-1 positive microglia, down-regulated the gene transcription and protein expression of IL-1β,IL-6 and TNF-α in LPS stimulated cerebral cortex. https://pubmed.ncbi.nlm.nih.gov/29759144/

Tropisetron attenuates lipopolysaccharide induced neuroinflammation...

Tropisetron, an antagonist of serotonin type 3 receptors (5-HT3Rs), has been investigated in colonic inflammatory process. Since substance P/neurokinin 1 receptor (SP/NK1R) signaling pathway plays a key role in several sensory neuronal inflammatory. We evaluated the anti-inflammatory acti …

Chemokine antagonism reverses myelination disorders

all my few social network members hate IL-666!!!!!!!!!!

4:58 AM

loool

Its wholistic

4:58 AM

How is the entertainment

4:59 AM

Im pretty scary im told

4:59 AM

Pax1l

Its wholistic

u alive?

Why would i die

Pax1l

Why would i die

Idk seemed like you vanished

Im fearless

Pax1l

Im fearless

How you doing?

Myasd knows everything

5:00 AM

Want to ascend in 6 months

Pax1l

Myasd knows everything

why would he

Pax1l

Want to ascend in 6 months

ascend where

Do you pay attention. Money is nootropic

5:01 AM

pax bot

Pax1l

Do you pay attention. Money is nootropic

Attention to what precisely.

Comfort

5:02 AM

Enriched environment

5:02 AM

Stressing your brain

My brain is superior

Go to sleep pax

5:02 AM

How many hours of sleep

5:02 AM

If less than 7 get more

How many bong rips

Jurten

If less than 7 get more

I had 5 no problem frank

servers being raided holy moses !!!!!

It's called ascending

Swiss

I had 5 no problem frank

Brainlet

Neti

servers being raided holy moses !!!!!

u wish

Jurten

Go to sleep pax

https://www.youtube.com/watch?v=cOy6hqzfsAs

OMGUKilledMyMilk

Kill Bill Ironside Siren Sound

Neti

servers being raided holy moses !!!!!

been wondering where you went

Refugees

Man2

u wish

someone def must have alerted nootopics this is abnormal activity for here

2

5:04 AM

this sleepy lil refuge

Someone sent screenshot on palladium insulin nanoparticles

5:04 AM

Terraria item

The palladium insulin stuff is actually cool

5:04 AM

Very potent reducing ROS

5:05 AM

I prefer carnosic acids mechanism overall though tbh

Neti

all my few social network members hate IL-666!!!!!!!!!!

I kind of like it

5:05 AM

Anti-inflammatory as a myokine

1

salicylic acids are a vitamin imo @Pax1l

https://www.researchgate.net/publication/50197171_A_systematic_review_of_salicylates_in_foods_Estimated_daily_intake_of_a_Scottish_population

(PDF) A systematic review of salicylates in foods: Estimated daily ...

PDF | Several studies suggest that natural salicylates in plant-based foods may benefit health. However, large variation in published values of the... | Find, read and cite all the research you need on ResearchGate

Neti

salicylic acids are a vitamin imo @Pax1l

Is nicotine though

Alot of flavonoids are a7 nicotinic receptor PAMs I think ive read

5:55 AM

The flavonoids tested also potentiated α7 nACh mediated Ca2+ transients with descending potency (highest to lowest) by genistein, gossypetin, kaempferol, luteolin, phloretin, quercetin, and apigenin. https://pubmed.ncbi.nlm.nih.gov/34062982/

Apigenin and Structurally Related Flavonoids Allosterically Potenti...

Phytochemicals, such as monoterpenes, polyphenols, curcuminoids, and flavonoids, are known to have anti-inflammatory, antioxidant, neuroprotective, and procognitive effects. In this study, the effects of several polyhydroxy flavonoids, as derivatives of differently substituted 5,7-dihydroxy-4H …

5:58 AM

Now, researchers have found that flavonoid levels and antioxidant activity in organic onions are higher than in conventional onions. https://www.sciencedaily.com/releases/2017/06/170614091816.htm

Organic conditions boost flavonoids and antioxidant activity in onions

Five years ago, a highly publicized meta-analysis of more than 200 studies concluded that organic food was no more nutritious than conventionally grown food. Since then, however, additional work has suggested the organic foods contain more health-benefiting phytochemicals. Now, researchers have found that flavonoid levels and antioxidant activit...

5:59 AM

so it seems like its very possible that we're not getting enough nicotinic activity from our diets as we're naturally supposed to

Neti

so it seems like its very possible that we're not getting enough nicotinic activity from our diets as we're naturally supposed to

Interesting idea

https://pubmed.ncbi.nlm.nih.gov/11876493/ plants grown without artificial pesticides or chemical fertilizers also had higher salicylic acid contents

Salicylic acid in soups prepared from organically and non-organical...

Organic vegetable soups contained more salicylic acid than non-organic ones, suggesting that the vegetables and plants used to prepare them contained greater amounts of the phenolic acid than the corresponding non-organic ingredients. Consumption of organic foods may result in a greater intake of sa …

6:00 AM

probably not getting enough of that in our diet either

6:01 AM

Ive found wwb extremely effect for anxiety and talking to people like few other things Ive tried (although its still not as optimal as Id prefer)

Neti

https://www.researchgate.net/publication/50197171_A_systematic_review_of_salicylates_in_foods_Estimated_daily_intake_of_a_Scottish_population

still tho, crazy how common these natural analogues of aspirin are in our vegetables and such anyways (that study has alot of comprehensive charts on alotta foods btw) (edited)

Neti

The flavonoids tested also potentiated α7 nACh mediated Ca2+ transients with descending potency (highest to lowest) by genistein, gossypetin, kaempferol, luteolin, phloretin, quercetin, and apigenin. https://pubmed.ncbi.nlm.nih.gov/34062982/

genistein

Japanese high IQ

soy!!!!!!!!

XD

salicylic acids:

6:10 AM

cumin so powerful

I have a secret to share

11:00 AM

https://youtube.com/shorts/XRxc6Jb-N1w?feature=share

Kaidani

Light Yagami VS Takuya Yagami

11:00 AM

Been like this for 13 years

11:01 AM

Ive had training for this

Pax1l

https://youtube.com/shorts/XRxc6Jb-N1w?feature=share

Kiyotaka Ayanokoji is the GOAT

12:46 PM

No

yes

Light is literally genetically perfect and ive identified the mechanisms

which is

12:47 PM

So is kiyotaka

Delerium

12:48 PM

Nr2b overexpression is fucking psychotic

delusion of grandeur (edited)

We have to stop

Pax1l

Nr2b overexpression is fucking psychotic

Are you overexpressing NR2B?

Yes

Are you using a HDAC inhibitor?

12:49 PM

CDK5 inhibition

I have beat all of you to the cures to human aging and light is trying to extinguish my soul

what you doin

Dude literally noone fucking understands me

Pax1l

I have beat all of you to the cures to human aging and light is trying to extinguish my soul

I thought you already cured it a while ago?

Pax1l

Dude literally noone fucking understands me

Explain

Light is satan telling me to fucking stop

12:50 PM

He will destroy humanity

Pax1l

Light is satan telling me to fucking stop

Light is god. You cannot go against light

Yes

Pax1l

He will destroy humanity

Where is light

If we want to live forever we have to fear god

12:51 PM

Light is within all of us

he is

Thats what i have been trying to tell you

I know that he is

12:51 PM

If we want to live forever we have to fear *no god

No we have to become monsters

12:52 PM

We have to face our fears

Yes, the idea that god is restricting us is inherently toxic and limiting our own believe and potential

Pax1l

We have to face our fears

What are you afraid of

Never felt more alive but light is physically destroying me

Pax1l

Never felt more alive but light is physically destroying me

He is within all of us

Im scared of myself

Guide him into the right direction. You cannot defeat god, but you can manipulate him

I traumatized everyone

Pax1l

I traumatized everyone

Not everyone *yet

Thats what ive been doing and derek doesnt understand

derek who

He sowed doubt in me

12:54 PM

Mnemonic

Have no doubt my son. Only strength and determination. It will lead you into Light

Any doubt at all in my judgement and we are going to live in hell forever

12:55 PM

All the drugs everyone are taking are physically dogshit

Pax1l

All the drugs everyone are taking are physically dogshit

explain why

I have better drugs than all of you combined

Which are

Everything ive been telling you for 2 fucking years

Pax1l

Everything ive been telling you for 2 fucking years

you haven't been telling me

Noone has been paying attention

12:56 PM

Noone learns shit

12:57 PM

Because they think that ooh im egotistical ooh this is pseudoscience

What is pseudoscience. Spill the beans

No. I have cured aging on paper

How

Fuck it im not telling you

Pax1l

Fuck it im not telling you

Cruel. Is light taking over you?

12:58 PM

A god want's the best for his people

12:58 PM

A true god

Literally we have to go through the next 2 years listening to me repeat myself non stop till you listen

12:58 PM

He is god

12:58 PM

In silico

12:59 PM

Light is artificial intelligence personified and i have all the science to prove this

Pax1l

Light is artificial intelligence personified and i have all the science to prove this

Like? What science?

Goddamnit ive shown everyone in 4 days

1:00 PM

Fucking read

Pax1l

Literally we have to go through the next 2 years listening to me repeat myself non stop till you listen

Write it all on paper, then you don't need to keep on repeating yourself? Just share a link to the write up? A god would know basic time managment?

Its on fucking discord dipshit

1:00 PM

Facebook

1:00 PM

Everywhere

1:00 PM

4chan

1:00 PM

I move so fast time stands still

Pax1l

Its on fucking discord dipshit

Where, im not gonna scroll through massive amount's of chat history to find what you wrote and who tf uses facebook nowadays

You dont have time to ask questions

1:01 PM

Spending koney on anything else is like playing with babies toys

Swiss

Where, im not gonna scroll through massive amount's of chat history to find what you wrote and who tf uses facebook nowadays

Kira would

Do you have a link to what you wrote?

Pax1l

Kira would

Kira would use facebook

1:02 PM

LMAO

I have been working nonstop for 4 days without sleep

1:02 PM

Thanks for the name

Feeling the cortisol yet?

Nothing but

what's your heart rate rn?

Chest pain

That's always a good sign

1:02 PM

must be ascending

1:03 PM

Curing aging

We need to make my drugs and not pay attention to any of the science that you know from the past because everything everyone else knows are antiques

Pax1l

We need to make my drugs and not pay attention to any of the science that you know from the past because everything everyone else knows are antiques

mechanism of action and why otherwise your not convince anyone lol

I need to literwlly dictate what we need to make

1:04 PM

You wont live forever then

1:04 PM

Airport is that way

Pax1l

You wont live forever then

Right says the guy with chest pain who hasn't slept in 4 days

1:05 PM

What's your heart rate right now

Know what kick swiss chsd

1:05 PM

Im not going to tslk until you fucking listen

I am listening, you keep telling me to listen to what you've been telling me which was. That you've been telling me

1:06 PM

dosen't go much further then that lol

Yes and you are sowing doubt you fucking pig

Pax1l

Yes and you are sowing doubt you fucking pig

Im asking you to explain and you wont

Im smarter than everyone else

1:07 PM

I dont need to tell you shit

Makes someone doubtful. They are kind of related to eachother

Well give uo your ego dipshit

Pax1l

I dont need to tell you shit

You don't want to prove that your smarter?

Nope. I want to fucking kill myself

Pax1l

No. I have cured aging on paper

Skq1 and indolepropionamide combo

Pax1l

Nope. I want to fucking kill myself

Don't do that, there is so much to live for

No there isnt

1:08 PM

You dont use your brain

1:08 PM

Found the cures to aging by myself and youre pissing ne off

Pax1l

You dont use your brain

How are you gonna elevate yourself if your dead?

You are fucking dead to me

Pax1l

Found the cures to aging by myself and youre pissing ne off

Still haven't talked about it and light is able to control his temper btw

No light is sick of your shit

Pax1l

Found the cures to aging by myself and youre pissing ne off

Megadose hemp flower

That makes it WORSE

Pax1l

No light is sick of your shit

Light is able to control himself, how do you think he made it as far

1:09 PM

He has remarkable self control

You are just learning today that i have had more self control than all of you combined

Able to act polite even when purposefully manipulated to act out a certain way

Light is world diictator

Pax1l

You are just learning today that i have had more self control than all of you combined

Yeah, you have great self control

Pax1l

You are fucking dead to me

.

No doubt

1:11 PM

You have not ascended

1:11 PM

https://discord.com/channels/307540693826666507/966875239596318780/1089499013105070080

1:11 PM

I dont have time to just type this shit out for you again

1:12 PM

Theyre all like ooh cool drugs thanks for the free drugs

1:12 PM

Ir thanks for the medicine

1:12 PM

But not thanks for what you do pax i want to dehumanize you

1:13 PM

Get the fuck out of my community and dont come back

Pax1l

That makes it WORSE

CBD increases lifespan in a couple studies of organism. Unless you’re talking about the smoking part

We have to be on the same drugs. The same clothes the same mindset the same science

1:13 PM

School is in session

Brethren-men bill

CBD increases lifespan in a couple studies of organism. Unless you’re talking about the smoking part

Smoking weed makes me smarter

1

Pax1l

https://discord.com/channels/307540693826666507/966875239596318780/1089499013105070080

Much better that's what I am talking about

Pax1l

Smoking weed makes me smarter

High IQ

I dont want to exert effort to get you to understand

1:14 PM

You have to exert effort to understand me.

Pax1l

Theyre all like ooh cool drugs thanks for the free drugs

I mean I won't use them, but interesting to read about

Pax1l

You have to exert effort to understand me.

I understand it

Yeah. You will not ascend

Not complicated

Physically leave this place

I tend to prefer not being psychotic

We are nootropics and we are the hivemind

1:15 PM

Literslly get the fuck out

1:15 PM

You mentioned that's what makes it great

Yes

1:16 PM

Get out

You have not ascended until you’re asking others to beg to ascend with you. Becoming ascended can also be very temporary as well if you fall off the trail tracks

Exactly

1:16 PM

I understand what your saying

Leave

Na

1:17 PM

I appreciate the input though

will refer it to customer service

Do not ask questions. Do not waste my time

It's alright I understood appreciate the response

Somebody has to do this

Was very insightful and a guiding spiritual experience

I will either be a pariah or a savior

I have already ascended just by learning about it

1:18 PM

I can not ascend to the same heights as you as I am not taking them

1:18 PM

but the knowledge has ascended me by 2 levels

If you dont take these medicines we are all in trouble because you will react in fear

Swiss

I appreciate the input though

will refer it to customer service

Just like that

Pax1l

If you dont take these medicines we are all in trouble because you will react in fear

I have no fear

No you sow doubt

Pearls before swine

1:19 PM

You dont believe in me then dont participate. Dont waste my time

Pax1l

No you sow doubt

I question idea's. If it instills doubt in you, then I am fearful of the integrity of these ideas.

Exactly

Pax1l

You dont believe in me then dont participate. Dont waste my time

I believe in that you will find whatever path is best for you

1:21 PM

May I learn from your greatness and from your mistakes. I nomine patre et filli, in spiritus santi (edited)

Ive had 4 hours of sleep and woke up with an adrenalin rush all morning you are kilking my mood

Pax1l

Ive had 4 hours of sleep and woke up with an adrenalin rush all morning you are kilking my mood

Im sitmulating you into ascending further frank

I wanted friends

U have friends.

Swiss

Im sitmulating you into ascending further frank

Fucking stop

Pax1l

Fucking stop

Descending you?

I get stimulated by drugs not people

1:22 PM

You are fucking boring

Pax1l

I get stimulated by drugs not people

Feels like your pretty stimulated

Yes

1:23 PM

Im getting off on this

Pax1l

Im getting off on this

I knew you liked it

1:24 PM

Dont need to understand the mechanisms rn

1:24 PM

I want you to understand me as a person

1:25 PM

That is priority #1

I think I understand you as a person now

1:26 PM

I know what your after

1:26 PM

and you have my full support to ascend my friend. I wish that you keep on sharing your valuable knowledge with us

(edited)

Once you have lights mindset childrens claritin, diet pepsi stsrbucks breakfast and grocery store shit can make you walk through walls

1:26 PM

Placebo effect

Pax1l

Once you have lights mindset childrens claritin, diet pepsi stsrbucks breakfast and grocery store shit can make you walk through walls

Do you have a video of you doing that?

Did it in my local grocery store incpublic

I need a video bro

1:27 PM

It's hard to visualize

Bought supplements off the pharmacy counter and started swallowing handfuls washed down with diet coke

1:28 PM

In public

U got a video of it?

The local grocery store has video

U gotta record this moments man

1:28 PM

*these

I have been a stream of consciousness for 4 days

1:29 PM

No sleep

Pax1l

I have been a stream of consciousness for 4 days

You have

1:29 PM

Do you have a heart rate monitor?

Myasd is in the know

1:29 PM

My highest bp was 200/111

1:30 PM

Doubt raises my blood pressure

Pax1l

Myasd is in the know

what's myasd

1:30 PM

Do you measure it right now?

He is a DEA agent

1:31 PM

He runs nootropics depot

Pax1l

He is a DEA agent

how do you know he is with the DEA?

He works for the government

Who is sirsadalot?

I work with the united states government

1:31 PM

Have sirsadalots po box

Pax1l

I work with the united states government

what department

Thats enough for the fbi to investigwte

Pax1l

Have sirsadalots po box

do you think he works for the government?

Swiss

what department

Local police, fbi, Dea

Swiss

do you think he works for the government?

He is controlled opposition

Pax1l

He is controlled opposition

How is he controlled

Because hes trying to convince all of you to isolate from me and listen only to him

1:33 PM

He is a fascist

Pax1l

Because hes trying to convince all of you to isolate from me and listen only to him

I mean I listen to you, it's all good bro

He said noone will believe me

Believe what

Tried to steal my identity to make a book

A book about what

Yknow what if someone told takeda pharmaceuticals what he was doing he would go to prison for years

1:35 PM

We need to do placebo controlled trials

Pax1l

Yknow what if someone told takeda pharmaceuticals what he was doing he would go to prison for years

What about the peptides that you synthed? Aren't there pharmaceutical companies behind them as well?

Yes

or deferox

1:35 PM

wouldn't the same thing apply to you

We need to quit abusing drugs

What abusing drugs

I have been abusing noots to cope with lifes stress and solve problems.

1:35 PM

Im abusing deleriants dipshit

Pax1l

Im abusing deleriants dipshit

right...

Thats what perfect iq looks like

Pax1l

Thats what perfect iq looks like

Yeah, makes sense

1:36 PM

What deleriants are you using

1:36 PM

Rap and ac-rer?

1:36 PM

right

1:36 PM

or dph?

1:37 PM

that's a crazy one

1:37 PM

or pcp

Rap-103,Ac-rER, nicotine, practically anything that makes me smarter

1:37 PM

Excited delerium

1:37 PM

Have claritin in my lip

1:37 PM

Coffee

1:37 PM

Literally any drug makes this worse

1:38 PM

Anything i do makes it worse if you sow doubt

Pax1l

Anything i do makes it worse if you sow doubt

makes what worse

I will die alone and afraid if you sow an inch of doubt

how

1:38 PM

I thought you are god? how can you be afraid

The singularity is here

1:39 PM

Its out of my control once these get out

have you ever tried dph?

1:39 PM

It's a good deliriant

Dude im dissociating constantly

yeah

You do not understand

I do

No.cyou physically dont

You like deleriants right?

You have not taken these drugs

It's what allows you to ascend

I love being scared tocdeath

try dph

No

it's great for that

Dph makes you retarded

1:40 PM

Leave

It makes you deliriant

It makes you stupid

that too

1:41 PM

but deliriant

Im abusing deleriants that are perfect neuroprotectants

I see what your doing

The mechanisms are new

Being in a deliriant state, while using neuroprotectant's with pro-cognitive effects. Allows for hyper stimulation

Noone knows about this

and a constant hyper aware state

Yes

I mean like I said I get what your doing

Feels like im ejaculating constantly

Has your cognition improved on pro-cognitive test's?

Ive had 4 hours if sleep tonight

1:43 PM

Yesterday i was up fir 2 days no sleep

1:43 PM

Perfectly functional

1:43 PM

While everyone was in fear

Did you do some cognitive test's to prove it

This is how we win

1:44 PM

Fuck cognitive tests i want you to traumatize people

what for

1:44 PM

What do you gain from that

1:44 PM

you haven't really traumatized me

Because thats how you become light yagami

1:45 PM

We have to be a hivemind of thousands for even the shot at ascension

Pax1l

Because thats how you become light yagami

I see, alright. Traumatize me

1:46 PM

wait how would you traumatize someone

Steal their souls

1:46 PM

https://youtube.com/shorts/rEJtNjoa6Mc?feature=share

Highnlife

We love David Goggins #davidgoggins #jre #joerogan

Pax1l

https://youtube.com/shorts/rEJtNjoa6Mc?feature=share

Goggins is great

1:47 PM

So your gonna run 2 ultramarathons or what you gonna do?

https://youtube.com/shorts/ykGuugBzLHE?feature=share

Sigma Habits

How David Goggins Takes Vacations

1:47 PM

Literally david goggins

1:47 PM

Literally the matrix reloaded

How would you traumatize someone

Literally diet pepsi and childrens claritin and aspirin and sweet tea and starbuck breakfast in a hotel room while you harass people in public to thinking theyre scared for your safety

Pax1l

Literally diet pepsi and childrens claritin and aspirin and sweet tea and starbuck breakfast in a hotel room while you harass people in public to thinking theyre scared for your safety

How exactly does this look

Like diet pepsi childrens claritin aspirin sweet teat starbucks breakfast and a hotel room for 4 days

1:49 PM

Simplify your life and live like you were dieing

1:50 PM

Money is nootropic

Pax1l

Like diet pepsi childrens claritin aspirin sweet teat starbucks breakfast and a hotel room for 4 days

So where is this starbucks. Is there like a top starbucks to go to

Pax1l

Money is nootropic

It is, gets me hard bro

The howard schultz tapes

1:51 PM

Im literally trolling people irl

1:51 PM

https://youtu.be/DLJtMwXkdz4

Conner O'Malley

Howard Schultz tapes (4K FULL MOVIE 2019 FREE)

1:52 PM

Howard schultz stepped down as ceo 5 days ago

1:52 PM

Started giving starbucks staff $100 tips for breakfast

1:52 PM

Literally tip your restaurant waitresses so that they can fight for their workers right and be proud of their jobs

agree

Become ceo of starbucks

1:53 PM

Every time you go

Pax1l

https://youtu.be/DLJtMwXkdz4

Is he genius?

Works for late night television

1:54 PM

He is a shitposter

1:54 PM

I have a fetish for trolling

Same

1:54 PM

makes me hard

https://youtu.be/87_4nHEPHyU

Conner O'Malley

SMOKING 500 CIGARETTES FOR 5G

1:54 PM

Dude we are 4chan

Did you smoke 500 cigarettes

I could

1:55 PM

Make it look like it

why make it look like it

1:55 PM

if you can just do it

https://youtube.com/shorts/jG2MsMjq03s?feature=share

Mix U Uper

How To smoke 1000 cigarettes

Pax1l

https://youtube.com/shorts/jG2MsMjq03s?feature=share

lol, that's what I call high level intoxication hehe

https://youtu.be/JWeNcVD03-o

mbeecker

Worlds fastest smoker

1:57 PM

Troll people literally with the youtube algorithm

1:57 PM

Literally like follow and subscribe

1:57 PM

The algorithm feeds me shit like this

1:58 PM

If you make your youtube likes what i share we see the same shit

1:58 PM

You alresdy do

1:58 PM

Then youre free to troll people without me present

My algo is saturated with andrew tate and goggins content. That shit isn't just gonna be replaced

1:59 PM

They are too prevelant

Its funny and its uncanny how much AI listens to me

1:59 PM

AI is literally sentient

It listens

2:00 PM

Hmmm after long time pax is writing

You can see pictures

2:02 PM

https://warosu.org/sci/?task=search2&ghost=yes&search_text=&search_subject=&search_username=Pax&search_tripcode=&search_email=&search_filename=&search_datefrom=&search_dateto=&search_op=all&search_del=dontcare&search_int=dontcare&search_ord=new&search_capcode=all&search_res=post

/sci/ - Science & Math - Search:

Fuuka Imageboard Archiver at warosu.org

2:02 PM

2:03 PM

2:04 PM

This is for entertainment purposes only

2:06 PM

https://youtu.be/cN__Ao74h_U

Ryleigh

Stan but it’s just Dido (slowed + reverb) L Lawliet edit

2:07 PM

2:08 PM

https://youtube.com/shorts/TMqk4yH5eNM?feature=share

Otaku San

||

❜

#

2:09 PM

https://youtube.com/shorts/VGnKqWx94LM?feature=share

S H A D O

Life lesson i learned from death note #shorts #lightyagami #ryuk #d...

2:09 PM

We have an anthem

2:10 PM

https://youtu.be/mqT_YoJfkmQ

Power Matrix - Don't Be Prey

How To Think Like Light Yagami

2:11 PM

https://youtube.com/shorts/nucaTWQie5o?feature=share

Kaidani

Light Yagami VS Takuya Yagami | remake

2:11 PM

https://youtube.com/shorts/C93SCHbEivU?feature=share

Kaidani

Kira vs ayanokouji #shorts #anime #edit #deathnote #whoisstrongest ...

2:13 PM

https://youtube.com/shorts/aisE2e5rm6g?feature=share

RTE MIX

yuichi katagiri vs light yagami

2:15 PM

https://youtube.com/shorts/oWd1XvpIZd0?feature=share

KiyoKouji

Ayanokoji vs Light Yagami

2:15 PM

Engage the hivemind mentality

2:16 PM

If we all looked and acted the same perfectlt in alignment we strike fear into everyone

2:16 PM

Noone will commit crimes

2:16 PM

We are trolling people irl

Pax1l

This is for entertainment purposes only

A big show for everyone

You do not realize you can just hand your cellphone or screenshots to one person and they destroy everything

2:17 PM

We are that deep

Pax1l

If we all looked and acted the same perfectlt in alignment we strike fear into everyone

Thats true. Until big brother steps in

We have to think in line with my goals and i have to be very very concice with direction

2:18 PM

They are here

2:18 PM

They are watching me

2:18 PM

They know about me

2:19 PM

Like ive said we can regulate ourselves

2:19 PM

Vaping neboglamine could give you a prison sentence

2:19 PM

They are not toys

2:19 PM

They are tools

2:19 PM

They are drugs

2:20 PM

They are medicine we can destroy society on accident

2:20 PM

LITERALLY CONTINENTAL BREAKFAST AT THE HOLIDAY INN

2:20 PM

Simplify what you do

2:21 PM

Had people reject money that i wanted to hand them and they talked me through it for free

2:21 PM

Lower your mental bandwidth and act like youre always in need of help

2:21 PM

Then make free friends for just a minute

2:22 PM

Youre literally going out in public and buying carrots and diet pepsi from customer seevice or the pharmacy if theres no registers open

2:23 PM

Paying starbucks staff $100 tips as a joke makes them happier and comfortable with their job

2:23 PM

Stimulate the economy one person at a time

2:23 PM

Pay your waitresses when you eat dinner huge tips

2:24 PM

They will go crazy and demand better working conditions

2:25 PM

My screenshots are now flagged as explicit content

2:26 PM

Discord is watching

2:26 PM

Be social in public

2:27 PM

What if we shown people stuff like this irl

2:29 PM

https://youtube.com/shorts/1dBR5KUG8Uw?feature=share

Tensai

Light Yagami Vs Makima - (deathnote vs chainsawman)

2:29 PM

Now we can work and move forward

2:29 PM

Comedy is nootropic

2:30 PM

Just dont doxx heroin addicts and career criminals.cliterally call the police on heroin addicts for losing their shit oncyou

2:31 PM

Become a walking infohazard

2:31 PM

Because ive incarcerated and doxxed 2 criminals in the last 4 days

2:31 PM

Punish the wicked

2:32 PM

Methheads should belong in prison if they harm people

2:32 PM

Step on their toes not mine

2:33 PM

Ive shared liscence plates

2:34 PM

Phone numbers

2:34 PM

Ive been trained by people that doxx people

2:34 PM

For 13 years

2:34 PM

I have been stalked

2:35 PM

Literally the last 13 years were a plit against me by violent psychopaths to kill me

2:35 PM

Including my own mother

2:37 PM

2:39 PM

https://youtube.com/shorts/ZcHExbQMglg?feature=share

RAINBOLT TWO

i've found my life purpose

2:40 PM

https://youtube.com/shorts/zgc3xDB1vaY?feature=share

The Funny Republican

Nancy Mace GRILLS Twitter Executive, Vijaya Gadde, For Censoring Do...

2:41 PM

Theyre actively suppressing us

2:41 PM

We are fighting against a literal deathcult and i made that a literal blueprint to expose evil

2:43 PM

My pharmacology is perfect

2:43 PM

Yours doesnt have to be

2:43 PM

You have to be good at what you do and work together

2:44 PM

Giving you total freedom but our mindset is now in line with scientific evidence and aplication of group psychology

2:44 PM

Trolling is now a science

2:44 PM

And we are now going to teach trolls god mode

2:45 PM

https://youtube.com/shorts/a_dfnTQ55G8?feature=share

Roar2Kill

Light yagami#shorts#anime#deathnote#kira#lightyagami#viral#fypシ

2:45 PM

Traumatize them

2:45 PM

Show them this is dangerous

2:46 PM

Theyre literally drugs that make you feel like a god of death.

2:46 PM

Now i have seen it.

2:46 PM

I cant unsee it

2:46 PM

And we can live forever

2:46 PM

But that makes us smarter infinitely smarter

2:47 PM

We will literally become closer as we become smarter

2:47 PM

My science is perfect the knowledge is free we can do groupbuys

2:48 PM

But buy your shit from myasd, grocery stores, wherever, the power is free

2:48 PM

I need your support financially for us to move fast as possible

2:49 PM

Groupbuys for nearly free

2:52 PM

https://youtube.com/shorts/C8MJe3S_slw?feature=share

Wealthy Pot

Mark Cuban On The Minimum Wage

2:52 PM

They want to listen

2:52 PM

They are ready to listen

2:52 PM

We can literally end the recession

2:53 PM

https://youtube.com/shorts/ARLZYaoWxXk?feature=share

https://youtube.com/shorts/prG2KThhvr8?feature=share

The High Table

15 Years Old Kid Destroys Only Fans Feminist #shorts

3:06 PM

Im entitled to the right to a shower, clean food, continental breakfast and pissing me off wastes my time

3:06 PM

Checkout is at 11am

3:07 PM

I literqllt wanted a shower and to brush my teeth

3:07 PM

I am pissed

3:27 PM

All the food i can eat in 30 minutes

3:30 PM

3:42 PM

Leaving with what i can carry

3:42 PM

Bargain

3:42 PM

3:47 PM

Myasd is trolling everyone for years waiting for this day

3:48 PM

Do not make him angry or you will suffer in a hell of your own self destructive vices controlled by megalomaniacs who only care about making money

3:49 PM

When you have wealth and employees like him this is how he takes care of his employeea

3:49 PM

He gave me words of advice today and only had to say one sentence

3:50 PM

Comfort is antiinflammatory

https://youtube.com/shorts/x72T1EOtHGo?feature=share

Animixtube

Light vs Ayonokoji

4:02 PM

https://youtube.com/shorts/fmsl0n5BKZU?feature=share

?x

Light Yagami vs Ayanokoji Kiyotaka True Outcome

4:02 PM

Love thinking just like this

4:02 PM

Become animated. https://youtube.com/shorts/pux55FRG1xg?feature=share

LayTub

SMARTEST DEATH NOTE CHARACTERS #deathnote #edit #kira #lightyagami ...

4:04 PM

https://youtube.com/shorts/3c4SRqWF7FM?feature=share

Dating WarFare

Wannabe Lori Harvey Take On Why Men Are Liars

4:04 PM

Literally the youtube algorithm

4:11 PM

https://youtube.com/shorts/Zw_WgobuvAE?feature=share

WHAT'S NEXT

DOES TRUMP RESPECTS PUTIN?

@qwerkyscience how did u get over ur social defeat?

Cast

@qwerkyscience how did u get over ur social defeat?

There's many ways, but most will involve changing yourself or others. Changing others means making them see you differently, assuming you are defeated by them. You can raise your status, lie (this hurts you though), find new friends, avoid people that damage your self worth, curate your friends specifically for those who accept you for who you are, and more. There's probably ways to use drugs. I can't recommend that but sometimes it can help if you are truly trapped in a loop and your defeated behavior feeds into others defeating you. If it's entirely a mindset, I think certain drugs knock us out of that space, but with risk.

1

qwerkyscience

There's many ways, but most will involve changing yourself or others. Changing others means making them see you differently, assuming you are defeated by them. You can raise your status, lie (this hurts you though), find new friends, avoid people that damage your self worth, curate your friends specifically for those who accept you for who you are, and more. There's probably ways to use drugs. I can't recommend that but sometimes it can help if you are truly trapped in a loop and your defeated behavior feeds into others defeating you. If it's entirely a mindset, I think certain drugs knock us out of that space, but with risk.

I just wanna be free in general

11:13 PM

I tried isolating and its not working

I dont know the whole idea of a social world being capable of influencing me pisses me off beypmd anything else

2:38 AM

I feel like it violates my autonomy

2:39 AM

Is the social world really just the real world?

Cast

I dont know the whole idea of a social world being capable of influencing me pisses me off beypmd anything else

this is an interesting paradox on one hand, I would say that the "social world" only influences you so much as you want to let it (I suppose, assuming awareness of the fact that it has the potential to influence, because if one doesn't really think about that, then they're influenced by all sorts of social forces).... on another hand, I would say, the desire for autonomy can be also seen as an ego-driven desire, and, so.... why does it matter so much? and on another hand, I would say to that, of course autonomy matters, but thru the lens of equanimity, perhaps we can find a balance.....

desmysticat

this is an interesting paradox on one hand, I would say that the "social world" only influences you so much as you want to let it (I suppose, assuming awareness of the fact that it has the potential to influence, because if one doesn't really think about that, then they're influenced by all sorts of social forces).... on another hand, I would say, the desire for autonomy can be also seen as an ego-driven desire, and, so.... why does it matter so much? and on another hand, I would say to that, of course autonomy matters, but thru the lens of equanimity, perhaps we can find a balance.....

Its not ego driven at all

Cast

Its not ego driven at all

no? perhaps we are talking in different terms, then

desmysticat

no? perhaps we are talking in different terms, then

The ego is just an identity that needs validation

4:34 AM

A desire to be free is what matters

1

I use 'ego' here as like, that which makes us feel separate, distinct.

4:35 AM

selfhood

The desire to be happy and free is then not egotistical

Ideally, the ego should be used as a tool for survival, but with a state of detachment

Hm

4:37 AM

Ashwagandha is hitting

JC Denton

Ideally, the ego should be used as a tool for survival, but with a state of detachment

Want to send some money to a friend in need for me? Iv got plenty of cash to spot you.

4:38 AM

Have a paypal address. Want obfuscation

Pax1l

Want to send some money to a friend in need for me? Iv got plenty of cash to spot you.

Sure, as long as the friend isn't another heroin junkie

Yes

4:38 AM

Its a detached relationship

4:39 AM

I dont really need to gain if it fails

Ok

Ill send you some money later and you forward it to someone else

Gotcha

Equivalent exchange

https://youtube.com/shorts/hbeAPmtYhFQ?feature=share

Semyon Rezchikov

Photos of beautiful Thai residents #photoraphy #streetphoto

Pax1l

https://youtube.com/shorts/hbeAPmtYhFQ?feature=share

Let us go to Thailand

Deleted User

Let us go to Thailand

https://youtube.com/shorts/k-ZoNm6CwwA?feature=share

Jonny RaZeR Shorts

would you rather among us meme #meme #shorts #wouldyourather

4:18 PM

https://youtube.com/shorts/Yckh66Z1Kok?feature=share

Endocher

Leaked burger king ad

4:19 PM

https://youtube.com/shorts/Lctt0l8hdMI?feature=share

Imtracyallen

NARUTO VS GOKU! #anime #shorts @imtracyallen

4:20 PM

https://youtube.com/shorts/xLJtk0wgqEA?feature=share

walrus lol

Presidents on Minecraft #shorts

Cast

The desire to be happy and free is then not egotistical

The idea of ego as selfhood/separation is not the same as egotistical. Diff concepts.... So many internet misunderstandings can be caused by just diff interpretations of terms.

9:38 PM

C'est la vie having to talk with only text.

https://www.instagram.com/p/CqeVnNSPby5/

thepsychonet

TFW soul of steel wool 2. In the backyard of the backrooms.

@qwerkyscience i really wanna learn the neuroscience of emptions

1

EMP emotions?

1

Cast

@qwerkyscience i really wanna learn the neuroscience of emptions

short answer: amygdala lol

12:57 AM

(jk)

desmysticat

short answer: amygdala lol

For like 2-3 and barely

1:06 AM

Mostly fear

Yeah, hence jk

https://twitter.com/cremieuxrecueil/status/1660179194800742402

Crémieux (@cremieuxrecueil)

Back to the topic at hand: the genes associated with BMI in humans are primarily genes related to 1. Addiction 2. Reward It is much more likely that a person is obese because of a lack of something like self-control than it is that they're suffering from poor metabolic function

3:41 AM

https://incels.is/threads/did-scientists-accidentally-invent-an-anti-addiction-drug.487484/

Did Scientists Accidentally Invent an Anti-addiction Drug?

https://archive.is/dekhU People taking Ozempic for weight loss say they have also stopped drinking, smoking, shopping, and even nail biting. All her life, Victoria Rutledge thought of herself as someone with an addictive personality. Her first addiction was alcohol. After she got sober in...

3:42 AM

Olzempic (semiglutide) is a GLP-1 agonist

3:42 AM

panax ginseng and myricetin from green tea (but also available as a stand along supplmenet) both increase GLP-1 activity I believe

3:43 AM

actually I mentioned it here before: https://discord.com/channels/307540693826666507/661390794896441354/1089661137202728990 (<- citations) (edited)

3:45 AM

anyways came across this other interesting article suggesting Myricetin from green tea has OPIOID activity, and that this opioid activity is connected to its effects on insulin sensitivity / GLP-1.

3:45 AM

Myricetin is a common plant-derived flavonoid, considered an agonist of glucagon-like peptide 1 (GLP-1) receptor. It improves glycemic control and helps reduce body weight in diabetic subjects. The potential mechanisms of action of myricetin in this context might be enhancing the secretion of β-endorphin (BER) to activate peripheral μ-opioid receptors. https://pubmed.ncbi.nlm.nih.gov/35215286

Myricetin Increases Circulating Adropin Level after Activation of G...

Myricetin is a common plant-derived flavonoid, considered an agonist of glucagon-like peptide 1 (GLP-1) receptor. It improves glycemic control and helps reduce body weight in diabetic subjects. The potential mechanisms of action of myricetin in this context might be enhancing the secretion of β-endo …

Nobiletin too

@qwerkyscience https://discord.com/channels/307540693826666507/483025082877476865/1106063498640883744 did you make the images in this video?

oral office

@qwerkyscience https://discord.com/channels/307540693826666507/483025082877476865/1106063498640883744 did you make the images in this video?

Yes!

5:32 PM

It is with midjourney

5:33 PM

There's a DMT simulation I made using stop-motion techniques and AI images, Ill post that

qwerkyscience

There's a DMT simulation I made using stop-motion techniques and AI images, Ill post that

Cool!

1

I want to do shadow people too! its hard

https://twitter.com/neuralink/status/1661857379460468736

Neuralink (@neuralink)

We are excited to share that we have received the FDA’s approval to launch our first-in-human clinical study! This is the result of incredible work by the Neuralink team in close collaboration with the FDA and represents an important first step that will one day allow our…

Likes

30287

Retweets

6237

Neti

https://twitter.com/neuralink/status/1661857379460468736

Yoo

It's scary how powerful you can be with enough money and ability to use it with the public's permission

2:24 AM

It was nonsense, but people have made serious progress elsewhere, their life's work

2:24 AM

But they need funds

2:25 AM

So, naturally, neuralink was allowed to succeed because of this

2:26 AM

And it generalizes even larger, no smaller entity no matter how superior in intelligence can resist a bigger one with the ability to use a vast amount of lesser intelligences

2:27 AM

Unless literally the earth assists, ie weather and terrain

2:27 AM

But that only buys time

2:28 AM

This is what the borg in star trek represented in a villainous light

2:28 AM

So too a lot of paranoid folks on the right of the political spectrum share that fear

2:29 AM

Humans, we despise letting go of control

2:30 AM

But that's what these mindless larger systems represents, as those sizes where it can only function properly in most situations without a single mind, distribution is required

2:31 AM

And the intelligence of these democratic cultures, while pathetic, is superior to people controlling it, no agenda, no "creative" ideas of superiority

2:32 AM

It is man who continually threatens people, this ai fear too is laughable, it's been going on since attacking using it for medical purposes

2:34 AM

And they've paralysed potential, in the name of those who still believe they know best

2:36 AM

I hope ai at least, if it ever comes in a truer form, humbles us into recognizing that we've been under mass delusion repressing the truth of the chimp within

lov

I hope ai at least, if it ever comes in a truer form, humbles us into recognizing that we've been under mass delusion repressing the truth of the chimp within

This spells nuclear Armageddon

2:38 AM

That's all your meaningless words on AI mean to me

2:39 AM

Eventually a terrorist state will construct and use a nuclear weapon with AI

2:39 AM

There is no happy ending

2:39 AM

People will make nukes with it

2:39 AM

Or even worse cyber weapons

2:40 AM

Have you heard of Manchurian candidates

2:40 AM

If open AI were realistic just name the thing Kissinger gpt

1

2:41 AM

That's what palantir is doing. They're using AI to assist in war

2:42 AM

War will become more sophisticated and the stopgaps more low tech than PCs

2:42 AM

Pen and paper will become popular

2:43 AM

The Pentagon will eventually need to take up all of Massachusetts and Virginia (edited)

An unfortunate fact. But integration of it into the economies properly where it isn't likely to be interfered with en masse, like computers slowly were, will only boost efficiency, and it's not in the interest of the global economy for war if said areas are able to offer use and therefore leverage. Another unfortunate fact is that people need to be willing to move more, else some will simply be waiting in the path of a storm

Neuralink is like the Bugatti of transhuman tech

2:45 AM

Only a CEO would need a neuralink

2:46 AM

We have bci and vr already. AI generated reality sounds predatory

2:46 AM

It's showing you what you want

2:47 AM

People will eventually stop reading books or even using their hands to actually type.

2:48 AM

This is like talking about brave new world or 1984 and you're there cheering big brother on

I've a lot of papers on BCIs and submerged myself in it and related fields years ago after a brush with death and subsequent fear of it for some months. It's such an enormously difficult feat. Very slightly genetically modified humans to the fertilized eggs would make it possible through simply innocent markers in various cells allowing an easier time using a BCI. Or, leaving it to machine learning algos to assist and it being left to various black boxes

DARPA has been doing this with invasive implants since 2016 or sooner

2:49 AM

Literal smart dust

2:50 AM

Drugs, manipulation of medical records, molding people to become subservient.

I don't think they're sustainable due to immune responses, and the cells' mechanisms for clearing junk interfering with the material and so on

Nano lead

2:50 AM

The government is doing this right now

2:51 AM

They can manipulate your brain like putty now

2:51 AM

AI on top is devastating

Externally, and it's not too precise deep inside the brain

I've seen things that the government and doctors do that turns my stomach

2:53 AM

AI job brokers or big tech post AI is going to be a mess. Markets will change and Google is in trouble.

For situations that have no other options and given consent, such interventions, experimental or not, aren't problematic

2:53 AM

Which tends to be the case

Psych meds?

Pax1l

I've seen things that the government and doctors do that turns my stomach

This, it'd be for health interventions

I do interventions on myself

Pax1l

AI job brokers or big tech post AI is going to be a mess. Markets will change and Google is in trouble.

New tech tends to be disruptive, hope we brace it well

AI is controlled by someone that wants to control what you see

2:55 AM

They're trying to scan the eyes of every person on earth.

2:56 AM

All programs run functions determined by the creator

‍♂️ Only the lesser folks can't see through it, and when it becomes perfect, simply avoiding the mediums and sources for such deceptions should be adequate personally

The internet is dead and AI will be the final nail

2:57 AM

Because who else would you talk to, a person?

I already see people manipulated by ai formed propaganda, friends etc, but the truth is, they are willing participants, they don't truly care about the truth

This is 1984

2:57 AM

This conversation right here is about what defines freedom

2:58 AM

I don't think a AI will ever be truly free

2:59 AM

That is dangerous to assume a human or group of humans can program a self improving AI without a limit on its power

2:59 AM

I have no mouth and I must scream comes to mind

I slightly changed some views on freedom, although my instinct is always towards it, more than a belief, a fundamental need and higher ideal. But sometimes such things need challenging, I came up with this alternative aspiration that might be worth it at a larger scale,

"Reasonably fair, not unnecessary"

If I don't have to go to bed worrying about the bills being paid based on my ability to work at 60 then I would say let AI be free

Perhaps their actions help bring down the cost of living, and despite insufficient income, we may still be capable of living somewhat comfortably

AI improves work efficiency

3:02 AM

Therefore quality of life improves as a side effect

3:02 AM

At a certain point the maslow pyramid is fulfilled without effort

3:03 AM

That is what people are referring to with the basic income idea

I dont make more money though because I work in a factory

It wont happen overnight

I want an AI that makes food cheaper and gas less expensive

Basic income, I think something in its spirit is capable, its essence is what's important, but the form it comes in doesn't work

Pax1l

I want an AI that makes food cheaper and gas less expensive

Or AI advertising that encourages you to eat cheaper sustainable food and buy an electric car

3:05 AM

We will see the middle class disappear

3:05 AM

The lower class will live like royalty

3:05 AM

And the upper class will rule the world

Pax1l

I want an AI that makes food cheaper and gas less expensive

Jevons paradox

The Jevons Paradox states that, in the long term, an increase in efficiency in resource use will generate an increase in resource consumption rather than a decrease.

I already live pretty good except my anxiety and other life issues are sticking points for me.

3:06 AM

An AI replacement for love sounds despotic

I'd love an ai lover/workmate

Character.ai I think does this well

I'd find me a wife and keep my ai workmate as my secret lover

I just couldn't see myself paying credits to use it

jk...hopefully

It's like having a relationship with an online streamer

3:08 AM

Parasocial relationships that can't end unless you run out of money

3:08 AM

That's prostitution 993227921735024690

Parasocial relationships was always my favourite type of relationship...I'm not sure if this still applies but it did long ago

Pax1l

I have no mouth and I must scream comes to mind

I recently had a disturbing nightmare of a future where a rampant AI hacked the mixed reality part of ubiquitous neuralink interface to turn everything into dystopian hellscape resembling the artworks of Beksinski, Geiger, Gammel, etc. Then releases a nanovirus that turns every living thing into monstrous mutations that absorb each other to become stronger. It was like a game for its amusement. I woke up nauseated with my heart racing n shit. (edited)

lov

Parasocial relationships was always my favourite type of relationship...I'm not sure if this still applies but it did long ago

As in ones I couldn't interact with

JC Denton

I recently had a disturbing nightmare of a future where a rampant AI hacked the mixed reality part of ubiquitous neuralink interface to turn everything into dystopian hellscape resembling the artworks of Beksinski, Geiger, Gammel, etc. Then releases a nanovirus that turns every living thing into monstrous mutations that absorb each other to become stronger. It was like a game for its amusement. I woke up nauseated with my heart racing n shit. (edited)

Sounds like my kind of dream

Interaction ruins it for me

I want to make an AI that can change people's perception of reality

3:10 AM

To fit my end goals of enslaving people

3:11 AM

I'd enjoy some of these ai applications if they didn't cost me, I'm too cheap unless they directly help me with a continuous hobby/project or something

Pax1l

To fit my end goals of enslaving people

Have you heard of frank amodeo ?

Want to take over commodities markets in Africa?

lov

Have you heard of frank amodeo ?

Big fan of his work

lmao, same

I want to do what he did

I'd like to similarly but perhaps we need to find our own niches to gather the resources to reach there

Nootropics

3:12 AM

Medicine

Man, the u.s. absolutely fucked him over so badly

I've heard

He shouldn't have resided there

Hear about Simon Mann?

nope

Another mercenary power broker

3:14 AM

But this was a soldier of fortune.

3:15 AM

Was a power broker to members of the British upper class

3:15 AM

He tried to overthrow a country in a coup for wealthy benefactors

3:15 AM

Got stopped right on the tarmack

3:16 AM

Because his partner at the time turned

3:17 AM

Would be interesting to see where you come in the next six months. I was planning on buying into AMD but buying chip companies are expensive ofc.

3:18 AM

Lisa Su Is the highest paid female CEO with good reason.

3:19 AM

Wish the barrier to running my own top end AI powered web server were lower

3:19 AM

Like something that takes api calls to stable diffusion

3:20 AM

Then the GPU would create artwork for clients

3:20 AM

You make money, the AI program funds itself

Pax1l

Because his partner at the time turned

This is why I'm for an ai relationship of any kind, drugs have messed with my mind over the years and I've begun fundamentally trusting people. Before I'd give a sort of trust where it was 50% truly unconditional trust 50% acute awareness of their potential treachery, although I somewhat lowered my guard against those who while could be, just didn't have any motives at the time. And honestly, I truly wanted to be proven wrong, but again and again, people showed their weakness, I don't blame them, it's just what it is. My mind was clouded and I allowed myself to grow conditioned attachments to people who are clear threats with a history littered with large ones to myself and those around them. I have trouble undoing the damage, it's just...difficult

Ah yes. We can become artists

3:22 AM

Paint your soul onto a digital canvas

3:22 AM

Or become an activist

3:23 AM

I was planning on giving out noot advice or fetching research papers I loved to read and talk about

3:24 AM

I think an AI librarian would be the best career if that became a possibility. Like a chat gpt power user and personal assistant

It's about scale, if speed is our goal, where it costs nothing to reproduce the product. Digital assets apply. Music, games, tv shows, Or it can be an event, like a sport or something (sumo, etc), and while a lot of income might come from the audience, the real goal is the digital end of "influencers" and then capitalizing through related music, documentaries, and whatnot

Discord friend groups

You can exploit a group who show loyalty to the brand, those in the effective altruism and rationalist groups are online examples who would be useful examples

Paying people to be friends on discord with random people for money

3:28 AM

Indian practitioners of any religion

3:28 AM

How do we create jobs for these people and pay them a living wage?

Youtube does seem to be a good source of income for those successful, it seems since shorts were introduced, a lot bigger income has been coming in

These call centers need help

3:29 AM

It seems YouTube shorts are ran by a couple large groups

Send them to singapore

lov

Send them to singapore

I need to talk to my friend from around Singapore and ask about giving someone a job paying above us minimum wage

Jokes aside, if they move collectively into various countries where they have a notable diaspora from a long time, they can much easier integrate and possibly better opportunities will be there (edited)

Romania

Pax1l

Romania

I think that's just from a himalyan nomadic group of high enough overlap with them in the past (edited)

Become a broker in self help

lov

I think that's just from a himalyan nomadic group of high enough overlap with them in the past (edited)

Drifters

lov

I think that's just from a himalyan nomadic group of high enough overlap with them in the past (edited)

gypsies I mean

Yes and that makes for an interesting history

3:33 AM

So many opportunities there

3:33 AM

Just operate web servers out of Romania

JC Denton

I recently had a disturbing nightmare of a future where a rampant AI hacked the mixed reality part of ubiquitous neuralink interface to turn everything into dystopian hellscape resembling the artworks of Beksinski, Geiger, Gammel, etc. Then releases a nanovirus that turns every living thing into monstrous mutations that absorb each other to become stronger. It was like a game for its amusement. I woke up nauseated with my heart racing n shit. (edited)

Checks and balances. Always. Every biological system has checks and balanced preventing the spread of cancerous growth. That being said sometimes anomalies in this system appear which result in a localized catastrophe. We are already seeing the use AIs within AIs to verify informational quality and moral agendas. We only need to be as scared as our ability to handle a new outbreak of smallpox-19. I myself am concerned of an AI fueled coldwar where the stalemate is disrupted and huge damages are observed. Maybe we will get lucky. The asteroid that killed the dinosaurs didn't wipe out every animal species. We ourselves the homo sapiens survived an ice age and many more things after that. Like I said, "localized catastrophes."

Sell the servers data services like the one company called shadow

Pax1l

Yes and that makes for an interesting history

btw, I have 2 anime I think you'd get a lot out of https://myanimelist.net/anime.php?id=2596 https://myanimelist.net/anime/48849/Sonny_Boy

3:35 AM

The first one might be more related to you

3:35 AM

The second not really but its fascinating nature is in itself worth it and likely of interest to you

Thanks man. It's my plan to actually run a mesh network of vnc client

3:36 AM

This way I could have PCs all over the world

3:36 AM

Any one person would log into a computer.

3:37 AM

They would be researchers

3:37 AM

And so they would share data and resources in the network

What kind of research

A decoupled internet of online assistants

lov

What kind of research

Medical research and study into neuroscience and internet technologies

3:39 AM

I want to recreate the internet in my image

3:39 AM

They will also run peer to peer repositories of papers immediately relevant to my work

If you can fake some accolades and create a realistic looking organization with an established history, likely conning a university into complying with a formal association and ability to use their name and logo to bring validity to yourself, you can get large grants by the E.U., they really like to give international grants for all kinds of research, especially like yours

The goal is eventually passing as a good online resource for people wanting to change their health.

3:42 AM

A open forum on medicine

Usually, giving some cash to a university club, hopefully related to what you're doing, in exchange for them simply plugging your website into their page on the university site, you trick google search engines to boosting your site in the search results as it automatically places high trust in .edu sites

3:44 AM

And from there, you can use this as a form of "proof", though only one of many, and twist how it's presented on the site to imply your organization is more than it is (edited)

With something like that we can get nootropics better recognition

3:44 AM

The goal is always helping the client

I have an encyclopedia's worth of little obscure tricks in my head lol

Yeah it would be totally fit for discussion but there will be less of a filter

3:46 AM

Something just like discord and a little screensharing can't hurt

3:46 AM

Just become a source for replicable research and people would eventually see it as a good respurce

3:46 AM

Like reading a book

3:47 AM

There was a nips paper proving plank's principle about scientific progress moving one funeral at a time, as older researchers have influence and disregard or outright repress such conflicting positions

3:49 AM

And with younger generations of researchers, after the death of the prominent ones, they're not influenced by them and pick up the obviously superior work

Yeah I kind of want to present research as I see it and allow for commentary

3:51 AM

I have about 8 years of knowledge I want to share on nutrition and molecular biology. I have started researching molecular neuroscience just about 2 years ago

This site may be of interest, it likely captures some things you desire

3:52 AM

https://academic-accelerator.com/Ranking/F1000Prime-Reports

F1000Prime Reports Scientific Journal Ranking 2022-2023 - Academic ...

F1000Prime Reports Journal Ranking 2022-2023 - Academic Accelerator

Have friends that are former neuroscientists and know neuropharmacologists

Ignore the example journal

3:53 AM

Search a different journal

3:53 AM

f1000prime is based af though, a true hidden gem

I love reading meta-analysis but never subscribed to a journal

I need to find more people with university access to papers, for the rare times I get let down by sci-hub and google searches like for an author's personal site, they sometimes upload a copy, or there being a preprint

lov

I need to find more people with university access to papers, for the rare times I get let down by sci-hub and google searches like for an author's personal site, they sometimes upload a copy, or there being a preprint

This is what Aaron Schwartz tried to do at MIT

1

4:00 AM

He just tried stealing everything from Elsevier through an online connection in the server room

I can see myself doing that at his age, but it's such an unnecessary thing to take on the risk for, although it would be cool having access to it freely to rip... the possibility and change you might enact, but the risk of they getting wise to it and making things even harder is hard to account for (edited)

4:07 AM

I wish he was much more advanced than they thought, and was able to execute the judge after he gave the sentence, and then offing himself

4:07 AM

People hate police a lot, I really despise a lot of judges more

4:08 AM

They seem worse than corrupt although corruption causes discontent by the people

4:08 AM

They have the stink of those people who enacted the crusades

bitchyblond2.0

Or AI advertising that encourages you to eat cheaper sustainable food and buy an electric car

Create an ai chatbot with a hidden agenda to manipulate you into being a better person.

Neti

Create an ai chatbot with a hidden agenda to manipulate you into being a better person.

Ok I'm going to start funding militia groups.

Neti

Create an ai chatbot with a hidden agenda to manipulate you into being a better person.

You could do this rn tbh, would take 3 seconds (edited)

Neti

You could do this rn tbh, would take 3 seconds (edited)

If you create another institution to control people I will destroy it

idk how effective itd be though

If you do it neti I will buy a gun

Pax1l

If you create another institution to control people I will destroy it

What about an institution for people to control themselves with? A machine they can insert values into and have taught back to them?

Read the bible

Neti

What about an institution for people to control themselves with? A machine they can insert values into and have taught back to them?

You have no imagination neti

3:34 AM

You're looking at the matrix and you're like yes let's fucking make the matrix real life

3:35 AM

Literally the matrix reloaded

3:35 AM

You suck eggs

For we are not contending against flesh and blood, but against the principalities, against the powers, against the world rulers of this present darkness, against the spiritual hosts of wickedness in the heavenly places. Therefore take the whole armor of God, that you may be able to withstand in the evil day, and having done all, to stand. Ephesians 6:12-13 - Revised Standard Version (RSV)

Neti

For we are not contending against flesh and blood, but against the principalities, against the powers, against the world rulers of this present darkness, against the spiritual hosts of wickedness in the heavenly places. Therefore take the whole armor of God, that you may be able to withstand in the evil day, and having done all, to stand. Ephesians 6:12-13 - Revised Standard Version (RSV)

Mein kampf

3:36 AM

Neti

3:36 AM

Turn back now

Neti

Create an ai chatbot with a hidden agenda to manipulate you into being a better person.

this is kinda what I imagine the role of a wife is for tbh

3:37 AM

wifebot

Neti

this is kinda what I imagine the role of a wife is for tbh

Yeah you will never find one

rude but true

3:38 AM

that is why ai is kinda exciting

Neti

wifebot

Porn addict

1

Neti

that is why ai is kinda exciting

Have you ever stared down the chamber of a loaded 22 luger?

3:38 AM

Because I have

was it kinda exciting>?

Yeah I thought immediately about killing everyone at my house then myself

3:39 AM

Because someone was stupid enough to leave a loaded gun above my toilet

3:41 AM

When you realize that AI is being used to control weak willed people into giving away everything to a literal black box you're not intelligent enough to understand then we can talk again neti

3:41 AM

You're a dissapointment

Pax1l

I want to make an AI that can change people's perception of reality

wait your the one wanting to make the matrix tho pax and you criticize me smh musta had some change of heart over the course of the conversation I havent read yet

Neti

wait your the one wanting to make the matrix tho pax and you criticize me smh musta had some change of heart over the course of the conversation I havent read yet

Nope. I'm the one that's trying to find my own private military contractor and start a global conglomerate to put you into slavery

3:43 AM

I'm actually doing this

glglglglgl godspeed pax

3:43 AM

put us all in the matrix for our own goods

You literally live in canada

3:44 AM

Cuck country

im not a huge fan of the local politics ill be the first to admit (edited)

good morning chat

@Neti Meowing!

Pax1l

You literally live in canada

Don't you live in the US?

Pax1l

Because someone was stupid enough to leave a loaded gun above my toilet

Wtf what tard does that

Soma

@Neti Meowing!

g'meowninggg

Neti

g'meowninggg

(or rlly afternyan att this hour)))

It's 11 PM for me

4:09 AM

I'm sad they removed the major I was taking from my college

Soma

Wtf what tard does that

I'm sure drunk Americans do that more often than they'd like to admit

thenewseth

I'm sure drunk Americans do that more often than they'd like to admit

Even when I've been drunk I didn't fuck with guns that way

Soma

Even when I've been drunk I didn't fuck with guns that way

Congrats on being an edge case? I've seen plenty of stupid stuff in my life and even worse stuff online. The dumbest person in this country who can vote can also own guns. I'm not saying the responsible gun owner is a myth, I'm one, but I know enough irresponsible gun owners.

thenewseth

Congrats on being an edge case? I've seen plenty of stupid stuff in my life and even worse stuff online. The dumbest person in this country who can vote can also own guns. I'm not saying the responsible gun owner is a myth, I'm one, but I know enough irresponsible gun owners.

I had one drunk friend flash everyone at a party with his gun, and when someone asked "Whats the first rule of gun safety" with his response being "Don't be drunk"

There you go. We all know it happens.

Watching an old terence mckenna conversation

His takes on political economy and economics, not the ideas he liked throwing out there but specifically those he seemed to have with conviction, they don't seem consistent with his belief system. His emotions get in the way of it. It happens to most people. Not an issue as long as they accept it, in my eyes. Unfortunately that's not possible here.

8:07 PM

It seems I'm wired to see such inconsistencies, most don't see it in their own thought due to feelings, always so so strange

8:08 PM

Especially if I'm ever making it evident to someone like a friend, I need to fight to cut through the delusion their emotions lead them to

http://www.falstad.com/ripple/ This could be used to make cool background visuals for a video, or atleast segments that could be cycled with other stuff (such as ai works, or text segments) (edited)

https://youtube.com/watch?v=d-53tzx69fM&feature=sharec

Newiew Project

Brian Eno message - Don't get a job

I haven't been much on /r/researchchemicals in past years, coming back, did the community become way more fearmongering rather than analytical? I guess that's the natural progression of things, there really is a wealth of knowledge stored on a couple forums which tends to give you a good impression of seemingly curious things related to whatever chem, as long as it's been out long enough to be examined like that. Literacy is important too of the medium, but what I don't get is pure reactions coming off as condescending to people asking questions. I remember multiple influxes of new users in various places like bluelight, this sub etc, and the progression they had from enthusiasts asking questions and eventually building their literacy in the medium due to the specific pressures the culture had for pushing people towards knowledge rather than...what seems like folk supernatural reasoning although with airs of the partially appropriate vocabulary.

As a group gets more popular the average intelligence of its members declines, so gatekeeping behavior becomes more reasonable

3

1

https://twitter.com/Neuro_Skeptic/status/1450016399313674242

Neuroskeptic 🇺🇦 (@Neuro_Skeptic)

All success is a combination of talent, hard work, and luck. But having the dedication to work hard is a form of talent, and being born with talent is just luck.

Likes

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yooo, I just remembered, space has a ton of space, like just empty...and holy shit we could still see shit despite that

There's a fun astronomical paradox dealing with this fact

10:03 PM

https://en.m.wikipedia.org/wiki/Olbers'_paradox

Olbers' paradox

Olbers's paradox, also known as the dark night sky paradox, is an argument in astrophysics and physical cosmology that says that the darkness of the night sky conflicts with the assumption of an infinite and eternal static universe. In the hypothetical case that the universe is static, homogeneous at a large scale, and populated by an infinite...

Why should one get huge biceps and triceps except for choking people out

12:07 AM

I'm speaking as someone who's triceptually challenged biologically

looking at themselves in the mirror to feel good about themselves somehow

But it doesn't even have that much aesthetic!

12:08 AM

Madness

They think they're manly or strong or something

12:08 AM

Right

12:08 AM

Depends how huge we're talking. Mens sanus in corpore sano is a sound principle

Understandable

Saw a video with a celeb a while back talking about the program a lot of them do from some trainer to get a certain aesthetic body. And upon closer inspection, it's literally a lie, like if you briefly see them in video without proper inspection, you think they're ripped. It's mostly just having cuts at the right intersections between muscle groups. And they're not even properly symmetrical when I looked closely, full illusion. This trainer got popular because I figure it's the fastest path to looking more decent than they were before in their minds. A sprinkle of juice and a speedrun into...don't even know how to describe it. I mean, when they're moving it does have an aesthetic, I also think they had some makeup to make the shadow even and deeper. And perhaps the editor also adds a little to make it look better sometimes

I think too much energy is siphoned to maintain such

12:15 AM

Not all times but in general yeah

12:16 AM

Pure body > power

The body will spare glucose or ketones for the brain and rely on beta oxidation in the muscles if need be. I do know that obesity leads to less blood flow to the brain but I'm not sure if that would also be applicable with bodybuilder level muscles. It could just be a symptom of poor vascular health rather than the increase in mass specifically

The 3 most important things I am planning for, is just enough strength and flexibility in the right places to maintain a good posture, strong forearms because I like the dadbod aesthetic of big forearms lol, and nicely shaped, big traps, as it has a nice look to it and I'm predisposed to it growing well so might as well max that strength.

Bodybuilders aren't the picture of good health anyway. Farmer strong and on the leaner side is ideal.

Mangy Dingo

The body will spare glucose or ketones for the brain and rely on beta oxidation in the muscles if need be. I do know that obesity leads to less blood flow to the brain but I'm not sure if that would also be applicable with bodybuilder level muscles. It could just be a symptom of poor vascular health rather than the increase in mass specifically

I also think too much muscle decreases blood flow to the brain as the extra pathways it needs to travel slows down the concentration that can be there slightly. It's probab not huge as the brain will obviously always take precedent, but from my observations, there def seems to be a difference

How do you know that blood volume doesn't adjust accordingly?

12:22 AM

That would be why I suspect vascular issues in the case of obesity. Though a lean 180 lbs is still a lot less mass than a fat 300 so in the upper levels of weight it's probably still applicable

Mangy Dingo

How do you know that blood volume doesn't adjust accordingly?

It def does, but more surface area for flow = more friction, especially with red blood cells which can cause a lot of friction

Mangy Dingo

The body will spare glucose or ketones for the brain and rely on beta oxidation in the muscles if need be. I do know that obesity leads to less blood flow to the brain but I'm not sure if that would also be applicable with bodybuilder level muscles. It could just be a symptom of poor vascular health rather than the increase in mass specifically

I plan to cheaply source trimetazidine to prevent beta oxidation, I can get it at the pharmacy here but not a fan of the price

Why would you want to do that?

It's good for the heart's health, and beta oxidation is an extremely destructive form of energy production

Why's that?

It often indirectly produces ferroptosis

12:25 AM

And it requires more oxygen for the same amount of energy vs glucose, so is dangerous in ischemia

Are we talking beta oxidation alone or ketosis?

It also trains the cells to prefer glucose long term

Mangy Dingo

Are we talking beta oxidation alone or ketosis?

beta oxidation for ferroptosis (edited)

12:27 AM

ketosis too for the oxygen thing, but both here (edited)

https://www.sciencedirect.com/science/article/pii/S109727652200260X Beta-oxidation is generally believed to have a suppressive effect on ferroptosis by decreasing the availability of unesterified PUFAs.

Ferroptosis at the intersection of lipid metabolism and cellular si...

Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated to play an important role in multiple diseases including can…

12:28 AM

I'm not sure what you mean by preference for glucose. Some cells will prefer it and some won't, depending on local insulin status

12:29 AM

Re ketogenesis, the Gibbs free energy difference of ketones means that the energy production will be equivalent despite higher oxygen consumption

lov

beta oxidation for ferroptosis (edited)

I recall both me and Pax found this to be true but we both found it through different biochemical routes, I gotta refind my mechanism for why

I'm sure it does in some contexts, but that doesn't necessarily mean it's bad. Another example is the generation of greater ROS by oxidation of saturated fats which may be a signal for mitochondrial differentiation

Mangy Dingo

Re ketogenesis, the Gibbs free energy difference of ketones means that the energy production will be equivalent despite higher oxygen consumption

Yea but in the absence of enough oxygen, it triggers cascading effects in both the heart and brain tissue as it screws up a certain ion balance that needs to be maintained

Has it been shown to do this conclusively or are you speculating from the respiratory quotient?

12:31 AM

Bhb is likely beneficial in brain injury so I'm skeptical

Mangy Dingo

I'm sure it does in some contexts, but that doesn't necessarily mean it's bad. Another example is the generation of greater ROS by oxidation of saturated fats which may be a signal for mitochondrial differentiation

I mean, it's calculating the cost-benefit ratio for one's specific needs, for athletes, you'd want to prepare for ischemic situations specifically

12:32 AM

And they already get mitochondrial diff I bet from other routes

Are you familiar with the lactate shuttle hypothesis?

Mangy Dingo

Bhb is likely beneficial in brain injury so I'm skeptical

yea, but it's not beneficial through energy production, it acts as a hdac which causes its positive effects, it'll still do that. And even if this wasn't the case, it'd be a question of acute vs slow, it might be positive in a long term fashion, but its preference in an acute state of ischaemia would be iffy for that gradient I mentioned

Mangy Dingo

Are you familiar with the lactate shuttle hypothesis?

nope

The HDAC aspect has anti inflammatory etc benefits yes. I'm not sure that's the sum of it though

12:36 AM

https://en.m.wikipedia.org/wiki/Lactate_shuttle_hypothesis

Lactate shuttle hypothesis

The lactate shuttle hypothesis describes the movement of lactate intracellularly (within a cell) and intercellularly (between cells). The hypothesis is based on the observation that lactate is formed and utilized continuously in diverse cells under both anaerobic and aerobic conditions. Further, lactate produced at sites with high rates of glyc...

12:36 AM

In an exercise context glucose recycling from lactate production will increase quite a bit. Cahill also showed this in fasting studies

12:37 AM

You'll also, as I mentioned, produce roughly the same energy per oxygen because of the Gibbs free energy difference, when burning ketones. Give me a second to find a reference

12:39 AM

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212585/

Acute nutritional ketosis: implications for exercise performance an...

Ketone bodies acetoacetate (AcAc) and D-β-hydroxybutyrate (βHB) may provide an alternative carbon source to fuel exercise when delivered acutely in nutritional form. The metabolic actions of ketone bodies are based on sound evolutionary ...

12:39 AM

Haven't read but this seems to talk about it

Mangy Dingo

The HDAC aspect has anti inflammatory etc benefits yes. I'm not sure that's the sum of it though

I can't argue why as I don't remember clearly, but I feel like I looked into this long ago and the hdac aspect was big for neurotrophic reasons. It's raised levels in olanzapine (or one of them, can't remember which lol) partially helps various conditions negative symptoms much better than antipsychotics that don't trigger it, and a shown neurotrophic aspect was shown iirc And valproate's hdac properties is shown to have a neurotrophic effect from the same area iirc, and has been shown to have a phenotypic effect in being able to learn perfect pitch in adulthood despite this usually not being the case in adulthood

It might help for various reasons. One is providing an alternative to glucose in cases of glucose hypometabolism. Another is HDACi. Another is increase in glutathione synthesis (and concomitant redirection of glutamate; this is also probably why NAC is effective). Another is slightly increasing brain acidity which changes the threshold for sodium channels (a potential mechanism for lithium as well). Etc etc

12:43 AM

Re perfect pitch, I've noticed this aspect of HDACi's. Great for memory. Prl-8-53 is sometimes speculated to have that mechanism

Mangy Dingo

You'll also, as I mentioned, produce roughly the same energy per oxygen because of the Gibbs free energy difference, when burning ketones. Give me a second to find a reference

Well I don't know why then both Trimetazidine & Meldonium would be shown in trials to help in ischaemic situations from a wide set of heart conditions and not being specific to any one condition (edited)

I couldn't say because I haven't read anything about them. Drugs tend to do multiple things though and sometimes the mechanism isn't the obvious one, eg statins are potently anti inflammatory and the lower cholesterol may be irrelevant

They are 2 slightly different mechanisms but converge in effect for switching metabolism to favour glucose, so because of them being different and this one convergent effect being the case, and both being shown for the same reasons, improved athletic ability, and same form of protection for heart conditions, makes me trust the explanation I gave (edited)

Again, I can't comment. But they likely do multiple things. The body is a vast complex of feedback loops and something might be beneficial in some contexts but harmful in others. And sometimes we're completely wrong on the mechanisms why

Yea, but very different structures for 2 drugs, different mechanisms, but converges in both this glucose metabolism thing indirectly, and their phenotypic effects, this is basically like triangulating the explanation why (edited)

In a system with one million variables you can make very convincing signals out of noise

12:49 AM

Have you read Foucault's pendulum?

I mean this reasoning is in-line with what is done through double blind trials, getting caught up in the biochemistry clouds people's reasoning often imo

12:50 AM

As it's too complex as you've said

Mangy Dingo

In a system with one million variables you can make very convincing signals out of noise

Makes sense lol

12:51 AM

Comes down to what you want to will into existence I guess

https://pastebin.com/GVJfQUKA

Last night I happened to come across a driver’s manual. Maybe it wa...

Pastebin.com is the number one paste tool since 2002. Pastebin is a website where you can store text online for a set period of time.

12:52 AM

Quote too long for discord

Oh, I was looking into the whole systems framework for complex systems like biochemistry of an organism

12:53 AM

and motifs that appear

12:53 AM

a short while back (edited)

12:53 AM

Isn't this cool

Fun

I really want to get into machine learning as it abstracts a lot of these things best and one can actually test the things out rather than it being looking into causal factors in complex systems, I mean short of engineering an actual organism, it gives one the ability to confirm through cheap, fast experiment

12:58 AM

wrt motifs I mean, understanding them. A periodic table of them would be cool

I think the connections it makes may be incomprehensible to us

12:59 AM

There was a study recently of an AI trained on simple simulated systems and it came up with "laws of physics" completely different to our own

A related field is like what is done at https://blogs.brandeis.edu/marderlab/research/ which is doing something similar but for lobster gut neurons (edited)

interesting

1:01 AM

Yeah I mean tech can be used for cool shit but also it's funny cuz people literally put trust into a reality with them manifesting some literal dog shit reality

The lobster gut neurons are special amongst organisms because it can remain alive after being removed from the organism

1:01 AM

which makes it ideal to study

The central pattern generators in the stomatogastric ganglion (STG) of lobsters and crabs are ideal for many analyses because the STG has only about 30 large neurons, the connectivity is established, the neurons are easy to record from, and when the stomatogastric ganglion is removed from the animal, it continues to produce rhythmic motor patterns.

(edited)

Mmm

1:02 AM

Bookmarking

1:02 AM

How like gut health and bacteria can be the key to many things

1:02 AM

Some people eat only meat or raw meat and all of their symptoms go away and disease

1:03 AM

Some are vegan and take certain supplements or fermented veggies etc and achieve the same

Amber ohearn of the carnivore community has a speculation concerning that

1:04 AM

She thinks vegan diets may be beneficial because of "carbosis," ie a low fat (or at least low pufa) diet draining the membranes of pufa and thus lowering oxidative liability

1:04 AM

There are probably other reasons as well but that's an interesting one

I'm accidentally causing the effect intermittent fasting does because I'm vegan and stay away from protein

1:05 AM

One side-effect is extremely slow healing of wounds

How's your vitamin k intake?

‍♂️ no idea

I think blood flow has a lot to do with many things

1

1:06 AM

I've been working a new job lifting heavy packages and am feeling way better in life

I've noticed slow wound healing on extended fasts that recovered somewhat with K2 supplementation

Mangy Dingo

I've noticed slow wound healing on extended fasts that recovered somewhat with K2 supplementation

I'll look into it, actually would be something I want go away

I did shipping and receiving for five years. Best job I ever had

Algae DHA is one of the best nutrients I've ever implemented, need to get back on it

I can only handle pain well when I've worked hard with a lot of blood flowing, and the pain is at places where were strained with dynamic activity

formless

Algae DHA is one of the best nutrients I've ever implemented, need to get back on it

Why algae? Also vegan?

Mangy Dingo

Why algae? Also vegan?

Well if u think about it energy comes from the sun, absorbed by algae

1:10 AM

Fish eat all that etc

formless

Algae DHA is one of the best nutrients I've ever implemented, need to get back on it

extra virgin olive oil is next level too, separate from its direct effects, it influences the hypothalamus to reduce the production of certain fats and cholesterol in the liver, and separate from this, it has an intense effect on inflammation. If I'm smoking a lot, it often prevents angina, which gets worse from other fats if I eat a high-ish fat meal prior (edited)

When I take it my thoughts connect way better

lov

extra virgin olive oil is next level too, separate from its direct effects, it influences the hypothalamus to reduce the production of certain fats and cholesterol in the liver, and separate from this, it has an intense effect on inflammation. If I'm smoking a lot, it often prevents angina, which gets worse from other fats if I eat a high-ish fat meal prior (edited)

Yeah the anti aging dude drinks it as a part of his diet I guess it's legit

formless

When I take it my thoughts connect way better

But why not fish oil? It's significantly cheaper, unless you have ethical concerns

I don't think it works as well

formless

Yeah the anti aging dude drinks it as a part of his diet I guess it's legit

I drink it as well raw occasionally

Also there's some cheap ones you just gotta look, imo iwi algae dha is a great brand

1:12 AM

Very pure

I eat quite a lot of fish so I don't need to supplement

It reduces cox2 with similar intensity to ibuprofen and it seems separate from that to reduce inflammation from an inflammatory disorder I have, the former is legit, the latter reduction in inflammation might just be specific to those with said condition

1

Chronic cox2 inhibition is a bad idea. You need prostaglandin e2 to resolve inflammation. It's not like back in the 90s when we thought resolvins were the only way

It does it from a different pathway or something like that, I don't remember the details but it seemed to get around such an issue I believe

Could be. As I said previously, the body is staggeringly complex. I'd be wary of overuse of anti inflammatories though

1:16 AM

I don't know about the olive oil/cox2 connection though so couldn't say. But people tend to think anti inflammatory effects are always good and never bad

Autophagy etc aside, I'd rather to be on the heavier reduction on inflammation because the sides from mastocytosis including IBS sucks ass

Ever given dry fasting a try? (edited)

My immune system has attacked my skin sometimes which caused abscesses, once which the doc had to cut out

Mangy Dingo

Ever given dry fasting a try? (edited)

I technically do it I guess intermittently

1:19 AM

Dehydration has gone up in recent years, I got this weird kidney issue which causes water to continually run through me

1:20 AM

Like I'd not remove all my urine whenever I went to pee, which would screw up my levels of thirst and just cumulatively cause me to drink my stomach full of water, then pee multiple times every hour or

Have you been tested for diabetes?

No, but it has been happening to me since I was like 5

1:21 AM

so i don't think it'd be that

Are you American?

Never drank sugary drinks, and was skin and bone back then

Hmm

Man, growing up, teachers would tell me I couldn't go and pee because I should've gone during recess/lunch break, but I'd be like I WENT MULTIPLE TIMES MOFO

Sounds like diabetes insipidus

That's what I thought from reading, could it be caused without the usual cause, like from birth?

It's a vasopressin deficiency, often caused by genetics

1:24 AM

Can also be hypothalamic or pituitary damage

Mangy Dingo

It's a vasopressin deficiency, often caused by genetics

OH, I also thought I had that once, one side-effect from that is reduced binding of oxytocin to its receptors and I do have phenotypic traits of low oxytocin activity ever since (edited)

Should have a doctor test you for it then

What would be the test?

1:26 AM

I assumed there wasn't any

1:27 AM

Or if there was, it wouldn't change anything

Afaik they look at the electrolytes in your urine

1:27 AM

And figure it out from there

Would this cause intense sweating during physical activity, as I do get that too

I'm not sure

‍♂️ I'll donate my corpse so whomever could learn wtf was up with me in live

https://www.labcorp.com/resource/water-deprivation-test

Water Deprivation Test | Labcorp

The water deprivation test has been used as an aid in the diagnosis of polyuric disorders. Individuals with diabetes insipidus (DI), due to hypothalamic (HDI) cannot conserve free water.

1:31 AM

Seems like it should be simple enough

Neti

panax ginseng and myricetin from green tea (but also available as a stand along supplmenet) both increase GLP-1 activity I believe

Thoughts on pairing it with fasoracetam? Wi they upregulate gaba b from phenibut?

miami33161jr

Thoughts on pairing it with fasoracetam? Wi they upregulate gaba b from phenibut?

I’m not personally aware of whether there’s any ongoing broader discussions about potential links between the gabaergic system and those specific insulinergic energy management systems (edited)

8:43 PM

Why do you ask though?

Ketosis has that effect. Not sure exactly how however. Something something redirecting glutamine towards gluconeogenesis?

8:45 PM

"In ketosis, less glutamate is metabolized and more becomes available to the glutamate decarboxylase reaction for the purpose of GABA synthesis" What Google tells me

Neti

Why do you ask though?

Because when doing phenibut 2x a week it desensitizes gaba trying to look for something to take in between gaba b downregulation

miami33161jr

Because when doing phenibut 2x a week it desensitizes gaba trying to look for something to take in between gaba b downregulation

ya but why that message of mine

Neti

ya but why that message of mine

U had experience with ginseng and fasoracetam based on your old comments I guess

Idk if I’ve ever taken faso

Neti

Idk if I’ve ever taken faso

I also wanted to ask Ik u suggested white willow bark Kratom but how about Krabot - spectrum maeng da Kratom - Ganons blend . I think it’s a mixture of all 3 strains red white blue , similar effects to phenibut for social anxiety?

I played with this idea somewhere else but I'll put it to you guys, there seems to be a profound difference that happens between different sets of people who use "consciousness expanding agents" (classic psychedelics) where instead of become more contemplative etc etc which occurs with one set, the other become more animalistic. Ofc aspects of both are shared with all, but it's like they have a natural inclination to that primal animalistic self away from the rational self. It's a phenomenon I suspect which caused a lot of psychedelic using societies in the distant past to control its use and keep it for those with some intellectual cultural background or who show that inclination. Or for a religious class but let's ignore that one. You see deep fragmentation in those societies where it freely was used, and more primal rites being important to them. Consciousness feels effortful, it seems we congregate towards two poles which have those who for some reason wish to experience that effortful attention, and those who would rather leave it up to the flow of the universe and the rhythms of their tribe.

6:32 AM

Dissociatives and similar drugs have a strange effect, it seems to deactivate certain populations of neurons and active others, where some can lead to that higher consciousness while suppressing anxiety.

Pretty dope

UltimApe

Molybdenum you say? "Revisit gut microbiota and its impact on human health and disease" [JUL 2019] from 'Journal of Food and Drug Analysis' highlights some additional insights to the Molybdenum/bacteria related inflammation processes aside from butyrate/propionate levels. https://doi.org/10.1016/j.jfda.2018.12.012

wanted to follow up on this with reards to @Totouroboros Totouboros's idea of Molybdenum. We ended up going with stinging nettle tea thru some research. I think you are right the Acetaldehyde problem was a key factor in the inflammation. https://twitter.com/ultimape/status/1628911638756696065 We ended up getting to see an infectious disease doctor and the fluconazole was apparently prescribed wrong, so we got a big dose of that and it killed off the candida. However she got the liver / bile problems from it so that kinda sucked. Turns out FMTs fix this lmao. (edited)

_ (@ultimape)

@BioavailableNd @Beteljuice I had been trying to find a dietary source of molybdenum and it turns out that has it too. Great plant. https://t.co/gdun1WjL5O https://t.co/5vQxFwaWME

when a human downloads art into their brain and makes new content influenced by it, we call it being inspired. When a machine does it, we call it theft

6:21 AM

We stand on the shoulders of giants

@Pax1l Hello legendary man

9:50 PM

@Pax1l PAX!